[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Yongtao Sun\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":183},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,77,105,132,158],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100629690","the-impact-of-automatic-lung-recruitment-postoperative-pulmonary-complications-100629690",false,"NCT07477951","The Impact of Automatic Lung Recruitment Postoperative Pulmonary Complications","The Effect of Automatic Lung Re-expansion on Postoperative Pulmonary Function in Elderly Patients Undergoing Laparoscopic Surgery Under Total Intravenous Anesthesia: A Prospective, Single-center, Randomized Controlled Trial","lung","Inclusion Criteria:\n\n* aged≥65 years\n* American Society of Anesthesiologists (ASA) grades I-III;\n* Body mass index (BMI) between 18-30kg\u002Fm²\n* No history of drug allergy or abnormal anesthesia;\n* Patients undergoing laparoscopic gastrointestinal surgery, and operative time\\> 2 hours;\n* Participants with a preoperative oxygen saturation not \\\u003C 94%\n* Participants for whom extubation is planned in the operating room.\n* The assess respiratory risk in surgical patients in Catalonia (ARISCAT) score is 26-44 or \\> 44.\n\nExclusion Criteria:\n\n* ALI or ARDS patient within 3 months; severe pulmonary dysfunction; severe COPD (FEV1 \\\u003C50% of predicted value) or pulmonary hypertension;\n* New York Heart Association classification: Class IV;\n* Chronic renal failure(GFR\\\u003C30ml min-11.73m-2);\n* Severe liver disease;\n* Patients with confusion and cognitive dysfunction;\n* Severe coagulation disorders;\n* Patients with tracheal tubes transported to the ICU;\n* Other reasons;","ALL","65 Years",{"count":20,"type":21},58,"ESTIMATED","INTERVENTIONAL",[24],"NA","Study Background and Purpose As society ages, an increasing number of elderly patients undergo surgery. Following surgery, particularly abdominal procedures, patients are susceptible to lung-related issues such as atelectasis (lung collapse) and infection, collectively known as Postoperative Pulmonary Complications (PPCs). These complications are a major factor affecting the recovery of elderly patients.\n\nOne method of general anesthesia is called Total Intravenous Anesthesia (TIVA). This study aims to investigate whether using an automated lung recruitment function, a smart feature available on modern anesthesia machines, can help protect lung function and reduce complications in elderly patients undergoing laparoscopic surgery under TIVA. The goal is to identify safer and more effective methods for anesthesia care.\n\nStudy Design\n\nThis is a clinical research study. Eligible elderly patients who provide consent will be randomly assigned to one of two groups:\n\nStudy Group: The automated lung recruitment function on the anesthesia machine will be used to manage breathing during surgery.\n\nControl Group: Current standard methods for breathing management will be used during surgery.\n\nThe primary goal is to observe and compare the blood oxygenation level 30 minutes after surgery (a key indicator of lung function) between the two groups. The investigators will also record the occurrence of any lung-related complications within the first 3 days after surgery.\n\nWhat Will Participants Do?\n\nIf participants agree to participate, they will be asked to:\n\nSign an informed consent form.\n\nUndergo some pre-operative assessments arranged by the research team.\n\nReceive the corresponding breathing management method during surgery, as determined by random assignment.\n\nAllow the research team to collect relevant medical data after surgery (e.g., blood gas analysis results, medical records). All data will be kept strictly confidential.\n\nParticipation does not involve any additional invasive procedures. All medical care and monitoring will adhere to the standard safety protocols required for the surgery, and may even be more meticulous.\n\nPotential Benefits and Risks of the Study\n\nPotential Benefits:\n\nDirect Benefit: Participants will receive more precise monitoring and care for their respiratory function during and after surgery.\n\nSocietal Value: Data from their participation will contribute to developing better anesthesia strategies for future elderly patients, potentially improving their recovery outcomes.\n\nPotential Risks and Protections:\n\nThe study intervention is integrated into standard anesthesia. The main risks are associated with routine anesthesia and surgery itself (e.g., temporary blood pressure fluctuations, low oxygen levels). These risks are possible in any similar surgical procedure.\n\nThe study will be conducted by experienced anesthesiologists with continuous, close monitoring. Comprehensive emergency plans are in place to ensure participant safety.\n\nParticipants have the right to withdraw from the study at any time, for any reason, without affecting their eligibility for any future standard medical care.\n\nAll personal information and study data will be kept strictly confidential. Data will be analyzed using coded identifiers only. Any published results will not contain information that could reveal the identity of participants.",[27],"Acute Lung Injury",[29,30,31,32],"Automated recruitment maneuver (Auto-RM)","Total Intravenous Anesthesia (TIVA)","postoperative pulmonary complications (PPCs)","acute lung injury (ALI)","NOT_YET_RECRUITING","2026-03-13",{"date":36,"type":37},"2026-03-17","ACTUAL",{"date":39,"type":21},"2026-04-01",{"date":41,"type":21},"2027-06-30",{"name":43,"class":44},"Yongtao Sun","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":45},"100528839","phase-4-liposomal-and-standard-bupivacaine-in-thoracic-paravertebral-block-for-post-thoracoscopic-pain-100528839","NCT06165991","Liposomal and Standard Bupivacaine in Thoracic Paravertebral Block for Post-Thoracoscopic Pain","The Effect of Bupivacaine Liposome Combined With Bupivacaine Hydrochloride on Thoracic Paravertebral Nerve Block for Postoperative Pain After Thoracoscopic Lung Surgery","Inclusion Criteria:\n\n* 1\\) Age ≥18 years old;\n\n  2\\) Patients undergoing unilateral initial thoracoscopic lobectomy under general anesthesia (TV or robot-assisted);\n\n  3\\) American Society of Anesthesiologists (ASA) Grade I - III;\n\n  4\\) Voluntarily participate in the study and sign the informed consent.\n\nExclusion Criteria:\n\n* 1\\) Pregnant or lactating women;\n\n  2\\) Pulmonary wedge-shaped resection;\n\n  3\\) ≥2 thoracic drainage tubes;\n\n  4\\) Abnormal liver function: ALT and\u002For AST\\>2×ULN, or\n\nTBIL≥1.5×ULN;\n\n5\\) Renal function impairment (serum creatinine \\>176μmol\u002FL), or received dialysis treatment within 28 days before surgery;\n\n6\\) Participate in another research trial involving an investigational drug within 6 months;\n\n7\\) A history of drug or alcohol abuse;\n\n8\\) Long-term use of opioids (more than 3 months or more than 5 mg daily morphine equivalent per day for 1 month);\n\n9\\) History of allergy to local anesthetics or one of the investigational drugs;\n\n10\\) Uncontrolled mental or neurological symptoms.","18 Years",{"count":55,"type":21},496,[57],"PHASE4","I. Research purpose\n\n1.1 Main Objective: To investigate the efficacy and safety of bupivacaine liposome thoracic paravertebral nerve block for postoperative analgesia after thoracoscopic lobectomy\n\n1.2 Exploratory Objective: To investigate the noninferiority of bupivacaine liposomes in thoracic paravertebral nerve block with standard bupivacaine",[60,61,62],"Thoracic Paravertebral Block","Postoperative Analgesia","Thoracoscopic Lobectomy",[64,65,66,67],"liposomal bupivacaine(LB)","Thoracic paravertebral nerve block","Postoperative analgesia","thoracoscopic lobectomy","RECRUITING","2026-01-07",{"date":71,"type":37},"2026-01-09",{"date":73,"type":37},"2024-06-01",{"date":75,"type":21},"2026-01-31",{"name":43,"class":44},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100589373","impact-of-frailty-on-nalbuphine-dose-for-postoperative-analgesia-in-elderly-patients-undergoing-laparoscopic-gi-surgery-100589373","NCT06953570","Impact of Frailty on Nalbuphine Dose for Postoperative Analgesia in Elderly Patients Undergoing Laparoscopic GI Surgery","Impact of Frailty on the Median Effective Dose of Nalbuphine in Patient-Controlled Intravenous Analgesia for Postoperative Pain in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Prospective, Double-Blind, Cohort Study","Inclusion Criteria:\n\n1. Patients who plan to undergo elective gastrointestinal surgery and are expected to stay in hospital for ≥3 days after surgery \\[except abdominal perineal combined with radical resection of rectal cancer (MILES)\\];\n2. ASA grade I-Ⅳ;\n3. Age ≥65 years (2);\n4. 18.5 kg\u002Fm²≤BMI\\\u003C30 kg\u002Fm²;\n5. Sign the informed consent form.\n\nExclusion Criteria:\n\n1. Severe cardiopulmonary, liver, kidney and coagulation dysfunction\n2. Chemotherapy and radiotherapy were administered 1 month before surgery, and sedatives, antiemetic or antipruritic drugs were administered 24 hours before surgery\n3. History of drug abuse, chronic pain, mental illness, or allergy to the drugs used in this study\n4. Plan postoperative intubation or transfer to ICU;\n5. Participated in other clinical studies within the past 3 months.",{"count":85,"type":21},120,"OBSERVATIONAL","This study aims to investigate the ED50 and ED95 of nalbuphine combined with dexmedetomidine in patient-controlled intravenous analgesia (PCIA) for elderly patients with different degrees of frailty, as well as their analgesic effects and complications. The results of this study can provide safe and effective dosage guidance for postoperative analgesia in frail patients, help optimize analgesic regimens, reduce the risk of complications, and improve the quality of postoperative recovery.",[89,90,91],"PCIA","Frailty","Laparoscopic Gastrointestinal Surgery",[93,94,89,95,96],"nalbuphine","ED50","laparoscopic gastrointestinal surgery","frailty","2025-04-23",{"date":99,"type":37},"2025-05-01",{"date":101,"type":21},"2025-10-01",{"date":103,"type":21},"2026-10-10",{"name":43,"class":44},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":45},"100570819","phase-4-effect-of-oxalidine-combined-with-reduced-opioid-anesthesia-on-multimodal-analgesia-in-morbidly-obese-patients-undergoing-bariatric-surgery-100570819","NCT06712199","Effect of Oxalidine Combined with Reduced-opioid Anesthesia on Multimodal Analgesia in Morbidly Obese Patients Undergoing Bariatric Surgery","Effect of Oxalidine Combined with Reduced-opioid Anesthesia on Multimodal Analgesia in Morbidly Obese Patients Undergoing Bariatric Surgery: a Prospective, Single-center, Randomized, Parallel Controlled Study","Inclusion Criteria:\n\n* Patients undergoing weight loss surgery under general anesthesia;\n* Age ≥18 years old;\n* American Society of Anesthesiologists ASA Grade I-III;\n* BMI≥35kg\u002Fm2 with complex signs of morbid obesity (such as metabolic syndrome)\n\nExclusion Criteria:\n\n* Pregnancy test positive or breastfeeding;\n* Patients with a history of substance abuse or dependence on opioids;\n* Patients with chronic pain or with severe heart, lung, liver or nervous system diseases.",true,{"count":114,"type":21},124,[57],"The goal of this study is to elucidate the efficacy and safety of oxelidine combined with oligopiate anesthesia for multi-modal analgesia in weight-loss surgery in morbidly obese patients, and to discover a new strategy for multi-modal analgesia management in weight-loss surgery, laying a foundation for the widespread application of oligopiate anesthesia in special patients.\n\nA total of 124 patients who underwent elective bariatric surgery in our hospital were selected, and the participants were randomly divided into two groups: the opioid anesthesia group (OBA group) and the low-opioid anesthesia group (OFA group) using a random number table to achieve simple randomization.\n\nInclusion criteria: 1.ASA grade I \\~ III; 2. Age ≥18 years old; 3. Bariatric surgery patients with BMI≥35kg\u002Fm2 and complex signs of morbid obesity (such as metabolic syndrome) 4. Sign the informed consent form.\n\nExclusion criteria: 1. Positive pregnancy test or breastfeeding; 2. Patients with a history of substance abuse or dependence on opioids; 3. Patients with chronic pain or with severe heart, lung, liver or nervous system diseases.\n\nAnesthesia implementation: 1. Routine monitoring after entry, intravenous administration of midazolam and atropine. Study participants were placed in the ramp position, bilateral recurrent laryngeal nerve block under ultrasound guidance, and the mouth contained dachronine gel. Radial artery puncture was performed and dexmedetomidine was injected intravenously. A laryngeal tube is used to test the sensation of the back of the oropharynx, and a laryngeal mask is placed while awake to connect the anesthesia circuit and deliver oxygen. Once the vocal cords are seen and the end-respiratory CO2 waveform is observed.\n\n2\\. The OBA group underwent combined anesthesia induction with propofol, rocuronium bromide and sufentanil, endotracheal intubation through visual laryngeal mask, intraoperative pump injection of propofol and remifentanil to maintain anesthesia, sufentanil bridging 10μg 30 minutes before the end of the operation; In OFA group, propofol, rocuronium bromide and esketamine were induced by combined anesthesia, and endotracheal intubation was performed through visual laryngeal mask. Intraoperative pump propofol and esketamine to maintain anesthesia; Oxeridine was bridged-1.5 mg 30min before the operation and administered in two doses, 0.75mg\u002F time, with an interval of 10min.\n\n3\\. Both groups were subjected to bilateral lower costal margin transversal nerve block under ultrasound guidance.\n\n4\\. Ondansetron was given before the end of the operation. After the operation, the tracheal cannula was removed under deep anesthesia, and the laryngeal mask was retained and transferred to the postoperative resuscitation room. Sugengosaccharide sodium was used to antagonize muscle pine during recovery. After the study participants were awake, the laryngeal mask was well tolerated. The laryngeal mask was removed after observation for 1h, and the laryngeal mask was safely transferred to the ward after continuous observation for 1h.\n\nPCA administration regimen in OBA group: Sufentanil + dexmedetomidine + Ondansetron; OFA group PCA administration regimen: oxelidine + dexmedetomidine + Ondansetron. Record the number of compressions, if the assessment of NRS≥4 points, then remedy 2mg oxycodone hydrochloride, and record the dosage.\n\nMain outcome measures: Consumption of oral morphine equivalent (OME) opioids in the 24 hours prior to surgery.\n\nSecondary outcome measures: Overall satisfaction with analgesia and Numerical Rating Scale (NRS, 0-10) pain score, area under the curve of resting and exercise NRS score (AUC) within 72 hours after surgery, time to first use of rescue analgesics within 72 hours, cumulative opioid consumption 72 hours after surgery (morphine milligram equivalent, morphine milligram equivalent, NRS score) MME), participants' satisfaction with postoperative analgesia, 15-item Quality of Recovery score Scale (QoR15) at 24, 48, and 72h after surgery, incidence of postoperative complications, incidence of nausea and vomiting, and incidence of adverse events were recorded.",[118],"Morbid Obesity",[120,121,122,123],"Oxeridine","Hypopiate anesthesia","Multimodal analgesia","Morbid obesity","2024-11-29",{"date":126,"type":37},"2024-12-02",{"date":128,"type":21},"2025-01-01",{"date":130,"type":21},"2026-12-31",{"name":43,"class":44},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":45},"100530015","effects-of-individualized-peep-guided-by-driving-pressure-on-postoperative-atelectasis-in-patients-with-morbid-obesity-100530015","NCT06181279","Effects of Individualized PEEP Guided by Driving Pressure on Postoperative Atelectasis in Patients With Morbid Obesity","Effects of Individualized Positive End-expiratory Pressure Guided by Driving Pressure on Postoperative Atelectasis After Bariatric Surgery in Patients With Morbid Obesity: A Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n* Age 18 to 60 years old;\n* Body mass index (BMI) ≥ 40 kg\u002Fm2;\n* ASA classification I to III;\n* Signing the informed consent form for this clinical study;\n\nExclusion Criteria:\n\n* Respiratory infection within 4 weeks; severe respiratory system diseases; history of pulmonary and\u002For thoracic surgery; neuromuscular dysfunction;\n* Serious cardiac, renal or haematopoietic diseases;\n* Contraindications to PEEP；","60 Years",{"count":141,"type":21},52,[24],"Atelectasis is a common complication in patients undergoing surgery under general anesthesia, particularly in obese patients. Postoperative atelectasis could last for more than 24h and contribute to a variety of other complications, including hypoxemia and pneumonia. We plan to conduct a single-center, randomized controlled trial in patients undergoing bariatric surgery to test the hypothesis that driving pressure guided PEEP could reduce the postoperative atelectasis.",[145,146],"Pulmonary Atelectasis","Obesity, Morbid",[148,149,150],"Individual Positive End-expiratory Pressure","Driving Pressure","Ventilator-induced Lung Injury",{"date":152,"type":37},"2024-06-04",{"date":154,"type":37},"2024-03-01",{"date":156,"type":21},"2024-12-31",{"name":43,"class":44},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":173,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":45},"100488112","phase-4-effects-of-low-dose-esmolol-on-myocardial-injury-after-non-cardiac-surgery-in-elderly-frail-patients-100488112","NCT05635877","Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients","Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients:A Multicenter, Prospective, Double-blind, Randomized Controlled Study","Inclusion Criteria:\n\n1. Age ≥ 65 years;\n2. ASA: ⅰ-ⅳ;\n3. Modified frailty index (mFI) ≥ 0.21;\n4. Patients undergoing non-cardiac surgery.\n\nExclusion Criteria:\n\n1. Refuse to participate;\n2. Expected hospital stay \\\u003C3 days;\n3. Preoperative β-blocker therapy;\n4. History of myocardial infarction or coronary artery disease;\n5. Preoperative bradycardia (heart rate \\[HR\\] \\\u003C 50 bpm) or arrhythmia;\n6. Significant cardiac insufficiency (i.e., pulmonary artery pressure \\>18 mm Hg, cardiac index ≤ 2.2 L\u002Fmin\u002Fm 2);\n7. Severe valvular heart disease;\n8. Severe lung disease (e.g. asthma or chronic obstructive pulmonary disease);\n9. Patients with perioperative troponin elevation due to nonischemic causes (e.g., sepsis, pulmonary embolism, arrhythmia);\n10. The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause.\n\n    \\-","90 Years",{"count":167,"type":21},2000,[57],"This topic will focus on the following questions:\n\n1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation.\n2. Part Two: To explore the effect of low-dose esmolol on myocardial injury after non-cardiac surgery in frail elderly patients.",[90,171,172],"Esmolol","Myocardial Injury",[174],"myocardial injury after non-cardiac surgery, MINS","2023-03-27",{"date":177,"type":37},"2023-03-29",{"date":179,"type":37},"2023-02-07",{"date":181,"type":21},"2026-12-30",{"name":43,"class":44},""]