[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Yuhui Qiu\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100599535","effects-of-acute-sleep-deprivation-on-individuals-with-different-apoe-genotypes-100599535",false,"NCT07085754","Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes","Inclusion Criteria:\n\n* Age 18-40 years, gender not limited\n* Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications\n* Cognitively normal (Mini-Mental State Examination (MMSE) score \\> 28)\n* Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)\n* Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study\n\nExclusion Criteria:\n\n* Presence of day-night sleep reversal\n* Shift work within the past 6 months\n* Travel across time zones or experience of jet lag within the past three weeks\n* Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL \\[or 8 g\\] of pure alcohol)\n* Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation\n* Family history of early-onset dementia\n* Self-Rating Depression Scale (SDS) score ≥ 53, Self-Rating Anxiety Scale (SAS) score ≥ 50\n* Female participants who are currently pregnant or breastfeeding\n* Individuals who need to drive or operate vehicles or machinery during the study period",true,"ALL","18 Years","40 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.",[27,28],"Sleep","Sleep Deprivation","RECRUITING","2025-12-18",{"date":32,"type":33},"2025-12-24","ACTUAL",{"date":35,"type":33},"2025-08-08",{"date":37,"type":21},"2026-12-31",{"name":39,"class":40},"Yuhui Qiu","OTHER",""]