[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Veterans Medical Research Foundation\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":228},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,74,100,127,159,183,202],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100609907","integrated-health-care-for-ptsd-100609907",false,"NCT07220681","Integrated Health Care for PTSD","A Hybrid I Evaluation of Integrative Health Care for PTSD","Inclusion Criteria:\n\n* clinical diagnosis\n* eligibility for Cognitive Processing Therapy (CPT) at a participating VA site\n* able to consent to study activities\n\nExclusion Criteria:\n\n* current, active engagement in one of the included approaches (per clinician judgment)\n* medical conditions that contraindicate engaging in the experimental interventions","ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to determine whether which types of integrative care, meaning a combination of psychotherapy and mind-body interventions, lead to the most changes in functioning among Veterans with posttraumatic stress disorder (PTSD). The main aims are:\n\n1. To evaluate the impact of integrative care approaches on functional outcomes among Veterans with PTSD.\n2. To examine factors relevant to the implementation of integrated treatments for PTSD from the perspective of patients, providers and administrators in the VA Healthcare System.\n\nParticipants will:\n\n1. Complete assessments at the beginning of the study and 12- and 24-weeks later.\n2. Engage in 12 weeks of integrated care, with the type being randomly assigned.",[26],"Posttraumatic Stress Disorder (PTSD)",[28,29,30,31],"PTSD","complementary and integrative health","Veterans","implementation","RECRUITING","2026-06-10",{"date":35,"type":36},"2026-06-12","ACTUAL",{"date":38,"type":36},"2026-04-23",{"date":40,"type":20},"2029-09-30",{"name":42,"class":43},"Veterans Medical Research Foundation","OTHER",5,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},"100617968","machine-learning-in-guiding-rtms-treatment-for-gwi-related-headaches-and-body-pain-100617968","NCT07325513","Machine Learning in Guiding rTMS Treatment for GWI-Related Headaches and Body Pain","SVM - GWI","Inclusion Criteria:\n\n* Male or female\n* Veteran or active military personnel\n* Between the ages of 18 and 65 years old\n* Served in the Persian Gulf region for at least 30 consecutive days between August 1, 1990, and July 31, 1991\n* Meets the CDC Criteria for GWVI (GWI), with symptoms starting during or after the 1990-1991 Persian Gulf deployment. Symptoms must be present for at least 6 months prior to enrollment in the study. Symptoms must be present in at least 2 of the 3 categories of fatigue, musculoskeletal, and mood cognitive.\n* Meets the Kansas Criteria for GWVI (GWI), with symptoms starting during or after the 1990-1991 Persian Gulf deployment. Symptoms must be present for at least 6 months prior to enrollment in the study. Qualifying symptoms must be at least moderate in severity and\u002For multiple symptoms must be present within at least 3 of 6 categories consisting of fatigue\u002Fsleep, neurological\u002Fcognitive\u002Fmood, pain, respiratory, gastroenterological, and dermatological symptomology.\n* Average Overall Daily Muscle Pain Intensity ≥3 on a 0-10 NPRS, present for at least 6 months\n* Average Overall Daily Extremities Joint Pain Intensity ≥3 on a 0-10 NPRS, present for at least 6 months\n* Average Headache Exacerbation Intensity ≥3 on a 0-10 NPRS, with headaches occurring for at least 6 months\n* Headache Exacerbation\u002Fattack ≥ 1 time per week with the average intensity ≥3 on a 0-10 NPS, lasting \\> 1 hour in the past three months\n* International Headache Society Criteria for Migraine Headache without aura\n\nExclusion Criteria:\n\n* Children under the age of 18\n* Pregnant women\n* Individuals with cognitive\u002Fdecisional impairment\n* Non-English speaking individuals\n* Prisoners of War\n* Incarcerated individuals\n* VA employees - including VA paid, IPA, or WOC\n* Students of the institution or of the investigator\n* Patients with cancer\n* History of pacemaker implant\n* Presence of ferromagnetic material (e.g., bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI\n* History of dementia, major psychiatric diseases, or life-threatening diseases\n* Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy\n* Known diagnosis of moderate to severe osteoarthritis and\u002For rheumatologic joint pain prior to the GWI deployment\n* Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy\n* Concurrent conditions, like lupus, that can produce symptoms compatible with GWVI\n* History of seizure\n* Pending litigation\n* History of Traumatic Brain Injury-related headaches\n* Chronic Tension or Cluster Headache. However, subjects with occasional tension headaches (less than once every three months and lasting no more than 24 hours) will not be excluded from the study.\n* Ongoing Cognitive Rehabilitation or Treatment of PTSD\n* Recent exacerbation of anxiety disorder symptoms, active substance dependence, and\u002For current psychotic symptoms\n* Ongoing suicidal\u002Fhomicidal ideation or recent (in the past 6 months) suicidal attempts\n* Patients who receive any narcotic-based analgesic, topical analgesics over the affected site, steroid and local anesthetic injection, anticonvulsants, and antipsychotic medications less than 7 days prior to the pretreatment assessment\n* Patients who do not agree to avoid use of non-pharmacologic treatments, including but not limited to, transcutaneous electrical nerve stimulation unit (TENS), acupuncture, acupressure, and therapeutic massage during the entire study.\n* Patients who do not agree to use additional acetaminophen (up to a maximum total of 3g per day) as the only rescue medication\n* Patients who have received rTMS within the past 6 months","65 Years",{"count":54,"type":20},140,[23],"The goal of this clinical trial is to create a machine learning algorithm to improve active repetitive transcranial magnetic stimulation (rTMS) treatments for veterans and\u002For active military personnel by alleviating Gulf War Illness related headaches and body pain (GWI-HAP). This study aims to develop and validate a Support Vector Machine (SVM) model that could replace the trial-and-error process by assessing functional connectivity provided by resting state functional magnetic resonance imaging (rs-fMRI) data to predict the most effective rTMS protocol for each person. All participants will be receiving active rTMS treatment.\n\nThe main questions it intends to answer are:\n\n1. Does the SVM model predict a more effective treatment response rate for predicted respondents undergoing active rTMS at the left dorsolateral prefrontal cortex (DLPFC) compared to predicted non-respondents?\n2. Does the SVM model predict a more effective treatment response rate while undergoing active rTMS at the left dorsolateral prefrontal cortex (DLPFC) and left motor cortex (LMC) in predicted respondents compared to predicted non-respondents?\n\nParticipants will undergo the following:\n\n1. Receive a total of 13 active rTMS treatment sessions over 3-4 months.\n2. Visit the clinic for a total of 15 visits for assessments, check ups, and treatments.\n3. Keep a daily log of their headaches, muscle and joint pain throughout the study.",[58,59,60],"Gulf War Illness","Headache","Muscle and Joint Pain",[62,63,59,64,60],"Repetitive Transcranial Magnetic Stimulation (rTMS)","Support Vector Machine (SVM)","Machine Learning","2026-04-08",{"date":67,"type":36},"2026-04-13",{"date":69,"type":36},"2026-03-25",{"date":71,"type":20},"2029-10",{"name":42,"class":43},1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":73},"100576536","interoceptive-training-enhanced-mindfulness-100576536","NCT06786572","Interoceptive Training Enhanced Mindfulness","Interoceptive Training Enhanced Mindfulness (ITEM): Acceptability and Measurement","ITEM","Inclusion Criteria:\n\n* Veteran status\n* able to read and speak English\n* ASI-3 score of 23 or higher\n* clinically meaningful distress\u002Fimpairment related to an emotional or somatic complaint as determined by a Clinical Global Impression Scale (CGI) of 3 or greater\n* Internet access via a device that can support remote study activities and ability to attend in person appointments\n\nExclusion Criteria:\n\n* serious mental illness, including bipolar disorder or psychotic illness\n* current, untreated alcohol or substance use disorder\n* moderate-severe suicidality that would likely result in the need for urgent intervention in the next 2 months\n* current regular meditation practice or treatment for AS-related condition\n* cognitive dysfunction that interferes with the ability to engage in treatment",{"count":83,"type":20},48,[23],"This pilot randomized controlled trial will compare a novel mindfulness training to interoceptive exposure to establish feasibility and acceptability as an intervention for anxiety sensitivity.",[87],"Anxiety Sensitivity",[89,90,91],"anxiety sensitivity","mindfulness","interoception","2026-01-28",{"date":94,"type":36},"2026-02-02",{"date":96,"type":36},"2025-09-10",{"date":98,"type":20},"2027-03-31",{"name":42,"class":43},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":21,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":73},"100531184","adapting-an-intervention-for-vaping-in-young-veterans-100531184","NCT06196489","Adapting an Intervention for Vaping in Young Veterans","Nicotine Cessation: Adapting a Counseling Program for Emerging Adults","Inclusion Criteria:\n\n* daily e-cigarette user for at least the past 6 months\n* 18-30 years old\n* willing to enroll in a program to quit nicotine use within 30 days\n* owns smartphone or computer\u002Ftablet with camera and internet connectivity\n* English speaker\n\nExclusion Criteria:\n\n* ICD-10 diagnosis of dementia\n* current use of combustible tobacco products at least weekly","30 Years",{"count":109,"type":20},20,[23],"The objective of this proposal is to adapt an evidence-based combustible tobacco counseling intervention following an evidence-based process to include e-cigarette use and update its components for emerging adults (EA).\n\n1. Examine factors related to e-cigarette use, barriers to cessation, and facilitators of use of cessation services among an EA population.\n2. Beta-test an initial version of the intervention, delivered via video telehealth and telephone, to examine usability and acceptability.",[113],"E Cigarette Use",[115,116,117,118],"Veteran","e-cigarette","vaping","young adult","2026-01-06",{"date":121,"type":36},"2026-01-08",{"date":123,"type":36},"2024-01-01",{"date":125,"type":20},"2026-06",{"name":42,"class":43},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":21,"phases":137,"briefSummary":138,"conditions":139,"keywords":144,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":73},"100616097","dod-atms-for-posttraumatic-peripheral-neuropathic-pain-100616097","NCT07301177","DoD AtMS for Posttraumatic Peripheral Neuropathic Pain","AtMS for Alleviating Posttraumatic Peripheral Neuropathic Pain (PTP-NP)","PTP-NP","Inclusion Criteria:\n\n* Veterans (men or women) of any race or ethnicity who are at least 18 years of age\n* Chronic peripheral neuropathic pain present for more than 4 months after a traumatic or surgical event per medical history\n* Have an average daily Numerical Pain Rating Scale (NPRS) score \\> 3\n* At least one negative or positive sensory sign or symptom confined to innervation territory of the lesioned nervous structure\n* Prior diagnostic tests confirming lesion or disease explaining neuropathic\n\nExclusion Criteria:\n\n* Pregnancy\n* Subjects with central neuropathic pain (ex: due to diabetic peripheral neuropathy, HIV, chemo\u002Fanti-viral therapy, carpal tunnel syndrome, post-traumatic pain classified as central rather than peripheral)\n* Subjects with pain due to Complex Regional Pain Syndrome\n* Phantom limb pain after amputation (stump pain and phantom sensation are allowed)\n* Subjects with skin conditions in the affected dermatome\n* Subjects with other pain such as lumbar or cervical radiculopathy that may confound assessment\n* Any subject considered at risk of suicide\n* Use of prohibited medications in the absence of appropriate washout periods\n* Participation in any other clinical trial within the 30 days prior to screening and\u002For during participation in this study\n* Heart pacemaker\n* Subjects with a current diagnosis of DSM-IV-TR Axis I disorder (GAD \\& MDD are allowed if clinically stable)\n* Subjects with pending lawsuits related to injury\n* Subjects who have previously received either transcranial or transcutaneous magnetic stimulation therapy in the past",{"count":136,"type":20},180,[23],"The goal of this clinical trial is to learn if adaptative transcutaneous magnetic stimulation (AtMS) works to reduce pain caused by post-traumatic peripheral neuropathic pain (PTP-NP) within Veterans and\u002For active duty military personnel. It will also learn about the safety of AtMS. The main questions it aims to answer are:\n\n1. What are the effects of adaptative tMS (AtMS) in alleviating patients' PTP-NP compared to fixed tMS (FtMS) and Sham-tMS?\n2. What are the effects of AtMS in improving functions in patients suffering from PTP-NP compared to FtMS and Sham-tMS?\n3. What are the effects of AtMS in improving mood in patients suffering from PTP NP compared FtMS and Sham-tMS?\n\nResearchers will compare AtMS, FtMS and Sham-tMS to see if AtMS is the best form of tMS in treating PTP-NP.\n\nParticipants will undergo the following:\n\n1. Receive a total of 8 AtMS, FtMS, or Sham-tMS treatments over 16 weeks.\n2. Visit the clinic a total of 12 times for assessments, check ups, and treatments.\n3. Keep a daily diary of their PTP-NP intensity, sleep interference, and pain medications used.",[140,141,142,143],"Posttraumatic Peripheral Neuropathic Pain","Peripheral Neuropathy","Peripheral Neuropathy Due to Surgical Trauma","Peripheral Neuropathy Due to Physical Trauma",[145,146,147,148,149,150],"adaptative transcutaneous magnetic stimulation (AtMS)","fixed transcutaneous magnetic stimulation (ftMS)","transcutaneous magnetic stimulation (tMS)","peripheral neuropathy","neuropathy","pain","2025-12-22",{"date":153,"type":36},"2025-12-24",{"date":155,"type":36},"2025-04-30",{"date":157,"type":20},"2029-03",{"name":42,"class":43},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":182},"100538849","massed-prolonged-exposure-for-ptsd-in-substance-use-treatment-100538849","NCT06296186","Massed Prolonged Exposure for PTSD in Substance Use Treatment","Clinical Effectiveness and Implementation of Massed Prolonged Exposure for PTSD Among Veterans in Intensive Outpatient Substance Use Treatment (MPE)","PREVAIL","Inclusion Criteria:\n\n* Veterans\n* age 18+\n* who have served since September 2001\n* who are enrolled in a SUD IOP at a participating VA\n* meet DSM-5 criteria for a current SUD (Tobacco Use Disorder alone not sufficient for inclusion)\n* meet DSM-5 criteria for PTSD\n* report substance use at least 20 of the last 90 days\n* are able to give informed consent.\n\nExclusion Criteria:\n\n* severe cognitive impairment\n* current suicidal or homicidal intent requiring immediate treatment\n* current unstable psychotic or manic symptoms not attributable to SUD",{"count":168,"type":20},200,[23],"The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. The main questions it aims to answer are:\n\n* Will the massed format help participants complete and benefit from Prolonged Exposure in terms of PTSD symptoms?\n* Will it help participants reduce substance use? Participants who are in intensive substance use treatment will be asked to complete Prolonged Exposure with either weekly sessions or multiple sessions per week.",[172,173],"Stress Disorders, Post-Traumatic","Substance Use Disorders","2025-04-16",{"date":176,"type":36},"2025-04-22",{"date":178,"type":36},"2024-09-01",{"date":180,"type":20},"2027-08",{"name":42,"class":43},4,{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":21,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":196,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":200,"locationsCount":201},"100538880","trauma-informed-guilt-reduction-therapy-compared-to-prolonged-exposure-100538880","NCT06296589","Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure","Clinical Effectiveness and Implementation of Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure (TrIGR)","PORT","Inclusion Criteria:\n\n* U.S. Veterans age 18 or older who served in the military since the start of Operation Enduring Freedom\u002FOperation Iraqi Freedom; OEF\u002FOIF)\n* meets diagnostic criteria for PTSD;\n* a score of 2 or higher (\"true\" to \"extremely true\") on feeling trauma-related guilt much or all of the time or scoring 3 or higher (\"very true\" or \"extremely true\") on at least one guilt cognition factor (hindsight bias\u002Fresponsibility, wrongdoing, or lack of justification) on the Trauma Related Guilt Inventory\n* not currently receiving trauma-focused treatment such as PE or CPT\n* willingness to attend psychotherapy and assessment sessions\n\nExclusion Criteria:\n\n* current risk of suicidal\u002Fhomicidal behavior that requires immediate intervention\n* current severe substance use disorder (in the past two months) based on DSM-5 criteria\n* current unmanaged psychosis or mania\n* life threatening or unstable medical illness\n* inability to read",{"count":192,"type":20},158,[23],"The goal of this clinical trial is to learn if receiving Trauma-Informed Guilt Reduction (TrIGR) Therapy is as effective as receiving Prolonged Exposure Therapy among veterans with PTSD and trauma related guilt. The main questions it aims to answer are:\n\nWill TrIGR be comparable to PE in terms of PTSD symptom reduction? Will it TrIGR be comparable to PE in improving functioning and reducing depression symptoms? Will it be superior in improving trauma-related guilt and shame?",[172],{"date":176,"type":36},{"date":198,"type":36},"2024-12-01",{"date":180,"type":20},{"name":42,"class":43},3,{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":209,"targetDuration":4,"studyType":21,"phases":211,"briefSummary":212,"conditions":213,"keywords":216,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":73},"100452813","combined-transcranial-magnetic-stimulation-and-therapy-for-mtbi-related-headaches-100452813","NCT05176392","Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches","Combined Nonpharmacological Therapies for MTBI-Related Headaches","Inclusion Criteria:\n\n1. Mild Traumatic Brain Injury (mTBI)\n2. Chronic headaches \\> 3 months after injury\n3. Aged 18-65\n4. No prior TMS treatment\n5. Persistent Headaches with an intensity \\> 30 \u002F 100\n6. No history of daily headache prior to mTBI\n\nExclusion Criteria:\n\n1. Pregnant\n2. Pacemaker or any metal in body that would prevent MRI\n3. History of dementia or major psychiatric disease, such as bipolar disorder or schizophrenia\n4. Presence of any other chronic neuropathic pain states\n5. History of seizure\n6. Pending litigation\n7. Can't understand English\n8. History of chronic headache like migraine prior to mTBI\n9. Evidence in chart of exacerbation of depressive\u002Fanxiety symptoms, active substance dependence, suicidal intent or attempt within previous month",{"count":210,"type":20},240,[23],"This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide marked reduction in mTBI related headaches and symptoms in comparison to their placebo counterparts.",[214,59,215],"TBI (Traumatic Brain Injury)","Depression",[217,218,219],"rTMS","transcranial magnetic stimulation","therapy","2024-11-18",{"date":222,"type":36},"2024-11-21",{"date":224,"type":36},"2022-01-01",{"date":226,"type":20},"2025-08-31",{"name":42,"class":43},""]