[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Utku Gürhan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":121},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100638384","blood-cell-ratios-as-predictors-of-response-to-platelet-rich-plasma-in-knee-osteoarthritis-100638384",false,"NCT07617233","Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis","Baseline Neutrophil-to-Lymphocyte Ratio and Related Complete Blood Count-Derived Inflammatory Indices as Predictors of Clinical Response to Intra-Articular Platelet-Rich Plasma in Knee Osteoarthritis: A Prospective Single-Arm Cohort Study","PRP-NLR","Inclusion Criteria:\n\n* Age 40 to 60 years\n* Symptomatic primary knee osteoarthritis, Kellgren-Lawrence grade 2 or 3 on weight-bearing radiographs\n* Body mass index below 40\n* Candidate for and scheduled to receive a course of intra-articular platelet-rich plasma for the index knee\n* Able and willing to provide written informed consent and to attend the 6-month follow-up schedule\n\nExclusion Criteria:\n\n* Systemic inflammatory or autoimmune disease\n* Active acute infection at the time of enrollment\n* Current anticoagulant or antiplatelet therapy, or current or recent chemotherapy\n* Any contraindication to platelet-rich plasma per the 2025 GRIIP recommendations\n* Intra-articular injection of the index knee within the previous 6 months\n* Inability to comply with the planned follow-up schedule","ALL","40 Years","60 Years",{"count":21,"type":22},120,"ESTIMATED","OBSERVATIONAL","Intra-articular platelet-rich plasma (PRP) injection is a widely used treatment for knee osteoarthritis, but patients respond to it very differently and there is currently no simple, inexpensive way to predict who will benefit. The neutrophil-to-lymphocyte ratio (NLR) and related indices derived from a routine complete blood count reflect a person's baseline inflammatory state. This prospective single-arm observational cohort study investigates whether the baseline NLR, together with the platelet-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII), and the monocyte-to-lymphocyte ratio (MLR), predicts the clinical response to intra-articular PRP in patients with Kellgren-Lawrence grade 2 to 3 knee osteoarthritis. The investigators will enroll 120 patients aged 40 to 60 years, each of whom receives a standardized course of three leukocyte-poor PRP injections one week apart. Patients are followed for 6 months, and the primary clinical outcome is the change in the WOMAC osteoarthritis index at 6 months. Outcome assessors are blinded to patients' blood-count values. If a baseline blood ratio predicts response, it could become a low-cost tool to guide patient selection for PRP.",[26,27],"Knee Osteoarthritis","Osteoarthritis",[29,30,31,32,33,34,35,36,37,38,39],"platelet-rich plasma","PRP","knee osteoarthritis","neutrophil-to-lymphocyte ratio","NLR","systemic immune-inflammation index","biomarker","predictor","intra-articular injection","WOMAC","inflammatory index","NOT_YET_RECRUITING","2026-06-18",{"date":43,"type":44},"2026-06-23","ACTUAL",{"date":46,"type":22},"2026-09",{"date":48,"type":22},"2027-07",{"name":50,"class":51},"Utku Gürhan","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},"100641416","patient-ai-trust-dynamics-before-and-after-orthopedic-consultation-ortho-op-gpt-100641416","NCT07631585","Patient AI Trust Dynamics Before and After Orthopedic Consultation (ORTHO-OP-GPT)","Longitudinal Pre-Post Patient AI Trust Dynamics in Orthopedic Outpatients: A Mixed-Methods Observational Study With Matched Physician-Patient Dyads","ORTHO-OP-GPT","Inclusion Criteria:\n\n* Age 18 years or older\n* Presenting to an orthopedic outpatient clinic for any consultation\n* Able to read and respond to a Turkish-language questionnaire\n* Provides informed consent\n\nExclusion Criteria:\n\n* Inability to complete a self-report questionnaire (e.g., severe cognitive impairment, language barrier)\n* Re-presentation within the same recruitment window (each patient is enrolled only once)\n* Refusal of consent for either T0 or T1","18 Years",{"count":63,"type":22},180,"Patients increasingly consult artificial intelligence (AI) chatbots such as ChatGPT for health information before clinical visits, yet the impact of an actual orthopedic consultation on patient trust in AI-derived information remains unknown. This prospective longitudinal observational study quantifies how a single orthopedic outpatient consultation modifies patient trust in AI chatbots, the concordance between AI-derived and physician-delivered information, and patient anxiety, using a paired pre-post survey design supplemented by a matched physician-side assessment. Adult patients (18 years and older) presenting to two orthopedic outpatient clinics in Cyprus complete a brief pre-consultation questionnaire (T0) capturing demographics, AI use patterns, prior AI consultation regarding the current complaint, baseline trust, expectations, and anxiety. Immediately after their consultation they complete a second questionnaire (T1) assessing concordance with physician advice, trust change, consultation facilitation, post-consultation anxiety, and future intention. The consulting physician completes a brief 30-second post-visit form capturing whether AI was discussed, the medical accuracy of AI-derived information conveyed by the patient, and the effect of the AI discussion on consultation duration. The primary outcomes are the paired within-patient change in AI trust between T0 and T1 and physician-patient concordance on AI versus physician advice. Target enrollment is 180 to obtain 150 paired completed assessments.",[66,67,68,69],"Patient Health Information Seeking Behavior","Trust","Health Literacy","Orthopedics",[71,72,73,74,75,76,77,78,79,80],"ChatGPT","large language model","artificial intelligence chatbot","patient education","health information seeking","trust","physician-patient communication","orthopedics","cross-sectional","pre-post","RECRUITING","2026-06-14",{"date":84,"type":44},"2026-06-17",{"date":86,"type":22},"2026-06",{"date":88,"type":22},"2027-01",{"name":50,"class":51},2,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":101,"conditions":102,"keywords":105,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":120,"locationsCount":5},"100642817","turkish-version-of-the-ankle-fracture-outcome-of-rehabilitation-measure-a-form-tr-a-multi-centre-validation-study-100642817","NCT07620015","Turkish Version of the Ankle Fracture Outcome of Rehabilitation Measure (A-FORM-TR): A Multi-Centre Validation Study","Cross-Cultural Adaptation and Psychometric Validation of the Turkish Version of the Ankle Fracture Outcome of Rehabilitation Measure (A-FORM-TR): A Multi-Centre Prospective Observational Study","A-FORM-TR","Inclusion Criteria:\n\n* Age 18 years or older\n* Radiographically confirmed unilateral ankle fracture (Weber A, B, or C)\n* Either surgical (open reduction and internal fixation) or conservative (cast, walker boot, or functional brace) treatment completed\n* Currently in the rehabilitation phase, 3 weeks to 12 months post-injury\n* Native Turkish speaker, able to read and self-complete a questionnaire\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Bilateral ankle fracture\n* Previous ipsilateral ankle fracture or any prior orthopedic surgery on the same ankle\n* Pathological fracture (tumour, metastasis, or other underlying bone pathology)\n* Concurrent significant ipsilateral lower-limb injury (for example pilon fracture, ipsilateral tibial or fibular shaft fracture, ipsilateral femoral or tibial plateau fracture)\n* Polytrauma (significant head, spine, abdominal, or contralateral lower-limb injury affecting function)\n* Cognitive or psychiatric impairment precluding self-completion of the questionnaire\n* Insufficient Turkish literacy\n* Inability to attend a follow-up visit for the test-retest assessment",{"count":100,"type":22},150,"Ankle fractures are common injuries that can affect a patient's mobility, mood, sleep, and everyday life for months. The Ankle Fracture Outcome of Rehabilitation Measure (A-FORM) is an English-language patient-reported outcome measure developed in Australia to capture this broader rehabilitation experience. No validated Turkish version of A-FORM currently exists. This prospective multi-centre observational study aims to translate the A-FORM into Turkish (A-FORM-TR), culturally adapt it for use in Turkish-speaking patients, and evaluate its psychometric properties. The investigators will recruit 150 adults with a unilateral ankle fracture, treated either surgically or conservatively, from three orthopedic centres in Turkiye and the Turkish Republic of Northern Cyprus. Participants complete the A-FORM-TR together with two established comparator questionnaires (AOFAS Ankle-Hindfoot Score and the Turkish Olerud-Molander Ankle Score). A subset of approximately 50 participants is re-administered the A-FORM-TR after 7 to 14 days to assess test-retest reliability, with a Global Rating of Change item identifying clinically stable patients. Analyses include classical test theory, confirmatory factor analysis, and Rasch measurement analysis.",[103,104],"Ankle Fractures","Ankle Injuries",[106,107,108,109,110,111,112,113],"patient-reported outcome measure","PROM","cross-cultural adaptation","psychometric validation","ankle fracture","rehabilitation","Rasch analysis","Turkish","2026-06-09",{"date":116,"type":44},"2026-06-12",{"date":118,"type":22},"2026-08",{"date":48,"type":22},{"name":50,"class":51},""]