[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Wills Eye\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":81},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100337589","caffeine-consumption-in-glaucoma-patients-and-healthy-subjects-100337589",false,"NCT03675412","Caffeine Consumption in Glaucoma Patients and Healthy Subjects","Acute Changes in Optic Nerve Head (ONH) and Macular Blood Flow After Caffeine Consumption in Glaucoma Patients and Healthy Subjects: A Quantitative Optic Coherence Tomography Angiography (OCTA) Study","Inclusion Criteria:\n\n* age 18 to 90 years\n* diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced)\n* healthy subjects with no eye disease\n\nExclusion Criteria:\n\n* Diseases, ophthalmic or systemic, that are likely to affect OCTA results\n* greater than moderate cataract\n* nystagmus\n* inability to look at target\n* macular degeneration other than mild drusen or pigmentary changes\n* diabetic retinopathy\n* neovascular glaucoma or non-glaucoma optic neuropathies\n* current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy\n* keratoconus, corneal ectasia, central corneal scarring\n* rheumatologic diseases or Raynaud's phenomena\n* pregnant and lactating women\n* mental illness or alcohol addiction\n* pre-existing bladder symptoms, cardiac disease or sleep disorder\n* refractive spherical diopter greater than 5 or cylinder greater than 3\n* possible tolerance to caffeine (drinking more than 1 cup coffee per day).",true,"ALL","18 Years","90 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.",[28],"Glaucoma, Primary Open Angle",[30,31,32,33,34],"Primary Open Angle Glaucoma (POAG)","Optical Coherence Tomography Angiography (OCTA)","Caffeine","Macular Blood Flow","Peripapillary Blood Flow","RECRUITING","2025-11-12",{"date":38,"type":39},"2025-11-14","ACTUAL",{"date":41,"type":39},"2018-12-30",{"date":43,"type":22},"2026-12-31",{"name":45,"class":46},"Wills Eye","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":47},"100079193","novel-glaucoma-diagnostics-100079193","NCT00286637","Novel Glaucoma Diagnostics","Novel Diagnostics for Ocular Structure","Inclusion Criteria:\n\n* Ability to provide informed consent and to understand the study procedures\n* Healthy volunteers\n* Age related macular degeneration (AMD), diabetic retinopathy, central serous chorioretinopathy, and\u002For glaucoma or glaucoma suspects\n* (AD Sub-Study ONLY): Subjects diagnosed with AD or MCI.\n\nExclusion Criteria:\n\n* Any medical treatment (e.g., chronic corticosteroid, hydroxychloroquine, chloroquine, thioridazine, canthaxanthine) or conditions that affect VF (e.g., stroke) and retinal thickness other than glaucoma.\n* Strabismus, nystagmus, or any condition that prevents fixation.\n* Presence of any media opacities that hinders clinical view of the fundus, and any intraocular non-glaucomatous abnormality\n* History of ocular trauma or intraocular surgery other than uncomplicated glaucoma interventions or cataract extraction at least 3 months previous to participating in the study.",{"count":56,"type":22},5000,"OBSERVATIONAL","The purpose of this research is to evaluate novel technologies for the assessment of ocular structure and function, including the scanning device called Optical Coherence Tomography (OCT). We will test the OCT and other devices in their ability to image diseases of the eye and also compare the measurements made with OCT to those of other imaging and visual field devices approved by the Food and Drug Administration (FDA). OCT may be useful for the early diagnosis and monitoring of a variety of types of eye diseases",[60,61],"Glaucoma","Macular Disease",[63,64,65,66,67,68,69,70,71,72],"OCT","CSLO","SLP","Perimetry","electrophysiology","glaucoma","macular degeneration","retinopathy","diabetes","macular hole","2024-08-13",{"date":75,"type":39},"2024-08-15",{"date":77,"type":39},"2000-08-01",{"date":79,"type":22},"2029-07-31",{"name":45,"class":46},""]