[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Vienna Institute for Research in Ocular Surgery\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":118},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,68,95],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100615841","eyelid-closure-in-keratometry-100615841",false,"NCT07297849","Eyelid Closure in Keratometry","The Effect of Eyelid Closure on the Quality Index of Keratometric Measurements: a Non-controlled Interventional Study","Inclusion Criteria:\n\n* Age 18 or older\n* Written informed consent\n* Keratometry quality index \"warning\"\n\nExclusion Criteria:\n\n* Severe corneal conditions that may compromise corneal integrity (such as corneal scarring, etc.)\n* Pregnancy (pregnancy test will be taken in women of reproductive age), nursing women\n* Ocular surgery in the study eye in the three months preceding the study\n* Inability of visual fixation (e.g. in patients with nystagmus)\n* Inability of eyelid closure (e.g. in patients with facial nerve paralysis)","ALL","18 Years",{"count":19,"type":20},29,"ESTIMATED","INTERVENTIONAL",[23],"NA","Cataract surgery is one of the most common performed surgeries in the world. While in the early beginnings of cataract surgery, visual rehabilitation was the main goal of the procedure, refractive outcome and subsequent relative spectacles independency is gaining increasing importance in patients' demands. Due to the improvements in measurement techniques and prediction formulas, the prediction of postoperative refraction is possible with high accuracy. However, there are still some sources of error that lead to deviations of predicted postoperative refraction. For instance, it was shown that tear film osmolarity, an established biomarker for dry eye disease (DED), plays an important role in preoperative precision of keratometry measurements. Keratometry, the measurement of corneal curvature, is an important part of preoperative biometry. Errors in preoperative keratometry measurements lead to nearly one-to-one deviations from the predicted refraction. Therefore, proper keratometry measurements are a key element in intraocular lens (IOL) power calculations. To counteract the issue of DED in preoperative biometry, the principle of using lubricating eye drops before ocular biometry has been investigated and it was shown that the use of ocular lubricants may lead to increased variability of keratometry measurements. From our clinical observations, another possible mechanism to improve keratometry is eyelid closure for some minutes. In contrast to the long-term use of ocular lubricants to stabilize the tear film, eyelid closure is an easy and fast intervention to possibly improve the precision of keratometry measurements. Additionally, a clinical trial investigating the usage of lubricating eye drops for two weeks found no improvement of variability of keratometry in DED patients.\n\nTherefore, this study aims to investigate the effect of eyelid closure on the quality index of keratometric measurements in patients with a warning for the quality of keratometric measurements. For this purpose, a single study day including 4 repeated measurements (2 without and 2 with lid closure for 3 minutes) using an ocular biometer (IOLMaster700) will be performed.",[26,27],"Dry Eye","Ocular Surface Disease","RECRUITING","2025-12-16",{"date":31,"type":32},"2025-12-22","ACTUAL",{"date":34,"type":32},"2024-11-07",{"date":36,"type":20},"2025-12-31",{"name":38,"class":39},"Vienna Institute for Research in Ocular Surgery","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":40},"100613087","visual-function-of-enhanced-monofocal-intraocular-lenses-100613087","NCT07262021","Visual Function of Enhanced Monofocal Intraocular Lenses","Comparison of Visual Function of Enhanced Monofocal Intraocular Lenses After Cataract Surgery","Inclusion Criteria:\n\n* age-related bilateral cataract\n* Age 21 or older\n* Visual acuity \\> 0.05\n* Axial length: 21.00-27.00mm\n* Astigmatism \\\u003C 1.0 dpt\n* Normal findings in the medical history and physical examination\n* Written informed consent prior to surgery\n\nExclusion Criteria:\n\n* Reduced contrast vision, binocularity or stereoscopic vision (e.g. amblyopia, strabismus)\n* Active ocular disease (e.g chronic uveitis, diabetic retinopathy, chronic glaucoma not responsive to medication, corneal dystrophies, etc.) precluding good post- operative visual acuity\n* Relevant other ophthalmic diseases such as pseudoexfoliation syndrome\n* Irregular astigmatism on corneal tomography\n* Pronounced dry eye disease\n* Nystagmus or pathologies that might affect patient's fixation\n* Previous ocular surgery or trauma\n* Persons who are pregnant or nursing","21 Years","105 Years",{"count":51,"type":20},30,[23],"Comparison of the visual function of two enhanced monofocal intraocular lenses after cataract surgery",[55],"Cataract",[55,57,58],"Cataract surgery","intraocular surgery","NOT_YET_RECRUITING","2025-11-21",{"date":62,"type":32},"2025-12-03",{"date":64,"type":20},"2025-12-01",{"date":66,"type":20},"2027-11-01",{"name":38,"class":39},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":21,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":40},"100586395","brillouin-microscopy-used-to-evaluate-corneal-mechanical-properties-100586395","NCT06914817","Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties","Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties in Patients With Corneal Dystrophies and Post-Corneal Surgery: a Pilot Study","Inclusion Criteria:\n\n* Written informed consent prior to surgery\n* Patients aged 18 years and older\n* Patients who have undergone one of the following corneal surgeries or are diagnosed with one of the following dystrophies:\n\n  * Penetrating Keratoplasty (PKP) and no longer have sutures following PKP o Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)\n  * Descemet Membrane Endothelial Keratoplasty (DMEK)\n  * Fuchs' Endothelial Dystrophy (FED)\n  * Map Dot Fingerprint Dystrophy (MDFD)\n* Healthy Controls: healthy eyes without any history of corneal diseases or surgeries\n\nExclusion Criteria:\n\nAny of the following will exclude a subject from the study:\n\n* Patients with inadequate corneal imaging or corneal scarring that would impact results\n* Patients with other corneal dystrophies or corneal diseases\n* Patients with active ocular infections or inflammatory conditions\n* Patients unable to undergo Brillouin imaging adequately\n* Patients that suffered an eye trauma according to their medical history\n* Patients with fixational problems (e.g., head tremor) or with any medical condition that could interfere with the measurements\n* Pregnancy (pregnancy test will be performed in women of reproductive age)",true,{"count":77,"type":20},100,[23],"This study aims to explore the mechanical properties of the cornea using a non-invasive imaging technique called Brillouin microscopy. This innovative method measures corneal elasticity by detecting small shifts in light frequency, which occur due to interactions with acoustic waves in the tissue. These measurements can provide insights into how corneal stiffness is altered in various eye diseases or after surgery.\n\nThe study includes 100 participants, divided into different groups: patients with Fuchs' Endothelial Dystrophy (FED), Map Dot Fingerprint Dystrophy (MDFD), and those who have undergone corneal surgeries such as Penetrating Keratoplasty (PKP), Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK), and Descemet Membrane Endothelial Keratoplasty (DMEK). Healthy individuals will also be studied as a control group.\n\nParticipants will first receive a standard eye exam, including a slit-lamp examination. Then, Brillouin microscopy will be used to measure the cornea's mechanical stiffness. Additional tests include optical coherence tomography (OCT), corneal topography and tomography, pachymetry (measuring corneal thickness), endothelial cell count, and intraocular pressure (IOP) measurement.\n\nThe purpose of this study is to better understand how diseases and surgeries affect corneal biomechanics. The researchers will also examine how well the Brillouin measurements match with findings from other clinical imaging tests. The results may help improve diagnosis and treatment options for corneal disorders.",[81,82,83,84,85,86],"Map Dot Fingerprint Dystrophy","Post-penetrating Keratoplasty","Post-Descemet Membrane Endothelial Keratoplasty","Healthy Corneas","Fuchs Endothelial Dystrophy","Ost-Descemet Stripping Automated Endothelial Keratoplasty","2025-04-02",{"date":89,"type":32},"2025-04-06",{"date":91,"type":20},"2025-04-01",{"date":93,"type":20},"2025-10-01",{"name":38,"class":39},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":107,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":40},"100562798","comparison-of-two-non--diffractive-extended-depth-of-focus-intraocular-lenses-100562798","NCT06607848","Comparison of Two Non- Diffractive Extended Depth of Focus Intraocular Lenses","Intraindividual Comparison of Two Non- Diffractive Extended Depth of Focus Intraocular Lenses Set for Emmetropia","Inclusion Criteria:\n\n* Age-related bilateral cataract\n* Age 21 or older\n* Visual acuity \\> 0.05\n* For patients with regular corneal astigmatism greater than or equal to 1.00 dpt toric IOLs will be implanted\n* Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically relevant\n* Written informed consent prior to surgery\n\nExclusion Criteria:\n\n* Active ocular disease (e.g chronic uveitis, diabetic retinopathy, chronic glaucoma not responsive to medication, corneal dystrophies, etc.) precluding good post-operative visual acuity\n* Relevant other ophthalmic diseases such as pseudoexfoliation syndrome (PEX)\n* Corneal decompensation or corneal endothelial cell insufficiency\n* Irregular astigmatism on corneal tomography\n* Pronounced dry eye disease\n* Previous ocular surgery or trauma\n* Persons who are pregnant or nursing (pregnancy test will be taken in women of reproductive age)",{"count":103,"type":20},40,[23],"Intra-individual comparison of the PureSee EDOF IOL with the Acunex Vario EDOF IOL set for emmetropia.",[55],[108,109,55],"EDOF IOL","presbyopia-correction","2024-09-19",{"date":112,"type":32},"2024-09-23",{"date":114,"type":32},"2024-07-29",{"date":116,"type":20},"2026-07-01",{"name":38,"class":39},""]