[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Yan Zhang\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100581338","inflammatory-and-metabolic-prognostic-assessment-in-critically-ill-neurological-patients-100581338",false,"NCT06849011","Inflammatory and Metabolic Prognostic Assessment in Critically Ill Neurological Patients","Development and Validation of a Prognostic Prediction Model for Adverse Outcomes in Neurocritical Patients Receiving Enteral Nutrition Based on Key Inflammatory and Metabolic Markers","IMPACT-NEURO","Inclusion Criteria:\n\n1. Age between 18 and 80 years, no gender restrictions.\n2. Within 7 days of disease onset and expected NICU stay of at least 7 days.\n3. Eligible for enrollment within 24 hours of NICU admission, with enteral nutrition (EN) initiated and continued for at least 7 days.\n4. Non-traumatic severe brain injury patients (including cerebrovascular disease and encephalitis) with a Glasgow Coma Scale (GCS) score ≤12.\n5. NRS 2002 score ≥3.\n6. Kuwata drinking test ≥ grade 3.\n7. Acute Gastrointestinal Injury (AGI) grade 1 or 2.\n8. Signed informed consent obtained from the patient or their legal representative.\n\nExclusion Criteria:\n\n1. Severe malnutrition prior to admission, defined as BMI \\\u003C 16 kg\u002Fm².\n2. Pregnant or lactating women.\n3. Receiving hypothermia treatment or core body temperature \\\u003C 36°C.\n4. End-stage disease with an expected survival time of \\\u003C 48 hours, or severe dysfunction of the heart, lungs, or other vital organs, leading to hemodynamic instability.\n5. Malignant tumors.","ALL","18 Years","80 Years",{"count":21,"type":22},1185,"ESTIMATED","OBSERVATIONAL","The study aims to develop and validate a prognostic prediction model for adverse outcomes in neurocritical patients receiving enteral nutrition based on key inflammatory and metabolic markers. This model will serve as a clinical tool to help physicians identify high-risk patients and guide individualized nutritional support strategies.",[26,27,28],"Stroke Acute","Encephalitis","Non-traumatic Brain Injury",[30,31,32,33],"enteral nutrition","adverse prognosis","prediction model","non-traumatic severe brain injury","NOT_YET_RECRUITING","2025-02-23",{"date":37,"type":38},"2025-02-27","ACTUAL",{"date":40,"type":22},"2025-03-01",{"date":42,"type":22},"2027-03-31",{"name":44,"class":45},"Yan Zhang","OTHER",19,""]