[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Wuerzburg University Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":442},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,44,76,105,132,154,185,207,240,265,290,314,339,361,383,412],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100641950","gustabor-phase-2---treating-taste-changes-during-cancer-therapy-a-randomized-study-evaluating-an-ai--based-nutrition-intervention-100641950",false,"NCT07649681","Gustabor Phase 2 - Treating Taste Changes During Cancer Therapy: A Randomized Study Evaluating an AI- Based Nutrition Intervention","GustaborRCT","Inclusion Criteria:\n\n* Age ≥ 18\n* Suffering from one of the following tumor entities: Multiple myeloma, melanoma, urogenital cancer or malignant tumor of the gastrointestinal tract\n* Mainly oral nutrition\n* Subjectively perceived tumor therapy-related taste disorder\n* At least two clinical presentations planned within 12 weeks with a minimum interval of three weeks\n* Ability to participate in nutritional intervention, including use of the online portal and implementation of recipe suggestions (e.g. resources and access to a kitchen), either independently or with third-party support (e.g. by relatives, outpatient care services).\n\nExclusion Criteria:\n\n* Pregnancy\n* Taste disorder explained by other causes (e.g. existing before therapy or COVID disease)\n* Placement in an inpatient care facility","ALL","18 Years",{"count":19,"type":20},198,"ESTIMATED","INTERVENTIONAL",[23],"NA","The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation. Although many non-pharmacological recommendations exist, it is unclear which methods are suitable for which individuals.\n\nThis randomized study aims to compare the effectiveness of individualized dietary recommendations (Gustabor group) with the current standard of care -general recommendations (Control group). Participants will undergo an objective assessment of taste disorders using taste strips and questionnaires. Based on the results, the Gustabor group will receive both general and specific dietary suggestions. These will be accomapnied by AI-generated recipe suggestions tailored to specific taste disorders (e.g., more cold foods in cases of metallic taste). The control group will receive the current standard: a flyer containing general dietary advice for oncology patients previously shown to be beneficial for managing taste alterations. The primary endpoint is the PG-SGA score within 12 weeks of inclusion.",[26,27,28,29,30],"Multiple Myeloma (MM)","GI Cancer","Taste Disorder","Melanoma (Skin Cancer)","Urogenital Cancers","NOT_YET_RECRUITING","2026-06-23",{"date":34,"type":35},"2026-06-26","ACTUAL",{"date":37,"type":20},"2026-07-01",{"date":39,"type":20},"2026-12-31",{"name":41,"class":42},"Wuerzburg University Hospital","OTHER",6,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100636097","exploratory-investigation-of-the-acceptance-and-utility-of-14-day-trial-periods-and-application-related-outcome-measurement-abem-within-the-routine-prescription-of-the-diga-axia-100636097","NCT07561255","Exploratory Investigation of the Acceptance and Utility of 14-day Trial Periods and Application-related Outcome Measurement (AbEM) Within the Routine Prescription of the DiGA Axia.","Real-world Quality Management Study With Axia to Evaluate the Measures of the DigiG (RAEMD Study)","RAEMD","Inclusion Criteria:\n\n* Willingness to use Axia.\n* Axia indication area.\n* Willingness to activate via onboarding brochure.\n\nExclusion Criteria:\n\n* Absence of the inclusion criteria",{"count":53,"type":20},200,[23],"This prospective, multicenter, controlled real-world quality management study explores the acceptance and utility of two measures discussed in the context of the German Digital Act (DigiG) for the digital health application (DiGA) Axia: a 14-day trial period and an application-related outcome measurement (AbEM). Patients with axial spondyloarthritis in Axia's indication area who are eligible for prescription in routine care will receive one of two onboarding brochure versions in a 1:1 allocation: either the standard access procedure or immediate 14-day trial access until the health insurance activation code arrives. The manufacturer will analyze aggregated anonymized data to compare voucher redemption and app activation frequencies between groups and to assess acceptance and return rates of a voluntary five-item AbEM questionnaire at weeks 6 and 12. Secondary analyses will descriptively evaluate AbEM results and anonymized usage data.",[57,58],"Spondylitis, Ankylosing","Mobile Phone Use",[60,61,62,63,64,65],"axial spondyloarthritis","mobile health","digitalization","onboarding","real-world","therapeutic app","RECRUITING","2026-04-27",{"date":69,"type":35},"2026-05-01",{"date":71,"type":35},"2026-04-10",{"date":73,"type":20},"2027-04-10",{"name":41,"class":42},7,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},"100599437","giant-cell-arteritis---ways-to-precision-medicine-100599437","NCT07084480","Giant Cell Arteritis - Ways to Precision Medicine","Riesenzellarteriitis - Wege Zur \"Precision Medicine\"","Inclusion Criteria:\n\n* Age greater or similar to 18 years\n* Primary diagnosis of GCA or PMR\n\nExclusion Criteria:\n\n* Age under 18 years\n* lack of capacity to consent",{"count":84,"type":20},400,"OBSERVATIONAL","Long-term follow-up of aortal adverse events, as well as glucocortioid-associated adverse events in patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA).",[88,89],"Giant Cell Arteritis","Polymyalgia Rheumatic (PMR)",[91,92,93,94,95],"non-interventional cohort study","aortic dilatation","innate lymhoid cells","optic coherence tomography","MRI","2025-12-15",{"date":98,"type":35},"2025-12-22",{"date":100,"type":35},"2025-11-14",{"date":102,"type":20},"2033-07-31",{"name":41,"class":42},1,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":114,"studyType":85,"phases":4,"briefSummary":115,"conditions":116,"keywords":120,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":125,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},"100586845","coloreg-a-register-for-gastrointestinal-endoscopy-reports-and-examination-videos-100586845","NCT06920680","ColoReg: A Register for Gastrointestinal Endoscopy Reports and Examination Videos","Inclusion Criteria:\n\n* Indication for diagnostic or therapeutic colonoscopy\n\nExclusion Criteria:\n\n\\-",true,{"count":113,"type":20},1834,"1 Year","With the participants help, the investigators aim to track treatment methods, treatment outcomes, and adverse events, as well as document the treatment strategies used during endoscopic colorectal cancer prevention and treatment. This will allow us to verify if the results from targeted clinical studies and current scientific knowledge are also reflected in the real world. Additionally, the investigators want to use the collected videos and findings to support the training of doctors. During each examination, doctors must be able to accurately assess the inside of the body. Teaching materials for this purpose are scarcely available, often outdated (especially images), and usually show obvious cases. The investigators aim to provide doctors with the opportunity to learn outside of real patient examinations and benefit from the experiences of others.\n\nFurthermore, the investigators want to make the findings and video data accessible to the scientific community. Since scientific studies rarely publish raw data for this purpose, there is currently no large and constantly updated database of findings, images, and videos. If a study requires such data, new data must be collected with great organizational and financial effort. As a result, different studies are only partially comparable, and their significance is reduced.\n\nBy publishing the data, a valuable information source for medical professionals in training, continuing education, and advanced training is created. Researchers also benefit from this data: New technologies, such as image analysis software, can be tested and compared on a consistent basis. Therefore, participation in this study makes a valuable contribution to the foundation of good medical care: education, research, and quality assurance.\n\nPrimary Study Goal:\n\nThe study aims to evaluate the effectiveness and safety of different endoscopic resection techniques. Effectiveness is defined as achieving a complete removal of the lesion (R0 resection) or having a clear follow-up in more than 90% of cases. Safety is defined as having less than 3% of cases result in complications like perforation, uncontrollable bleeding, or the need for unplanned follow-up due to issues like interval bleeding or perforation. The target diagnostic accuracy is 95%.\n\nSecondary Study Goals:\n\n1. Ensure that in 90% of cases, the recommended follow-up interval aligns with current national guidelines based on the number, size, and histopathology of polyps.\n2. Achieve successful retrieval of polyps in more than 95% of cases.\n3. Document minor bleedings, defined as continuous bleeding for over 30 seconds that requires clipping.\n\nTertiary Study Goal:\n\nDevelop software that can identify and mask sensitive information (such as names, birth dates, examination dates, and video sections outside the human body) in videos from 1,000 examinations, or flag them for manual review. Similarly, the software should identify and remove sensitive text information in the reports, such as names, birth dates, case numbers, examiners, and phone numbers, or mark the text for manual review.",[117,118,119],"Colorectal Cancer","Colonoscopy","Polypectomy",[121,122,123,124],"colorectal cancer","colonoscopy","standardized documentation","interventional endoscopy",{"date":98,"type":35},{"date":127,"type":35},"2024-10-01",{"date":129,"type":20},"2027-10",{"name":41,"class":42},2,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":104},"100481355","psma-in-gastroenterologic-tumors-gipsma-100481355","NCT05547919","PSMA in Gastroenterologic Tumors (GIPSMA)","A Molecular Imaging-Derived Biomarker of PSMA Expression - Revealing Theranostic Potential in Gastroenterologic Tumors","GIPSMA","Inclusion Criteria:\n\n* Patients with newly diagnosed GET prior to initiation of guideline-compatible, anti-tumor therapy\n* Available tissue specimen to conduct PSMA expression profiling\n* Male\u002Ffemale, above 18 years old\n* Patients must provide written informed consent\n* Patients must be willing to comply with study procedures and available for follow-up examinations\n\nExclusion Criteria:\n\n* Curative setting\n* Not sufficient tumor tissue available\n* Male Patients: No prostate carcinoma\n* Other malignant neoplasms in patient's history\n* Pregnancy or Breastfeeding\n* Contraindications for PET\u002FCT",{"count":141,"type":20},46,[23],"The theranostic principle is based on the use of radiolabeled compounds which can be applied for diagnostic molecular imaging and targeted delivery of radiation to the tumor. Gastroenterologic tumors (GET), including hepatocellular Carcinoma, Colorectal Carcinoma, Pancreatic Adenocarcinoma, Cholangiocellular Carcinoma, gastroenteropancreatic neuroendocrine neoplasms also express a phenotypic biomarker called prostate-specific membrane antigen (PSMA), thereby rendering it a potential diagnostic (through positron emission tomography (PET) scan imaging) and therapeutic target for radioligand therapy. Aim is to evaluate whether PSMA-directed in-vivo imaging can be also applied to GET patients to determine if i) biopsy-derived tissue of newly diagnosed patients exhibit a PSMA expression profile, ii) PSMA-PET shows upregulated PSMA expression in-vivo, iii) such a molecular imaging approach identifies more disease sites relative to conventional imaging, and iv) if the PSMA PET signal predicts further clinical course and outcome under guideline-compatible treatment.",[145],"Gastrointestinal Cancer","2025-09-23",{"date":148,"type":35},"2025-09-29",{"date":150,"type":35},"2022-10-01",{"date":152,"type":20},"2026-10-01",{"name":41,"class":42},{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":162,"minAge":4,"maxAge":4,"enrollmentInfo":163,"targetDuration":165,"studyType":85,"phases":4,"briefSummary":166,"conditions":167,"keywords":170,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":184},"100602048","liquid-biopsy-under-psma-radioligand-therapy-100602048","NCT07118436","Liquid Biopsy Under PSMA Radioligand Therapy","Liquid Biopsy as a Biomarker in Patients Treated With PSMA Radioligand Therapy","LOOPS","Inclusion Criteria:\n\n* Patients with mCRPC eligble for PSMA RLT\n* In-lable use for PSMA RLT\n* PSMA PET\u002FCT not older than 8 weeks prior to first cycle of PSMA RLT\n* One previous line of antiandrogen receptor pathway treatment and one previous line of taxan based therapy\n* Age ≥ 18 years\n* Written informed consent\n* Sufficient knowledge of the German language or presence of a translator\n\nExclusion Criteria:\n\n* Unwilling to adhere to study procedures\n* Missing interdisciplinary tumor conference advise for PSMA RLT","MALE",{"count":164,"type":20},100,"40 Weeks","Prostate cancer is the second most common cause of cancer death in men worldwide. After exhausting guideline-compliant therapies or in accordance with the approval of 177Lu-PSMA-617 (Pluvicto®), patients with metastatic castration-resistant prostate cancer (mCRPC) can be offered radioligand therapy (RLT) that targets the prostate-specific membrane antigen (PSMA). Despite an initially high response rate to PSMA-RLT, the disease often progresses rapidly again. The underlying mechanisms are still poorly understood.\n\nLiquid biopsy (LBx) involves the collection and analysis of body fluids, particularly blood. Its major advantage compared to a tissue sample is its non-invasive nature, allowing for multiple samplings, as well as the examination of more than just a single punctured lesion. Among other things, circulating tumor DNA (ctDNA) can be detected in the blood.\n\nThe aim of this study is to apply LBx before, during, and after PSMA-RLT in patients with mCRPC to determine prognostic factors before therapy and to assess the value of LBx in evaluating treatment response. Furthermore, LBx will be used to gather information on the course of potential tumor heterogeneities and to determine resistance mechanisms against PSMA-RLT.\n\nTo this end, patients receiving PSMA-RLT will be enrolled in the study at three sites (University Hospital Wuerzburg, University Hospital Augsburg, Klinikum rechts der Isar Munich). The evaluation of clinical and imaging parameters will be carried out centrally at the University Hospital Wuerzburg, while the analysis of LBx will be performed at the University Hospital Augsburg.",[168,169],"Prostate Cancer Metastatic Castration-Resistant","Prostate Cancer",[171,172,173,174,175],"mCRPC","PSMA","radioligand therapy","liquid biopsy","cfDNA","2025-08-08",{"date":178,"type":35},"2025-08-12",{"date":180,"type":35},"2024-09-01",{"date":182,"type":20},"2028-08",{"name":41,"class":42},3,{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":111,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":21,"phases":194,"briefSummary":195,"conditions":196,"keywords":199,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":104},"100558422","training-physicians-to-differentiate-the-paris-classification-using-artificial-colon-polyp-images-100558422","NCT06550908","Training Physicians to Differentiate the Paris Classification Using Artificial Colon Polyp Images","LUTETIA2","Inclusion Criteria:\n\n* Physicians with or without experience in colonoscopy",{"count":193,"type":20},70,[23],"Training in endoscopy is essential for the early detection of precursors of colorectal cancer. Up to now, this training has been carried out with image collections of findings and in practice when working on patients. The investigators want to use artificial intelligence (AI) to better train doctors to recognise these precursors. By using generative AI, the investigators were able to create realistic images that comply with data protection regulations and whose content can be predefined. Parts of the image can also be regenerated so that it is possible to create different precancerous stages in the same place in the image.\n\nIn this study the investigators want to train physicians using real images or artificial images in order to compare which version helps classify polyps better.",[197,198],"Colonic Polyp","Colon Adenoma",[118],"2025-08-06",{"date":178,"type":35},{"date":203,"type":35},"2025-04-15",{"date":205,"type":20},"2025-08-31",{"name":41,"class":42},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":111,"sex":215,"minAge":17,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":218,"conditions":219,"keywords":228,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":239,"locationsCount":104},"100599361","non-invasive-detection-of-iron-deficiency-in-obstetrics-100599361","NCT07083492","Non-invasive Detection of Iron Deficiency in Obstetrics","Point-of-care Transcutaneous Longitudinal Non-invasive Detection of Iron Deficiency in Obstetrics (PICCOLINO-Trial)","PICCOLINO","Inclusion Criteria:\n\n* any timepoint during or up to 3 months after pregnancy\n* age ≥ 18 years\n* written informed consent\n\nExclusion Criteria:\n\n* previous participation in this study\n* refusal of blood sampling\n* incapacity to give informed consent","FEMALE",{"count":217,"type":20},500,"Validation of non-invasive measurement of zinc protoporphyrin for detection of iron deficiency in pregnancy.\n\nIn addition, the impact of iron deficiency on the incidence of postpartum depression, restless legs syndrome, obstetric complications and quality of life will be examined.",[220,221,222,223,224,225,226,227],"Iron Deficiency Anemia of Pregnancy","Iron-deficiency","Restless Leg Syndrome in Pregnancy","Restless Leg Syndrome Due to Iron Deficiency Anaemia","Postpartum Hemorrhage","Postpartum Depression","Pregnancy Anemia","Iron Deficiency (Without Anemia)",[229,230,231,232],"Zinc protoporphyrin","Non-invasive detection","Obstetric anesthesia","Patient blood management","2025-07-23",{"date":235,"type":35},"2025-07-24",{"date":237,"type":35},"2022-11-15",{"date":39,"type":20},{"name":41,"class":42},{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":21,"phases":249,"briefSummary":250,"conditions":251,"keywords":254,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":184},"100596033","gustabor-phase-1---ai-based-creation-of-a-nutritional-plan-to-compensate-for-chemotherapy-induced-taste-disorders-100596033","NCT07040189","Gustabor Phase 1 - AI-based Creation of a Nutritional Plan to Compensate for Chemotherapy-induced Taste Disorders","GustaborPilot","Inclusion Criteria:\n\n* Age ≥ 18\n* Suffering from one of the following tumor entities: Multiple myeloma or malignant tumor of the gastrointestinal tract\n* Mainly oral nutrition\n* Subjectively perceived tumor therapy-related taste disorder\n* At least two clinical presentations planned within 12 weeks with a minimum interval of three weeks\n* Ability to participate in nutritional intervention, including use of the online portal and implementation of recipe suggestions (e.g. resources and access to a kitchen), either independently or with third-party support (e.g. by relatives, outpatient care services).\n\nExclusion Criteria:\n\n* Pregnancy\n* Taste disorder explained by other causes (e.g. existing before therapy or COVID disease)\n* Placement in an inpatient care facility",{"count":248,"type":20},51,[23],"The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation. Although many non-pharmacological recommendations exist, it is unclear which methods are suitable for which individuals. This pilot study aims to use an AI-based, or rule-driven system to generate personalized recommendations based on patients' specific impairments and taste disorder. For the pilot study, the AI will be trained on recipes to create individualized meal plans, helping to identify foods that are likely to be better. The primary endpoint is the assessment of the nutritional intervention as helpful at the second visit within 12 weeks of inclusion.",[252,27,253],"Multiple Myeloma","Taste Disorders",[255,256],"taste disorders","AI","2025-06-17",{"date":259,"type":35},"2025-06-27",{"date":261,"type":20},"2025-08-01",{"date":263,"type":20},"2025-12-31",{"name":41,"class":42},{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":21,"phases":274,"briefSummary":275,"conditions":276,"keywords":279,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":104},"100556334","trabeculopuncture-as-predictive-test-for-the-success-of-ab-interno-trabeculectomy-100556334","NCT06523751","Trabeculopuncture as Predictive Test for the Success of Ab Interno Trabeculectomy","Determining Distal Outflow Tract Function in Open Angle Glaucoma as a Predictive Test for the Success of Ab Interno Trabeculectomy","Inclusion Criteria:\n\n* individuals ≥ 18 years of age\n* clinical diagnosis of: primary open angle glaucoma, pigmentary glaucoma, or pseudoexfoliation glaucoma\n* uncontrolled intraocular pressure (IOP) with maximally tolerated medical therapy\n* progressive thinning of retinal nerve fiber layer assessed by Spectral domain optical coherence tomography (p \\\u003C 0.05)\n* progression of visual field defects\n* visually significant cataract and indication to reduce IOP or glaucoma medication burden\n\nExclusion Criteria:\n\n* clinical diagnosis of neovascular glaucoma, angle-closure glaucoma, uveitic glaucoma, neovascular glaucoma\n* prior glaucoma surgery\n* preexisting conditions affecting the episcleral venous pressure including Grave's ophthalmopathy, Sturge-Weber syndrome, Arteriovenous fistulas (carotid-cavernous fistula)",{"count":273,"type":20},55,[23],"The purpose of this study is to perform trabeculopuncture a test to determine the distal outflow tract function to predict the success of ab interno trabeculectomy.",[277,278],"Open Angle Glaucoma","Pseudoexfoliation Glaucoma",[280,281,277],"Ab Interno Trabeculectomy","Trabeculopuncture","2025-04-02",{"date":284,"type":35},"2025-04-03",{"date":286,"type":35},"2023-06-13",{"date":288,"type":20},"2026-01-31",{"name":41,"class":42},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":297,"targetDuration":299,"studyType":85,"phases":4,"briefSummary":300,"conditions":301,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":104},"100580023","radiotherapy-of-head-and-neck-cancer-with-sib-100580023","NCT06831903","Radiotherapy of Head and Neck Cancer With SIB","Simultaneous Integrated Boost in the Primary and Adjuvant Therapy of Head and Neck Cancer: Quality Control Registry Prospective Longitudinal Obervation Trial","Inclusion Criteria:\n\n* Patients aged 18 and older with histologically confirmed malignant head and neck tumors, undergoing definitive or adjuvant radio(chemo)therapy at the University Hospital Würzburg\n\nExclusion Criteria:\n\n* missing informed consent\n* mental or physical disorders leading to inability to understand and\u002For fill the quationary\n* judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures",{"count":298,"type":20},750,"5 Years","Title: Simultaneous Integrated Boost in Primary and Adjuvant Therapy of Head and Neck Tumors: Quality Control Registry Prospective Longitudinal Observational Study\n\nShort Title: Radiotherapy for Head and Neck Tumors with SIB\n\nObjective: To evaluate the efficacy and safety of definitive and adjuvant radio(chemo)therapy with simultaneous integrated boost (SIB) in patients with head and neck cancers. The study aims to assess local and regional control, overall survival, metastasis-free survival, therapy-related toxicities, and quality of life.\n\nStudy Design: A prospective, longitudinal, non-interventional registry study documenting real-world outcomes and quality measures of therapy applied according to existing clinical guidelines.",[302,303,304,305],"Quality of Life (QOL)","Head and Neck Cancer","Radiotherapy Side Effect","Radiotherapy, Conformal (IMRT)","2025-02-12",{"date":308,"type":35},"2025-02-18",{"date":310,"type":35},"2019-05-21",{"date":312,"type":20},"2039-10-01",{"name":41,"class":42},{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":215,"minAge":17,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":131},"100564138","rapid-point-of-care-bacteriuria-and-microbial-susceptibility-for-women-with-suspected-uncomplicated-urinary-tract-infections-diagnostic-accuracy-in-general-practice-100564138","NCT06625268","Rapid Point-of-care Bacteriuria and Microbial Susceptibility for Women With Suspected Uncomplicated Urinary Tract Infections: Diagnostic Accuracy in General Practice.","Machbarkeit Und Explorative Validierung Des PA-100-AST-Systems Bei Frauen Mit Verdacht Auf Eine Unkomplizierte Harnwergsinfektion in Der Hausarztpraxis - Eine Pilotstudie","Inclusion Criteria:\n\n* Female sex\n* Age 18 or older\n* Clinically suspected UTI according to the general practitioner\n\nExclusion Criteria:\n\n* Urinary catheter\n* Severe urinary tract abnormality (such as cancer or strictures)\n* Immunosuppression (such as chronic immunosuppressant use or AIDS)\n* Dementia or any other condition (including insufficient knowledge of the German language) that could affect informed consent\n* Known pregnancy",{"count":53,"type":20},"In this study, adult women presenting at their general practitioner with a likely bladder infection (with symptoms like a burning sensation when urinating, pain in the lower abdomen, and frequent or urgent need to urinate) will be invited. After informed consent, women provide a urine sample, which is tested using a new system called the PA-100-AST (from the manufacturer Sysmex). This point-of-care test showed first evidence to be able to quickly detect the presence of bacteria commonly responsible for bladder infections. If bacteria are found, the test also checks which antibiotics may work best to treat the infection. Additionally, a sample of the urine is sent to a lab for a traditional culture test, which is considered the most accurate method. The goal of this study is to compare the accuracy of the PA-100-AST system to the lab-based test to see how well it works in general practice.",[324],"Urinary Tract Infection (Diagnosis)",[326,327,328,329,330,331],"urinary tract infection","women","general practice","diagnosis","primary care","point-of-care test",{"date":333,"type":35},"2025-02-17",{"date":335,"type":35},"2024-08-01",{"date":337,"type":20},"2025-04-30",{"name":41,"class":42},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":346,"targetDuration":4,"studyType":21,"phases":348,"briefSummary":349,"conditions":350,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":104},"100446712","dystonia-image-based-programming-of-stimulation-a-prospective-randomized-double-blind-crossover-trial-100446712","NCT05097001","Dystonia Image-based Programming of Stimulation: A Prospective, Randomized, Double-blind Crossover Trial","DIPS","Inclusion Criteria:\n\n* Chronic deep brain stimulation (\\> 1 year) in the internal globus pallidus in patients with isolated dystonia.\n* Deep brain stimulation settings and dystonia medication stable for \\> 3 months.\n* Understanding about and consent to the study and signed informed consent form.\n\nExclusion Criteria:\n\n* Relevant comorbidities that might interfere with study endpoints (esp. palliative disease and severe neurologic or psychiatric comorbidities).",{"count":347,"type":20},80,[23],"The primary objective of this exploratory study is to prospectively evaluate the feasibility of image-guided programming of pallidal deep brain stimulation (DBS) for dystonia. The dystonias are a heterogeneous group of movement disorders that share the core clinical feature of abnormal involuntary muscle contractions in common. Pallidal DBS is an established therapy for severe cases with an average improvement in dystonia severity of 50-60%. However, outcomes are variable and difficult to predict, and clinical trials report up to 25% of Nonresponders. Variability in electrode placement and inappropriate stimulation settings may account for much of this variability in outcome. In addition, improvement in dystonia is delayed, often days to weeks after a change in DBS therapy, complicating programming.\n\nOur group recently developed a computer model to predict optimal individualized stimulation settings in patients based on the outcome of a large cohort of of chronically treated patients. In-silico testing showed a 16.3% better mean group improvement with computer-assisted programming compared with physician-assisted programming and a dramatic reduction in non-responders (from 25% to 5%).\n\nIn this prospective study, the computer model will be compared in a randomized, controlled, and double blinded setting against best clinical DBS programming. The primary outcome will be a responder analysis in which dystonia severity will be compared between conventional clinical and model-based programming will be compared.",[351,352],"Dystonia","Deep Brain Stimulation","2025-01-23",{"date":355,"type":35},"2025-01-28",{"date":357,"type":35},"2021-11-01",{"date":359,"type":20},"2025-12",{"name":41,"class":42},{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":21,"phases":371,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":104},"100553908","impact-of-a-high-fiber-diet-on-the-microbiome-and-disease-activity-in-patients-with-rheumatoid-arthritis-100553908","NCT06492200","Impact of a High-fiber Diet on the Microbiome and Disease Activity in Patients With Rheumatoid Arthritis","Einfluss Ballaststoffreicher Ernährung Auf Das Mikrobiom Und Die Krankheitsaktivität Von Patientinnen Und Patienten Mit Rheumatoider Arthritis","Inclusion Criteria:\n\n* Patients over 18 years old\n* Diagnosis of Rheumatoid Arthritis according to the ACR criteria of 2010\n* The patient can understand the scope of the study and consents in writing to participate.\n\nExclusion Criteria:\n\n* Age under 18\n* Lack of consent capability\n* Insufficient knowledge of the German language\n* Chronic inflammatory bowel disease\n* Liver cirrhosis\n* History of mechanical ileus\n* Patients with altered gastrointestinal passage (e.g., stoma patients)\n* Use of antibiotics within the past three months\n* Use of ground psyllium husks four weeks prior to study inclusion","99 Years",{"count":370,"type":20},52,[23],"The goal of this clinical trial is to learn if increasing dietary fiber can improve the gut microbiome and reduce disease activity in adults with rheumatoid arthritis (RA). The main questions it aims to answer are:\n\n* Can a higher fiber diet improve gut bacteria and produce beneficial short-chain fatty acids (SCFAs)?\n* Does a higher fiber diet reduce RA symptoms and help with weight loss?\n\nResearchers will compare two groups: one group will receive dietary counseling and take 10 grams of psyllium husk daily, while the other group will continue their usual diet.\n\nParticipants will:\n\n* Complete dietary questionnaires at the start, 6 months, and 12 months.\n* Provide stool samples for gut bacteria and SCFA analysis.\n* Have their RA activity and body weight monitored regularly.\n* Receive regular phone calls to support the dietary changes.\n\nThe study will involve adults with diagnosed RA who can provide informed consent and meet other inclusion criteria.",[374],"Arthritis, Rheumatoid","2024-07-01",{"date":377,"type":35},"2024-07-09",{"date":379,"type":35},"2024-06-01",{"date":381,"type":20},"2026-12-30",{"name":41,"class":42},{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":389,"eligibilityCriteria":390,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":391,"enrollmentInfo":392,"targetDuration":4,"studyType":21,"phases":394,"briefSummary":395,"conditions":396,"keywords":400,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":131},"100479188","lymphatic-organs-and-myocardium-after-myocardial-infarction-100479188","NCT05519735","Lymphatic Organs and Myocardium After Myocardial Infarction","Multimodal Characterization of Lymphatic Organs and Myocardium in Patients After Acute Myocardial Infarction","LOMI","Inclusion Criteria:\n\n* patients with acute myocardial infarction (STEMI) who were treated with immediate catheterization\n* stable clinical course\n* male\u002Ffemale, above 18 years old\n\nExclusion Criteria:\n\n* hemodynamic instablity \\> 48 h after immediate catherization\n* known CAD\n* known structural heart disease\n* multi vessel disease\n* NSTEMI\n* sarcoidosis\n* immunosuppressive therapy\n* acute inflammatory disease\n* no consent obtainable\n* contraindiations for CMR\n* impaired renal function\n* active cardiac implants, ferromagnetic implants\n* pregnancy, breast-feeding","90 Years",{"count":393,"type":20},57,[23],"The adaptive immune response plays an important role in myocardial healing and remodeling after acute myocardial infarction in patients. Therefore, the involved lymphocytes represent a novel target for therapeutic interventions. However, there are no established blood-derived biomarkers to predict the quantity and quality of the adaptive immune response to cardiac injury. Multimodal imaging of the heart and immunologic organs might provide such information.\n\nRecent retrospective analysis of patients after MI revealed enlarged mediastinal lymph nodes associated with increased CXCR4 radiotracer accumulation, thereby indicating that CXCR4 PET-based lymph node imaging provides a non-invasive quantitative readout of the local adaptive immune response. These considerations are further fuelled by the fact that, within lymph nodes, CXCR4 is expressed almost exclusively on lymphocytes, whereas various other cell types express CXCR4 within the myocardium.\n\nThis leads to the hypothesis that the size of mediastinal lymph nodes and their respective CXCR4 PET signals correlate with the adaptive immune response to cardiac injury and might provide predictive information for functional cardiac decline during follow-up.\n\nThis prospective clinical study will use multimodal imaging to monitor chemokine receptor 4 (CXCR4) expression in the lymph nodes, myocardium, spleen, and bone marrow after acute MI. The combination of cardiac magnetic resonance (CMR), echocardiography, and positron emission tomography (PET) along with blood collection for immunophenotyping will allow to determine i) if the size of mediastinal lymph nodes and their respective PET-derived CXCR4 signals at baseline correlate with the adaptive immune response to acute cardiac injury; and ii) if they predict cardiac adverse remodelling during longitudinal follow-up.",[397,398,399],"Myocardial Infarction","Myocardial Injury","Myocardial Inflammation",[401,402,403,397],"CXCR4","CMR","Lymphatic organs","2023-05-24",{"date":406,"type":35},"2023-05-25",{"date":408,"type":35},"2022-04-01",{"date":410,"type":20},"2026-12",{"name":41,"class":42},{"id":413,"slug":414,"hasResults":11,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":418,"eligibilityCriteria":419,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":420,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":422,"conditions":423,"keywords":428,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":104},"100313569","evaluation-of-heart-involvement-in-patients-with-fabry-disease-100313569","NCT03362164","Evaluation of HEArt invoLvement in Patients With FABRY Disease","Prospective Monocentric Cohort Study to Evaluate Predictors for Heart Failure and Sudden Cardiac Death in Patients With Fabry Disease","HEAL-FABRY","Inclusion Criteria:\n\n* Fabry disease (genetically confirmed)\n* Signed informed consent\n* 18 years and older\n\nExclusion Criteria:\n\n* No informed consent\n* Withdrawal of informed consent",{"count":421,"type":20},650,"This study evaluates predictors for the incidence of arrhythmias and sudden cardiac death as well as terminal heart failure in patients with Fabry disease.",[424,425,426,427],"Rare Diseases","Fabry Disease","Fabry Disease, Cardiac Variant","Hypertrophic Cardiomyopathy",[429,430,431,432,433],"Fabry","Fibrosis","Dialysis","Stroke","Chronic kidney disease","2022-07-06",{"date":436,"type":35},"2022-07-07",{"date":438,"type":35},"2001-01",{"date":440,"type":20},"2032-03",{"name":41,"class":42},""]