[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Xiaolong Li\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":73},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100605449","a-study-on-the-modulation-of-gut-microbiota-by-oral-sialic-acid-in-healthy-subjects-100605449",false,"NCT07162662","A Study on the Modulation of Gut Microbiota by Oral Sialic Acid in Healthy Subjects","Modulation of Gut Microbiota by Oral Sialic Acid: A Mechanistic Study","MFMOSA","Inclusion Criteria:\n\n* Aged between 18 and 75 years\n* No history of major diseases, no previous surgical history, and no history of cardiometabolic diseases (such as hypertension, diabetes mellitus, obesity, etc.)\n* No use of drugs that may affect gut microbiota or metabolic function (e.g., antibiotics, probiotics, immunosuppressants, etc.);\n* Voluntarily participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\n* Comorbidities: Complicated with other severe diseases (e.g., immunodeficiency, chronic liver disease, renal insufficiency, malignant tumors, etc.).\n* Recent infections: Registration records indicate a history of severe infections in the recent period (within 3 months) or currently receiving anti-infective treatment.\n* Special populations: Pregnant women, lactating women, or women planning to become pregnant.\n* Poor compliance: Volunteers who are unable to cooperate with the study protocol or follow-up",true,"ALL","18 Years","75 Years",{"count":22,"type":23},42,"ESTIMATED","INTERVENTIONAL",[26],"NA","This is a single-center prospective cohort study conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital). The purpose of this study is to explore and clarify the effects of sialic acid intervention on gut microbiota structure, with a focus on the proliferation of pathogens (e.g., Escherichia coli, Klebsiella pneumoniae), and to develop novel prevention and treatment strategies for improving intestinal homeostasis.",[29,30],"Taking Sialic Acid to Regulate the Gut Microbiota","Healthy",[32,33,30],"Oral Sialic Acid","Gut Microbiota","RECRUITING","2025-12-03",{"date":37,"type":38},"2025-12-10","ACTUAL",{"date":40,"type":38},"2025-09-10",{"date":42,"type":23},"2027-08-01",{"name":44,"class":45},"Xiaolong Li","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":46},"100607523","study-on-the-correlation-between-serum-and-fecal-sialic-acid-levels-and-tumor-characteristics-as-well-as-postoperative-anastomotic-leakage-in-patients-with-colorectal-tumors-100607523","NCT07189663","Study on the Correlation Between Serum and Fecal Sialic Acid Levels and Tumor Characteristics as Well as Postoperative Anastomotic Leakage in Patients With Colorectal Tumors","Inclusion Criteria: For the retrospective Part : Age between 18 and 80 years; Patients who underwent radical resection of colorectal cancer in our hospital from January 2010 to December 2020; Preoperative serum sialic acid level was measured (a routine test item in liver function biochemical tests in our hospital from 2010 to 2020); Complete postoperative pathological data.\n\n* For the prospective Section:Age between 18 and 80 years; Patients who underwent radical resection of colorectal cancer in our hospital from August 2025 to August 2026; Voluntarily sign the informed consent form for fecal sample collection.\n\nExclusion Criteria:\n\n* Emergency surgery, palliative surgery, or concurrent other malignant tumors; Preoperative neoadjuvant chemoradiotherapy (may affect SA levels and microbiota); Recent infection: history of severe infection within 3 months before surgery.",{"count":54,"type":23},1468,"OBSERVATIONAL","This is a Single-center bidirectional cohort study combined with prospective sample analysis conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital).\n\nThe purpose of this study was to retrospectively collect the preoperative serum sialic acid content and postoperative pathological data of colorectal cancer patients in our hospital's medical order system (including tumor size and stage, etc.) and anastomotic leakage, and analyze the correlation between serum sialic acid content and pathological characteristics of tumor and the correlation between anastomotic leakage; and further collect the feces of colorectal cancer patients in our hospital for 16S microbiome sequencing, and detect their sialic acid content, and observe the relationship between fecal sialic acid content and tumor size and stage; Intestinal flora composition and postoperative anastomotic leakage correlation, provide a new theoretical basis for the prevention and treatment of postoperative anastomotic malhealing.",[58,59],"Colorectal Neoplasia","Anastomotic Leakage",[61,62,63],"colorectal neoplasia","anastomotic leakage","sialic acid","NOT_YET_RECRUITING","2025-09-22",{"date":67,"type":38},"2025-09-24",{"date":69,"type":23},"2025-09-25",{"date":71,"type":23},"2026-11-10",{"name":44,"class":45},""]