[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Wan-Jin Chen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":96},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,38,58,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100362992","a-registered-cohort-study-on-spastic-paraplegia-100362992",false,"NCT04006418","A Registered Cohort Study on Spastic Paraplegia","Inclusion Criteria:\n\n* Patients with the clinical diagnosis of spastic paraplegia\n* Clinical diagnosis of patients with spastic paraplegia\n* Unrelated healthy controls\n\nExclusion Criteria:\n\n* Decline to participate.\n* There are serious interferences with individual participation and adherence to the research protocol, including but not limited to neurological, psychological, and\u002For medical conditions.",true,"ALL",{"count":18,"type":19},500,"ESTIMATED","20 Years","OBSERVATIONAL","The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias(HSP) and related disorders in a prospective multicenter natural history study, to assess the clinical, genetic and epigenetic features of patients with Spastic Paraplegias to optimize clinicalmanagement..",[24],"Spastic Paraplegia","RECRUITING","2022-01-16",{"date":28,"type":29},"2022-01-19","ACTUAL",{"date":31,"type":29},"2019-07-01",{"date":33,"type":19},"2049-12",{"name":35,"class":36},"Wan-Jin Chen","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":44,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":46,"conditions":47,"keywords":49,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":55,"completionDateStruct":56,"leadSponsor":57,"locationsCount":37},"100363472","a-registered-cohort-study-on-wilsons-disease-100363472","NCT04012658","A Registered Cohort Study on Wilson's Disease","Inclusion Criteria:\n\n* Patients with the genetic diagnosis of Wilson's Disease\n* Asymptomatic Wilson's Disease carriers\n* Relatives of Wilson's Disease patients or carriers\n* Unrelated healthy controls\n* Participants or Parent(s)\u002Flegal guardian(s) willing and able to complete the informed consent process\n\nExclusion Criteria:\n\n\\* Participants are unable to comply with study procedures and visit schedule",{"count":45,"type":19},2000,"The aim of this study is to determine the clinical spectrum and natural progression of Wilson's Disease in a prospective multicenter natural history study, to assess the clinical, genetic, epigenetic features and biomarkers of patients with Wilson's Disease to optimize clinical management.",[48],"Wilson's Disease",[48,50,51],"Nature history","Genetics","2019-09-19",{"date":54,"type":29},"2019-09-23",{"date":31,"type":29},{"date":33,"type":19},{"name":35,"class":36},{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":72,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":37},"100363283","a-registered-cohort-study-on-brain-calcification-100363283","NCT04010201","A Registered Cohort Study on Brain Calcification","Inclusion Criteria:\n\n* Patients with brain calcium deposit(s) based on examinations of CT scans\n* Patients with total calcification score(TCS) greater than the physiological threshold\n* Relatives of brain calcification patients.\n* Unrelated healthy controls\n* Participants or Parent(s)\u002Flegal guardian(s) willing and able to complete the informed consent process\n\nExclusion Criteria:\n\n* Brain calcification caused by specific secondary factors such as infection, poisoning, and trauma\n* Participants declining or unable to comply with trial procedures and visit schedule",{"count":45,"type":19},"Brain calcification is a common neuroimaging feature in patients with metabolic, neurological, or developmental disorders, infectious diseases, traumatic or toxic history, as well as in otherwise normal older people. To understand the clinical and genetic characteristics of brain calcification, we establish a cohort of brain calcification to follow up patients with brain calcification.",[67],"Brain Calcification",[69,70,71],"brain calcification","natural history","genetics",{"date":54,"type":29},{"date":74,"type":29},"2019-08-25",{"date":76,"type":19},"2079-12-31",{"name":35,"class":36},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":15,"sex":16,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":91,"startDateStruct":92,"completionDateStruct":93,"leadSponsor":95,"locationsCount":37},"100363314","a-registered-cohort-study-on-sma-100363314","NCT04010604","A Registered Cohort Study on SMA","A Registered Cohort Study on Spinal Muscular Atrophy","Inclusion Criteria:\n\n* Patients with SMA types I, II and III\n* Asymptomatic SMA carriers\n* Relatives of SMA patients or carriers\n* Unrelated healthy controls\n* Participants or Parent(s)\u002Flegal guardian(s) willing and able to complete the informed consent process\n\nExclusion Criteria:\n\n\\* Participants are unable to comply with trial procedures and visit schedule","1 Week","70 Years",{"count":45,"type":19},"Spinal muscular atrophy (SMA) is an autosomal recessive disease that causes progressive muscle wasting and weakness due to loss of motor neurons in the spinal cord. This is a registered cohort of spinal muscular atrophy (SMA) type I，II and III in China. This study will provide further insights into the clinical course of SMA including overall survival, demographic characteristics, motor function, respiratory support, feeding and nutritional support, growth and development. The correlation of genotype and phenotype will be conducted.",[90],"Spinal Muscular Atrophy",{"date":54,"type":29},{"date":31,"type":29},{"date":94,"type":19},"2049-12-31",{"name":35,"class":36},""]