[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Virginia Polytechnic Institute and State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":557},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,41,63,88,109,139,159,182,207,231,253,284,307,330,358,383,404,423,447,467,489,511,536],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100538689","etms-for-veterans-and-first-responders-with-ptsd-100538689",false,"NCT06294106","eTMS for Veterans and First Responders With PTSD","Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder (PTSD)","Inclusion Criteria:\n\n* Veteran or first responder\n* diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above\n\nExclusion Criteria:\n\n* Claustrophobia\n* Contraindications to MRI\n* Pregnant\n* Uncontrolled medical, psychological, or neurological conditions\n* Unable to calculate EEG alpha frequency\n* History of ECT or rTMS\n* History of intracranial lesion or increased intracranial pressure\n* History of stroke\n* History of other neurologic conditions\n* Family history of epilepsy\n* Personal history of epilepsy\n* certain medications","ALL","18 Years","65 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.",[27],"Post Traumatic Stress Disorder","RECRUITING","2026-06-30",{"date":31,"type":32},"2026-07-02","ACTUAL",{"date":34,"type":32},"2024-06-10",{"date":36,"type":21},"2028-09",{"name":38,"class":39},"Virginia Polytechnic Institute and State University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":57,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":40},"100520186","neural-and-metabolic-factors-in-carbohydrate-reward-100520186","NCT06053294","Neural and Metabolic Factors in Carbohydrate Reward","Neural and Metabolic Factors in Carbohydrate Reward: An Examination of Speed","CARB","Inclusion Criteria:\n\n1. BMI between 18.5-30 kg\u002Fm2\n2. Not pregnant or planning to become pregnant during study participation\n3. Residing in the Roanoke area and\u002For willing\u002Fable to attend sessions at the Fralin Biomedical Research Institute\n4. Able to speak and write in English\n\nExclusion Criteria:\n\n1. Current inhaled nicotine use\n2. History of alcohol dependence.\n3. Current or past diagnosis of diabetes or thyroid problems.\n4. Taking medications known to influence study measures (including antiglycemic agents, thyroid medications, sleep medications)\n5. Active medical or neurologic disorder.\n6. Current shift work (typical pattern of work\u002Factivity overnight)\n7. Previous weight loss surgery\n8. Adherence to a special diet within the past 3 months (e.g., low-carb or ketogenic diet, exclusion of food groups\u002Fspecific macronutrients, intermittent fasting, etc.)\n9. Allergy to any food or ingredient included in the study diets, meals, or beverages\n10. Currently pregnant or planning to become pregnant during study participation\n11. Claustrophobia\n12. Contraindications for MRI, including pacemaker, aneurysm clips, neurostimulators, cochlear or other implants, metal in eyes, regular work with steel, etc.",true,"45 Years",{"count":52,"type":21},64,[24],"Dietary factors contributed to nearly 50% of all cardiometabolic deaths in the US in 2012, making it one of the leading causes of preventable death in the US, second only to tobacco use. Human diets and food choices can't help but be influenced by the ubiquitous availability of processed foods of high-energy density and low nutrient content, consumption of which can lead to obesity, type II diabetes, heart disease, and other types of metabolic dysfunction. Surprisingly, food reinforcement does not rely on perceived energy density. Rather food reinforcement is associated with actual energy density and therefore, on an implicit knowledge of caloric content. That implicit knowledge must have a neural signature and a mechanism by which the gut communicates nutritive value to the brain. There is evidence, at least for fat and carbohydrates, that these pathways are separable, but terminate in a common neural structure, the dorsal striatum or caudate. This could be one mechanism by which modern processed foods high in both fat and carbohydrate are so sought after and readily consumed, In fact, when experimentally tested, fat and carbohydrate combinations were more reinforcing calorie for calorie than fat or carbohydrates alone and the level of reinforcement correlated with activity in reward- related brain areas. Beyond simple reinforcing value, it is known from the literature on drugs of abuse that the faster a drug is arrives at the brain, the higher it's abuse potential, however, little is known about how the kinetics of nutrient excursion influence food preference, choice, and brain activity. This project aims to test this specifically for carbohydrate reward.",[56],"Carbohydrate Metabolism",{"date":31,"type":32},{"date":59,"type":32},"2023-05-01",{"date":61,"type":21},"2029-05-01",{"name":38,"class":39},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":49,"sex":16,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":74,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":4},"100641282","cooking-health-oriented-meals-to-prevent-dementia-and-diabetes-100641282","NCT07661368","Cooking Health-Oriented Meals to Prevent Dementia and Diabetes","CHOMPDD","Inclusion Criteria:\n\n* Age: 50 - 75 yrs\n* Score of 5 or greater on ADA (diabetes) screener\n* Self-report family history of dementia or AD\n* Smartphone (iOS or Android)\n* Verbal and written informed consent\n\nExclusion Criteria:\n\n* Food allergies or conditions requiring a specialized diet that would limit participation","50 Years","75 Years",{"count":73,"type":21},40,[24],"Previous research demonstrates that 1) adherence to a DASH dietary pattern and diets low in certain UPFs are linked to lower likelihood of experiencing cognitive impairments in later life (Seago et al., 2025a, 2025b), that 2) engagement in cooking is linked to healthier eating, reduced UPF consumption, and higher food self-efficacy (Lahne et al., 2017), and 3) that cooking activity itself in midlife is associated with reduced incidence of dementia (Tani et al., 2026). There may be multiple pathways through which cooking engagement facilitates healthier cognitive aging- including the benefits of healthier meals on cardiometabolic and neural health, but also the role of cooking as a cognitively-engaging activity - one that has been identified as a potential contributor to cognitive reserve during aging. While at least one computerized cognitive training program is based on cooking activities and has demonstrated improvements to untrained EF processes in older adults, no intervention has used actual cooking as a form of cognitive training. Part of the promise of such an intervention is that this sort of activity, while still engaging EF processes in a way that might lead to generalizable improvements, is much closer to real-world instrumental activities of daily living and may reinforce consumption of a brain- and cardiometabolic- health promoting dietary pattern. This pilot study involves a randomized controlled trial of a behavioral change intervention to promote a healthy diet by increasing cooking self-efficacy (agency), and for this study, cooking self-efficacy is the primary focus.",[77,78],"Type 2 Diabetes","Dementia","NOT_YET_RECRUITING","2026-06-16",{"date":82,"type":32},"2026-06-22",{"date":84,"type":21},"2026-07",{"date":86,"type":21},"2026-12",{"name":38,"class":39},{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":40},"100533898","tracking-a-tactile-signal-along-the-nervous-system-100533898","NCT06231810","Tracking a Tactile Signal Along the Nervous System","Inclusion Criteria:\n\n-right-hand dominance for participants who are neurotypical\n\nFor Aim 1:\n\n-age range of 18-23\n\nFor Aim 2:\n\n* participants who are neurotypical will be a similar age to the participants with stroke\n* participants who are neurotypical will have no musculoskeletal and neurological conditions\n* participants with stroke will have a single stroke incident resulting in a unilateral lesion (ischemic and hemorrhagic)\n* participants with stroke will be in the chronic phase (\\>1 year from stroke onset)\n* participants with stroke will have an onset of stroke after the age of 18\n* participants with stroke who meet the criteria of having the capacity to provide informed consent, regardless of aphasia\n\nExclusion Criteria:\n\n* minors\n* pregnant women\n* prisoners\n* adults not capable of consenting on their own behalf.\n\nFor Aim 2:\n\n* participants with stroke who have used antispastic injections in the past six months\n* participants with stroke who have a lesion in the brainstem and\u002For cerebellum\n* participants with stroke who have a stroke arising due to brain surgery\n* participants with stroke who have hemineglect",{"count":95,"type":21},60,[24],"Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2).",[99,100],"Stroke","Tactile Perception","2026-06-15",{"date":103,"type":32},"2026-06-17",{"date":105,"type":32},"2024-02-29",{"date":107,"type":21},"2028-07-01",{"name":38,"class":39},{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":125,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":4},"100643285","the-influence-of-obesity-and-insulin-sensitivity-on-reward-processing-and-decision-making-100643285","NCT07638059","The Influence of Obesity and Insulin Sensitivity on Reward Processing and Decision Making","No acronym","Inclusion Criteria:\n\n* 18 to 45 years of age\n* Self-reported weight stable (within 5 lbs) for previous 3 months\n* Not pregnant or planning to become pregnant during study participation\n* Weigh more than 110 lbs (due to blood draws used in study)\n* Residing in Roanoke, VA, area and\u002For willing to attend sessions at the Fralin Biomedical Research Institute\n\nExclusion criteria:\n\n* BMI \\\u003C 18.5 or \\> 40 kg\u002Fm2\n* Hemoglobin A1c \\> 6.4%\n* Fasting blood glucose \\> 126 mg\u002FdL\n* 2-hour blood glucose \\> 200 mg\u002FdL\n* Self-reported current diagnosis of diabetes or other endocrine\u002Fmetabolic disorder\n* Self-reported current inhaled nicotine use\n* Self-reported history of alcohol dependence\n* Self-reported use of medications known to influence study measures (including antiglycemic agents, thyroid medications, etc.)\n* Self-reported neurological or psychological disorder\n* Self-reported claustrophobia or discomfort with mock fMRI training\n* Self-reported history of head injury resulting in loss of consciousness for more than 10 minutes\n* Contraindications to MRI, including pacemaker, aneurysm clip, neurostimulator, cochlear implant, metal in eyes, steel worker, other implants\n* Self-reported previous metabolic\u002Fweight loss surgery\n* Self-reported adherence to special or restrictive diet within the past 3 months (e.g., low-carb, ketogenic, exclusion of food groups\u002Fspecific macronutrients, etc.)\n* Self-reported allergy to ingredient used in the study drinks",{"count":117,"type":21},50,[24],"Reward learning and decision-making processes, which operate largely outside of conscious control, shape food choices and eating behaviors. Excess adiposity is associated with differences in brain structure and functional connectivity underlying these processes, and insulin resistance, which commonly co-occurs with excess adiposity, has been linked with dopamine signaling that is crucial for these processes. However, whether and how excess adiposity and insulin resistance affect reward learning and decision-making remains poorly understood. This study will address that gap, examining the effects of excess adiposity and insulin resistance, and their interaction, on processes of reward learning and decision-making in food-specific and general contexts.",[121,122,123,124],"Adiposity","Insulin Sensitivity\u002FResistance","Decision-Making","Reward Learning",[126,127,128,129,130],"flavor nutrient learning","insulin sensitivity","adiposity","decision-making","probabilistic learning","2026-06-05",{"date":133,"type":32},"2026-06-10",{"date":135,"type":21},"2026-07-01",{"date":137,"type":21},"2029-07-01",{"name":38,"class":39},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":40},"100462572","study-of-low-intensity-focused-ultrasound-effects-on-heat-evoked-fmri-signals-100462572","NCT05303415","Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals","Inclusion Criteria:\n\n* Healthy volunteers, all ethnicities, who understand and speak English.\n\nExclusion Criteria:\n\nClaustrophobia (scanning environment may be uncomfortable). Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.\n\nContraindications to CT: pregnancy Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's) History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor) History of head injury resulting in loss of consciousness for \\>10 minutes. History of alcohol or drug dependence (through self-report).",{"count":146,"type":21},80,[24],"Study of LIFU on fMRI pain signals. Participants receive low-intensity focused ultrasound (LIFU) and fMRI scans to measure changes in both resting and heat pain signals. Physiology may also be measured. Questionnaires and symptom monitoring will take place. The study takes place over 4 study visits.",[150],"Pain","2026-06-04",{"date":153,"type":32},"2026-06-08",{"date":155,"type":32},"2022-05-06",{"date":157,"type":21},"2027-12",{"name":38,"class":39},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":168,"conditions":169,"keywords":171,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":40},"100628136","remote-haptic-rehabilitation-for-parkinsons-disease-100628136","NCT07457710","Remote Haptic Rehabilitation for Parkinson's Disease","Enhancing Parkinson's Disease Rehabilitation Through Remote Haptic Guidance: Field Study","Inclusion Criteria:\n\n* Over 18 years old\n* Diagnosed with PD\n\nExclusion Criteria:\n\n* Hoehn and Yahr stage outside 1-3\n* Lives outside the 48 contiguous states in the USA\n* Unable to move hands and head without assistance\n* Unable to remain seated in an upright position for up to an hour",{"count":20,"type":21},[24],"Individuals with Parkinson's Disease (PD) often have motor difficulties that can negatively impact daily activities and their quality of life. Research has shown that to slow the progression of these symptoms, patients should partake in effective physical rehabilitation. However, effective physical rehabilitation has many barriers, including timing, cost, and other personal or system-level challenges. The purpose of this study is to evaluate the haptic remote rehabilitation system for patients with PD using a randomized controlled trial (RCT) in a field environment.",[170],"Parkinson's Disease (PD)",[172,173,174],"Parkinson's Disease","Haptic","Remote Rehabilitation","2026-06-03",{"date":131,"type":32},{"date":178,"type":32},"2026-03-25",{"date":180,"type":21},"2027-06-30",{"name":38,"class":39},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":189,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":193,"conditions":194,"keywords":196,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":206},"100603911","effects-of-tax-proposals-and-cigarette-availability-on-tobacco-purchasing-100603911","NCT07142668","Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing","The Impact of Availability of Conventional Cigarettes and LNCs in the Context of Innovative Tax Proposals","Inclusion Criteria:\n\n* provide informed consent\n* provide a breath carbon monoxide sample ≥ 8 ppm,\n* be at least 21 years of age (the legal age to purchase tobacco),\n* smoke at least 10 cigarettes daily, and\n* use other tobacco products less than weekly.\n\nExclusion Criteria:\n\n* report uncontrolled physical or mental health conditions (e.g., uncontrolled diabetes, high blood pressure, major depressive disorder, etc.),\n* use of smoking cessation medications (e.g., nicotine replacement, bupropion, varenicline) in the past 30 days,\n* report concrete, immediate plans to alter\u002Fquit using their usual tobacco products in the next 30 days,\n* be pregnant or lactating, or\n* have plans to move out of the area during the experiment.","21 Years",{"count":191,"type":21},316,[24],"This study will investigate the effects of normal-nicotine versus low-nicotine cigarette availability in the context of four tax proposals (Tobacco Parity, Nicotine-Content, Harm-Reduction, and Modified Risk Tobacco Product-based taxes) on tobacco product purchasing patterns in a virtual marketplace.",[195],"Cigarette Smoking",[197],"Experimental Tobacco Marketplace","2026-05-15",{"date":200,"type":32},"2026-05-19",{"date":202,"type":32},"2025-08-14",{"date":204,"type":21},"2026-09-30",{"name":38,"class":39},2,{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":49,"sex":16,"minAge":70,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":40},"100610584","potatoes-type-2-diabetes-and-cardiometabolic-health-100610584","NCT07229482","Potatoes, Type 2 Diabetes, and Cardiometabolic Health","Cardiometabolic Effects of a Potato-rich Diet in Older Adults at Increased Risk of Developing Type 2 Diabetes: A Randomized Controlled Feeding Study","Inclusion Criteria:\n\n* Age 50-70 years\n* Weight stable for previous 3 months (±5% body weight)\n* Sedentary to recreationally active\n* ADA-Risk Screener questionnaire score of at least 5\n* No plans to gain or lose weight or change physical activity level\n* Willing to pick up food daily and consume foods provided for a 14-week period\n* Verbal and written informed consent\n* Estrogen or testosterone use, lipid-lowering medication and thyroid replacement medication is acceptable, if on stable dose for \\>6 months\n\nExclusion Criteria:\n\n* Body mass index \\>40 m2\u002Fkg\n* Diabetes or diabetes medication\n* Weight loss medication or medication influencing glucose metabolism\n* Antibiotic, prebiotic or probiotic use in prior 3 months\n* TCHOL \\>6.2 mmol\u002FL; TG \\>4.5 mmol\u002FL\n* Blood pressure (BP) \\> 159\u002F99 mmHg or taking antihypertensive medication\n* Diagnosed inflammatory bowel disease\n* Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease\n* Vegetarian or vegan\n* Pregnant or plans to become pregnant\n* Food allergies or aversions to diet foods provided\n* Estrogen or testosterone usage or lipid-lowering medication usage \\\u003C6 months","70 Years",{"count":216,"type":21},42,[24],"Type 2 diabetes (T2D) is a major chronic health condition which increases risk of coronary artery disease, frailty, cognitive decline, and mortality. Additionally, hypertension is a major comorbidity for individuals with T2D, further increasing the risk of adverse cardiovascular outcomes. The prevalence of both conditions increases with advancing age. There is an urgent need to identify new approaches to prevent the development of T2D and improve cardiometabolic health in older adults 50-70 years of age.\n\nWhole white potatoes are an unprocessed food rich in essential nutrients often under-consumed by Americans, including potassium, fiber, magnesium, vitamins C and B6, and phytochemicals. Each of these nutrients individually are associated with cardiometabolic health benefits. Potatoes account for a significant amount of the intake of these nutrients in the US diet and are well-positioned to be a foundational element of a healthy dietary pattern. However, there are few interventional studies evaluating the effect of potatoes on cardiometabolic health, and the evidence from observational studies is mixed, leaving a significant gap in knowledge regarding the potential for potatoes to be included in healthy dietary patterns.\n\nThe results of our proposed study will provide foundational data that inform future dietary guidelines regarding the inclusion of white potatoes as part of a healthy US dietary pattern.",[220,221,222],"T2D","Blood Pressure","Cardiometabolic Health","2026-04-09",{"date":225,"type":32},"2026-04-13",{"date":227,"type":21},"2026-06",{"date":229,"type":21},"2029-03",{"name":38,"class":39},{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":238,"enrollmentInfo":239,"targetDuration":4,"studyType":22,"phases":241,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":4},"100633006","early-phase-1-testing-an-intervention-for-college-students-with-food-insecurity-and-binge-eating-100633006","NCT07521072","Testing an Intervention for College Students With Food Insecurity and Binge Eating","Building an Intervention for College Students With Food Insecurity and Binge Eating","Inclusion Criteria:\n\n* college student status, ages 18-30 years, current food insecurity, current binge eating, and interest in changing binge eating behaviors. Food security status will be determined by 2-item the Hunger Vital Sign screening, which demonstrates high sensitivity and specificity in identifying individuals with food insecurity; scores must report mild or greater food insecurity to participate. Binge eating and related impairment will be evaluated by the Eating Disorder Diagnostic Scale and the Clinical Impairment Assessment, and the binge eating items from the Eating Disorder Examination interview. Eating behaviors must be consistent with a DSM-5-TR binge spectrum eating disorder diagnosis, whereby an individual reports binge eating episodes at minimum one time per week for the current month and at least two times per month for the prior two months, to participate. Participants will be permitted to report other mild level symptoms of psychopathology due to the high comorbidity between anxiety, depression, and binge eating among individuals with food insecurity.\n\nExclusion Criteria:\n\n* Severe levels of anxiety and depression symptoms.","30 Years",{"count":240,"type":21},10,[242],"EARLY_PHASE1","This study is being conducted to test a new intervention. We are interested in whether it is easy to use and complete and whether you find it helpful in reducing concerns about your eating.",[245],"Binge Eating","2026-04-02",{"date":223,"type":32},{"date":249,"type":21},"2026-12-01",{"date":251,"type":21},"2028-05-01",{"name":38,"class":39},{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":259,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":16,"minAge":261,"maxAge":262,"enrollmentInfo":263,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":270,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":40},"100571817","regulating-emotions-like-an-expert-among-adolescents-with-adhd-100571817","NCT06725186","Regulating Emotions Like An eXpert Among Adolescents With ADHD","Improving Emotion Dysregulation and Interpersonal Conflict Among Families of Adolescents With ADHD","RELAX","Inclusion Criteria:\n\n* child with ADHD in middle or high school at time of study entry\n* child has an estimated verbal IQ \\>=80 based on the Wechsler Intelligence Scale for Children, Fifth Edition Verbal Comprehension Index\n* child has no evidence of severe developmental delay either from genetic origins (e.g., Down Syndrome) or complications during pregnancy\u002Fbirth (e.g., infection, micropremature)\n* participating parent\u002Flegal guardian has custody\u002Fmedical decision making of the child\n* family uses English as one of their primary languages (i.e., able to participate in study visits and intervention conducted in English)\n\nExclusion Criteria:\n\n* child not diagnosed with ADHD as confirmed by prior documented diagnosis and\u002For current comprehensive ADHD assessment as part of intake visit\n* having a child outside of the eligible age range of 11-16 at time of study enrollment\n* participating parent not having legal custody of the child\n* having parents or children who are not fluent in English\n* having a child with a severe developmental delay either from genetic origins (e.g., Down Syndrome) or complications from pregnancy\u002Fbirth (e.g., infection, micro-premature)\n* child has an IQ \\\u003C 70.","11 Years","16 Years",{"count":95,"type":21},[24],"This study consists of a randomized controlled trial assessing the acceptability, feasibility, and efficacy of the RELAX (Regulating Emotions Like An eXpert) Intervention. Following randomization, 30 families will receive the RELAX intervention and 30 families will receive psychoeducational materials as part of a control condition. Additionally, 10 families from the RELAX condition will participate in a pilot study and focus groups to give feedback on developed smartphone apps to support skill use during and following completion of RELAX.",[267,268,269],"RELAX Telehealth Intervention","Psychoeducational Waitlist Control","EMI Smartphone App Pilot",[271,272,273,274,275],"ADHD","telehealth","emotion regulation","family conflict","parenting","2026-03-27",{"date":278,"type":32},"2026-03-30",{"date":280,"type":32},"2025-01-15",{"date":282,"type":21},"2028-12",{"name":38,"class":39},{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":11,"sex":16,"minAge":189,"maxAge":4,"enrollmentInfo":291,"targetDuration":4,"studyType":22,"phases":293,"briefSummary":294,"conditions":295,"keywords":297,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":40},"100605148","generalized-and-domain-specific-episodic-thinking-for-smoking-cessation-100605148","NCT07158749","Generalized and Domain-Specific Episodic Thinking for Smoking Cessation","Generalized and Domain-Specific Episodic Thinking for Smoking Cessation: An 8-Week Pilot and Feasibility Trial","Inclusion Criteria:\n\n* smoked cigarettes daily for the last 30 days;\n* salivary cotinine \\> 30 ng\u002FmL, consistent with tobacco use;\n* plan to quit smoking in the next 30 days\n\nExclusion Criteria:\n\n* prior diagnosis with a smoking-related illness (e.g., respiratory disease);\n* past 30-day use any smoking cessation treatment;\n* anxiety or mood disorders; and\n* medical contraindications for use of nicotine replacement therapy (e.g. pregnancy).",{"count":292,"type":21},134,[24],"Cigarette smoking remains common, particularly in rural areas, despite ample evidence that smoking causes cancer and respiratory disease. Successful smoking cessation yields the majority of its health benefits (e.g., avoidance of lung cancer) after years of sustained behavioral change; however, people who smoke cigarettes tend to show elevated rates of delay discounting (i.e., devaluation of delayed outcomes) and a bias for immediate gratification. The overall goal of this project is to develop different versions of an episodic future thinking intervention (i.e., visualization of the future) and test their feasibility and efficacy for smoking cessation in rural and urban populations.",[296],"Cigarette Smoking Behavior",[298,299],"Cigarette smoking","episodic future thinking",{"date":301,"type":32},"2026-03-31",{"date":303,"type":21},"2026-05-01",{"date":305,"type":21},"2027-05-01",{"name":38,"class":39},{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":16,"minAge":189,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":316,"briefSummary":317,"conditions":318,"keywords":319,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":40},"100596201","effects-of-tobacco-abuse-liability-dependent-taxes-in-the-etm-100596201","NCT07042373","Effects of Tobacco Abuse Liability-dependent Taxes in the ETM","Innovative Policy: Effects of Tobacco Abuse Liability-dependent Taxes in the ETM","Inclusion criteria:\n\n* Provide informed consent\n* Be at least 21 years of age or older\n* Provide a breath sample for measuring carbon monoxide (CO ≥ 8 ppm)\n* Smoke at least 10 cigarettes daily\n* Use other tobacco products less than weekly\n\nExclusion criteria:\n\n* Have uncontrolled physical or mental health conditions\n* Use of smoking cessation medications (e.g., nicotine replacement, bupropion, varenicline) in the past 30 days\n* Report concrete, immediate plans to alter\u002Fquit using their usual tobacco products in the next 30 days\n* If they are pregnant or lactating\n* Have plans to move out of the area during the experiment",{"count":315,"type":21},51,[24],"In a within-subject design, cigarette smokers, stratified by age, will purchase tobacco products under three tax rate conditions based on abuse liability, that is taxes based on: (1) product category score (i.e. score ranging from 0-1 based on abuse liability effect sizes); (2) product category rank (i.e. position of a product relative to all others; e.g. 1st, 5th); and (3) product tiers (i.e. low-, medium-, high abuse liability), as well as a control. In the ETM, the effects of these interventions will be examined on cigarette demand and other products substitution.\n\nThe investigators will use a repeated-measures (within subject) analysis of variance (ANOVA) to test if there are differences between conditions (i.e., tax proposals) independently for each product. The models will include study design parameters for order effects to account for counterbalancing the tax conditions in the ETM. Each tax condition will be compared to the control. All distributional assumptions will be checked prior to analyses and the appropriate transformations will be employed, if needed. For each significant result from the omnibus test, the investigators will perform planned contrasts to test the proposed hypotheses previously described. Note that the omnibus test can result in a significant finding while the contrasts of interest may be non-significant. In this case, the investigators will only report the results from the planned contrasts.\n\nAdditional analyses might be conducted.",[296],[320,197,321],"Cigarettes","Abuse Liability","2026-03-23",{"date":324,"type":32},"2026-03-24",{"date":326,"type":21},"2026-07-31",{"date":328,"type":21},"2027-04-07",{"name":38,"class":39},{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":49,"sex":16,"minAge":70,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":22,"phases":339,"briefSummary":340,"conditions":341,"keywords":343,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":40},"100600980","strength-training-response-of-muscle-in-glp-1-users-100600980","NCT07104539","Strength Training Response of Muscle in GLP-1 Users","STRONG-GLP","Inclusion Criteria:\n\n* Age, 50y+\n* Be taking GLP-1 medicine (Weygovy or Zepbound) for 1 month or less\n* Weight \\\u003C300 lb\n* Pass a health and exercise readiness screening\n\nExclusion Criteria:\n\n* Age \\\u003C50\n* Weight \\>300 lb\n* Osteoporosis\n* Active metabolic, neoplastic, or cardiovascular disease\n* Unable or unwilling to provide consent",{"count":338,"type":21},30,[24],"GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function. Moreover, any loss of muscle mass or muscle function with GLP-1 treatment may impair balance and increase fall risk. This is a particular concern among older adults already susceptible to the common muscle strength and muscle function loss with age, yet there is little evidence among this population. This study will address a gap in knowledge regarding the effects of GLP-1 treatment on muscle mass, muscle function, and balance\u002Ffall risk among adults age 50 and older.",[342],"Muscle Mass",[344,345,346,347,348,349],"Weight loss","GLP-1 agonist","Obesity","Lean mass","Body composition","Strength training","2026-01-16",{"date":352,"type":32},"2026-01-21",{"date":354,"type":32},"2025-10-08",{"date":356,"type":21},"2027-05",{"name":38,"class":39},{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":362,"acronym":4,"eligibilityCriteria":363,"healthyVolunteers":11,"sex":16,"minAge":364,"maxAge":17,"enrollmentInfo":365,"targetDuration":4,"studyType":367,"phases":4,"briefSummary":368,"conditions":369,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":377,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":40},"100310789","the-fbri-vtc-neuromotor-research-clinic-100310789","NCT03325946","The FBRI VTC Neuromotor Research Clinic","Inclusion Criteria:\n\n* Neuromotor Impairment\n\nExclusion Criteria:\n\n* fragile health","3 Months",{"count":366,"type":21},500,"OBSERVATIONAL","The FBRI VTC Neuromotor Research Clinic was established and opened in May of 2013 to provide intensive therapeutic services to individuals with motor impairment secondary to neuromotor disorders. It is direct by Dr. Stephanie DeLuca and based on the principles surrounding ACQUIREc Therapy.\n\nACQUIREc Therapy is an evidenced-based approach to pediatric constraint-induced movement therapy, which refers to a multi-component form of therapy that is focused on helping children who have asymmetric motor abilities between the two sides of the body. Historically, ACQUIREc Therapy has the unimpaired or less impaired upper extremity constrained (by a cast or a splint) while also receiving active therapy from a specially trained therapist who shapes new skills and functional activities with the child's more impaired upper extremity but who is also a licensed Occupational or Physical Therapist (OT\u002FPT). Therapy dosages are high much higher than tradition OT or PT - often lasting many hours per day, up to 6 hours a day, 5 days a week, for 2-4 weeks.\n\nInvestigators have developed further treatments based on the same principles of intensive services combined with behavior shaping for other areas of the body that are also affected by weakness (e.g., the leg and trunk) also, but which usually do not involve constraint. These have been more generally labeled ACQUIRE Therapy.\n\nAll forms involve intensive, play-based therapy for children with asymmetric motor impairments of the arms and hands. The primary focus of treatment is to facilitate the acquisition of new motor skills in the child's weaker body parts through high levels of intensive therapy using scientifically-based behavioral guidelines. Therapy is also delivered in naturalistic environments.\n\nACQUIREc Therapy as a treatment method has been tested in two randomized controlled trials, and a specific manual for its implementation has been developed. Dr. (s) Ramey and DeLuca previously founded a similar clinic, The Pediatric Neuromotor Research Clinic, at the University of Alabama at Birmingham where Dr. DeLuca directed the research clinic for 13 years and oversaw the implementation of the ACQUIREc Therapy treatment protocol in more than 400 cases.\n\nThis research will involve analyzing and interpreting the clinical data of children going through clinical procedures at the FBRI VTC Neuromotor Research Clinic. All participation is voluntary and no children will denied services if families choose not to participate.",[370,371,372,373,374,375,376],"Neuromotor Impairments","Cerebral Palsy","Microcephaly","Autism","Trauma, Brain","Acquired Brain Injury","Pediatric Stroke",{"date":352,"type":32},{"date":379,"type":32},"2013-01-01",{"date":381,"type":21},"2029-12-31",{"name":38,"class":39},{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":11,"sex":16,"minAge":189,"maxAge":4,"enrollmentInfo":389,"targetDuration":4,"studyType":22,"phases":391,"briefSummary":392,"conditions":393,"keywords":395,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":40},"100605325","effects-of-a-low-nicotine-standard-and-tobacco-prices-on-illegal-cigarette-purchasing-100605325","NCT07161050","Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing","Inclusion Criteria:\n\n* Provide informed consent Be at least 21 years of age or older Provide a breath sample for measuring carbon monoxide (CO ≥ 8 ppm) Stable tobacco use patterns for at least two months\n\nExclusion Criteria:\n\nFor exclusive cigarette smokers:\n\nSmoke at least 10 cigarettes daily and do not use NVPs regularly (no more than 9 times in the last month).\n\nFor dual cigarette\u002FNVP users:\n\nSmoke at least 10 cigarettes daily and use NVPs at least 3 times in a week (report use of closed nicotine salt system)\n\nFor both groups:\n\nHave plans to move out of the area Have a serious or unstable physical or mental health condition Taking a tobacco cessation medication or medication that interferes with nicotine metabolism, motivation or reinforcement Report concrete, immediate plans to alter\u002Fquit using their usual nicotine products at the beginning of the study Being pregnant or lactating",{"count":390,"type":21},70,[24],"This study will investigate the effects of a very-low-nicotine cigarette (VLNC) standard, e-cigarette price, and illegal cigarette price on illegal product purchasing and alternative product use in a virtual marketplace.",[195,394],"E-cigarette Use",[197,396],"Illegal cigarette","2026-01-14",{"date":350,"type":32},{"date":400,"type":32},"2025-12-01",{"date":402,"type":21},"2026-10-07",{"name":38,"class":39},{"id":405,"slug":406,"hasResults":11,"nctId":407,"briefTitle":408,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":410,"targetDuration":4,"studyType":22,"phases":411,"briefSummary":412,"conditions":413,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":4},"100462573","study-of-low-intensity-focused-ultrasound-effects-on-cognitive-fmri-signals-100462573","NCT05303428","Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals","Inclusion Criteria:\n\n* Healthy volunteers, all ethnicities, who understand and speak English.\n\nExclusion Criteria:\n\n1. Claustrophobia (scanning environment may be uncomfortable).\n2. Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.\n3. Contraindications to CT: pregnancy\n4. Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's)\n5. History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor)\n6. History of head injury resulting in loss of consciousness for \\>10 minutes.\n7. History of alcohol or drug dependence (through self-report).",{"count":146,"type":21},[24],"Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and cognitive brain signaling using structured tasks. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.",[414],"Cognitive Change","2025-12-08",{"date":417,"type":32},"2025-12-09",{"date":419,"type":21},"2026-10",{"date":421,"type":21},"2028-04",{"name":38,"class":39},{"id":424,"slug":425,"hasResults":11,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":11,"sex":16,"minAge":430,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":22,"phases":432,"briefSummary":433,"conditions":434,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":40},"100465161","non-nutritive-sweetener-consumption-and-glucose-homeostasis-in-older-adults-with-prediabetes-100465161","NCT05337098","Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes","Non-Nutritive Sweetener Consumption (Aspartame and Sucralose) and Glucose Homeostasis in Older Adults With Prediabetes","Inclusion Criteria:\n\n* Age 40+ years\n* Prediabetic (fasting glucose concentration of 100-125 mg\u002FdL, 2-hour oral glucose tolerance test glucose concentration of 140-199 mg\u002FdL, or a HbA1c value of 5.7% to 6.4%)\n* Weight stable for previous 6 months (±2 kg)\n* BMI \\\u003C40 kg\u002Fm2\n* Sedentary to recreationally active\n* No plans to gain\u002Flose weight or change physical activity level\n* Willing to pick up food daily and consume foods provided for an 8-week period\n* Verbal and written informed consent\n* Approval by Medical Director\n* Consume less than one serving of non-nutritive sweetener per week\n\nExclusion Criteria:\n\n* BMI \\>40 kg\u002Fm2\n* Diabetes or diabetes medication\n* Antibiotic, prebiotic or prebiotic use in prior 3 months\n* Uncontrolled hypertension (blood pressure (BP) \\> 159\u002F99 mmHg)\n* Diagnosed inflammatory bowel disease\n* Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease\n* Vegetarian or vegan\n* Pregnant or plans to become pregnant\n* Breastfeeding\n* Food allergies or aversions, Phenylketonuria (PKU)\n* Estrogen or testosterone usage","40 Years",{"count":338,"type":21},[24],"Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged\u002Folder adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-concept for alterations in glucose homeostasis following intake of sucralose, but not aspartame, in middle-aged\u002Folder adults with prediabetes compared to a eucaloric diet with no NNS.",[435,436,437,438],"Continuous Glucose Monitoring","Oral Glucose Tolerance","Insulin Sensitivity","Inflammatory Markers","2025-12-03",{"date":441,"type":32},"2025-12-04",{"date":443,"type":32},"2023-04-18",{"date":445,"type":21},"2026-02-28",{"name":38,"class":39},{"id":448,"slug":449,"hasResults":11,"nctId":450,"briefTitle":451,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":49,"sex":16,"minAge":70,"maxAge":4,"enrollmentInfo":453,"targetDuration":4,"studyType":22,"phases":455,"briefSummary":456,"conditions":457,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":40},"100504056","water-intake-and-weight-control-in-older-adults-100504056","NCT05843318","Water Intake and Weight Control in Older Adults","Inclusion Criteria:\n\n* aged 50+ years\n* BMI ≥25 kg\u002Fm2\n* weight stable (+\u002F- 2 kg) in past 6 months\n* willing to provide consent and comply with study protocol\n\nExclusion Criteria:\n\n* usual plain drinking water intake \\>1500 ml\u002Fd\n* uncontrolled hypertension (\\>159\u002F99 mmHg)\n* medical condition requiring specialized diet prescription (eg, T2D, CHF wih fluid restriction)\n* medical condition that precludes participating in a physical activity program (eg, orthopedic injury)\n* current or history of GI disease (eg, Crohn's), GI surgery, or medications which impact GI function\n* allergies or aversions to foods included in the test meals",{"count":454,"type":21},375,[24],"This study is a randomized controlled intervention trial in adults aged 50+ years with overweight or obesity, which will compare three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each main meal) with a hypocaloric diet; 2) 1500 ml water consumed throughout the day with a hypocaloric diet; 3) hypocaloric diet with no instructions regarding water consumption. Smart water bottles will objectively assess water intake timing and volume. Urine osmolality, urine volume, and serum osmolality will be used as objective indicators of compliance with the water intake prescription. We will investigate changes in perceived hunger and fullness and appetite-regulating hormones as potential mechanisms by which premeal water could improve appetite regulation. We will also investigate the impact of water consumption and hydration on executive function capabilities, which may influence intervention adherence. Although increasing water intake could be an effective weight management strategy, no evidence-based recommendations exist for the timing of water intake needed for this benefit.",[458],"Overweight and Obesity","2025-11-12",{"date":461,"type":32},"2025-11-14",{"date":463,"type":32},"2023-11-13",{"date":465,"type":21},"2028-03-31",{"name":38,"class":39},{"id":468,"slug":469,"hasResults":11,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":4,"eligibilityCriteria":473,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":474,"targetDuration":4,"studyType":22,"phases":476,"briefSummary":477,"conditions":478,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":488,"locationsCount":40},"100538927","low-intensity-focused-ultrasound-and-the-complex-patient-100538927","NCT06297200","Low-Intensity Focused Ultrasound and the Complex Patient","Investigations of Low-Intensity Focused Ultrasound Towards Treatment for the Complex Patient","Inclusion Criteria:\n\n1. Males and females aged 18-65 years\n2. Current diagnosis of Chronic Back Pain as defined by pain duration of at least three months, with back pain being an ongoing problem for at least half the days of the last six months.\n3. Have evidence of central sensitization (CS) as measured by the Widespread Pain\u002FSymptom Severity Index (WPSSI) with a score of Widespread Pain Index (WPI) ≥ 7 and Symptom Severity (SS) ≥ 5 or WPI = 3-6 and SS ≥ 9.\n4. Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for current opiate use disorder as diagnosed by the Structured Clinical Interview for DSM-5.\n5. Be in treatment for opioid use disorder (OUD) including buprenorphine or methadone.\n6. Meet the DSM-5 criteria for a current anxiety disorder: generalized anxiety disorder, post-traumatic stress disorder or social anxiety disorder as diagnosed by the Structured Clinical Interview for DSM-5.\n\nExclusion Criteria:\n\n1. Evidence of neuropathic pain\n2. Previous spine surgery\n3. Current substance use disorder other than OUD or tobacco use disorder\n4. Current DSM-5 diagnosis of schizophrenia or schizo-affective disorder\n5. Chronic Pain Conditions other than chronic back pain\n6. Daily opiate use other than buprenorphine\u002Fmethadone for OUD\u002Fpain control\n7. Pregnant or breastfeeding\n8. History of head injury, seizures, neurologic disorders including cerebrovascular disease, stroke, brain surgery, brain tumor, multiple sclerosis, or neurodegenerative diseases\n9. History of metastasizing cancers, inflammatory disorder (rheumatoid arthritis, polymyalgia rheumatica, scleroderma, lupus or polymyositis), unintended weight loss of 20 pounds or more in the last year, or cauda equina syndrome\n10. Ferromagnetic implants or other contraindications for magnetic resonance imaging (MRI)\n11. Evidence of arteriovenous malformation, aneurysm, infarct, meningioma, parenchymal brain tumor or evidence of neurodegenerative processes and\u002For white matter lesions greater than that expected for age as determined by the study neuroradiologist\n12. Unstable medical conditions such as congestive heart failure, unstable angina, poorly controlled arrhythmia active system infection end stage renal disease",{"count":475,"type":21},25,[24],"Studying the effects of Low Intensity Focused Ultrasound (LIFU) on measures of pain, craving, and anxiety in a complex patient population.",[479,480,481],"Opioid Use Disorder","Chronic Pain","Anxiety Disorder","2025-10-31",{"date":484,"type":32},"2025-11-03",{"date":486,"type":32},"2024-12-04",{"date":419,"type":21},{"name":38,"class":39},{"id":490,"slug":491,"hasResults":11,"nctId":492,"briefTitle":493,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":11,"sex":495,"minAge":17,"maxAge":496,"enrollmentInfo":497,"targetDuration":4,"studyType":22,"phases":499,"briefSummary":500,"conditions":501,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":510,"locationsCount":40},"100515891","the-effect-of-a-mindset-management-approach-on-stress-levels-in-women-with-infertility-100515891","NCT05997407","The Effect of a Mindset Management Approach on Stress Levels in Women With Infertility","Inclusion Criteria:\n\n* Speaks and reads English\n* New patient at Shady Grove Fertility in Roanoke or Richmond\n* Access to smartphone, tablet, or computer, and internet\n\nExclusion Criteria:\n\n* Has seen a fertility specialist (reproductive endocrinologist) before AND underwent fertility treatment under that provider\n* Is currently engaging with the Organic Conceptions method","FEMALE","42 Years",{"count":498,"type":21},66,[24],"The goal of this clinical trial is to test the effect of a mindset management intervention on stress levels in women with infertility. The main question it aims to answer is:\n\nCan the Organic Conceptions approach decrease stress levels in women with infertility?\n\nParticipants in both groups will be asked to complete three surveys at three time points. The intervention group will complete the Organic Conceptions program, while the control group will not complete an intervention.\n\nResearchers will compare the intervention group and control group to see if the Organic Conceptions mindset management program decreases stress levels in women with infertility.",[502,503],"Stress","Infertility, Female","2025-09-03",{"date":506,"type":32},"2025-09-10",{"date":508,"type":32},"2023-11-10",{"date":86,"type":21},{"name":38,"class":39},{"id":512,"slug":513,"hasResults":11,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":11,"sex":16,"minAge":518,"maxAge":70,"enrollmentInfo":519,"targetDuration":4,"studyType":22,"phases":521,"briefSummary":522,"conditions":523,"keywords":525,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":534,"leadSponsor":535,"locationsCount":40},"100468774","valuation-in-depressed-mood-anhedonia-and-anxiety-100468774","NCT05384158","Valuation in Depressed Mood, Anhedonia, and Anxiety","Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix","Inclusion Criteria:\n\n* mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.\n\nExclusion Criteria:\n\n* history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI","25 Years",{"count":520,"type":21},252,[24],"This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and\u002For anxiety.",[524],"Neurobehavioral Components of Reward and Loss Valuation",[526,527,528],"depression","anxiety","anhedonia","2025-09-02",{"date":531,"type":32},"2025-09-09",{"date":533,"type":32},"2021-08-01",{"date":84,"type":21},{"name":38,"class":39},{"id":537,"slug":538,"hasResults":11,"nctId":539,"briefTitle":540,"officialTitle":541,"acronym":4,"eligibilityCriteria":542,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":71,"enrollmentInfo":543,"targetDuration":4,"studyType":22,"phases":545,"briefSummary":546,"conditions":547,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":556,"locationsCount":40},"100483407","the-role-of-the-locus-coeruleus-in-age-related-distractibility-100483407","NCT05574634","The Role of the Locus Coeruleus in Age-related Distractibility","Losing Specificity: the Role of the Locus Coeruleus in Age-related Distractibility","Inclusion:\n\n* Healthy adult participants\n* No younger than 18 and no older than 75 yrs of age\n* Ability to provide written informed consent\n\nExclusion:\n\n* History of surgery involving metal implants\n* Possible metal fragments in the eyes\n* Pacemaker\n* A history of claustrophobia\n* Braces\n* Weighing over 250 pounds\n* Pregnant or possibility of being pregnant.\n* Severe medical or psychiatric conditions (e.g., blind or deaf, head trauma)\n* Learning disabilities or developmental disabilities",{"count":544,"type":21},200,[24],"A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.",[548,549],"Aging","Alzheimer Disease","2025-08-13",{"date":552,"type":32},"2025-08-19",{"date":554,"type":32},"2023-04-11",{"date":180,"type":21},{"name":38,"class":39},""]