[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Xingwang Zhu\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100622002","combined-oscillation-volume-guarantee-study-100622002",false,"NCT07377955","Combined Oscillation-Volume guarantEe Study","Combined Volume Guarantee High-Frequency Oscillatory Ventilation (HFOV-VG) Versus Conventional High-Frequency Oscillatory Ventilation (HFOV) on Grade 2 to 3 Bronchopulmonary Dysplasia (BPD) or Death in Preterm Infants \u003C32 Weeks With Respiratory Distress Syndrome (RDS)","Inclusion Criteria:\n\n* Gestational age 24+0\u002F7\\\u003C 320\u002F7 weeks\n* Diagnosis of RDS within 72 hours after birth, requiring endotracheal ventilation for both elective and rescue HFOV\n\nExclusion Criteria:\n\n* Severe birth defects: severe congenital heart disease, diaphragmatic hernia, gastrointestinal malformations, congenital brain developmental abnormalities, congenital pulmonary cysts\n* Uncorrected shock\n* Existence of grade 3-4 IVH before ventilated\n* Other conditions deemed unsuitable for enrollment by neonatologists, including endotracheal intubation performed specifically for the purpose of the INSURE or INRECSURE technique.","ALL",{"count":18,"type":19},348,"ESTIMATED","INTERVENTIONAL",[22],"NA","Respiratory Distress Syndrome (RDS) remains the most common respiratory complication in the early postnatal period among preterm infants born before 32 weeks' gestational age. For this population, implementing lung-protective ventilation strategies is essential to shorten the duration of intubation, reduce the incidence and severity of bronchopulmonary dysplasia (BPD), lower mortality, and improve overall outcomes.\n\nHFOV-VG was first reported in 2015 to be safely applied in neonates. The fundamental principle lies in its ability to stabilize the tidal volume of high-frequency ventilation (VThf), thereby reducing sheer stress from amplitude fluctuations, while simultaneously permitting lower VThf settings to minimize volutrauma.\n\nThis study aims to evaluate whether HFOV+VG is superior to HFOV in reducing the composite outcome of grade 2-3 BPD or death at 36 weeks' post-menstrual age (PMA).",[25,26],"Respiratory Distress Syndrome (& [Hyaline Membrane Disease])","Bronchopulmonary Dysplasia (BPD)","NOT_YET_RECRUITING","2026-01-22",{"date":30,"type":31},"2026-01-30","ACTUAL",{"date":33,"type":19},"2026-02-01",{"date":35,"type":19},"2028-02-01",{"name":37,"class":38},"Xingwang Zhu","OTHER",""]