[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Waikato Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100601816","improving-a-bile-duct-drainage-procedure-in-patients-with-inoperable-cancer-blocking-the-bile-ducts-comparing-two-types-of-endoscopically-placed-internal-stents-to-prevent-blockage-of-a-lumen-apposing-metal-stent-100601816",false,"NCT07115420","Improving a Bile Duct Drainage Procedure in Patients With Inoperable Cancer Blocking the Bile Ducts: Comparing Two Types of Endoscopically Placed Internal Stents to Prevent Blockage of a Lumen Apposing Metal Stent","Optimising EUS-guided Choledochoduodenostomy With Lumen Apposing Metal Stent With Stent in Stent Placement: a Randomised Study Between Double Pigtail Stent and Fully Covered Self-Expanding Metal Stent. The Opti-LAMS Study","Opti-LAMS","Inclusion Criteria:\n\n* Age ≥18 years.\n* Radiologically or histologically proven malignant distal bile duct obstruction with unresectable or metastatic disease, including those who have already failed ERCP\n* Indication for biliary drainage with presence of obstructive jaundice biochemically and dilated biliary system on imaging.\n* Informed consent provided.\n* Common bile duct (CBD) size of at least 12mm on EUS imaging\n\nExclusion Criteria:\n\n* Previous biliary stenting or surgery precluding EUS-CDS.\n* Inability to provide informed consent.\n* Pregnancy.\n* Significant coagulopathy that is not correctable.\n* Futility of intervention e.g. pre-terminal patients","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study looks at the best way to treat bile duct blockage in people with advanced cancer that cannot be removed by surgery. A blocked bile duct can cause serious symptoms like yellowing of the skin (jaundice), infection, and pain.\n\nA common procedure called ERCP sometimes doesn't work in these patients. A newer method called EUS-guided choledochoduodenostomy (EUS-CDS) uses internal ultrasound to place a special metal tube (called a LAMS) to allow bile to drain. However, over time this stent can still become blocked.\n\nTo reduce this risk, doctors can place a second stent inside the first. This study is comparing two types of these second stents:\n\n* A plastic stent (double pigtail stent or DPS)\n* A metal stent (fully covered self-expanding metal stent or FCSEMS)\n\nThe study will include patients at Waikato Hospital. After the first stent is placed, they will be randomly assigned to receive either a DPS or FCSEMS. Patients will be followed for 6 months to see how well the stents work.\n\nThe aim is to find out which approach keeps the bile duct open longer and reduces the need for further procedures or hospitalisation, helping improve care and comfort for people with advanced cancer",[27,28,29,30],"Malignant Biliary Obstruction","Advanced Pancreatic Cancer and Cholangiocarcinoma","Inoperable Malignant Biliary Obstruction","Lumen Apposing Metal Stents","NOT_YET_RECRUITING","2025-08-03",{"date":34,"type":35},"2025-08-11","ACTUAL",{"date":37,"type":21},"2025-09",{"date":39,"type":21},"2028-03",{"name":41,"class":42},"Waikato Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100469756","cpap-for-motion-management-in-breast-radiotherapy-and-lung--liver-sabr-100469756","NCT05396950","CPAP for Motion Management in Breast Radiotherapy; and Lung & Liver SABR","A Non Randomised Comparative Phase II Trial to Determine the Benefit of Continuous Positive Airway Pressure-assisted Radiotherapy vs Deep Inspiration Breath Hold in Breast Cancer and in Lung & Liver Stereotactic Ablative Body Radiotherapy","CPAP-RT","Inclusion Criteria:\n\n* Any patient with pathologically-confirmed invasive breast cancer and planned for adjuvant radiotherapy to the breast or chest-wall with regional lymph node coverage\n* Any patient deemed suitable for lung or liver SABR as per departmental guidelines\n* Must have signed written informed consent\n\nExclusion Criteria:\n\n* Cannot tolerate CPAP e.g due to severe claustrophobia\n* Re-irradiation",{"count":53,"type":21},70,[24],"A phase II trial to determine the proportion of patients where the use of continuous positive airway pressure (CPAP) results in a superior radiation plan compared to standard planning procedures. The rationale for using CPAP with radiotherapy is based on its ability to increase the tidal volume, flatten the diaphragm thus reducing respiratory excursions.The resultant lung hyperinflation and reduced respiratory excursions can be harnessed for radiotherapy purposes by:\n\n1. Displacing the heart away from the radiotherapy field\n2. Reducing the volume of functional lung irradiated\n3. Reducing the radiotherapy target motion\n\nCPAP has been shown to be superior to free breathing radiotherapy (RT), however it remains unclear how much benefit it confers vs other motion management adjuncts such as deep inspiration breath hold (DIBH) or 4-DCT.",[57],"Cancer",[59,60,61,62,63],"SABR","CPAP","Breast","Lung","Liver","2025-04-21",{"date":66,"type":35},"2025-04-24",{"date":68,"type":21},"2025-10",{"date":70,"type":21},"2026-07",{"name":41,"class":42},""]