[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Vrinnevi Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100587816","distraction-as-treatment-for-pain-in-children-in-resource-scarce-settings-100587816",false,"NCT06933303","Distraction as Treatment for Pain in Children in Resource-scarce Settings","DISTRACT","Inclusion Criteria:\n\n* Pediatric patients between the age of 7 and 12 years old with burn injuries requiring dressing changes in the outpatient clinic, who in regular practice (non-research setting) would not receive any analgesics;\n* Type of burn injury: partial thickness burns with a burned area not greater than 10% at the moment of the first dressing change measurement as part of this research\n\nExclusion Criteria:\n\n* Patients who received split skin grafts for their burns;\n* Patients on sedatives or anti-epileptics;\n* The use of pain-relieving medication other than paracetamol or ibuprofen;\n* Painful additional injuries other than the burn injury;\n* Patients who are nursed in isolation;\n* Physical or mental impairments which make it impossible to adequately comply with the trial protocol. For example, visual impairments, impaired ability to communicate, psychological comorbidities, and burns that limit the use of a kaleidoscope (facial burns or burns to both hands);\n* Retrospective exclusion if the patient in the intervention group did not look through the kaleidoscope for more than 50% of the procedure time.","ALL","7 Years","12 Years",{"count":20,"type":21},126,"ESTIMATED","INTERVENTIONAL",[24],"NA","Pain alleviation in pediatric patients can be challenging for medical professionals working in resource scarce settings due to limited availability of medication, monitoring equipment, or training in this field of expertise. This poses the need for a readily available tool for pain reduction that does not rely on expensive equipment or medication and which can easily be applied in resource scarce settings around the world. With this research project we aim to assess the effectiveness of a simple, inexpensive, non-electronic distraction method: a kaleidoscope, to reduce acute pain in pediatric patients undergoing dressing changes in resource scarce environments.\n\nA randomized controlled trial will be performed at the Edendale Hospital in Pietermaritzburg KwaZulu Natal, South Africa. Pediatric patients between the age of 7-12 years with partial thickness burn injuries who require dressing changes in the outpatient clinic will be randomized into two groups: one group (control) will receive standard practice of care which concerns a dressing change without any pain alleviation other than paracetamol or a non-steroidal anti inflammatory drug (NSAID), and one group (intervention) will receive distraction by use of a kaleidoscope as method for potential pain alleviation on top of standard medical care. The primary outcome will be the difference in mean change in pain score (from before to during the dressing change) between the control and distraction group.\n\nThis study is expected to demonstrate that the use of a non-electronic distraction technique effectively alleviates pain in children undergoing dressing changes and that its use is feasible in low resource settings. The distraction technique can be applied as add-on to pharmacological treatment, or stand-alone when no pharmacological treatment is available. Distraction is expected to be safe and can even be applied by an accompanying parent, resulting in lower barriers for healthcare workers to apply it. Appropriate pain relief will improve psychological wellbeing of pediatric patients undergoing painful procedures, and it might even improve recovery and physical rehabilitation since pain has been associated with physical as well as mental morbidity.",[27],"Pain, Acute",[29,30,31,32,33],"Distraction","Pain","Burn injury","Dressing change","Pediatric","RECRUITING","2025-04-16",{"date":37,"type":38},"2025-04-18","ACTUAL",{"date":40,"type":38},"2025-03-30",{"date":42,"type":21},"2026-12-31",{"name":44,"class":45},"Vrinnevi Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":5},"100546800","impact-of-inflammatory-indexes-and-gene-scores-in-prediction-of-atrial-fibrillation-100546800","NCT06399666","Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation","Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation - IERV Trial","IERV","Inclusion Criteria:\n\n* Persistent atrial fibrillation (ICD-10 I48.1)\n* Age over 18 years\n\nExclusion Criteria:\n\n* Autoimmune disease\n* Inflammatory diseases\n* Acute or chronic liver dysfunction\n* Ongoing infectious diseases\n* Thyroid disorders\n* Any other conditions known to impact inflammatory activity (including medication use and hematological diseases)",true,"18 Years",{"count":58,"type":21},182,"OBSERVATIONAL","Because of the high recurrence rates following electrical cardioversion and high morbidity in AF patients there is a need to explore prediction models for AF recurrence following ECV. Previous studies have primarily focused on high-sensitivity CRP (hsCRP), CRP, and IL-6, while other inflammatory indexes and gene scores might hold greater value.\n\nThis prospective cohort study is planning to include 182 patients with persistent atrial fibrillation, planned for electrical cardioversion, and \\>18 years at two medium-sized hospitals in Sweden. Blood samples will be collected prior to electrical cardioversion and at 7-, 30-, 90-, and 180-days follow-up. Atrial fibrillation recurrence will be evaluated at follow-up or upon patient request and diagnosed with 12-lead ECG.\n\nAn interim analysis will be conducted after more than 80 patients have been included. If the results from univariate and\u002For multivariable logistic regression on inflammatory markers and genetic expression regarding atrial fibrillation recurrence are significant, the study will be concluded.",[62,63,64],"Atrial Fibrillation","Inflammation","Genetic Predisposition to Disease","2024-09-11",{"date":67,"type":38},"2024-09-19",{"date":69,"type":38},"2023-10-30",{"date":71,"type":21},"2026-02-28",{"name":44,"class":45},""]