[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of the Philippines\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100445386","bacterial-cellulose-monolaurin-hydrogel-for-acute-radiation-dermatitis-100445386",false,"NCT05079763","Bacterial Cellulose-monolaurin Hydrogel for Acute Radiation Dermatitis","Bacterial Cellulose-monolaurin Hydrogel for Preventing Therapy-induced High-grade Acute Dermatitis Among Filipinos With Breast Adenocarcinoma: a Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Female sex at birth\n* Age at least 18 years at the time of invitation\n* Eastern Cooperative Oncology Group (ECOG) Performance Status score of either 0 or 1\n* With histopathologic diagnosis of breast carcinoma\n* Already completed prescribed mastectomy and chemotherapy (adjuvant or neoadjuvant) interventions\n* Scheduled to receive hypo fractionated postmastectomy-postchemotherapy radiation therapy\n\nExclusion Criteria:\n\n* Pregnant or lactating\n* With concurrent or previous history of any malignancy\n* With history of mediastinal or thoracic irradiation\n* With current bilateral synchronous breast carcinoma\n* With diagnosis of metastases from any form of breast cancer\n* With any skin lesion in the planned radiation field deemed deramtologically and\u002For radiotherapeutically relevant\n* With concomitant disease states deemed clinically significant (connective tissue diseases, infections, uncontrolled chronic disorders, renal failure, hepatic dysfunction, etc.)\n* With known history of hypersensitivities and\u002For reactions against any component of either experimental or comparator interventions\n* Inability to personally provide informed consent or to personally comply with skin care instructions","FEMALE","18 Years","80 Years",{"count":20,"type":21},54,"ESTIMATED","INTERVENTIONAL",[24],"NA","Acute radiation dermatitis (ARD) is almost universally experienced by patients with cancer during or after radiation therapy. This condition potentially leads to detrimental clinical outcomes as it adversely affects adherence to prescribed subsequent management and further worsens quality of life. Nevertheless, there remains no consensus on the appropriate intervention for ARD. This pilot two parallel-group randomized trial aims to clinically assess the potential of bacterial cellulose-monolaurin hydrogel, compared to placebo cream, to prevent high-grade ARD among Filipinos with breast cancer up to four weeks after last radiotherapy session.",[27],"Acute Radiation Dermatitis",[29,30,31,32],"ARD","postmastectomy","breast cancer","breast adenocarcinoma","RECRUITING","2026-01-08",{"date":36,"type":37},"2026-01-12","ACTUAL",{"date":39,"type":37},"2021-09-01",{"date":41,"type":21},"2028-12-31",{"name":43,"class":44},"University of the Philippines","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":54,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":45},"100500832","monitoring-drug-efficacy-in-patients-with-alzheimers-disease-100500832","NCT05801380","Monitoring Drug Efficacy in Patients with Alzheimer's Disease","Monitoring Drug Efficacy Through Multi-omics Research Initiative in Alzheimer's Disease","MEMORI-AD","Inclusion Criteria:\n\n* newly diagnosed with mild or moderate dementia using the Montreal Cognitive Assessment and Clinical Dementia Rating (CDR) performed by a licensed psychometrician\n* clinically diagnosed by an expert adult neurologist as having probable AD using the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria\n* treatment naive for any acetylcholinesterase inhibitors or memantine OR those who have not taken any acetylcholinesterase inhibitors or memantine in the last three months for any reasons except for adverse drug reaction\n* age 65 years old\n* residing in the National Capital Region\n* able to read and understand written and spoken English and Filipino\n\nExclusion Criteria:\n\n* with structural or vascular causes of dementia other than subcortical lacunes (2 or less) as seen in plain CT scan\n* dementia diagnosis other than AD as determined by an expert adult neurologist\n* with untreated depression or related psychiatric disorders in the last 6 months\n* use of systemic antibotics in the previous three months prior to providing fecal specimens\n* use of corticosteroids, immune stimulating medications, and immunosuppressive agents within the past 2 weeks or those who regularly need them for immune-related disorders\n* use of proton-pump inhibitors, H2-receptor antagonists, H2-receptor antagonists, tricyclic antidepressants, narcotics, anticholinergic medications, laxatives or anti-diarrheal in the past 4 weeks\n* large doses of commercial probiotics consumed (greater than or equal to 108 cfu or organisms per day)\n* major dietary change during previous month (defined as eliminating or significantly increasing a major food group)\n* major GI tract surgery in the past 5 years, with the exception of cholecystectomy and appendectomy\n* major bowel resection at any time\n* active uncontrolled GI disorders or diseases, including inflammatory bowel disease, indeterminate colitis, irritable bowel syndrome, persistent infectious gastroenteritis, colitis or gastritis, persistent or chronic diarrhea of unknown etiology, recurrent Clostridium difficile infection, untreated Helicobacter pylori infection, chronic constipation","ALL","65 Years",{"count":57,"type":21},60,"OBSERVATIONAL","This study will explore the different factors associated with drug response to acetylcholinesterase (AChE) inhibitor (donepezil) and NMDA receptor antagonist (memantine) in patients with Alzheimer's Disease.",[61],"Alzheimer Disease",[63,64],"multiOMICs","drug response","2025-01-05",{"date":67,"type":37},"2025-01-07",{"date":69,"type":37},"2022-02-14",{"date":71,"type":21},"2026-02-14",{"name":43,"class":44},""]