[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Western Health, Australia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100591035","phase-2-minimising-total-radiation-exposure-in-preterm-infants-100591035",false,"NCT06975189","MINImising Total Radiation EXposure in Preterm Infants","Lung Ultrasound to Reduce the Number of Chest X-rays in Very Preterm Infants in the First 2 Weeks After Birth: A Randomised Controlled Trial","MINI T-Rex","Inclusion Criteria:\n\nAll infants born \\\u003C32 weeks' gestation and admitted to the neonatal intensive care unit (NICU) who require lung imaging for respiratory indications will be considered eligible. Each infant must meet all the following criteria to be enrolled in this study:\n\n* The infant is born from 22 to 31+6 weeks' gestation by best obstetric estimate and admitted to the NICU\n* The infant is considered to require lung imaging for respiratory indications\n* The infant has a parent\u002Fguardian who can provide informed consent.\n\nExclusion Criteria\n\n* The infant will only require CXR to be performed solely to confirm device position i.e. central line, endotracheal tube, gastric tubes\n* The infant will only require CXR to be performed for specifically for non-respiratory indications i.e. assessment of cardiac silhouette\n* The infant's Clinician has concern regarding clinical stability and tolerability of ultrasound scans\n* The infant's skin integrity will not tolerate ultrasound gel\n* Refusal of informed consent by their parent\u002Fguardian\u002Flegally acceptable representative\n* The infant does not have a parent\u002Fguardian who can provide informed consent.","ALL","24 Hours",{"count":20,"type":21},180,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Being born too early (preterm birth) is the leading cause of death in children world-wide. In Australia, 97% of very preterm babies who are admitted to Neonatal Intensive Care Units need breathing support after birth to survive. Despite this significant global impact, neonatal clinicians have few tools available to guide breathing support. Currently, the only lung imaging tool that is routinely used in the Neonatal Intensive Care Unit is a chest X-ray. To reduce radiation exposure, chest X-rays are usually only performed one or two times a day. As chronic lung disease in babies who survive preterm birth is increasing, there is an urgent need to develop new ways to monitor the lungs of these fragile babies.\n\nLung ultrasound is a form of imaging that is fast, gentle and radiation free. However, it has not been routinely adopted into caring for preterm babies in most countries. This is because there are no randomised controlled trials that have demonstrated the benefit and safety of using lung ultrasound as the first-line imaging tool in preterm babies. The investigators will conduct a randomised controlled trial to demonstrate that lung ultrasound is a quick, safe and accurate alternative to chest x-rays in preterm babies.",[27,28],"Neonatal Respiratory Distress Syndrome","PreTerm Neonate",[30,31,32],"Lung ultrasound","Respiratory Distress Syndrome","Prematurity","RECRUITING","2026-04-13",{"date":36,"type":37},"2026-04-16","ACTUAL",{"date":34,"type":37},{"date":40,"type":21},"2029-12-01",{"name":42,"class":43},"Western Health, Australia","OTHER_GOV",""]