[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Watim Medical & Dental College\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":182},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,69,97,119,141,159],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100053257","phase-4-preoperative-dexamethasone-injection-to-improve-local-anesthesia-success-in-endodontic-treatment-100053257",false,"NCT07699315","Preoperative Dexamethasone Injection to Improve Local Anesthesia Success in Endodontic Treatment","Preoperative Intraligamentary Injection of Dexamethasone Can Improve the Anesthetic Success Rate of 2% Lidocaine During the Endodontic Management of Mandibular Molars With Symptomatic Irreversible Pulpitis","DILAS","Inclusion Criteria:\n\n1. Patients with pain VAS \\>\u002F= 6\n2. Carious exposed mandibular molar with symptomatic irreversible pulpitis\n3. Patients between ages 18-60 years\n4. American Society of Anesthesiologists class I or II medical histories -\n\nExclusion Criteria:\n\n1\\. Patients with contraindications to local anesthesia solution or dexamethasone 2.Pregnant or breast-feeding females 4.Tooth having fused\u002Fextra roots, full coverage crowns, or poor periodontal status 5. Patients taking drugs which could affect the pain perception\n\n\\-","ALL","18 Years","60 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study aims to determine whether giving a single dose of 4mg dexamethasone before root canal treatment can reduce the amount of pain patients experience during the procedure . Patients diagnosed with symptomatic Irreversible Pulpitis requiring endodontic treatment will be enrolled. Participants will receive either dexamethasone or placebo before treatment , and pain during the procedure will be measured using a Visual Analogue Scale (VAS) .\n\nThe findings may help improve pain management strategies during root canal treatment .",[28],"Symptomatic Irreversible Pulpitis",[28,30,31,32,33,34,35],"Dexamethasone","Root canal Treatment","Intraoperative pain","Endodontics","local anesthesia","Inferior Alveolar Nerve Block","NOT_YET_RECRUITING","2026-07-09",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":22},"2026-07",{"date":44,"type":22},"2026-12",{"name":46,"class":47},"Watim Medical & Dental College","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100645015","phase-4-this-study-aims-to-compare-the-efficacy-and-safety-of-lumateperone-and-cariprazine-in-patients-with-bipolar-i-depression-using-montgomery-sberg-depression-rating-scale-madrs-and-clinical-global-impression-bipolar-severity-scale-cgi-bp-s-and-recording-treatment-emergent-adverse-effects-100645015","NCT07676669","This Study Aims to Compare the Efficacy and Safety of Lumateperone and Cariprazine in Patients With Bipolar I Depression Using Montgomery-Åsberg Depression Rating Scale (MADRS) and Clinical Global Impression Bipolar Severity Scale (CGI-BP-S) and Recording Treatment Emergent Adverse Effects.","Comparison Of Efficacy And Safety Of Lumateperone And Cariprazine as Adjunctive Treatment in Bipolar I Depression","LUCAR-BD","Inclusion Criteria:\n\n* Patients aged 18-60 years\n* Diagnosed with bipolar I depression according to DSM-5 criteria\n* On stable dose of mood stabilizer (lithium or valproate) for at least 2 weeks\n* Moderate to severe depressive symptoms (baseline MADRS score ≥20)\n* Willing to provide informed consent\n\nExclusion Criteria:\n\n* • Current manic or mixed episode\n\n  * Rapid cycling bipolar disorder\n  * Substance use disorder\n  * Severe neurological illness or medical emergency\n  * Pregnancy or lactation\n  * Treatment-resistant depression requiring ECT\n  * Active suicidal risk requiring emergency intervention",{"count":57,"type":22},140,[25],"This study aims to compare the efficacy and safety of lumateperone and cariprazine as adjuncts in patients with depression associated with bipolar I using standardized efficacy assessment tools such as the Montgomery-Åsberg Depression Rating Scale (MADRS) and Clinical Global Impression bipolar severity scale (CGI-BP-S) and recording treatment emergent adverse effect.\n\nParticipants will undergo baseline assessment on day 0 using these scales. Follow-up assessments using MADRS and CGI scales will be conducted at Day 15, Day 30 and Day 45. Safety analysis will be performed for all participants who receive at least one dose of study medication. Vitals and treatment-emergent adverse events (TEAEs) will be recorded at every visit",[61],"Bipolar 1 Depression","2026-06-23",{"date":64,"type":40},"2026-06-30",{"date":44,"type":22},{"date":67,"type":22},"2027-08",{"name":46,"class":47},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":77,"maxAge":19,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},"100618353","comparison-of-conventional-buccal-nerve-block-versus-buccal-nerve-trunk-block-during-extraction-of-posterior-mandibular-teeth-100618353","NCT07330518","Comparison of Conventional Buccal Nerve Block Versus Buccal Nerve Trunk Block During Extraction of Posterior Mandibular Teeth","Comparison of Conventional Buccal Nerve Block Versus Buccal Nerve Trunk Block for Anaesthesia of Buccal Mucosa During Extraction of Mandibular Posterior Teeth","Buccal Trunk","Inclusion Criteria:\n\n* Patients aged 20 to 60 years\n* Patients of both gender\n* Patient requiring extraction of mandibular molars\n\nExclusion Criteria:\n\n* Pregnant women\n* Pathologies associated with teeth i.e. cysts, tumors\n* Patients on radiotherapy or chemotherapy\n* Patients with mandibular fracture","20 Years",{"count":79,"type":22},100,[81],"NA","This randomised control trial will compare the efficacy of conventional buccal nerve block versus buccal trunk block using visual analogue scale to evaluate pain and additional anesthesia injection during extraction of mandibular molars.",[84],"Pain (Visceral, Somatic, or Neuropathic)",[86],"Buccal Trunk Block","RECRUITING","2026-02-01",{"date":90,"type":40},"2026-02-04",{"date":92,"type":22},"2026-03-20",{"date":94,"type":22},"2027-01-01",{"name":46,"class":47},1,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":96},"100615770","distolingual-infiltration-verses-conventional-nerve-block-in-mandibular-third-molar-extraction-100615770","NCT07296926","Distolingual Infiltration Verses Conventional Nerve Block in Mandibular Third Molar Extraction","Comparison of Efficacy of Distolingual Infiltration in Conjugation With Conventional Inferior Alveolar Nerve Block to Conventional Inferior Alveolar Nerve Block Alone for Extraction of Mandibular Third Molar","Inclusion Criteria:\n\n* Healthy individuals\n\n  * Male and female\n  * Age 18-45 years\n  * Mandibular third molar impaction - all positions\n  * Mandibular third molar impaction - all classes\n\nExclusion Criteria:\n\n* ASA status III and above\n\n  * Patients requiring multiple extractions in the same appointment\n  * Allergy to lignocaine\n  * Patients in whom adrenaline is contraindicated\n  * Medically compromised individuals e.g. poorly controlled diabetes, hypertension",true,"45 Years",{"count":107,"type":22},120,[81],"This randomized controlled trial will compare the effectiveness of adding distolingual infiltration to conventional inferior alveolar and buccal nerve blocks for mandibular third molar extraction. A total of 120 patients will be allocated into two groups. Pain during flap elevation and bone guttering will be assessed using the Visual Analogue Scale.",[84],"2025-12-30",{"date":113,"type":40},"2026-01-06",{"date":115,"type":40},"2024-08-15",{"date":117,"type":22},"2026-04-15",{"name":46,"class":47},{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":104,"sex":17,"minAge":4,"maxAge":105,"enrollmentInfo":127,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":96},"100618141","comparison-of-two-different-suture-knot-techniques-on-post-operative-trismus-and-swelling-after-impacted-third-molar-surgery-100618141","NCT07327762","Comparison of Two Different Suture Knot Techniques on Post-Operative Trismus and Swelling After Impacted Third Molar Surgery","COMPARISON OF TWO DIFFERENT SUTURE KNOT TECHNIQUES ON POST-OPERATIVE TRISMUS AND SWELLING AFTER IMPACTED THIRD MOLAR SURGERY","Impacted molar","Inclusion Criteria:\n\n* • Healthy individuals\n\n  * Gender: male and female\n  * Age: 18-45 years\n  * Mandibular third molar impaction all positions\n  * Mandibular third molar impaction all classes\n\nExclusion Criteria:\n\n* • Patients with ASA status III and above\n\n  * Patients requiring multiple extractions in same appointment\n  * Patients allergic to Lignocaine\n  * Patients in whom adrenaline is contraindicated\n  * Medically compromised individual such as those with poorly controlled diabetes, hypertension and pregnancy, etc.",{"count":21,"type":22},[81],"To compare the two different suture knot techniques, locked and unlocked, in terms of mean on postoperative trismus and swelling after impacted mandibular third molar surgery.",[131,132],"Trismus","Swelling","2025-12-25",{"date":135,"type":40},"2026-01-08",{"date":137,"type":22},"2026-07-01",{"date":139,"type":22},"2027-01-31",{"name":46,"class":47},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":104,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":157,"leadSponsor":158,"locationsCount":96},"100612003","postoperative-pain-and-swelling-after-flap-vsflapless-technique-for-mandibular-third-molar-surgery-100612003","NCT07247929","Postoperative Pain and Swelling After Flap vsFlapless Technique For Mandibular Third Molar Surgery","Comparison of Postoperative Pain and Swelling in Flap Versus Flapless Technique for Surgical Removal of Partially Impacted Mandibular Third Molars: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18-45 years\n\n  * Either gender\n  * Partially impacted mesioangular mandibular third molar confirmed clinically and radiographically\n  * Second episode of pericoronitis\n  * Swelling present on the affected side\n  * No bone recession or periodontal disease on radiograph\n\nExclusion Criteria:\n\n* HIV or HBV infection\n\n  * Diabetes or other metabolic disorders\n  * Bleeding disorders including von Willebrand disease, thalassemia, hemophilia, thrombocytosis, or thrombocytopenia\n  * Periapical infection or acute pericoronitis at time of surgery\n  * Severe trismus\n  * Immunocompromised status",{"count":149,"type":22},160,[81],"This randomized controlled trial evaluates postoperative pain and facial swelling following surgical removal of partially impacted mandibular third molars using flap versus flapless techniques. The aim is to determine which method results in lower postoperative morbidity on the second postoperative day.",[84],"2025-11-20",{"date":155,"type":40},"2025-11-25",{"date":115,"type":40},{"date":117,"type":22},{"name":46,"class":47},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":169,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":96},"100551128","phase-1-efficacy-of-pure-honey-dressing-in-contrast-to-alvogyl-in-the-resolution-of-dry-socket-100551128","NCT06456060","Efficacy of Pure Honey Dressing in Contrast to Alvogyl in the Resolution of Dry Socket","Exploring the Efficacy of Pure Honey Dressing in Contrast to Alvogyl in the Resolution of Dry Socket: A Comparative Analysis","Inclusion Criteria:\n\n1. Patients over 18 years of age of both genders.\n2. Patients who underwent extraction of teeth and were clinically diagnosed with dry socket at the OMFS department of NID, Multan.\n3. Patients which give informed consent.\n\nExclusion Criteria:\n\n1. Patients below the age of 18 and above the age of 70.\n2. Patients with various bone diseases, including osteoporosis \\& a history of taking oral or intravenous bisphosphonates\n3. Patients with a history of radiotherapy on the head, neck, and jawbones were excluded from this study,\n4. Patients with systemic diseases such as diabetes mellitus, hepatic dysfunctions, blood dyscrasias, and bleeding disorders\n5. Patients with allergy to Ibuprofen \\& honey\n6. Patients having symptoms similar to dry socket due to retained root pieces, oroantral communication, or any bony or soft tissue pathology by the help of a radiograph\n7. Patients who did not give informed consent.","70 Years",{"count":168,"type":22},40,[170],"PHASE1","Dry socket, or Alveolar Osteitis, is the most common complication that can follow a tooth extraction. Over the years, various approaches have been employed to expedite the healing process and alleviate the associated symptoms. Among these, Alvogyl has been the most commonly used dry socket dressing all over the globe. However due to Alvogyl's potential side effect of causing a foreign body reaction \\& ultimately necrosis of the alveolar bone if left in the socket along with its high cost, scientists have sought to develop new techniques. Among them, Honey dressing has heralded promising properties in facilitating the resolution of dry socket, thus opening the window of a side-effect free natural viable alternative to Alvogyl. In this research, we aim to compare the efficacy of pure Honey as a dry socket dressing in comparison to Alvogyl.",[173],"Dry Socket","2024-07-22",{"date":176,"type":40},"2024-07-23",{"date":178,"type":40},"2024-06-01",{"date":180,"type":22},"2025-01-30",{"name":46,"class":47},""]