[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of the Basque Country (UPV\u002FEHU)\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":76},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100631300","lasaion-is-an-evidence-informed-multimodal-self-regulation-program-designed-to-reduce-emotional-distress-and-strengthen-stress-regulation-skills-by-combining-transcutaneous-auricular-vagus-nerve-stimulation-tavns-with-breathing-supported-by-heart-rate-variability-biofeedback-hrv-b-emwave-100631300",false,"NCT07498881","LasaiON is an Evidence-informed, Multimodal Self-regulation Program Designed to Reduce Emotional Distress and Strengthen Stress-regulation Skills by Combining Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Breathing Supported by Heart-rate Variability Biofeedback (HRV-B; emWave).","LasaiOn: An Intervention Program to Reduce Emotional Distress","LasaiON","Inclusion Criteria:\n\n* Ability to provide written informed consent\n* Physically healthy, with no relevant uncontrolled medical condition\n* Availability to complete the 5-day study protocol (1 session\u002Fday), including baseline and post-intervention assessments\n* Intact external ear and suitability for electrode placement on the tragus and acquisition of study recordings (EEG, EDA, HRV)\n\nExclusion Criteria:\n\n* History of cardiovascular disease, diabetes, or hypertension\n* Severe bradycardia\n* Active implanted electronic device (e.g., pacemaker, cochlear implant, neurostimulator)\n* History of vagus nerve transection surgery (cervical vagotomy)\n* Pregnancy\n* Current or past clinically significant psychiatric disorder\n* Current or past clinically significant neurological disorder\n* Use of CNS-active medication\n* Substance misuse, including nicotine or alcohol\n* Dermatitis, infection, or lesions of the ear that could interfere with electrode application\n* Ongoing treatment with medications that modulate autonomic nervous system activity or may alter psychophysiological measures (e.g., HRV, EDA, EEG)",true,"ALL",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate whether the LasaiON program, which combines transcutaneous auricular vagus nerve stimulation (taVNS) with breathing supported by heart rate variability biofeedback (HRV-B; emWave), reduces emotional distress and improves stress-regulation processes in adults. The study will also assess the safety, tolerability, and feasibility of the intervention.\n\nThe main questions it aims to answer are:\n\n1. Does the LasaiON program reduce emotional distress in adults?\n2. What physiological, psychological, and verbal-cognitive changes are observed following the intervention?\n3. What discomforts, adverse effects, or tolerability issues do participants experience during the program?\n\nResearchers will use a prospective 2 × 2 factorial randomized controlled design to examine the effects of stimulation condition (active taVNS vs. sham taVNS) and training condition (active HRV-biofeedback vs. control training), as well as their potential interaction. Participants will be randomly allocated in equal proportions (1:1:1:1) to one of four groups: sham taVNS + control training, sham taVNS + HRV-biofeedback, active taVNS + control training, or active taVNS + HRV-biofeedback.\n\nParticipants will:\n\n* undergo baseline assessments on Day 1 before the intervention;\n* complete 5 consecutive daily 60-minute sessions according to group allocation;\n* undergo post-intervention assessments on Day 5 after the final session;\n* complete psychometric, physiological, and verbal-cognitive assessments, including STAI, HAM-D, WHO-5, EEG, skin conductance, startle response, heart rate variability measures derived using Kubios HRV Premium, and daily five-word reports with valence ratings analyzed using IRaMuTeQ;\n* have adherence and tolerability recorded at each session using a checklist.",[27],"Adult",[29,30],"slow, paced breathing","transauricualr vagus nerve stimulation","NOT_YET_RECRUITING","2026-03-23",{"date":34,"type":35},"2026-03-27","ACTUAL",{"date":37,"type":21},"2026-03-30",{"date":39,"type":21},"2028-03-30",{"name":41,"class":42},"University of the Basque Country (UPV\u002FEHU)","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":17,"sex":18,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":43},"100625045","active-pauses-for-musculoskeletal-disorder-prevention-in-workers-100625045","NCT07417527","Active Pauses for Musculoskeletal Disorder Prevention in Workers","Prevention Program for Musculoskeletal Disorders Through Active Pauses for Workers in the Basque Country","Inclusion Criteria:\n\n* Active workers.\n* Aged 18 years or older.\n* Capability to perform vigorous physical exercise.\n\nExclusion Criteria:\n\n* Medical contraindications to physical exercise.\n* Recent surgery.\n* Pregnancy.","18 Years",{"count":53,"type":21},150,[24],"The goal of this clinical trial is to learn if short exercise breaks at work can prevent muscle and joint pain in workers. The main questions it aims to answer are:\n\nDo strength exercises help workers move better and feel less pain?\n\nAre strength exercises better than stretching exercises for worker health?\n\nResearchers will compare a strength exercise program to a mobility (stretching) program to see which one works better to improve physical health and work ability.\n\nParticipants will:\n\nPerform short exercise breaks (5 minutes) at their workplace every day for 8 weeks.\n\nAttend one supervised session per week to learn the exercises.\n\nComplete simple physical tests (like standing up from a chair) and answer surveys about their health at the start and end of the study.",[57,58,59,60],"Musculoskeletal Disorders (MSDs)","Occupational Diseases","Sedentary Behaviors","Prevention",[62,63,64,65,66],"Active Pauses","Workplace Exercise","Strength Training","Stretching","Occupational Health","RECRUITING","2026-02-17",{"date":70,"type":35},"2026-02-19",{"date":72,"type":35},"2026-01-01",{"date":74,"type":21},"2029-12",{"name":41,"class":42},""]