[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"VU University of Amsterdam\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":263},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,50,87,118,144,183,209,235],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100591335","implementation-of-dwm-in-dutch-smes-100591335",false,"NCT06979089","Implementation of DWM in Dutch SMEs","Improving the Mental Health of Working Adults in Dutch Small and Medium-Sized Enterprises (SMEs): A Cluster RCT of WHO's Doing What Matters in Times of Stress (DWM)","Inclusion Criteria (SMEs):\n\n* Having 10 to 250 employees\n* Being located in the Netherlands\n* (In case of insufficient recruitment among SMEs, a mitigation strategy is to recruit individual departments from larger organizations)\n\nInclusion Criteria (Individual participants):\n\n* 18 years or older\n* Having elevated levels of psychological distress (Kessler Psychological Distress Scale; K10 scores \\> 15.9)\n* Sufficient literacy and mastery (written and spoken) of one of the languages the DWM intervention is being delivered in (i.e., Dutch or English)\n* Having access to an electronic device with internet access to follow the intervention\n* Written informed consent before entering the study\n\nExclusion Criteria (Individual participants):\n\n* Imminent suicide risk, or expressed acute needs or protection risks that require immediate follow-up\n* Currently receiving specialized psychological treatment (e.g., EMDR or CBT) at the time of screening\n* In case of current psychotropic medication use: being on an unstable dose for at least 2 months or a change in dosage over the past 2 months.\n* Having participated in the preceding ASCEND trial as supervisor (see NCT ID: NCT06989398)","ALL","18 Years",{"count":19,"type":20},518,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this cluster randomized controlled trial is to explore if mental health in Dutch small and medium-sized enterprises (SMEs) can be improved by the World Health Organization's online program Doing What Matters in Times of Stress (DWM). The main questions it aims to answer are:\n\n* Does DWM improve the mental health of employees working in Dutch SMEs?\n* Does DWM improve work-related outcomes in employees working in Dutch SMEs?\n* How can DWM be implemented at a large scale in Dutch SMEs?\n\nResearchers will compare two groups to see if the DWM program is effective. One group will receive the DWM program and Care-as-Usual (group 1), and the other group will receive Care-as-Usual only (group 2).\n\nParticipants will:\n\n* Follow the online DWM program for 5 weeks (only group 1).\n* Take part in 6 telephone appointments with a facilitator (helper) that provides extra support to complete the program (only group 1).\n* Complete 3 sets of questionnaires. Each set of questionnaire takes about 15 minutes to be completed (group 1 and group 2).",[26,27,28],"Anxiety","Depression","Psychological Distress",[27,26,28,30,31,32,33,34,35,36],"Mental health","Work-place mental health","Employee well-being","Digital intervention","Online intervention","Doing What Matters in Times of Stress","Small and medium-sized enterprises","RECRUITING","2025-11-27",{"date":40,"type":41},"2025-12-05","ACTUAL",{"date":43,"type":41},"2025-05-19",{"date":45,"type":20},"2026-09",{"name":47,"class":48},"VU University of Amsterdam","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":86,"locationsCount":49},"100592128","implementation-of-the-ascend-training-for-supervisors-in-dutch-small-and-medium-sized-enterprises-smes-100592128","NCT06989398","Implementation of the ASCEND Training for Supervisors in Dutch Small and Medium-sized Enterprises (SMEs)","Cluster RCT of the WHO's Advancing Supervisor Capabilities for Mental Health at Work (ASCEND) in Dutch Small and Medium-sized Enterprises (SMEs)","Inclusion for SMEs:\n\n* Having 10 to 250 employees\n* Being located in the Netherlands\n\nIn case of insufficient recruitment among SMEs, a mitigation strategy is to recruit individual departments from larger organizations.\n\nEligibility criteria for individual participants:\n\nSupervisors are included if they fit the following inclusion criteria:\n\n* 18 years or older\n* Working in an organization in the Netherlands\n* Sufficient mastery (written and spoken) of the language in which the ASCEND intervention is being delivered (i.e., Dutch or English)\n* Written informed consent before entering the study\n* Supervise at least 1 supervisee within the same organization\n\nSupervisees are included if they fit the following inclusion criteria:\n\n* 18 years or older\n* Have a direct supervisor who is participating in ASCEND (either intervention or control group)\n* Sufficient mastery of English or Dutch\n* Written informed consent before entering the study",true,{"count":59,"type":20},148,[23],"This cluster randomized controlled trial (cRCT) aims to evaluate the effectiveness of an in-person group intervention for workplace supervisors - Advancing Supervisors' Capacity for Mental Health at Work (ASCEND) - in Dutch Small and Medium-sized Enterprises (SMEs). The ASCEND intervention is designed to equip supervisors with the skills to: i) know when to support their workers; ii) how to direct workers to support, and iii) advocate for action on mental health at work.\n\nThe primary objectives of this project are to:\n\n* Assess to what extent the novel, WHO-developed ASCEND intervention is effective in enhancing supervisors' confidence, responsiveness, mental health literacy, and SelfCare practices, and in reducing supervisor stigma towards mental health conditions within Dutch SMEs.\n* Evaluate the impact of the ASCEND intervention on employee outcomes, including mental health and work-related outcomes among supervisees (i.e., subordinates), as well as overall organizational absenteeism rates.\n* Identify barriers, facilitators, and key implementation and adoption indicators to support future opportunities for scaling up the ASCEND intervention in the context of Dutch SMEs.\n\nResearchers will compare two groups to evaluate the effectiveness of the ASCEND intervention. One group will receive the training (the intervention group), while the other group will receive the training after the final follow-up period (the control group).\n\nData will be collected from both supervisors and their supervisees (i.e., subordinates) via online questionnaires at various time points. In addition, general organizational information, including absenteeism rates, will be gathered through a representative from each participating organization.\n\nTo further explore the feasibility of scaling up the ASCEND intervention within the Netherlands, qualitative data will be collected through interviews and\u002For focus group discussions.",[63,64,65,66,67],"Occupational Health","Stress","Burnout","Mental Health Conditions","Sickness Absence",[69,70,71,72,73,74,75,32,76,77,78,79],"Workplace mental health","Occupational stress","Sickness absence","Supervisors","Line managers","Absenteeism","Presenteeism","Workplace intervention","Manager training","ASCEND","Advancing Supervisors' Capacity for Mental Health at Work","2025-11-18",{"date":82,"type":41},"2025-11-19",{"date":84,"type":41},"2025-05-14",{"date":45,"type":20},{"name":47,"class":48},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":21,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},"100607893","zeroocd-learn-to-overcome-contamination-ocd-with-your-smartphone-100607893","NCT07194473","ZeroOCD: Learn to Overcome Contamination OCD With Your Smartphone","ZeroOCD: Learn to Overcome Contamination OCD With Your Smartphone: An Augmented Reality Cognitive Behavioral Therapy App for Obsessive-Compulsive Disorder: Randomized Controlled Trial","ZeroOCD","Inclusion Criteria:\n\n* • OCD symptoms, mean score \\> 7 on the Yale Brown Obsessive Compulsive Scale (Y-BOCS)\n\n  * Fear of contamination OCD symptoms, mean score \\> 6 on the Padua Inventory contamination fear subscale (PI)\n  * Having access to a compatible smartphone\n  * Having an internet connection\n  * Proficiency in one of the countries' languages (i.e., Dutch\u002F Flemish, German, or Swedish)\n  * Willing to participate in the research study and provide informed consent\n\nExclusion Criteria:\n\n* • Having been diagnosed with bipolar or psychotic disorder (self-report)\n\n  * Severe depressive symptoms (Patient Health Questionnaire, PHQ-9, score \\> 20)\n  * Reporting suicidality (PHQ-9, item 9 \\> 2 points at screening)\n  * Fear of contamination due to disorder other than OCD (clinical judgment based on results from the Yale Brown Obsessive Compulsive Scale, Y-BOCS, Generalized Anxiety Disorder-7 items, GAD-7, Short Health Anxiety Inventory, SHAI)\n  * Parallel psychological treatment\n  * Non-stable dosage of psychoactive medication during the last three months or planned changes during the study period.","64 Years",{"count":97,"type":20},189,[23],"This study is a three-arm randomized controlled trial designed to evaluate the efficacy of a smartphone-based augmented reality (AR) cognitive behavioral therapy (CBT) app, called ZeroOCD, for individuals with elevated contamination-related obsessive-compulsive disorder (OCD) symptoms. The AR-CBT app will be compared to both an active control condition (manualized CBT via videoconferencing) and a waitlist control group.",[101],"Obsessive Compulsive Disorder (OCD)",[103,104,105,106,107],"Obsessive Compulsive Disorder","Augmented Reality","Smartphone","Randomized Controlled Trial","Cost-effectiveness","NOT_YET_RECRUITING","2025-09-18",{"date":111,"type":41},"2025-09-26",{"date":113,"type":20},"2025-09-21",{"date":115,"type":20},"2027-05",{"name":47,"class":48},4,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":125,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":21,"phases":130,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":4},"100539635","phase-4-sleeping-through-menopause-100539635","NCT06306404","Sleeping Through Menopause","The Role of Online Sleep Intervention and Hormone Therapy on Sleep, Climacteric Symptoms and Mood in the Perimenopause","Inclusion Criteria:\n\n* Age between 40-55 years old\n* Insomnia severity index score =\\>10\n* Green Climacteric Score =\\>13\n* Self-considered capability of completing online questionnaires and diaries in Dutch\u002FEnglish\n* Presence of a menstruation (whether regular or not) and the last menstruation must be less than 12 months ago\n\nExclusion Criteria:\n\n* CBTi treatment in past year\n* Bipolar disorder or psychotic disorder\n* Contra-indication for Menopausal Hormone Therapy\n* Alcohol or drugs dependency (scores of ≥ 20 on the AUDIT and ≥25 on the DUDIT)\n* Women using thyroid medication, lamotrigine, aromatase, tamoxifen, because of interaction effects with MHT\n* Use of drugs known to interfere with cytochrome P450 enzyme (CYP) 3A4\n* Known hypersensitivity to the excipients in the estradiol patch: acrylate copolymer, polyethylene terephthalate, alfa-tocopherol, soy allergy (component of progesterone capsule).\n* All women on hormonal contraceptives will be excluded.\n* All women already on MHT will be excluded.","FEMALE","40 Years","55 Years",{"count":129,"type":20},222,[131],"PHASE4","Sleepless nights during the menopausal period: what treatment works? About half of the women have trouble sleeping during the years around the menopause, the perimenopause. This is a period characterised by fluctuating sex hormones. Insomnia during the perimenopause can make women more likely to develop more severe climacteric symptoms and other mental health problems. It is therefore important to find the right treatment to treat insomnia. Currently, we do not know what the best treatment is for managing insomnia during the perimenopause. The Sleeping Through Menopause study is the first to evaluate, side by side, two interventions: menopausal hormone therapy (MHT) and combined cognitive behavioural and circadian therapy for insomnia (CBCTi). The study aims to evaluate how well these treatments alleviate insomnia and climacteric symptoms including hot flashes, and by doing so alleviate or prevent other mental health issues. It will also explore how personal factors might affect treatment success.\n\nIn the study, 222 women with both insomnia and climacteric symptoms will be randomly assigned to one of four groups: MHT, CBCTi, a combination of both MHT and CBCTi, or a group with no treatment. The main goal is to evaluate how each treatment alleviates insomnia after 8 and 15 weeks. Secondary outcomes are sleep quality, climacteric symptoms including hot flashes, mental health, and daily functioning.\n\nThis study will help us understand the best ways to treat sleep problems during menopause and whether better sleep can improve other mental health and menopausal symptoms as well.",[134,135],"Menopause","Insomnia","2025-08-18",{"date":138,"type":41},"2025-08-24",{"date":140,"type":20},"2025-10-01",{"date":142,"type":20},"2030-01-01",{"name":47,"class":48},{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":21,"phases":154,"briefSummary":155,"conditions":156,"keywords":159,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":49},"100510557","feasibility-and-acceptability-of-problem-management-plus-pm-for-prisoners-in-the-netherlands---a-pilot-rct-100510557","NCT05927987","Feasibility and Acceptability of Problem Management Plus (PM+) for Prisoners in the Netherlands - a Pilot RCT","Feasibility and Acceptability of Problem Management Plus (PM+) for Prisoners in the Netherlands - a Pilot Randomised Controlled Trial","PROSPER","Inclusion Criteria:\n\n* 18 years old or above;\n* Imprisoned in a Dutch prison;\n* Held on remand;\n* Dutch-speaking;\n* Elevated levels of psychological distress (K10 \\>15);\n\nExclusion Criteria:\n\n* Enclosed in a penitentiary psychiatric centre;\n* Presents a potential security risk to the research team (PM+ helper and\u002For research team)\n* Acute medical condition;\n* Imminent suicide risk or expressed acute needs\u002Fprotection risks (e.g., someone who expresses that they are at acute risk of being assaulted or killed);\n* Severe mental disorder (psychotic disorders, substance dependence) ;\n* Severe cognitive impairment (e.g., severe intellectual disability or dementia);\n* Currently enrolled in a specialised psychological treatment program (e.g., EMDR, CBT);\n* Less than two months on a stable dose of psychotropic medication (if applicable).",{"count":153,"type":20},60,[23],"The goal of this pilot randomised controlled trial is to evaluate the feasibility and acceptability of the - specifically to the prison context adapted - World Health Organization's Problem Management Plus (PM+) intervention for individuals detained in Dutch remand prisons. The main question\\[s\\] it aims to answer are:\n\n* To what extent is the contextually adapted PM+ intervention feasible and acceptable for individuals detained in Dutch remand prisons?\n* To what extent are there preliminary indications of pre to post-effects of the PM+ intervention on, for example, anxiety and depression symptoms?\n\nResearchers will compare two groups to answer these questions. Participants will either receive the PM+ intervention and Care-as-Usual or only Care-as-Usual.",[157,28,158],"Anxiety Disorders","Depressive Disorder",[160,161,162,163,164,165,166,167,168,169,170,28,171,172,173,174],"Pilot Randomised Controlled Trial","Pilot RCT","Prisoner","Remand Prisoner","Remand custody","Prison","Dutch prison","Dutch prisons","PM+","Problem Management Plus","WHO intervention","Anxiety Disorder","Depressive disorder","Common Mental Health problems","Common Mental Health disorders","2024-12-03",{"date":177,"type":41},"2024-12-05",{"date":179,"type":41},"2024-06-13",{"date":181,"type":20},"2025-12-31",{"name":47,"class":48},{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":21,"phases":193,"briefSummary":194,"conditions":195,"keywords":197,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":49},"100551059","eerder-erbij-the-path-towards-offering-timely-support-for-people-with-dementia-and-their-caregivers-100551059","NCT06455163","Eerder Erbij: The Path Towards Offering Timely Support for People With Dementia and Their Caregivers","Eerder Erbij: Een Vroege Ondersteuning Voor Mensen Met Dementie en Hun Mantelzorgers. The Path Towards Offering Timely Support for People With Dementia and Their Caregivers","EE","Inclusion Criteria:\n\n* Informal caregivers can be spouses, relatives, or friends who care for and support the person with dementia without pay. If the caregiver does not live with the person with dementia, they have to visit the person with dementia at least 3 times a week to be eligible for the study.\n* The person with dementia must be living at home cared for by the caregiver.\n* The person with dementia should have a diagnosis of dementia or experience severe cognitive impairments suggesting dementia. Type of dementia is not an inclusion criterion.\n* The person with dementia is not yet receiving formal care related to personal activities of daily living on account of his or her dementia more than once a week (defined by receiving assistance from a paid worker by e.g., health or social care professional as help with dressing\u002Fundressing; washing\u002Fbathing\u002Fshowering; toileting; feeding\u002Fdrinking; or taking medication).\n\nExclusion Criteria:\n\n* Main exclusion criteria for both the caregiver and the person with dementia will be major mental or physical illness, such as major depression or stroke, that would affect their ability to participate in this study.\n* Person with dementia or informal caregiver is participating in another intervention or similar support program.\n* Dementia is caused by human immunodeficiency virus (HIV), acquired brain impairment, Down syndrome, chorea associated with Huntington's disease, or alcohol abuse.\n* Inability to give informed consent will also be an exclusion criterion.\n* Informal caregiver is younger than 18 years old.",{"count":192,"type":20},102,[23],"INTRODUCTION AND RATIONALE\n\nIt has been estimated that at least 50% of the home living persons with dementia in the Netherlands receive little or no formal care and support (Zorgstandaard Dementie, 2013). Reasons why persons with dementia and their informal caregivers receive no formal care vary, include absence of diagnosis, denial of illness, embarrassment or the complexity of the care and referral system. A common concern among health care professionals is that by the time the person with dementia or informal caregiver do seek or receive formal care it may be too late. The difficulties at home may already be so severe that there is little that community-based care can do and admission to residential care may follow soon after. Appropriate support at an earlier stage may prevent more serious difficulties and postpone admission to residential care. Therefore, health care professionals are looking for strategies to reach persons with dementia and caregivers in an earlier stage of dementia and encourage them to accept some form of help or support. The rationale of this study is to investigate how persons living with dementia and their close others can be encouraged to accept support and whether support at an early stage is effective in preventing severe deterioration in wellbeing, behavioural difficulties and high care costs later on.\n\nOBJECTIVES\n\n* Estimate the effect of EE on caregiver self-efficacy compared to usual care\n* Estimate the effect of EE on the total care costs of caregiver and person with dementia compared to usual care\n* Estimate the cost-effectiveness and cost-utility of EE compared to usual care\n* Perform a process evaluation to monitor delivery of EE and experiences of persons with dementia, caregivers and care professionals\n* Explore treatment responsiveness of EE in terms of self-efficacy and quality of life\n\nSTUDY DESIGN\n\nPragmatic, cluster randomised controlled trial.\n\nSTUDY POPULATION\n\nInformal caregivers and people with early-stage dementia, who are community dwelling and receive little or no dementia-related formal ADL care.\n\nINTERVENTION\n\nThe intervention (Eerder Erbij, EE) is a person-centred, manual-based intervention consisting of education, information and a support group.\n\nMAIN STUDY PARAMETERS\u002FENDPOINTS\n\nPrimary: self-efficacy. Cost-utility: EQ5D, RUD. Secondary: quality-of-life, caregiver burden.\n\nDATA COLLECTION\n\nMeasurements consist of questionnaires (total duration is approximately 1 hour; administered at home; take place at baseline, 3, 6, and 12 months).",[196],"Dementia, Mild",[198,199,200],"Early-stage dementia","Informal caregiver","Informal care","2024-08-13",{"date":203,"type":41},"2024-08-15",{"date":205,"type":41},"2021-06-01",{"date":207,"type":20},"2026-05-31",{"name":47,"class":48},{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":219,"phases":4,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":49},"100557512","skeletal-muscle-mitochondria-in-ageing-100557512","NCT06539078","Skeletal Muscle Mitochondria in Ageing","Exercise as a Countermeasure Against the Effects of Ageing on Muscle Mitochondria, Diffusive Oxygen Transport and Muscle Volume","AGAMEMNON","Inclusion Criteria:\n\nIn order to be eligible to participate in this study, young sedentary participants must meet all of the following criteria:\n\n* Aged between 18-30 years\n* Male or female\n* Not currently engaging in any formal exercise training or competitive sports\n* No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise\n\nIn order to be eligible to participate in this study, young trained participants must meet all of the following criteria:\n\n* Aged between 18-30 years\n* Male or female\n* Currently engaging in formal training (at least 3 times per week) in competitive endurance sports\n* No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise\n\nIn order to be eligible to participate in this study, older sedentary participants must meet all of the following criteria:\n\n* Aged between 50-65 years\n* Male or female\n* Not currently engaging in any formal exercise training or competitive sports\n* No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise\n\nIn order to be eligible to participate in this study, older trained participants must meet all of the following criteria:\n\n* Aged between 50-65 years\n* Male or female\n* Currently engaging in formal training (at least 3 times per week) in competitive endurance sports\n* No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise\n\nExclusion Criteria:\n\n* Age that falls outside of 18-30 years (young groups) or 50-65 years (middle-aged groups)\n* Inability to provide informed consent\n* History of claustrophobia\n* Ineligibility to perform the exercise test described in this study protocol or follow instructions\n* Taking any medications known to interfere with the physiological responses to exercise, e.g. e.g. systemic corticosteroids, statins, SGLT2 inhibitors, GLP1 receptor agonists\n* Contraindication for MRI (e.g. pacemaker, claustrophobia)\n* Being under investigation for non-diagnosed disease at the time of investigation\n* Body Mass Index (BMI) \\>30 due to adiposity, since this is known to cause difficulties in obtaining muscle biopsies and NIRS measurements\n* Pregnancy\n* Are current smokers or have been a regular smoker within the last 12 months","65 Years",{"count":153,"type":20},"OBSERVATIONAL","Healthy ageing is associated with the loss of muscle mass and physical function. As a result, older people are limited in their independence. The aging of muscles typically begins around the age of 30. From this age onward, muscle strength, muscle mass, and the maximum oxygen uptake of muscles decrease. The reasons for this are not entirely clear, but it seems to be partly related to how oxygen moves from our blood vessels to the muscles and how muscles burn energy. The precise role of age and physical fitness, as well as whether exercise can counteract the effects of ageing, is still unknown. Therefore, in this study, we aim to investigate the muscle function of both physically active and inactive young and middle-aged individuals. We hypothesise that endurance training can mitigate some of the effects of ageing.",[222],"Aging",[224,225,226],"Exercise","Mitochondria","Skeletal muscle","2024-08-02",{"date":229,"type":41},"2024-08-06",{"date":231,"type":41},"2024-03-25",{"date":233,"type":20},"2026-12",{"name":47,"class":48},{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":16,"minAge":242,"maxAge":17,"enrollmentInfo":243,"targetDuration":4,"studyType":21,"phases":245,"briefSummary":246,"conditions":247,"keywords":249,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":49},"100489741","effectiveness-and-feasibility-of-structured-efft-100489741","NCT05657067","Effectiveness and Feasibility of Structured EFFT","Effectiveness and Feasibility of Structured Emotionally Focused Family Therapy: A Pilot Study","Inclusion criteria:\n\nFor this pilot study we will include families with\n\n1. adolescents aged 12-18 years (the so called 'identified' patient), and\n2. families coping with mild problems.\n\nExclusion criteria:\n\nThe latter means that we will exclude:\n\n1. blended families because of the more complex loyalties that exist between children and stepparents,\n2. families of which individual members cope with serious trauma such as sexual and physical abuse and severe neglect, and\n3. families of which the parents or children are diagnosed with severe DSM disorders (substance abuse or psychosis).","12 Years",{"count":244,"type":20},15,[23],"The goal of this clinical pilot study is to assess effectiveness and feasilibity of structured Emotionally Focused Family Therapy (EFFT) for parents and adolescents.\n\nParticipants will fill out questionnaires before, during and after the EFFT treatment Finally, feasibility will be assessed by semi-structured interviews.",[248],"Emotion Regulation",[250,251,252,253,254],"Attachment","Adolescents","Family","Mental Health Problems","Emotionally Focused Family Therapy (EFFT)","2024-06-03",{"date":257,"type":41},"2024-06-04",{"date":259,"type":41},"2022-07-26",{"date":261,"type":20},"2026-06-30",{"name":47,"class":48},""]