[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Wolfson Medical Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":368},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,56,80,108,132,159,197,231,261,290,311,336],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100620851","early-phase-1-topical-tranexamic-acid-to-reduce-blood-loss-during-cesarean-delivery-100620851",false,"NCT07362992","Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery","Does Topical Use of Tranexamic Acid During a Cesarean Delivery Reduce Intra-surgical Bleeding? A Randomized ,Multi-center Trial","Inclusion Criteria:\n\n* Women aged 18 to 51 years\n* Singleton pregnancy\n* Elective cesarean delivery scheduled at ≥37+0 weeks of gestation\n* First or second cesarean delivery only\n* Low transverse uterine incision planned\n* Double-layer uterine closure using 1-0 Vicryl sutures\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to tranexamic acid (TXA)\n* History of bleeding or coagulation disorders\n* Previous postpartum hemorrhage\n* Placenta previa or placenta accreta spectrum\n* Presence of uterine myomas\n* Current use of anticoagulant or antiplatelet medications\n* Planned or intraoperative conversion to general anesthesia\n* Known uterine malformations\n* Known bleeding tendency or thromboembolic disease",true,"FEMALE","18 Years","51 Years",{"count":21,"type":22},112,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo. The study will include pregnant women aged 18-51 undergoing elective cesarean delivery at term (37 weeks or more).\n\nThe main questions it aims to answer are:\n\n* Does topical TXA shorten uterine closure time?\n* Does topical TXA reduce the need for additional hemostatic sutures? Researchers will compare women receiving topical TXA to those receiving placebo (normal saline) to see if TXA reduces intraoperative bleeding and improves surgical outcomes.\n\nParticipants will:\n\n* Be randomly assigned to receive either topical TXA or placebo during cesarean delivery.\n* Have standard surgery and postoperative care identical in both groups.\n* Provide routine clinical data, including hemoglobin levels and recovery outcomes, from their medical records.",[28,29,30,31],"Cesarean Delivery","Postpartum Hemorrhage (PPH)","Intraoperative Blood Loss","Hemostasis",[33,34,35,28,36,37,38,39,40,41,42,43],"Tranexamic Acid","Topical Tranexamic Acid","Hexakapron","Cesarean Section","Elective Cesarean","Postpartum Hemorrhage","Intraoperative Bleeding","Blood Loss Prevention","Uterine Closure","Randomized Controlled Trial","Maternal Outcomes","RECRUITING","2026-07-01",{"date":47,"type":48},"2026-07-02","ACTUAL",{"date":45,"type":48},{"date":51,"type":22},"2028-12-31",{"name":53,"class":54},"Wolfson Medical Center","OTHER_GOV",4,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":73,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100605165","home-ultrasound-in-routine-high-risk-care-of-patients-with-gestational-diabetes-mellitus-gdm-100605165","NCT07158970","Home-Ultrasound in Routine High-Risk Care of Patients With Gestational Diabetes Mellitus (GDM)","Effect of Home Ultrasound in Routine High-Risk Care of Patients With Gestational Diabetes Mellitus","Inclusion Criteria:\n\n* Singleton pregnancy\n* GDM diagnosed by OGTT or glucose monitoring\n* Hebrew speaking\n* Compatible cellphone\n\nExclusion Criteria:\n\n* Pregestational diabetes\n* Fetal anomalies\u002Fgenetic abnormalities\n* Multifetal pregnancy\n* Late GDM diagnosis (after 34 weeks)",{"count":64,"type":22},90,[66],"NA","This study evaluates the impact of incorporating home-ultrasound (home-US) devices into telemedicine care for patients with gestational diabetes mellitus (GDM). The study will compare satisfaction, clinical outcomes, and healthcare costs between standard high-risk pregnancy care and care augmented by home-US.",[69],"Gestational Diabetes Mellitus",[71,72],"home ultrasound","telemedicine",{"date":47,"type":48},{"date":75,"type":48},"2026-03-01",{"date":77,"type":22},"2027-11-01",{"name":53,"class":54},1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":79},"100622114","are-there-benefits-of-using-energy-based-devices-for-opportunistic-salpingo-oophorectomy-during-vaginal-hysterectomy-compared-to-a-standard-cold-approach-100622114","NCT07379411","Are There Benefits of Using Energy-based Devices for Opportunistic Salpingo-oophorectomy During Vaginal Hysterectomy Compared to a Standard Cold Approach?","Energy-based Opportunistic Salpingo-oophorectomy During Vaginal Hysterectomy - is it Better Than Conventional \"Knot-and-cut\" Approach? A Randomized Controlled Study","Inclusion Criteria:\n\n* Women aged 18 years or older.\n* Scheduled to undergo vaginal hysterectomy for pelvic organ prolapse.\n* Recommended to undergo opportunistic salpingo-oophorectomy according to standard clinical indications.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Suspected or known pelvic malignancy.\n* Lack of informed consent.\n* Planned opportunistic salpingo-oophorectomy using a non-vaginal surgical approach.\n* Planned opportunistic salpingo-oophorectomy using a vNOTES (vaginal natural orifice transluminal endoscopic surgery) approach.\n* Intraoperative need to deviate from the assigned surgical technique due to anatomical or technical considerations.",{"count":88,"type":22},70,[66],"This study compares two methods for removing the fallopian tubes and ovaries during vaginal hysterectomy for pelvic organ prolapse.\n\nOne method uses an energy-based surgical device called LigaSure Maryland, which seals blood vessels using electrical energy. The other method is the standard surgical approach, which involves clamping, cutting, and suturing the tissue. The purpose of the study is to determine whether the use of the LigaSure device is as safe as, or more effective than, the standard technique, in terms of procedure duration, blood loss, postoperative pain, length of hospital stay, and complication rates.\n\nWomen who are scheduled to undergo vaginal hysterectomy for pelvic organ prolapse and for whom removal of the fallopian tubes and ovaries is recommended may participate in the study. Participants will be randomly assigned to one of two groups, receiving either the LigaSure technique or the standard surgical technique.\n\nThe decision to perform removal of the fallopian tubes and ovaries will be made before surgery based on standard medical indications. Participants will not be informed which surgical technique is used during their operation. Surgical outcomes between the two groups will be compared to evaluate safety and effectiveness.",[92],"Pelvic Organ Prolapse (POP)",[94,95,96,97,98,99],"pelvic organ prolapse","vaginal surgery","vaginal hysterectomy","salpingo-oophorectomy","prophylactic salpingo-oophorectomy","vaginal salpingo-oophorectomy","2026-01-26",{"date":102,"type":48},"2026-01-30",{"date":104,"type":48},"2025-10-16",{"date":106,"type":22},"2027-09",{"name":53,"class":54},{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100618986","educational-video-anxiety-and-mode-of-delivery-after-previous-cesarean-100618986","NCT07338747","Educational Video, Anxiety, and Mode of Delivery After Previous Cesarean","Does an Educational Video Increase Trial of Labor After Cesarean and Reduce Anxiety Among Women With a Prior Cesarean? A Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women with a singleton pregnancy.\n* History of one previous cesarean delivery with a low transverse uterine incision.\n* Eligible for a trial of labor after cesarean (TOLAC) according to clinical assessment and Israeli national clinical guidelines.\n* Age 18 years or older.\n* Hebrew-speaking.\n* Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Medical or obstetric conditions contraindicating vaginal delivery, including but not limited to placenta previa or marginal placenta previa.\n* History of uterine surgery other than one prior low transverse cesarean section that precludes vaginal delivery.\n* History of two or more prior cesarean deliveries.\n* Non-vertex fetal presentation or any presentation unsuitable for a trial of labor.\n* Multiple gestation.\n* Diagnosed severe anxiety disorder or other significant psychiatric disorder that may interfere with participation in the study or completion of questionnaires.",{"count":64,"type":22},[66],"This interventional study evaluates whether video-based patient education regarding Trial of Labor After Cesarean (TOLAC) reduces maternal anxiety compared with standard verbal counseling. Pregnant women eligible for TOLAC will be randomized to receive either a structured educational video or routine verbal counseling. Maternal anxiety levels will be assessed using the State-Trait Anxiety Inventory (STAI).",[119,120,121,122],"Anxiety","TOLAC","Previous Cesarean Delivery","Trial of Labor After Cesarean","NOT_YET_RECRUITING","2026-01-01",{"date":126,"type":48},"2026-01-14",{"date":128,"type":22},"2026-01",{"date":130,"type":22},"2027-12",{"name":53,"class":54},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":147,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":4},"100605873","the-effect-of-reflexology-on-time-to-delivery-during-induction-of-labor-100605873","NCT07168187","The Effect of Reflexology on Time to Delivery During Induction of Labor","The Effect of Reflexology Treatment on Maternal Anxiety During Induction of Labor With an Extra-amniotic Balloon","Inclusion Criteria:\n\n* Age of ≥18 years\n* Gestational age of \\>37 weeks\n* Vertex presentation\n* Intact membranes\n* Station of the fetus's head \\\u003C S-4\n* Bishop score of \\\u003C6.\n\nExclusion Criteria:\n\n* Patients who had undergone a previous cesarean delivery\n* Patients with a contraindication for vaginal delivery\n* Patients with a known fetal malformation patients undergoing termination of pregnancy.",{"count":140,"type":22},84,[66],"This prospective, randomized controlled trial evaluates the effect of reflexology on maternal anxiety, labor duration, and pain in women undergoing labor induction with an extra-amniotic balloon (EAB). Eligible participants are women with a singleton, term pregnancy, cephalic presentation, intact membranes, and a Bishop score \\\u003C6, without prior cesarean delivery or contraindications to vaginal delivery.\n\nParticipants will be randomized to two groups: an intervention group receiving reflexology by a certified practitioner following EAB placement, and a control group receiving standard care. Maternal anxiety will be assessed using the State-Trait Anxiety Inventory (STAI) before and after the intervention. Labor duration and pain scores will also be recorded.\n\nThe study plans to enroll 84 participants over two years. Reflexology is a safe, non-invasive complementary therapy, and this study aims to determine whether it provides measurable benefits during labor induction.",[144,145,146],"Reflexology","Labor Induction","Extra Amniotic Balloon",[148,149,150],"induction to delivery time","labor induction","maternal anxiety","2025-12-02",{"date":153,"type":48},"2025-12-10",{"date":155,"type":22},"2025-12-30",{"date":157,"type":22},"2026-08-01",{"name":53,"class":54},{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":169,"briefSummary":170,"conditions":171,"keywords":174,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":79},"100605859","informative-video-before-lmwh-postpartum---randomized-controlled-trial-100605859","NCT07168005","Informative Video Before LMWH Postpartum - Randomized Controlled Trial","Does an Informative Video Reduce Anxiety and Pain Before LMWH Treatment Postpartum? - A Randomized Controlled Trial","Inclusion Criteria:\n\nWomen 18-45 years, postpartum, indicated for LMWH, Hebrew-literate, gave consent\n\nExclusion Criteria:\n\nUse of LMWH pre-delivery, IUFD, pregnancy termination, language\u002Fcognitive barrier","45 Years",{"count":168,"type":22},160,[66],"This single-center randomized controlled trial evaluates whether a short informative video can reduce anxiety and pain before the first postpartum administration of low molecular weight heparin (LMWH, Clexane). Eligible women will be randomized to receive either standard explanation alone or standard explanation plus a short educational video. The primary outcome is anxiety level assessed via the State-Trait Anxiety Inventory (STAI). Secondary outcomes include pain, satisfaction, and treatment adherence.",[172,173,119],"Venous Thromboembolism (VTE)","Postpartum Care",[175,176,177,178,179,180,119,181,182,183,184,185,173,186,187,188],"Postpartum","Venous Thromboembolism","VTE","LMWH","Low Molecular Weight Heparin","Clexane","Pain","Patient Education","Informative Video","State-Trait Anxiety Inventory","STAI","Women's Health","Obstetrics","Adherence","2025-09-03",{"date":191,"type":48},"2025-09-11",{"date":193,"type":22},"2025-10-15",{"date":195,"type":22},"2027-10-15",{"name":53,"class":54},{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":166,"enrollmentInfo":205,"targetDuration":4,"studyType":23,"phases":207,"briefSummary":208,"conditions":209,"keywords":210,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":79},"100597878","an-informative-video-about-perineal-tears-during-labor-for-anxiety-reduction-a-randomized-controlled-trial-100597878","NCT07064213","An Informative Video About Perineal Tears During Labor for Anxiety Reduction: A Randomized Controlled Trial","Effect of an Informative Video About Perineal Tears on Anxiety During Labor: A Randomized Controlled Trial","VITAL","Inclusion:\n\nPrimiparous women\n\nAge ≥18\n\nGestational age ≥37 weeks\n\nFluent in Hebrew (able to complete STAI-S)\n\nExclusion:\n\nIUFD\n\nPregnancy termination\n\nDiagnosis of anxiety disorder\n\nLanguage barrier (cannot complete STAI-S)",{"count":206,"type":22},110,[66],"This study evaluates the impact of an informative video about perineal tears on maternal anxiety during labor. Perineal trauma during childbirth, especially severe tears such as obstetric anal sphincter injuries (OASIS), is associated with significant physical and psychological consequences, including anxiety, shame, fear, and social isolation. Despite growing awareness, many women report inadequate knowledge and preparation regarding these outcomes before labor.\n\nThis prospective, single-center, randomized controlled trial will be conducted at Edith Wolfson Medical Center in Holon, Israel. A total of 110 primiparous women admitted for induction or early labor will be recruited prior to the active phase of labor. Participants will be randomized into two groups in a 1:1 ratio. The intervention group will watch a 2-minute educational video explaining the types, implications, and prevention strategies related to perineal tears. The control group will receive standard care without video exposure.\n\nThe primary objective is to assess change in maternal anxiety using the validated State-Trait Anxiety Inventory (STAI-S) questionnaire, measured at baseline and 2-24 hours postpartum. Secondary outcomes include satisfaction with the video (in the intervention group), rates of perineal tears, episiotomy, and OASIS. Data will be collected from the hospital's EMR system and patient-reported questionnaires, stored securely and coded. The study aims to determine whether increasing knowledge through a short educational intervention can reduce childbirth-related anxiety and improve the birth experience.",[119],[211,212,213,214,215,216,217,218,219,220,221,222],"Perineal Tears","Childbirth Education","Primiparous Women","Labor and Delivery","Childbirth-Related Anxiety","Intrapartum Anxiety","Obstetric trauma","Episiotomy","Vaginal delivery","OASIS","STAI-S","Maternal mental health","2025-07-02",{"date":225,"type":48},"2025-07-14",{"date":227,"type":22},"2025-07-10",{"date":229,"type":22},"2026-07-10",{"name":53,"class":54},{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":239,"targetDuration":4,"studyType":23,"phases":241,"briefSummary":243,"conditions":244,"keywords":247,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":79},"100589163","phase-4-antipyretic-treatment-for-intrapartum-fever-dipyrone-vs-acetaminophen-rct-100589163","NCT06950840","Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT)","Intravenous Dipyrone Compared With Intravenous Acetaminophen for Maternal Fever During Labor: A Randomised Controlled Trial","PARADIP","Inclusion Criteria:\n\n* Women undergoing a trial of vaginal delivery, with suspected intra-amniotic infection defined as isolated maternal fever of 39°C or greater, or an sustained oral temperature of 38-38.9°C for at least 30 minutes or with one or more of the following: maternal leukocytosis, purulent cervical drainage, or fetal tachycardia.\n\nExclusion Criteria:\n\n* Known history of adverse events for dipyrone or acetaminophen\n* Age \\\u003C18 years\n* Gestational age \\\u003C24 weeks\n* Intrauterine fetal death\n* Fever onset prior to delivery\n* Known liver disease\n* Known leukopenia\n* In addition, those who will develop allergic event or any adverse event possible related to any of the antipyretics used will be excluded from the",{"count":240,"type":22},140,[242],"PHASE4","Chorioamnionitis, or intraamniotic infection, is a common condition affecting 2-5% of all term births. This condition poses well-recognized maternal and neonatal risks, and entails a series of clinical management decisions concerning both the mother and neonate. Therefore, timely detection and treatment of chorioamnionitis is of paramount importance. The occurrence of chorioamnionitis is associated with a higher risk of labor abnormalities, which increase the risk of cesarean delivery (CD) 3 to 4 fold.\n\nAs recommended by current guidelines, treatment of suspected intraamniotic infection should include broad-spectrum antibiotics. In addition, the use of antipyretics is advocated. This is particularly important during the intrapartum period since fetal acidosis in the setting of fever has been associated with a marked increase in the incidence of neonatal encephalopathy. Maternal fever even in the absence of documented fetal acidosis is associated with adverse neonatal outcomes, particularly neonatal encephalopathy, though it is unclear to what extent the etiology of the fever rather than the fever itself is causative . Furthermore, treating intrapartum fever with antipyretics may also be helpful in reducing fetal tachycardia thereby avoiding the tendency to perform cesarean for a non-reassuring fetal status. Nevertheless, it remains understudied which is the most appropriate antipyretic agent in this regard, where both dipyrone and acetaminophen are safe alternatives . Antipyretic agent with a faster onset of action may be preferable in this setting.",[245,246],"Intrapartum Fever","Chorioamnionitis",[248,249,250,251,252],"maternal fever","labour","acetaminophen","dipyrone","metamizole","2025-06-30",{"date":255,"type":48},"2025-07-03",{"date":257,"type":22},"2025-08-01",{"date":259,"type":22},"2027-05",{"name":53,"class":54},{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":270,"briefSummary":271,"conditions":272,"keywords":274,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":79},"100584086","routine-activity-and-preterm-delivery-risk-in-women-with-a-short-cervix-100584086","NCT06884761","Routine Activity and Preterm Delivery Risk in Women With a Short Cervix","The Effect of Routine Activity on the Risk for Preterm Delivery in Women With a Short Cervix. A Randomized Control Trial","Inclusion Criteria:\n\n* Singleton pregnancies between 24+0 and 34+6 weeks.\n* Short cervical length (\\\u003C25 mm) confirmed via transvaginal ultrasound.\n* No medical contraindications to physical activity.\n\nExclusion Criteria:\n\n* Twin pregnancies or higher-order multiples.\n* Medical indications for reduced mobility (e.g., symphysiolysis, fall risk).\n* Maternal comorbidities, fetal distress, vaginal bleeding, PPROM, or need for immediate delivery.",{"count":269,"type":22},100,[66],"The goal of this clinical trial is to evaluate the effect of routine activity versus rest on the risk of preterm delivery in pregnant women with a short cervix diagnosed between 24 and 34 weeks of gestation. The main questions it aims to answer are:\n\nDoes routine activity influence the gestational age at delivery? How does routine activity affect secondary outcomes such as preterm labor, premature rupture of membranes, delivery mode, maternal anxiety, and satisfaction?\n\nResearchers will compare women instructed to maintain routine activity (control group) to women advised to practice maximal rest (intervention group) to see if physical activity impacts preterm birth outcomes.\n\nParticipants will:\n\nWear a smart band to monitor step counts over a two-week period. Be randomized into two groups: one encouraged to maintain routine activity and the other advised to follow strict rest protocols.\n\nUndergo regular follow-ups at a high-risk pregnancy clinic and have their data collected through hospital records and smart band tracking.\n\nThis randomized controlled trial will assess gestational age at delivery as the primary outcome, along with secondary maternal and neonatal outcomes, providing insight into the role of physical activity in managing pregnancies complicated by a short cervix.",[273],"Cervical Shortening",[275,276,277,278,279,280,281],"Preterm delivery","Physical activity","cervical shortening","Bed rest","Cervical length","High-risk pregnancy","Randomized controlled trial","2025-04-14",{"date":284,"type":48},"2025-04-17",{"date":286,"type":48},"2025-01-15",{"date":288,"type":22},"2027-12-29",{"name":53,"class":54},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":166,"enrollmentInfo":297,"targetDuration":4,"studyType":23,"phases":299,"briefSummary":300,"conditions":301,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":79},"100544965","the-impact-of-a-customized-informative-video-prior-to-induction-of-labor-on-anxiety-relieve-100544965","NCT06375746","The Impact of a Customized Informative Video Prior to Induction of Labor on Anxiety Relieve.","The Impact of a Customized Informative Video Prior to Induction of Labor on Anxiety Relieve - a Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women, aged 18-45, undergoing medical IOL at term.\n* Unfavorable cervix (BISHOP score \\\u003C6).\n* Cervical ripening with either prostaglandin E2 (PGE2) tablets or extra-amniotic balloon (EAB).\n* Provided consent to participate in the study.\n* No language barrier preventing completion of the questionnaire.\n\nExclusion Criteria:\n\n* Sensitivity to PGE2.\n* Preterm labor.\n* Premature rupture of membranes.\n* Stillbirth.\n* Elective pregnancy termination.",{"count":298,"type":22},180,[66],"To determine whether watching a personalized video prior to medically indicated labor induction among term parturients reduces anxiety levels according to the STAI questionnaire, compared to a standard counselling.",[302],"Induction of Labor Affected Fetus \u002F Newborn","2024-07-28",{"date":305,"type":48},"2024-07-30",{"date":307,"type":48},"2024-05-01",{"date":309,"type":22},"2024-08-31",{"name":53,"class":54},{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":23,"phases":321,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":333,"leadSponsor":335,"locationsCount":79},"100532257","speculum-insertion-during-embryo-transfer-100532257","NCT06210451","Speculum Insertion During Embryo Transfer","Lubricant Gel Versus Sterile Water for Speculum Insertion During Embryo Transfer: a Randomized Non-inferiority Clinical Trial","Inclusion Criteria:\n\n* Age 18-40\n* Fresh and thawed ET\n* Patients undergoing their 1st-3rd ET\n* ET of 1-2 embryos\n\nExclusion Criteria:\n\n* Age\\>40\n* Egg donation cycles","40 Years",{"count":320,"type":22},416,[66],"Lubrication gels are widely used in numerous gynecologic procedures in order to ease the insertion of speculum and visualize the cervix. It was shown that applying lubricating gels significantly decreases patient pain during vaginal speculum examination. While many fertility specialists use lubrication gels to insert the speculum during embryo transfer (ET), others are strongly reluctant to use gels due to concern that they might have a detrimental effect on embryos and ET success. Similar concern was prevalent regarding the use of lubrication gel during Pap-smear for detection of cervical dysplasia. However, several studies have shown that the use of small amount of water-soluble gel does not change cervical cytology. Lubrication gels might have deleterious effect on sperm motility. However, there wasn't any study examining the effect of lubricant gel on ET success.\n\nThe investigators hypothesize that using a lubrication gel will not reduce the live birth rate per transfer, but decrease patient pain during procedure.",[324],"IVF",[324,326,327,328],"Embryo transfer","Gel","RCT","2024-07-22",{"date":331,"type":48},"2024-07-24",{"date":307,"type":48},{"date":334,"type":22},"2026-12-31",{"name":53,"class":54},{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":11,"sex":344,"minAge":345,"maxAge":346,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":348,"briefSummary":349,"conditions":350,"keywords":354,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":367},"100500071","combination-of-diet-and-oral-budesonide-for-ulcerative-colitis-100500071","NCT05791487","Combination of Diet and Oral Budesonide for Ulcerative Colitis","Remission With Diet for Ulcerative Colitis Exacerbations: A Single Blinded, International Randomized Controlled Clinical and Translational Trial","ReDUCE","Inclusion Criteria:\n\n* Informed consent\n* Established diagnosis of UC with mild to moderate active disease, 5 ≤ SCCAI ≤ 10\n* Age: 17-65 years (inclusive)\n* Extent E1-E3 by the Montreal classification\n* Active colitis in the rectum or sigmoid colon on sigmoidoscopy\n* Stable medication use of oral 5ASA for at least 8 weeks, thiopurines, vedolizumabs, Ustekinumab or tofacitinib for at least 12 weeks\n\nExclusion Criteria:\n\n* Severe colitis (SCCAI\\>10) hospitalization for acute severe colitis (ASC) in the previous 6 months\n* Use of steroids in the previous 3 months\n* Patients treated with Anti-TNF currently or in patients who had previously failed or lost response to anti TNF\n* Vegans (vegetarians may enroll)\n* Pregnancy\n* Inability use of budesonide due to severe adverse events\n* Extraintestinal manifestations such as arthritis, spondyloarthropathy or uveitis\n* Presence of baseline hypoalbuminemia\n* Fever \\>38°C\n* Evidence for Clostridioides difficile infection\n* Renal failure\n* Hepatitis or PSC (Primary Sclerosing Cholangitis)\n* Active malignancy (excluding skin BCC).","ALL","17 Years","65 Years",{"count":64,"type":22},[66],"The ReDUCE Trial is a multinational single-blinded randomized controlled trial in mild to moderate flare of Ulcerative colitis (UC) disease patients. The purpose of the study is to validate the clinical efficacy of the UCED (Ulcerative colitis Exclusion Diet) with partial enteral nutrition (PEN) using a novel formula.\n\nThe investigators anticipate that adding a novel specifically designed dietary intervention in addition to drug will lead to superior remission and mucosal healing via changes in the microbiome.",[351,352,353],"Ulcerative Colitis","Ulcerative Colitis Chronic Mild","Ulcerative Colitis Chronic Moderate",[355,356,357,358],"Ulcerative colitis","Diet","Partial enteral nutrition","Microbiome","2024-05-21",{"date":361,"type":48},"2024-05-23",{"date":363,"type":48},"2023-12-01",{"date":365,"type":22},"2026-09-01",{"name":53,"class":54},6,""]