[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Vilnius University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":220},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,54,89,113,137,163,192],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100625756","comparison-of-outpatient-rehabilitation-versus-self-training-for-the-treatment-and-prevention-of-postpartum-pelvic-floor-dysfunction-100625756",false,"NCT07426770","Comparison of Outpatient Rehabilitation Versus Self-training for the Treatment and Prevention of Postpartum Pelvic Floor Dysfunction","Prevention of Female Pelvic Floor Dysfunction Rehabilitation Postpartum.","DDDPREV","Inclusion Criteria:\n\n* 18 years or older\n* This pregnancy was singleton\n* No contraindications for physical activity\n* No connective tissue disorders (for example Ehlers-Danlos syndrome)\n* No neurological disorders to influence pelvic floor symptoms (for example clinically significant spinal disc herniation)\n\nExclusion Criteria:\n\n* Younger than 18 years\n* Twins or triplet pregnancy\n* Contraindications for physical activity\n* Connective tissue disorders\n* Neurological disorders",true,"FEMALE","18 Years","50 Years",{"count":22,"type":23},80,"ESTIMATED","INTERVENTIONAL",[26],"NA","The main goal of this study to compare self-training postpartum and training with a specialist support (physiotherapist and physical medicine and rehabilitation doctor) effect on pelvic floor dysfunction prevention and treatment in postpartum period.\n\nHypothesis: The implementation of postpartum rehabilitation helps to alleviate existing symptoms of pelvic floor dysfunction and prevents pelvic floor dysfunction.\n\nStudy goals:\n\n* To objectively evaluate changes in pelvic organ position and pelvic floor muscle function in postpartum period, before and after specialised rehabilitation program\n* To objectively evaluate pelvic floor symptoms and their influence on woman life quality\n* To compare data (changes in pelvic floor muscle coordination and strength, pelvic organ position and changes in life quality according to validated questionnaires)\n\nStudy participants will:\n\n* Get an examination by obstetrician-gynaecologist, physical medicine and rehabilitation doctor and physiotherapist in 6 to 10 weeks postpartum period.\n* One group of participants will attend physiotherapy, biofeedback and electro stimulation procedures with a guidance of a specialist.\n* Other group of participants gets a recommendations and instructions of training and self-trains at home. To remind of training and help record training time \"squeezy\" app (an application designed for a mobile device) will be offered.\n* All groups of participants will be asked to fill life quality related questionnaires: (ICIQ-UI SF: International Consultation on Incontinence Questionnaire; P-QoL: Prolapse Quality-of-Life Questionnaire; PISQ-IR: Pelvic Organ Prolapse\u002F Urinary Incontinence Sexual Questionnaire IUGA revised; FSFI: female sexual function index; MOS-SF36 Medical Outcomes Study Short Form-36).",[29,30,31,32,33,34],"Pelvic Floor Dysfunction","Postpartum Care","Postpartum Comfort","Female Urinary Incontinence and Pelvic Organ Prolapse","Rectus Diastasis","Sexual Dysfunction Female",[36,37,38,39,40],"Pelvic floor dysfunction postpartum","Postpartum urinary incontinence","Postpartum sexual dysfunction","Diastasis postpartum","Rehabilitation postpartum","RECRUITING","2026-02-16",{"date":44,"type":45},"2026-02-23","ACTUAL",{"date":47,"type":45},"2024-01-30",{"date":49,"type":23},"2029-09-30",{"name":51,"class":52},"Vilnius University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":24,"phases":66,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},"100529623","a-comparative-prospective-study-of-the-arthroscopic-meniscal-repair-methods-100529623","NCT06176183","A Comparative Prospective Study of the Arthroscopic Meniscal Repair Methods","A Comparative Prospective Study of Meniscal Repair Methods in Young Patients With Traumatic Meniscal Tears.","Inclusion Criteria:\n\n* Individuals who provide consent to participate in the study, including patients and their care providers. The inclusion criteria for this study are as follows: being under the age of 19, having a traumatic isolated full-thickness meniscal tear longer than 1cm that has been confirmed by both preoperative MRI and arthroscopy, and not having undergone any previous surgery on the affected knee.\n\nExclusion Criteria:\n\n* This investigation excludes patients with developmental disabilities who are unable to read or interpret in their native language.","ALL","0 Years","19 Years",{"count":65,"type":23},100,[26],"Performing arthroscopic meniscus repair following a traumatic meniscus tear as an alternative to a meniscectomy is now an acceptable choice. Preserving meniscus tissues is crucial due to the significant role they play as an essential part of the knee joint. It is essential to comprehend the additional tools that can impact the recovery of the meniscus after suturing. Patients have been randomly assigned into two groups using the computer \"www.randomiser.org,\" and the treatment outcomes were compared after one year. One group of patients has received a standard meniscus suturing technique, whereas another group has experienced the meniscus suturing treatment with an additional fibrin clot approach. Data pertaining to demographics, clinical characteristics, radiological findings, and survey responses have been carefully collected prospectively.",[69,70,71],"Meniscus Tear Caused by a Traumatic Event","Fibrin Clot Augmentation","Meniscal Repair",[73,74,75,76,77,78,79],"meniscal tear","meniscal repair","fibrin clot","augmentation","arthroscopy","knee","young patients","2025-08-22",{"date":82,"type":45},"2025-08-28",{"date":84,"type":45},"2021-05-26",{"date":86,"type":23},"2026-12-26",{"name":51,"class":52},2,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":61,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":24,"phases":101,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":53},"100590387","comparison-of-continuous-positive-airway-pressure-cpap-and-non-invasive-positive-pressure-ventilation-nippv-in-preterm-newborns-with-respiratory-distress-syndrome-100590387","NCT06966752","Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Preterm Newborns With Respiratory Distress Syndrome.","Randomized Control Trial: Nasal CPAP vs. NIPPV in Preterm Infants With Respiratory Distress Syndrome","NC3","Inclusion Criteria:\n\n1. gestational age (GA) between 22+0 and 34+6 weeks (estimated on the postmenstrual date and early gestation ultrasonographic findings).\n2. Need of respiratory support (deemed by a clinician).\n\nExclusion Criteria:\n\n1. Major congenital anomalies\n2. Cardiovascular instability\n3. Consent refused or not provided","0 Minutes","44 Weeks",{"count":100,"type":23},150,[26],"Primary objective: to evaluate safety and efficacy of two different non-invasive respiratory support modalities in preterm neonatal patients with respiratory distress syndrome.\n\nSecondary objective is to compare different respiratory support mode performance in different gestational age groups.\n\nPrimary endpoint is treatment failure.\n\nWith this study, the following hypotheses will be tested:\n\nHypothesis 1: NIPPV has a lower failure rate compared to CPAP mode. Hypothesis 2: NIPPV complication rate is non-superior compared to CPAP.",[104],"Respiratory Distress Syndrome (RDS)","2025-05-07",{"date":107,"type":45},"2025-05-13",{"date":109,"type":45},"2025-03-25",{"date":111,"type":23},"2027-05-01",{"name":51,"class":52},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":61,"minAge":19,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":88},"100577032","diagnosis-treatment-and-outcome-assessment-of-septic-cardiomyopathy-using-an-integrated-mathematical-model-100577032","NCT06793020","Diagnosis, Treatment, and Outcome Assessment of Septic Cardiomyopathy Using an Integrated Mathematical Model","Use of an Integrated Mathematical Model for the Diagnosis, Treatment and Outcome Assessment of Septic Cardiomyopathy","Inclusion Criteria:\n\n* Age 18 years or older;\n* Sepsis according to SEPSIS-3 criteria:\n* Suspected\u002Fconfirmed infection and\n* SOFA (Sequential Organ Failure Assessment) score ≥ 2 or qSOFA score ≥ 2;\n* Septic shock according to SEPSIS-3 criteria:\n* Sepsis is diagnosed and\n* Vasopressor infusion is used to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and\n* Lactate \\> 2 mmol\u002Fl;\n* Cardiovascular support requirement for norepinephrine \\> 0.1 mcg\u002Fkg\u002Fmin infusion;\n* Signed informed consent form (ICF);\n\nExclusion Criteria:\n\n* Individuals under 18 years of age;\n* Has uncompensated cardiovascular disease:\n* Cardiogenic shock;\n* Congenital heart disease;\n* Heart failure NYHA functional class IV;\n* Refusal to participate in the study.",{"count":65,"type":23},"OBSERVATIONAL","The goal of this observational study is to evaluate whether a new integrated mathematical model can improve the accuracy of diagnosing septic cardiomyopathy and predicting clinical outcomes in adult patients with suspected septic cardiomyopathy. The study aims to determine whether the integrated mathematical model enhances diagnostic accuracy and improves the prediction of clinical outcomes in these patients.",[124],"Septic Cardiomyopathy",[126,127,128],"Septic cardiomyopathy","Sepsis","Septic shock","2025-01-24",{"date":131,"type":45},"2025-01-27",{"date":133,"type":45},"2024-03-17",{"date":135,"type":23},"2028-03",{"name":51,"class":52},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":17,"sex":61,"minAge":19,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":146,"conditions":147,"keywords":153,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":53},"100554716","bile-acids-and-microbiome-in-early-colorectal-carcinogenesis-100554716","NCT06502704","Bile Acids and Microbiome in Early Colorectal Carcinogenesis","Bile Acids and Microbiome - Possible Novel Progression Factors and Diagnostic Indicators in Early Colorectal Carcinogenesis","Inclusion Criteria:\n\n\\- Patients that have clinical indications for colonoscopy\n\nExclusion Criteria:\n\n* Pregnancy\n* Immunocompromised\n* Previously diagnosed colorectal diseases\n* Radiotherapy to the pelvis\n* Long term antibiotic use within 6 months\n* Continuous use of proton pump inhibitors",{"count":145,"type":23},60,"Currently colorectal cancer pathogenesis is mainly explained by the adenoma-carcinoma sequence theory that was proposed more than half a century ago. It mainly focuses on the explanation of genetic mutations that develop throughout the disease course. However, several studies argue that there are also noticeable bile acid metabolism changes and microbiome composition changes within in colorectal cancer patients. However, carcinoma is the final step in the sequence, and prior steps are noticeably less well studied. Thus, the investigators hypothesize, that changes within microbiome and the changes in the urine, serum and gut bile acid composition further leads to the development of colorectal adenoma and subsequent invasive carcinoma.\n\nAdult participants (15 per group) referred for colonoscopy and histologically diagnosed with small (\\\u003C1cm) adenomas, large (\\>1cm) adenomas, invasive CRC will be included in the study, as well as 15 healthy controls. Fecal samples will be collected from all participants before bowel preparation. Additionally, urine and serum samples will be collected. Participants will undergo polypectomy, endoscopic mucosal resections, depending on the location, size and histology of the polyp found. During colonoscopy the mucosal biopsy specimens from the lesion and from the healthy bowel -terminal ileum, and colon will be obtained using sterile biopsy forceps. The collected samples will be stored for bile acid and microbiome analysis and for possible further pathology and genetic testing. Healthy participants without visible colorectum pathology during colonoscopy will undergo colon and terminal ileum mucosal sampling.\n\nThe investigators plan to evaluate the correlation between the urine and gut microbiome changes and bile acid composition and concentration in adenoma-carcinoma sequence and possibly determine novel bile acids. In addition, fecal, urine and tissue samples will be explored for gut microbiota and bile acid composition changes in healthy and along the adenoma-carcinoma sequence, with the possibility to propose a diagnostic test.",[148,149,150,151,152],"Colorectal Neoplasms","Colorectal Cancer","Colorectal Polyp","Microbiome","Bile Acid Malabsorption",[148,149,150,151,154],"Bile Acid","2024-07-08",{"date":157,"type":45},"2024-07-16",{"date":159,"type":23},"2024-07-05",{"date":161,"type":23},"2025-01-01",{"name":51,"class":52},{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":61,"minAge":19,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":24,"phases":173,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":183,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":4},"100552640","guided-internet-based-trauma-focused-cbt-programme-for-post-traumatic-stress-disorder-spring-100552640","NCT06475716","Guided Internet-based Trauma-focused CBT Programme for Post-traumatic Stress Disorder 'Spring'","Efficacy of a Guided Internet-based Trauma-focused CBT Intervention 'Spring' for ICD-11 Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial","SPRING-LT","Inclusion Criteria:\n\n* Aged 18 years or over\n* Ability to read and write fluently in Lithuanian\n* Have regular access to a device with an internet connection to use the programme\n* Provide informed consent for participation\n* Experience PTSD symptoms followed by a non-prolonged and non-repetitive traumatic experience as measured by the ITI\n\nExclusion Criteria:\n\n* Regularly seeing a therapist or counsellor for mental health issues\n* Change in psychotropic medication in the last month\n* CPTSD diagnosis\n* Psychosis\n* Severe suicide risk\n* Substance dependence\n* Experiencing ongoing threat",{"count":172,"type":23},50,[26],"The main aim of the study is to evaluate the efficacy of the Lithuanian version of the internet-based guided self-help programme (Spring) in reducing ICD-11 PTSD symptoms.",[176],"Posttraumatic Stress Disorder",[178,179,180,181,182],"trauma","posttraumatic stress","treatment","cognitive behavior therapy","internet-based intervention","NOT_YET_RECRUITING","2024-06-25",{"date":186,"type":45},"2024-06-26",{"date":188,"type":23},"2024-09-10",{"date":190,"type":23},"2025-12-20",{"name":51,"class":52},{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":61,"minAge":19,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":24,"phases":201,"briefSummary":202,"conditions":203,"keywords":206,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":219},"100515330","hypoxaemic-respiratory-failure-and-awake-prone-ventilation-100515330","NCT05990101","HYPoxaEmic Respiratory Failure and Awake Prone Ventilation","Hyper-AP","Inclusion Criteria:\n\n* Adult patients admitted to intensive care unit for acute hypoxemic respiratory failure.\n* Acute hypoxemic respiratory failure is defined by respiratory rate ≥25 breaths\u002Fmin, and partial pressure of oxygen in the arterial blood (PaO2)\u002Ffraction of inspired oxygen (FiO2) ≤300 mm Hg or oxygen saturation (SpO2)\u002Ffraction of inspired oxygen (FiO2) ratio \\\u003C235 while spontaneously breathing under standard oxygen with oxygen flow rate of at least 10 L\u002Fmin, high flow oxygen therapy or non-invasive ventilation. For patients under standard oxygen, FiO2 is calculated according to the following formula: FiO2=0.21 + 0.03 per litre of supplemental oxygen.\n* Informed consent\n\nExclusion Criteria:\n\n* impaired consciousness - Glasgow coma score \\\u003C14;\n* inability to cooperate or prone position intolerance;\n* immediate indications for endotracheal intubation;\n* patients with do-not-intubate order at time of inclusion;\n* patients with contraindication to high flow oxygen therapy (HFOT) or non-invasive ventilation (NIV);\n* Partial pressure of carbon dioxide (PaCO2) above 50 mm Hg and quantitative measure of the acidity (pH) \\\u003C7,3;\n* vasopressor dose \\>0.3 µg\u002Fkg\u002Fmin of norepinephrine-equivalent to maintain systolic blood pressure \\>90 mmHg;\n* Covid-19 positive",{"count":200,"type":23},262,[26],"The goal of this prospective multi-centre randomised controlled trial is to determine if addition of awake prone positioning to standard oxygen, high flow oxygen therapy and non-invasive ventilation may reduce the rates of endotracheal intubation and mechanical ventilation.",[204,205],"Respiratory Failure","Hypoxemia",[207,208,209,210],"Awake prone","Respiratory failure","ARDS","Hypoxaemia","2023-08-04",{"date":213,"type":45},"2023-08-14",{"date":215,"type":45},"2023-05-12",{"date":217,"type":23},"2028-09-01",{"name":51,"class":52},4,""]