[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Xiaguang Duan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":162},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,63,87,106,124,146],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100576780","enhanced-recovery-after-urologic-surgery-100576780",false,"NCT06789744","Enhanced Recovery After Urologic Surgery","Enhanced Recovery After Urologic Surgery: a Prospective Observational Study Comparing Regional with Conventional Anesthetic Techniques","Inclusion Criteria:\n\n* any age.\n* American Society of Anesthesiologists (ASA) physical status classification of I-III.\n* undergo urological surgery.\n* receive one of the following analgesic techniques: epidural analgesia (EA), paravertebral block (PVB), transversus abdominis plane (TAP) block, intravenous patient-controlled analgesia (PCA), or intrathecal morphine.\n* provided voluntary informed consent.\n\nExclusion Criteria:\n\n* a bleeding disorder or coagulopathy.\n* infection at the intended puncture site or systemic infection.\n* a known allergy to local anesthetics.\n* spinal deformity or spinal injury.\n* a psychiatric disorder that could impair their ability to cooperate with the study protocol.\n* pregnant or breastfeeding.\n* severe cardiovascular or pulmonary dysfunction.\n* chronic opioid use (defined as \\>1 month) at high doses.","ALL",{"count":18,"type":19},150,"ESTIMATED","INTERVENTIONAL",[22],"NA","This clinical trial aims to investigate the analgesic efficacy of several perioperative pain management strategies-specifically, epidural analgesia, paravertebral blockade, transversus abdominis plane (TAP) block, intravenous patient-controlled analgesia (PCA), and intrathecal morphine-in patients undergoing a range of urological procedures. These procedures include pediatric circumcision, hydrocelectomy, inguinal hernia repair, renal cyst excision, and transurethral resection of the prostate. The trial will also evaluate the safety profiles of two specific local anesthetics, liposomal bupivacaine and ropivacaine. The primary research question is whether these different analgesic techniques reduce postoperative opioid requirements in patients undergoing urological surgery. A secondary question explores the adverse events associated with the use of liposomal bupivacaine and ropivacaine in this population.\n\nParticipants will be:\n\nUrological surgery patients undergoing one of the aforementioned procedures. These participants will be randomized to receive one of the following pain management modalities: epidural analgesia, paravertebral blockade, TAP block, intravenous PCA, or intrathecal morphine. Patient assessments will be conducted in the post-anesthesia care unit (PACU) and at 2, 6, 12, and 24 hours postoperatively. Outcome measures will include: Numeric Rating Scale (NRS) pain scores, total postoperative analgesic consumption, recovery status, patient satisfaction, and time to return of bowel function.",[25,26,27,28,29],"Circumcision","Hydrocelectomy","Hernia","Renal Cyst","Prostate","NOT_YET_RECRUITING","2025-01-22",{"date":33,"type":34},"2025-01-24","ACTUAL",{"date":36,"type":19},"2025-02-01",{"date":38,"type":19},"2025-05-20",{"name":40,"class":41},"Xiaguang Duan","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":60,"leadSponsor":62,"locationsCount":42},"100577466","multimodal-nerve-block-and-pulse-radiofrequency-for-acute-herpes-zoster-pain-100577466","NCT06798662","Multimodal Nerve Block and Pulse Radiofrequency for Acute Herpes Zoster Pain","Multimodal Nerve Block and Pulse Radiofrequency for Acute Herpes Zoster Pain: a Prospective, Randomized, Controlled, Triple-blind Trial","Inclusion Criteria:\n\n* Presence of typical clinical manifestations of herpes zoster (shingles), including vesicular and painful rash.\n* Diagnosis of postherpetic neuralgia (PHN) lasting for more than one month, unresponsive to conventional treatment.\n* Visual Analog Scale (VAS) score ≥ 4.\n* Involvement of thoracic nerve roots.\n\nExclusion Criteria:\n\n* Refusal to provide written informed consent.\n* Inability to cooperate with study assessments.\n* History of systemic autoimmune disease, organ transplantation, or cancer.\n* Prior receipt of other invasive pain treatments, such as spinal cord stimulation.\n* Presence of a central nervous system (CNS) disorder.\n* Presence of coagulopathy.\n* Skin infection at the puncture site.\n* Pregnancy or breastfeeding.","20 Years",{"count":52,"type":19},120,[22],"The primary objective of this clinical trial is to evaluate the efficacy of liposomal bupivacaine and ropivacaine in the treatment of pain associated with herpes zoster (shingles). This trial will also assess the safety profiles of both liposomal bupivacaine and ropivacaine.\n\nThe study aims to address the following key questions:\n\nDoes nerve blockade with liposomal bupivacaine or ropivacaine reduce the required dosage of gabapentin in participants? What medical issues, if any, arise in participants undergoing paravertebral block, intercostal nerve block, RISS (Radiofrequency Intervention for Spinal Segment); or pulsed radiofrequency (PRF)? Can nerve blocks, specifically paravertebral block, intercostal nerve block, RISS; and PRF, effectively treat severe postherpetic neuralgia (PHN)? The study will compare these interventions.\n\nStudy Procedures:\n\nParticipants will:Receive ultrasound-guided nerve blocks or pulsed radiofrequency every 48 hours, for a total of 3 treatments.\n\nUndergo assessments, either in-person or via telephone, at the following time points: before therapy (baseline), on the day of treatment (Day 1), Day 7, Day 30, and Day 90 post-treatment.\n\nHave their symptoms recorded, along with their scores on the Numerical Rating Scale (NRS) and the Zoster Brief Pain Inventory (ZBPI).",[56],"Herpes Zoster (HZ)",{"date":58,"type":34},"2025-01-29",{"date":36,"type":19},{"date":61,"type":19},"2025-06-10",{"name":40,"class":41},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":70,"minAge":71,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":20,"phases":74,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":84,"leadSponsor":86,"locationsCount":42},"100576005","regional-anesthesia-techniques-in-breast-surgery-100576005","NCT06779656","Regional Anesthesia Techniques in Breast Surgery","Regional Anesthesia Techniques in Breast Surgery: a Comparative Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status classification I-III.\n* Age of 18 years or older.\n* Scheduled to undergo breast surgery, including augmentation, fibroadenoma excision, or mastectomy.\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics.\n* Pregnancy or lactation.\n* Coagulation disorders.\n* Severe cardiopulmonary disease.\n* Local infection at the injection site.\n* Unstable psychiatric illness.","FEMALE","18 Years",{"count":73,"type":19},180,[22],"This clinical trial aims to evaluate the efficacy of liposomal bupivacaine and ropivacaine, when administered via paravertebral block, the rhomboid intercostal and subserratus plane (RISS) block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block, in patients undergoing breast surgery (including augmentation, fibroadenoma excision, and mastectomy). The primary objectives are to determine:\n\n1. Whether the use of liposomal bupivacaine or ropivacaine reduces the postoperative analgesic requirements in participants.\n2. What potential adverse events participants experience when using liposomal bupivacaine or ropivacaine.\n3. Which of the following regional anesthesia techniques provides superior analgesia: paravertebral block, RISS block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block.\n\nParticipants will undergo one of the following regional anesthesia techniques upon arrival to the surgical suite: paravertebral block, RISS block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block. Following regional anesthesia administration, general anesthesia with endotracheal intubation will be performed. Participants' vital signs, postoperative analgesic consumption, and recovery will be recorded.",[77,78,79],"Augmentation","Fibroadenoma","Mastectomy","2025-01-16",{"date":82,"type":34},"2025-01-17",{"date":36,"type":19},{"date":85,"type":19},"2025-05-10",{"name":40,"class":41},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":94,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":20,"phases":96,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":105,"locationsCount":42},"100576029","multimodal-analgesia-versus-peripheral-nerve-block-for-postoperative-pain-management-after-lower-limb-injury-surgery-100576029","NCT06779968","Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury Surgery","Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Patients (or their guardians) voluntarily participate in this study and sign a written informed consent form\n* Patients (or their guardians) are able to understand the study content and cooperate with the study protocol\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics or opioid analgesics.\n* Presence of contraindications to local or epidural anesthesia.\n* Presence of undiagnosed or poorly characterized neuropathic pain.\n* Presence of severe mental illness that would impede the participant's ability to cooperate with study assessment and treatment procedures.\n* Clinically significant coagulopathy or current use of anticoagulant medications.\n* Presence of infection at the planned puncture site or systemic infection.\n* Pregnancy or lactation.","2 Years",{"count":18,"type":19},[22],"The purpose of this clinical trial is to understand the effectiveness of femoral nerve block, combined sciatic and femoral nerve block, lumbar plexus block, epidural block, and intravenous analgesia pump in the application of lower limb injury (total knee replacement, knee arthroscopy, patella fracture, femoral shaft fracture) surgery. It will also understand the safety of the drugs liposomal bupivacaine and ropivacaine. The main question it aims to answer is: Does nerve block reduce the number of times participants need to use analgesics postoperatively? The researchers will compare femoral nerve block, combined sciatic and femoral nerve block, lumbar plexus block, epidural block, and intravenous analgesia pump to see which analgesic method has the best postoperative analgesic effect. Participants will: undergo nerve block first, then endotracheal intubation general anesthesia after entering the operating room; record vital signs during surgery, record postoperative analgesic doses, NRS pain scores, patient satisfaction, and postoperative nausea and vomiting.",[99],"Lower Limb Injury","2025-01-14",{"date":82,"type":34},{"date":103,"type":19},"2025-01-20",{"date":85,"type":19},{"name":40,"class":41},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":94,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":20,"phases":115,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":121,"completionDateStruct":122,"leadSponsor":123,"locationsCount":42},"100576004","efficacy-and-safety-of-liposomal-bupivacaine-and-ropivacaine-in-upper-limb-surgery-100576004","NCT06779643","Efficacy and Safety of Liposomal Bupivacaine and Ropivacaine in Upper Limb Surgery","Efficacy and Safety of Liposomal Bupivacaine and Ropivacaine in Upper Limb Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age: Two years or older.\n* ASA Physical Status: American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.\n* Surgical Indication: Patients requiring surgical treatment for any of the following upper limb injuries: Burn injuries. Digital replantation. Upper limb fractures, including fractures of the radius, ulna, humerus, and carpal bones. Hand fractures, including fractures of the phalanges and metacarpals.\n* Patients scheduled to undergo either a continuous brachial plexus block combined with general anesthesia or general anesthesia alone.\n* Patients (or their legal guardians) provided voluntary written informed consent.\n\nExclusion Criteria:\n\n* Known allergy to local anesthetic agents.\n* Presence of infection or skin disease at the planned puncture site.\n* Severe coagulation disorders or current use of anticoagulant medications that cannot be safely discontinued for the procedure.\n* Presence of severe cardiopulmonary or neurological disease.\n* Inability to cooperate with regional or general anesthesia.\n* Pregnancy or lactation.\n* Presence of severe psychiatric illness or cognitive impairment that would hinder participation.\n* Long-term use of analgesic medications.",{"count":114,"type":19},60,[22],"This clinical trial aims to evaluate the efficacy and safety of liposomal bupivacaine and ropivacaine when used in different brachial plexus blocks and epidural anesthesia for the management of pain associated with burn injuries, digital replantation, and upper limb fractures (including radial, ulnar, humeral, and carpal fractures), as well as hand fractures (including phalangeal and metacarpal fractures). The primary objective is to determine whether liposomal bupivacaine or ropivacaine reduces the required postoperative analgesic dosage in these patient populations.\n\nSpecifically, this study will compare brachial plexus blockade with either liposomal bupivacaine or ropivacaine, combined with general anesthesia, against general anesthesia alone to assess the effectiveness of these two local anesthetics in achieving postoperative analgesia.\n\nEnrolled participants will be randomized to one of two treatment arms: either brachial plexus block followed by endotracheal intubation and general anesthesia or general anesthesia alone. Postoperative vital signs, analgesic requirements, and recovery parameters will be continuously monitored and recorded.",[118],"Upper Limb Injury","2025-01-13",{"date":80,"type":34},{"date":36,"type":19},{"date":85,"type":19},{"name":40,"class":41},{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":131,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":20,"phases":133,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":143,"completionDateStruct":144,"leadSponsor":145,"locationsCount":42},"100575459","desflurane-potentially-induces-postoperative-cognitive-dysfunction-in-elderly-patients-undergoing-perioperative-procedures-by-modulating-cdc42-and-clock-proteins-100575459","NCT06772558","Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins","The Potential Mechanism by Which Desflurane Induces Postoperative Cognitive Dysfunction in Elderly Perioperative Patients Involves the Modulation of Cdc42 and Clock Proteins, and Their Related Signaling Pathways.","Inclusion Criteria:\n\n* Age \\> 70 years\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Scheduled to undergo elective surgery requiring general anesthesia with desflurane\n* Able and willing to provide voluntary written informed consent\n* Able to understand the study procedures and complete follow-up assessments\n\nExclusion Criteria:\n\n* Pre-existing diagnosis of dementia or any other neurodegenerative disease that could affect cognitive function\n* Preoperative Montreal Cognitive Assessment (MoCA) score \\\u003C 20\n* History of severe psychiatric disorders, including psychosis, severe depression, or bipolar disorder\n* Unstable angina, uncontrolled hypertension, or a history of myocardial infarction within the past 6 months\n* Severe chronic obstructive pulmonary disease (COPD) with significant respiratory compromise, or other significant respiratory disease\n* Severe hepatic or renal impairment, defined as Child-Pugh class C for liver disease, or glomerular filtration rate (GFR) \\\u003C 30 mL\u002Fmin\u002F1.73 m2 for kidney disease\n* History of stroke, transient ischemic attack (TIA), or other significant neurological disorders\n* History of alcohol or drug abuse\n* Patients with visual, auditory, or language impairments that would interfere with cognitive testing.\n* Known allergy or contraindication to any of the study drugs\n* Other conditions at the discretion of the investigator that could interfere with the conduct of the study or the interpretation of the results","70 Years",{"count":114,"type":19},[22],"This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins. The primary research questions are: (1) Does desflurane administration contribute to POCD in this patient population? and (2) Are alterations in Cdc42 and Clock protein levels associated with desflurane-induced POCD in elderly patients? To address these questions, elderly patients will be administered desflurane for anesthesia maintenance. Postoperative assessments will then compare blood levels of Cdc42 and Clock proteins, and examine related signaling pathways, between a control group and a POCD group.\n\nStudy participants will receive desflurane anesthesia maintained at a Bispectral Index (BIS) value of 40-60. Postoperative cognitive function will be assessed on the second day using the Montreal Cognitive Assessment (MoCA), and participants will be categorized into either a control group or a POCD group based on MoCA performance. Cognitive function and blood levels of Cdc42 and Clock proteins will be recorded. Furthermore, the study will also investigate associated signaling pathways.",[136,137,138,139,140],"Avascular Necrosis of the Femoral Head","Coronary Artery Disease (CAD)","Benign Prostatic Hyperplasia (BPH)","Cholecystitis","Knee Osteoarthritis","2025-01-12",{"date":100,"type":34},{"date":36,"type":19},{"date":85,"type":19},{"name":40,"class":41},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":16,"minAge":71,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":20,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":158,"startDateStruct":159,"completionDateStruct":160,"leadSponsor":161,"locationsCount":4},"100575458","study-on-the-effects-of-multimodal-analgesia-regimens-on-postoperative-analgesia-and-gastrointestinal-function-recovery-after-laparoscopic-abdominal-surgery-100575458","NCT06772545","Study on the Effects of Multimodal Analgesia Regimens on Postoperative Analgesia and Gastrointestinal Function Recovery After Laparoscopic Abdominal Surgery","A Prospective Comparative Study on the Effects of Multimodal Analgesia Regimens on Postoperative Analgesia and Gastrointestinal Function Recovery After Laparoscopic Abdominal Surgery","Inclusion Criteria:\n\n* \\>18 years old\n* ASA I-III\n* Ability to understand and voluntarily sign the informed consent form\n* No prior use of long-acting or addictive analgesic drugs before surgery.\n\nExclusion Criteria:\n\n* History of previous abdominal surgery\n* Presence of severe cardiovascular, respiratory, hepatic, renal, neurological, or psychiatric disorders\n* Pre-existing chronic pain conditions\n* Known allergy to any analgesic drugs used in this study\n* Presence of spinal deformities, neurological conditions, or coagulopathy that may affect the performance of regional anesthesia.\n* Pregnant or breastfeeding women\n* Inability to cooperate with study procedures or understand pain rating scales\n* History of opioid abuse or addiction.",{"count":52,"type":19},[22],"This clinical trial aims to investigate the impact of multimodal analgesia regimens on postoperative pain management and gastrointestinal function recovery following laparoscopic abdominal surgery. The primary objectives are to determine:\n\nWhich analgesic regimen is most effective in reducing postoperative pain? Which analgesic regimen is most effective in accelerating gastrointestinal function recovery? This study will compare epidural analgesia (EA), paravertebral block (PB), transversus abdominis plane block (TAP), and patient-controlled intravenous analgesia (PCIA) to identify the optimal method for pain control and the most beneficial for gastrointestinal recovery.\n\nParticipants will receive one of the following treatments postoperatively: epidural analgesia, paravertebral block, TAP block, or patient-controlled intravenous analgesia. Rest pain (measured using the Numerical Rating Scale, NRS), dynamic pain (NRS), morphine equivalent consumption (mg), quality of sleep on the first night (Likert scale, 1-5), time to return of bowel function (h), time to recommence oral intake (h), time to first mobilization (h), quality of recovery (QoR, 0-15) on postoperative day 1, and length of hospital stay (days) will be recorded at 4, 8, 12, and 24 hours post-procedure.",[157],"Laparoscopic Abdominal Surgery",{"date":100,"type":34},{"date":36,"type":19},{"date":85,"type":19},{"name":40,"class":41},""]