[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Wageningen University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":366},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,46,69,101,133,155,180,208,236,260,287,309,339],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100626079","the-effect-of-muscle-stimulation-and-amino-acid-intake-on-protein-metabolism-during-critical-illness-100626079",false,"NCT07430969","The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness","The Effect of a Single Session of Whole-body Neuromuscular Electrical Stimulation (NMES), With or Without Subsequent Intake of an Amino Acid Bolus, on Whole-body Protein Turnover in Sedated Intensive Care Unit (ICU) Patients","SPICE I","Inclusion Criteria:\n\n* Aged ≥18 years\n* Expected to need mechanical ventilation for at least 48 hours, judged by physician\n* Expected to reach a Richmond Agitation-Sedation Scale (RASS) score of -4 or -5 (complete sedation), judged by physician\n* Informed consent obtained from the next-of-kin\n* Able to or are receiving gastric tube feeding\n* Have an arterial and a venous line in situ\n\nExclusion Criteria:\n\n* Spinal cord injury\n* Previous surgery\u002Flocal wounds that prohibit whole-body NMES\n* Conditions that prohibit NMES (such open wounds)\n* Chronic neuromuscular disorders (such as Amyotrophic lateral sclerosis (ALS))\n* Acute Kidney Injury (AKI) II and III\n* Undergoing continuous veno-venous hemofiltration (CVVH)\n* Rhabdomyolysis\n* Neuromuscular blocking agents\n* In the caloric restriction period of refeeding syndrome\n* In prone position\n* Burn wounds\n* ICD\u002Fpacemaker\n* Pregnant\n* Deemed not suitable to participate based upon the judgement of the treating intensivist","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients. The main questions to answer are:\n\n* Does electrostimulation improve the balance of muscle protein in ICU patients?\n* Does combining electrostimulation with amino acid help build muscle and prevent muscle loss?\n\nResearchers will compare three groups of patients:\n\n1. Sham electrostimulation (no current applied) + the standard nutrition\n2. Electrostimulation + the standard nutrition\n3. Electrostimulation + a 20g amino acid bolus\n\nParticipants will:\n\n* Receive either real or sham electrostimulation\n* Get their standard nutrition or a 20g amino acid bolus\n* Have marked amino acids given through an IV\n* Have blood samples taken to measure the amino acids and glucose in the blood\n* Undergo ultrasound of the upper arm to measure the blood flow",[27],"Muscle Wasting in Critically Ill",[29,30,31,32],"NMES","Skeletal Muscle Metabolism","Protein","ICU","RECRUITING","2026-07-01",{"date":36,"type":37},"2026-07-02","ACTUAL",{"date":39,"type":21},"2026-07-18",{"date":41,"type":21},"2027-12",{"name":43,"class":44},"Wageningen University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":63,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":45},"100573762","forearm-immobilization-in-t2d-100573762","NCT06750497","Forearm Immobilization in T2D","The Impact of Short-term Forearm Immobilization on Forearm Muscle Glucose and Amino Acid Metabolism of Volunteers With or Without Type 2 Diabetes","FIT2D","Inclusion criteria\n\n* Males and females with or without diagnosed type 2 diabetes\n* Use lifestyle changes, metformin, gliclazide, or a combination thereof as oral glucose-lowering treatments for T2D\n* Aged 18-80 years at the time of signing informed consent\n* 18.5 ≥ BMI ≤ 35 kg·m2\n\nExclusion criteria\n\n* Type 1 or a genetic form of diabetes\n* Any diagnosed cardiovascular (heart) disease or high blood pressure (≥160 mmHg systolic and\u002For ≥100 mmHg diastolic)\n* Chronic use of any prescribed or over-the-counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) that interact with muscle substrate metabolism (e.g. selective serotonin reuptake inhibitors)\n* Consumption of a low-carbohydrate diet\n* Smoking or chewing tobacco\n* Known anaemia\n* Regular use of dietary protein and\u002For amino acid supplements (\\>3 times per week)\n* Currently involved in a structured progressive resistance training program (\\>3 times per week)\n* A personal or family history of thrombosis (clots)\n* Any previous motor disorders or inborn errors in muscle and\u002For lipid metabolism\n* History of kidney disease\n* History of liver disease\n* Pregnant or breastfeeding\n* History of any drug or alcohol abuse in the past two years\n* Claustrophobia\n* Unable to give consent",true,"80 Years",{"count":57,"type":21},26,[24],"The aim of the present study is to assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics in individuals with T2D compared with a control group with normoglycaemia.",[61,62],"Healthy","Type 2 Diabetes",{"date":36,"type":37},{"date":65,"type":37},"2024-11-21",{"date":67,"type":21},"2027-04-30",{"name":43,"class":44},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":54,"sex":17,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},"100643653","shift-workers-health-behavior-action-program-across-europe-100643653","NCT07631767","Shift Workers' Health Behavior Action Program Across Europe","SHAPE","Inclusion Criteria:\n\n* Age ≥ 21 years\n* Work ≥ 24 hours per week\n* Shift work duration \\> 3 years and currently doing night shifts\n* Expected to continue night shiftwork for at least 1 year after inclusion\n* On average working ≥ 4 night shifts per month\n* Working generally ≥ 2 consecutive night shifts\n* In possession of a smartphone and willing to download the study application\n\nExclusion Criteria:\n\n* Body Mass Index (BMI) \\\u003C 18.5 or \\> 40 kg\u002Fm2\n* Pregnant or lactating\n* Chronic diseases with ongoing therapy (e.g. renal failure, active hepatitis, cirrhosis, myocardial infarction, chronic obstructive pulmonary disease and cancer)\n* Current or recent use of medications interfering with sleep, including: Central nervous system stimulants (e.g., Ritalin, Adderall, Modafinil or similar); Chronic use of sleep agents (e.g., benzodiazepine, non-hypnotic benzodiaze-pine, first-generation antihistamine, melatonin receptors agonists or similar); Other medications or combinations significantly affecting sleeping patterns\n* Recent or ongoing psychotherapy for sleep disorders\n* Current or recent use of medications affecting appetite or weight regulation, including: Appetite-enhancing\u002Fweight-gain medications (e.g., atypical antipsychotics, cor-ticosteroids such as prednisone, mirtazapine or similar); Appetite-suppressing\u002Fweight-loss medications (e.g., CNS stimulants such as Ritalin, Adderall, GLP-1 receptors agonists or similar); Other medications or combinations significantly influencing appetite or body weight\n* Participation in another human trial, lifestyle program or weight loss intervention within the past 3 months\n* Planned surgical procedure during the study period\n* History of or planned bariatric surgery\u002Ftreatment","21 Years",{"count":78,"type":21},400,[24],"This study evaluates the effects of a Combined Lifestyle Intervention Program (CLIP) on sleep, lifestyle behaviors, obesity risk and health in night-shift workers. The primary objective is to assess the effect of the CLIP on objectively measured sleep duration. Secondary objectives include behavioral outcomes related to sleep, diet, physical activity, and stress, as well as body weight and metabolic outcomes, . It is hypothesized that CLIP participants will show a greater increase in sleep duration than controls, alongside favorable changes in lifestyle and health outcomes.",[82,83,84],"Night Shift Work","Obesity & Overweight","Circadian Misalignment",[86,87,88,89,90],"Lifestyle","Stress","Sleep","Diet","Physical Activity","NOT_YET_RECRUITING","2026-06-01",{"date":94,"type":37},"2026-06-08",{"date":96,"type":21},"2026-05-15",{"date":98,"type":21},"2027-12-01",{"name":43,"class":44},5,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":118,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":45},"100626622","energy-reduction-and-umami-100626622","NCT07438028","Energy Reduction and Umami","Interactive Effects of Umami Taste Intensity and Energy Density on Longer Term Food Intake","Season","Inclusion Criteria:\n\n* Healthy: as judged by the participant;\n* Age 16-65 years at the time of inclusion, assessed by date of birth;\n* Proper understanding of the Dutch language, as questionnaires will be in Dutch;\n* Able to visit Wageningen University, as required for dietary intervention and testing;\n* Body mass index 20-30 kg\u002Fm2;\n* Having normal taste ability, assessed using Mueller taste strip test, ≥12 out of 20 assessed correctly.\n\nExclusion Criteria:\n\n* Suffering from endocrine- or gastro-intestinal diseases or other diseases that might influence study outcomes (such as diabetes, Crohn's disease, cardiovascular disease, hypertension, etc.);\n* Diagnosed with eating disorders (currently or in the past);\n* Diagnosed with taste or smell disorders in the past six months;\n* Pregnant or lactating during the study intervention;\n* Following a strict dietary regime;\n* Extreme physical activity (\\>10 hours per week moderate\u002Fhigh intensity exercise);\n* Gain or loss of more than 5 kgs in the last six months prior to study entry;\n* Suffering from lack of appetite for any reason;\n* Use of medication that may influence the appetite (medication will be judged by the medical investigator);\n* Having a food allergy and\u002For intolerance for foods used in the dietary intervention (e.g. lactose intolerance, gluten intolerance, MSG sensitivity). This will be assessed with an open question;\n* Consumes more than 14 (women) or 21 (men) glasses of alcohol per week;\n* Consumes MSG-rich sauces (soy sauce, ketjap and\u002For curry paste) more than once per day, or consumes more than 3 savoury food items (paprika chips, instant noodles, sundried tomatoes and\u002For pre-packaged seasonings) per day. This will be assessed with a frequency of consumption table;\n* Irregular eating pattern. This will be measured with a frequency of meal\u002Ffood consumption table, and is defined as: frequency of breakfast consumption less than once per week;\n* Unwilling to maintain regular exercise pattern during the study period. This will be assessed with a yes\u002Fno question;\n* Unwilling to quit use of soft or hard drugs during the intervention;\n* Student or personnel of the division of Human Nutrition and Health, Wageningen University;\n* Participating in any other intervention study\u002Fstudies or planning to participate in another intervention study during the study period.","65 Years",{"count":20,"type":21},[24],"People tend to regulate intake by the weight of food rather than its energy content, making energy dense foods, especially those combining salty, fatty, and umami tastes, more likely to promote passive overconsumption. Lowering energy density can reduce daily energy intake, but often decreases palatability, whereas umami can enhance palatability, and sometimes decrease food intake. This suggests that adding umami to a regular energy dense diet could reduce food intake over time, and that adding umami to a reduced energy dense diet could sustain palatability and limit compensatory energy intake. Therefore, the aim of this study is to assess the effect of a 2-week dietary intervention of adding umami and\u002For lowering energy density on food intake. Secondary objectives are whether adding umami and\u002For lowering energy density affect dietary satisfaction, appetite, perceived umami intensity, food preferences, bodyweight and composition, and wellbeing ratings.\n\nThis will assessed in a double-blind crossover, randomized controlled trial of three times two weeks, each separated by two weeks washout in 33 healthy Dutch adults between 18-65 years of age, with a BMI between 20-30. Umami taste will be added through MSG supplementation of the three main meals. Supplementation will depend on both intervention group, and individual participants' body weight. Energy density will be lowered by swapping regular products for low-fat, low-sugar or higher water products.\n\nThe three intervention diets will vary in umami taste intensity, and\u002For energy density: 1) regular energy density without added umami (control), 2) regular energy density with added umami, 3) reduced energy density with added umami. Umami will be supplemented by supplementing food items with 55-60 mg MSG per kg bodyweight daily, divided over three eating occasions. Foods will be offered ad libitum, and participants will add a seasoning sachet containing MSG to their selected portion.\n\nThe primary objective will be to compare average daily food intake (kcal) over two weeks between the three dietary interventions differing in umami taste intensity and energy density. Secondary outcomes are dietary satisfaction, appetite, perceived umami intensity, food preferences, bodyweight and composition, and wellbeing ratings.",[114,115,116,117],"Sensory Testing","Umami Taste","Energy Density","Food Intake Measurement",[119,120,121,122,123,124],"umami","taste","intensity","ad libitum","intake","reduced energy","2026-05-22",{"date":127,"type":37},"2026-05-27",{"date":129,"type":21},"2026-09",{"date":131,"type":21},"2026-12",{"name":43,"class":44},{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":54,"sex":141,"minAge":18,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":154,"locationsCount":45},"100638585","effect-of-a-nutritional-supplement-on-muscle-recovery-100638585","NCT07586839","Effect of a Nutritional Supplement on Muscle Recovery","The Role of a Nutritional Formulation Containing Caprylic Acid and Omega 3 Fatty Acids in Promoting Skeletal Muscle Function Recovery to Damaging Exercise in Healthy, Young Volunteers","RECOVER","Inclusion Criteria:\n\n* Young (≥18 and ≤35 years)\n* Male sex\n* Non-obese (≥18.5 and ≤27.5 kg\u002Fm2)\n* Recreationally active (performing non-competitive exercise at least one time a week for minimally 30 minutes)\n\nExclusion Criteria:\n\n* Smoking\n* Participation in structural exercise with a major eccentric component (e.g. soccer, basketball, trail running, etc…)\n* Chronic use of any prescribed over the counter pharmaceuticals\n* Any history of medical or surgical events that may effect the study outcomes\n* Following a specific diet (e.g. weight loss, ketogenic, vegan)\n* Taking protein supplements","MALE","35 Years",{"count":144,"type":21},28,[24],"The aim is to develop a food supplement drink that supports muscle health by combining specific fatty acids, which can positively affect metabolic and inflammation processes that are important for muscle health.",[61],"2026-05-07",{"date":150,"type":37},"2026-05-14",{"date":152,"type":37},"2025-09-26",{"date":129,"type":21},{"name":43,"class":44},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":54,"sex":17,"minAge":163,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":45},"100631608","modulating-immune-responses-after-consistent-lipid-exposure-100631608","NCT07502898","Modulating Immune Responses After Consistent Lipid Exposure","The MIRACLE Study: Modulating Immune Responses After Consistent Lipid Exposure","MIRACLE","Inclusion Criteria:\n\n* Apparently healthy man or woman\n* Age 40-70y at the time of screening\n* BMI of 22-27 kg\u002Fm2\n* Having a Hb value above 8.4 (men) or 7.4 (women) mmol\u002FL\n* Having veins suitable for blood sampling via a catheter cannula (judged by study nurse\u002F medical doctor)\n* Willing to have dairy-based breakfast every day\n* Having a mobile phone suitable for installing the research app\n* Signed informed consent and able to adhere to the protocol\n\nExclusion Criteria:\n\n* A history of cardiovascular diseases, such as a stroke or heart disease;\n* Having an eating disorder;\n* Having diabetes (type I or type II);\n* Having used antibiotics in the past 3 months;\n* Using diabetes medication;\n* Using medications that may affect the study results (as assessed by the study physician);\n* Suffering from stomach or intestinal problems, such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, or having undergone major digestive system surgery;\n* Having known food allergies or intolerances to foods used in the study (e.g., cow's milk);\n* Having an Hb level of less than 8.5 mmol\u002FL (for men) or less than 7.5 mmol\u002FL (for women) - to be tested during the eligibility assessment;\n* Being allergic or intolerant to medical skin patches;\n* Suffering from chronic or acute inflammatory diseases, such as rheumatoid arthritis or psoriatic arthritis;\n* Having an autoimmune disease;\n* Having thyroid problems;\n* Having recently donated blood (within 2 months before the eligibility assessment) or planning to donate blood during the study period;\n* Having recently participated in another medical-scientific study (within 2 months before the eligibility assessment);\n* Suffering from severe kidney or liver problems or a chronic kidney or liver disease;\n* Following a specific diet that may affect the results or is unsuitable for the study, such as a vegan diet;\n* Using tobacco\u002Fdrugs or smoking (including snus and\u002For vaping);\n* Drinking more than 14 (for women) or 21 (for men) alcoholic drinks per week;\n* Being pregnant, planning to become pregnant, or breastfeeding;\n* Gained or lost more than 5 kg body weight in the past 3 months;\n* Intention to lose or gain more than 5 kg during the study period;\n* Intention to change exercise intensity during the study period;\n* Not having a mobile phone suitable for using a research application;\n* Having another serious medical condition that may interfere with participation, thus being deemed unsuitable for participation in the study as assessed by the study physician or principal investigator (e.g., displaying inappropriate behavior);\n* Inability to comply with the study diet\n* Inability to understand study information\u002Fcommunicate with staff;\n* Being employed or doing an internship at the Department of Human Nutrition and Health of Wageningen University or FrieslandCampina.","40 Years","70 Years",{"count":166,"type":21},39,[24],"Background of the study:\n\nEnhanced immune responses can lead to chronic hyperinflammation, which contributes to the development of non-communicable diseases such as type 2 diabetes and cardiovascular disease. Poor dietary habits, particularly the consumption of high-fat meals, are thought to trigger this process by increasing the concentration of triglyceride-rich lipoproteins in the bloodstream, resulting in postprandial triglyceridemia. This state stimulates immune cell activation, elevates circulating lipopolysaccharide levels, and enhances the production of inflammatory mediators including IL-6, TNFα, VCAM1, and ICAM1, as well as changes in inflammatory gene expression in peripheral blood mononuclear cells. Until now, most research investigating the relationship between fat intake and postprandial inflammation has focused on the effects of a single high-fat meal. However, in daily life, individuals typically spend the majority of the day-up to 18 hours-in a postprandial state, continuously exposed to multiple meals containing a mix of macronutrients and fats from diverse sources. It remains unclear how repeated fat intake influences the timing, magnitude, and overall pattern of the postprandial immune response. The MIRACLE study is designed to address this gap by exploring how repetitive postprandial fat exposure affects circulating immune cells in healthy individuals, comparing the effects of plant-derived and dairy-derived lipids. The study employs a double-blind, randomized, cross-over, two-armed intervention design in which each participant acts as their own control.\n\nObjective of the study:\n\nThe primary objective of the MIRACLE study is to determine how daily repetitive exposure to lipids from the same source modulates the postprandial immune response, as reflected by IL-6 levels, compared with acute exposure. Postprandial IL-6 concentrations will be measured using multiplex ELISA assays at multiple time points following the high-fat shake at baseline (T0) and after repeated exposure (T1). These data will allow calculation of protein dynamics and incremental area under the curve (iAUC) values for IL-6.\n\nSecondary objectives:\n\nSecondary objectives include comparing postprandial IL-6 iAUC values across T0, T1, and T2; comparing IL-6 responses between the plant- and dairy-derived fats; and identifying mechanisms underlying lipid-induced immunomodulation in PBMCs, including changes in immune cell functioning, phenotypes, and circulating inflammatory parameters. The study will also assess the effects of repeated fat intake on postprandial metabolic markers such as glucose and triglyceride levels. Glucose will be continuously monitored using glucose sensors, while other metabolic parameters will be measured in plasma. Additionally, the relationship between body composition, as assessed by Dual Energy X-ray Absorptiometry (DXA), and postprandial immune and metabolic responses will be evaluated at T0, T1, and T2.\n\nStudy design:\n\nOn each test day, a catheter cannula will be inserted into an antecubital vein, followed by a 30-minute rest period before measurements begin. Baseline blood samples (t = 0) will be drawn from the catheter, after which participants consume a 0.6 L high-fat shake containing 95 grams of fat from one of the two lipid sources. Subsequent blood samples will be collected at 0.5, 1, 2, 3, 4, and 6 hours post-consumption to monitor postprandial responses. Following the first test day, participants will consume smaller breakfast shakes (\\~300 mL, \\~20 grams of fat) daily for four consecutive weeks, using lipid powders corresponding to the same fat source. After these four weeks, the postprandial test day will be repeated following the same procedures as on the first day.\n\nAfter the second test day, a washout period of two weeks will take place before participants return for a third test day, again following the same protocol. This will be followed by another washout period of two weeks to three months before beginning the second arm of the study, during which participants will consume lipids from the alternate fat source. Thus, each participant completes both the plant-derived and dairy-derived fat interventions in a randomized order, ensuring within-subject comparison.\n\nStudy population:\n\n39 healthy male or female volunteers, age 40-70, BMI 22-27.\n\nIntervention:\n\n2 different breakfast shakes based on either plant-derived or dairy-derived fat.",[170,171],"Lipid Metabolism","Postprandial Inflammation","2026-03-24",{"date":174,"type":37},"2026-03-31",{"date":176,"type":37},"2026-01-05",{"date":178,"type":21},"2026-05",{"name":43,"class":44},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":54,"sex":17,"minAge":187,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":45},"100620729","sweetspot---the-effect-of-non-nutritive-sweeteners-on-health-100620729","NCT07361406","SweetSpot - The Effect of Non-nutritive Sweeteners on Health","SweetSpot - The Effect of Non-nutritive Sweeteners on Glucose Regulation, Gut Microbiome, and Gut Hormone Secretion in Healthy Adults: a Fully Controlled Cross-over Intervention Study","Inclusion Criteria:\n\n* Age 45-79 years;\n* BMI of 20-35 kg\u002Fm2;\n* Having veins suitable for placement of a venflon catheter.\n\nExclusion Criteria:\n\n* Diseases or prior surgeries affecting the stomach, liver, kidneys or intestines (allowed i.e. appendectomy);\n* Cardiovascular diseases (e.g. heart failure) or cancer (e.g. non-invasive skin cancer allowed);\n* Diagnosed with type 1 or type 2 diabetes;\n* Drug treated thyroid diseases (well substituted hypothyroidism is allowed for inclusion);\n* HbA1c level \\>6.5% (\\>48 mmol\u002Fmol), as measured during the screening visit;\n* Anaemia defined as Hb concentrations \\\u003C8.5 mmol\u002FL for men and \\\u003C7.5 mmol\u002FL for women via finger prick;\n* Regular use of\u002Freceiving medication interfering with research outcomes (as judged by research physician), such as use of glucose lowering drugs, insulin, or use of medication that impacts the gastro-intestinal system;\n* Use of antibiotics over the last 3 months before study start;\n* Donated blood within 2 months prior to the screening;\n* Food allergies, intolerances (including lactose\u002Fgluten intolerance) for products used in the study design and\u002For dietary restrictions interfering with the study (including special diets and eating disorders);\n* Followed a diet that can interfere with the study outcomes within 1 month prior to the screening (e.g. ketogenic, sugar free, carbohydrate free);\n* Not willing to eat all products in the study diet, including eggs and dairy. Vegetarian is possible;\n* Not willing to consume non-nutritive sweeteners;\n* Not willing to quit the use of supplements that can interfere with the study outcomes (e.g. pre- or probiotics).\n* Intention to change the intensity of exercise during the study period or planning to join a intensive sport event (e.g. marathon or triathlon);\n* Intention to lose or gain weight;\n* Working night shifts regularly;\n* Smoking regularly\n* Use of soft and\u002For hard drugs (cannabis included);\n* Abuse of alcohol (defined as \\>14 glasses (women) or \\>21 glasses (men) of alcoholic beverages per week);\n* Being pregnant or lactating or planning to become pregnant;\n* Inability to understand study information and\u002For communicate with staff;\n* Participation in another study that involves an intervention within two months prior to the intervention;\n* Working or doing a thesis\u002Finternship at the division of Human Nutrition \\& Health, or the Food, Health \\& Consumer Research group of Wageningen Food \\& Biobased Research.","45 Years","79 Years",{"count":190,"type":21},60,[24],"The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and preference, and the excretion of NNS in urine.",[194],"Healthy Adult",[196,197,198,199],"glucose metabolism","gut microbiome","gut hormones","non-nutritive sweeteners","2026-02-24",{"date":202,"type":37},"2026-02-27",{"date":204,"type":37},"2026-02-23",{"date":206,"type":21},"2026-11-26",{"name":43,"class":44},{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":221,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":234,"locationsCount":235},"100532439","dietary-fiber-before-colorectal-cancer-surgery-100532439","NCT06212817","Dietary Fiber Before Colorectal Cancer Surgery","FiberUP in Clinical Practice: Increasing Preoperative Dietary Fiber Intake in Colorectal Cancer Patients.","Inclusion Criteria:\n\n* Age ≥18 years;\n* Being diagnosed with CRC and planned to undergo elective CRC resection;\n\nExclusion Criteria:\n\n* Previously have had a large abdominal resection, excluding appendectomy and cholecystectomy;\n* Diagnosed with Crohn's disease, Ulcerative Colitis, Celiac Disease;\n* Currently having a stoma;\n* Known allergic reactions to plants from the Asteraceae (Compositae) family (e.g., lettuce, daisies, sunflowers, artichokes, sage, tarragon, chamomile, chicory etc.);\n* Currently following a strict diet and unwilling or unable to change (e.g., gluten free or ketogenic diet);\n* Currently using fiber supplements, prebiotics and\u002For probiotics and unwilling to stop using these for the duration of the intervention;\n* Having a habitual dietary fiber intake \\>30 g\u002Fday for women and \\>40 g\u002Fday for men, measured with a food frequency questionnaire;\n* Dementia or other cognitive disabilities that makes it impossible to fill out questionnaires correctly;\n* Illiteracy (inability to read and understand Dutch).",{"count":216,"type":21},54,[24],"The aim of this randomized controlled trial is to investigate the feasibility of increasing preoperative dietary fiber intake in individuals with colorectal cancer who will undergo surgery. This will be done using 1) digital personalized dietary advice or 2) a dried vegetable product compared to 3) habitual diet (control).",[220],"Colorectal Cancer",[222,223,224,225,226,227],"Dietary fiber","Postoperative complications","Surgery","Gut microbiota","Colorectal cancer","Prehabilitation","2025-11-14",{"date":230,"type":37},"2025-11-18",{"date":232,"type":37},"2024-04-29",{"date":178,"type":21},{"name":43,"class":44},3,{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":142,"enrollmentInfo":244,"targetDuration":4,"studyType":22,"phases":246,"briefSummary":247,"conditions":248,"keywords":250,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":45},"100597751","the-effect-of-repeated-whole-body-nmes-sessions-with-or-without-protein-intake-on-muscle-protein-synthesis-during-3-days-of-bed-rest-in-healthy-young-volunteers-100597751","NCT07062562","The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers","The Effect of Repeated Sessions of Whole-body Neuromuscular Electrical Stimulation (NMES), With or Without Subsequent Intake of a Protein Bolus, on Muscle Protein Synthesis in Healthy, Young Volunteers During 3 Days of Bed Rest","SPRINT","Inclusion Criteria:\n\n* Aged from 18-35 years\n* 18.5 \\\u003C BMI \\\u003C 30 kg·m2\n* Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)\n\nExclusion Criteria:\n\n* Employed or undertaking a thesis or internship at the department of Human and Animal Physiology at Wageningen University\n* Smoking\n* Diabetes (Type 1, Type 2, or genetic form of diabetes)\n* Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and\u002For\n\n  ≥90 mmHg diastolic)\n* Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)\n* Known allergy to lidocaine\n* Prone to keloid forming (i.e. hyperplastic growth of scars)\n* All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g.\n\narthritis, spasticity\u002Frigidity, all neurological disorders and paralysis)\n\n* Regular use of dietary protein and\u002For amino acid supplements (\\>3 times per week)\n* Currently involved in a structured progressive resistance training programme (\\>3 times per week)\n* A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia\n* Any previous motor disorders or disorders in muscle and\u002For lipid metabolism\n* Any back, leg, knee, neck, shoulder or postural complaints\n* Presence of an ulcer in the stomach or gut and\u002For strong history of indigestion\n* Contra-indications for DXA scans (e.g. undergoing radiologic examination)\n* Lactose intolerance\n* Known severe kidney problems\n* Pregnant or breastfeeding\n* Unable to give consent",{"count":245,"type":21},42,[24],"The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years). The main questions to answer are:\n\n* Does whole-body NMES followed by protein intake improve muscle protein synthesis rates during 3 days of bed rest?\n* Does repeated NMES sessions offer protective effects on muscle mass and function during extended periods of inactivity?\n\nResearchers will compare sham electrical electrostimulation, electrical stimulation and electrical stimulation + protein groups to see if whole-body electrostimulation combined with protein intake offers the greatest improvement in muscle protein metabolism and muscle preservation.\n\nParticipants will:\n\n* Undergo 3 days of bed rest while receiving one of the following interventions:\n\n  * Sham-NMES followed by standard nutrition (CON)\n  * Whole-body NMES followed by standard nutrition(NMES)\n  * Whole-body NMES followed by a bolus of 20g protein (NMES+PRO)\n* Receive heavy water (D2O) to assess body water turnover.\n* Undergo leg extension exercises to assess muscle function.\n* Have quadriceps muscle thickness measured via ultrasound.\n* Provide saliva samples for analysis.\n* Have calf circumference measured to monitor changes in muscle mass.",[249],"Muscle Wasting",[29,30,31,251],"Disuse","2025-07-09",{"date":254,"type":37},"2025-07-14",{"date":256,"type":37},"2025-05-22",{"date":258,"type":21},"2027-05",{"name":43,"class":44},{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":22,"phases":269,"briefSummary":270,"conditions":271,"keywords":273,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":286},"100595737","rehabilitation-after-a-hip-fracture-the-effects-of-dietary-protein-and-exercise-on-bone-and-muscle-health-and-quality-of-life-100595737","NCT07036341","Rehabilitation After a Hip Fracture: the Effects of Dietary Protein and Exercise on Bone and Muscle Health and Quality of Life","ProBUS","In order to be eligible to participate in this study, a subject must meet all of the following criteria:\n\n* Age ≥ 65 years\n* Acute hip fracture\n* Able to give written informed consent\n* Mentally competent, as judged by the treating physician\n* Admission to a rehabilitation centre that participates in this research\n\nA potential subject who meets any of the following criteria will be excluded from participation in this study:\n\n* Allergic, intolerant or hypersensitive to milk\u002Flactose (self-reported)\n* Not willing to stop using dietary supplements with exception of calcium and vitamin D\n* Pathological fracture or periprosthetic fracture\n* Abnormal hepatic or renal laboratory parameters, such as estimated glomerular filtration rate (eGFR) \\\u003C30 ml\u002Fmin\u002F1,73 m2 (data from hospital)\n* Diagnosis of disorders\u002Fdiseases where a high protein intake can be harmful, such as renal impairment or failure, or liver disease (geriatric care physician has the decisive voice)\n* Diagnosis of bone metabolic disorders such as primary hyperparathyroidism, Paget's disease, or myeloma.\n* Taking medication other than bisphosphonates known to strongly alter bone, calcium or muscle metabolism, such as oestrogen, hormone replacement therapy, corticosteroids, anabolic agents, or calcitonin.\n* Disorders\u002Fdiseases which may affect ability to follow study protocol and which cannot be overcome with help of a caregiver\n* Current participation in other scientific research\n* No permission to request information from the general practitioner\u002F treating specialist(s) about medical history, medication use, liver and kidney values, and details about the broken hip",{"count":268,"type":21},102,[24],"Hip fractures often lead to functional limitations, loss of independence, weight loss and decreased well-being. Only half of the patients regain their functional level and 24% die within the following year. Financial consequences are significant due to costly surgery and long-term care. Hip fracture incidence is expected to increase sharply due to the ageing population, reducing accessibility to and quality of rehabilitation care. Therefore, optimizing treatment is essential.\n\nPrevious protein and exercise studies showed improved muscle and bone health in healthy or frail community-dwelling older adults, but effects in older hip fracture patients are not known. Better rehabilitation may improve bone and muscle health, nutritional status, quality of life, lower costs and lower burden for healthcare.\n\nThe overall objective is to investigate the effectiveness, costs and cost-effectiveness of a protein-enriched diet and resistance exercise for 3 months compared to usual care on bone and muscle health, and quality of life in older adults recovering from an acute hip fracture.",[272],"Hip Fractures",[274,31,275,276,277],"Hip fracture patients","Resistance Exercise","Bone health","Muscle health","2025-06-23",{"date":280,"type":37},"2025-06-25",{"date":282,"type":37},"2024-09-01",{"date":284,"type":21},"2026-08",{"name":43,"class":44},2,{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":11,"sex":17,"minAge":294,"maxAge":55,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":297,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":308,"locationsCount":286},"100526147","the-effect-of-a-2-week-preoperative-vegan-diet-versus-omnivorous-diet-on-the-protein-turnover-in-the-osteoarthritic-knee-100526147","NCT06130956","The Effect of a 2-week Preoperative Vegan Diet Versus Omnivorous Diet on the Protein Turnover in the Osteoarthritic Knee","KneeT-vegan","Inclusion Criteria:\n\n* Written informed consent;\n* Patients scheduled for total knee arthroplasty;\n* BMI between 20-32 kg\u002Fm2;\n* Aged 60 - 80 years;\n* Mentally competent, as judged by the treating physician;\n\nExclusion Criteria:\n\n* Following a vegetarian or vegan diet or a diet that affects protein intake during the six months prior to the study;\n* Participating in a structured progressive exercise training program in the past three months;\n* Lost more than 4 kg body weight during three months prior to the study;\n* Chronic use of medications that affect protein metabolism (i.e. systemic corticosteroids, or prescription strength acne medications);\n* Being diagnosed with one of the following: diabetes mellitus, rheumatoid arthritis, peripheral artery disease Fontaine III or IV, COPD GOLD III or IV, neoadjuvant chemotherapy or radiotherapy, phenylketonuria, collagen disorders (e.g. Marfan and Ehler-Danlos);\n* Alcohol abuse;\n* Surgical intervention to the knee in the past four weeks;\n* Total parenteral nutrition at day of surgery;\n* Glomerular filtration rate (GFR) \\\u003C20 mL\u002Fmin\u002F1.73 m2;\n* Allergic or intolerant to any product included in the diets;\n* Osteoarthritis of the knee secondary to septic arthritis, osteonecrosis, fracture, osteochondritis dissecans, or malignant processes;\n* Any other medical condition that may interfere with the safety of the participants or the outcome parameters, in the investigators judgement;\n* Not willing to stop nutritional supplements, with the exception of vitamin D and supplements on medical advice.\n* Investigator's uncertainty about the willingness or ability of the participant to comply with the protocol instructions;\n* Participation in other studies that may have an impact on the outcomes during the three months before the start of the current study.","60 Years",{"count":296,"type":21},40,[24],"Rationale: Protein from plant-based foods may be unable to stimulate protein synthesis due to a suboptimal essential amino acid content and a lower digestibility. However, a more optimal amino acid profile may be achieved by increasing portions sizes and blending multiple plant-based sources. Studies investigating the anabolic properties of vegan diets (total elimination of animal-based foods) rather than single plant-based foods in older adults are scarce. It remains unknown if a vegan diet can also affect protein synthesis rates in other musculoskeletal tissues than muscle.\n\nPrimary objective: To assess the effects of a 2-week preoperative vegan diet in comparison to an omnivorous diet on protein synthesis rates in Hoffa's fat pad, synovium, tendon, bone, ligaments, menisci, and cartilage in older adults with knee osteoarthritis undergoing total knee arthroplasty.\n\nSecondary objective: To assess the effects of a 2-week preoperative vegan diet in comparison to an omnivorous diet on blood pressure and plasma amino acids in older adults with knee osteoarthritis undergoing total knee arthroplasty.\n\nStudy design: Multi-center, randomized, controlled trial with an intervention and a control group.\n\nStudy population: 40 older adults (60 - 80 years) with osteoarthritis of the knee undergoing total knee replacement.\n\nIntervention: Controlled vegan diet versus controlled omnivorous diet, for a duration of 14 days.\n\nMain study parameters\u002Fendpoints: Primary study parameters are protein synthesis rates of Hoffa's fat pad, synovium, tendon, bone, ligament, menisci, and cartilage. Secondary parameters include blood pressure and plasma amino acids.",[300,301],"Osteo Arthritis Knee","Protein Synthesis","2025-03-25",{"date":304,"type":37},"2025-04-01",{"date":306,"type":37},"2024-10-22",{"date":131,"type":21},{"name":43,"class":44},{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":54,"sex":17,"minAge":317,"maxAge":55,"enrollmentInfo":318,"targetDuration":4,"studyType":22,"phases":320,"briefSummary":321,"conditions":322,"keywords":324,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":45},"100475658","impact-of-a-dried-vegetable-on-bowel-function-and-gut-microbiota-100475658","NCT05473793","Impact of a Dried Vegetable on Bowel Function and Gut Microbiota","The Impact of a Dried Vegetable on Bowel Function and Gut Microbiota in Subjects With Bowel Function Issues","HappYFiber","Inclusion Criteria:\n\n* 20 - 80 years old\n* Unsatisfied with bowel functions (self-reported), rated on a visual analogue scale (VAS, 0-10) as less than 6\n* Four or less bowel movements per week (low stool frequency) and\u002For\n* Hard, lumpy or solid stools (Bristol stool form 1-4) during 90% of bowel movements (hard to solid consistency)\n* Able to read and understand Dutch or English\n\nExclusion Criteria:\n\n* Having a history of medical or surgical events that may significantly affect the study outcome: e.g., IBS or IBD patients and subjects with medically diagnosed constipation (i.e., constipation related to anatomic, medication-related, or readily identifiable physiological causes.)\n* Less than one bowel movement per week during the screening\n* Medical drug use:\n\n  * Antibiotic use within 3 months of the study screenings day\n  * Chronic use of antacids and PPI's\n  * Use of laxatives during the screening\n  * Chronic use of blood glucose lowering medication\n* Consumption of supplements containing fibres (other than laxatives), pro-\u002F post-\u002F synbiotics 1 month before the screening\n* Not willing to provide faecal samples\n* Unable to comply with proper study procedures\n* For women of childbearing age: current or planned pregnancy, lactation\n* Known allergic reactions to plants from the Asteraceae (Compositae) family (e.g., lettuce, daisies, sunflowers, artichokes, sage, tarragon, chamomile, chicory etc.)\n* Reported unexplained weight loss or weight gain of greater than 5 kg in the month prior to pre-study screening\n* Reported slimming or medically prescribed diet\n* Reported macrobiotic lifestyle\n* Personnel the Division of Human Nutrition \\& Health or the Laboratory of Microbiology\n* Current participation in other medical scientific research\n* Not having a general practitioner\n* Not willing to be informed about accidental discoveries in relation to the subjects health","20 Years",{"count":319,"type":21},160,[24],"A randomized, placebo-controlled, parallel, double-blind trial with three intervention arms and a period of four intervention-weeks that assesses the intake of different dosages of a complex fiber product on bowel function via microbiota changes in subjects that are unsatisfied with their current bowel function.",[323],"Bowel Function Dissatisfaction",[325,326,327,328,329,330],"bowel function issues","constipation","gut microbiota","fiber intake","vegetable","intrinsic fiber","2025-02-22",{"date":333,"type":37},"2025-02-25",{"date":335,"type":37},"2022-08-22",{"date":337,"type":21},"2025-06",{"name":43,"class":44},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":345,"eligibilityCriteria":346,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":347,"targetDuration":4,"studyType":349,"phases":4,"briefSummary":350,"conditions":351,"keywords":356,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":45},"100309092","the-geolynch-cohort-study-100309092","NCT03303833","The GEOLynch Cohort Study","The GEOLynch Cohort Study: Genetic, Environmental and Other Factors That Influence Tumour Risk Among Persons With Lynch Syndrome","GEOLynch","Inclusion Criteria:\n\n* Persons with a known mutation in a gene that causes Lynch syndrome, i.e. with an inherited monoallelic pathogenic germline mutation in either the MLH1, MSH2, MSH6, PMS2 or EPCAM gene.\n* Aged between 18 and 80 years at inclusion.\n\nExclusion Criteria:\n\n* Additional carrier of another hereditary colon cancer predisposition syndrome (e.g. FAP)\n* (Chronic) Inflammatory bowel disease\n* Non-Dutch speaking\n* Dementia or another mental condition that makes it impossible to fill out questionnaires\n* Terminally ill persons",{"count":348,"type":21},1000,"OBSERVATIONAL","The GEOLynch cohort study has been established to investigate the influence of genetic, environmental and other factors on tumour risk in persons with Lynch syndrome.",[352,353,354,355],"Lynch Syndrome","Neoplasms","Hereditary Nonpolyposis Colorectal Cancer","Colorectal Neoplasms",[86,357],"Nutrition","2017-10-05",{"date":360,"type":37},"2017-10-06",{"date":362,"type":37},"2006-07-01",{"date":364,"type":21},"2030-12",{"name":43,"class":44},""]