[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Yuvell\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100623602","prospective-non-interventional-study-assessing-perioral-rejuvenation-procedure-100623602",false,"NCT07398768","Prospective, Non-interventional Study Assessing Perioral Rejuvenation Procedure","A Prospective, Non-interventional, Single-Centre Study Assessing the Time Course of a Holistic Perioral Rejuvenation Procedure","Inclusion Criteria:\n\n1. 18 years or older at time of treatment.\n2. At least mild static perioral lines and maximum of thin lips, as assessed by the investigator.\n3. Participant has a stable medical condition with no uncontrolled systemic disease.\n4. Willingness to participate in the routine follow-up after 12 weeks and a signed ICF.\n5. Participant already visiting the clinic for the specific treatment.\n\nExclusion Criteria:\n\n1. Pregnancy and breast feeding.\n2. Known impairment of blood coagulation.\n3. Presence of acute infection or inflammation at the proposed injection sites.\n4. Hyaluronic Acid-Filler treatment in the perioral area within the last 6 months.\n5. Patients with a history of autoimmune disease or who are receiving immune therapy.\n6. History of hypersensitivity to hyaluronic acid, lidocaine hydrochloride or other amidetype local anaesthetics.",true,"ALL","18 Years",{"count":20,"type":21},34,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how a perioral rejuvenation procedure affects perioral line severity and lip volume over time in adults undergoing routine aesthetic treatment in a single clinical center. The main questions it aims to answer are:\n\n* What proportion of participants achieves a ≥1-point improvement from baseline on both the Lip Fullness Scale (LFS) and the Static Perioral Lines Assessment Scale (SPLAS) at Week 12?\n* How do skin wrinkling\u002Fsurface roughness, lip and perioral volume, and patient satisfaction change over 6 and 12 weeks?\n\nParticipants will:\n\n* Receive a routine (non-study-mandated) holistic perioral rejuvenation procedure as decided by their treating clinician.\n* Attend study visits at approximately baseline, Week 6, and Week 12.\n* Undergo independent clinical assessments (assessor not involved in treatment delivery) of LFS and SPLAS.\n* Have skin wrinkling and surface roughness documented by VISIA skin analysis (baseline, Week 6, Week 12).\n* Have lip and perioral volume measured by VECTRA M3 volume analysis (baseline, Week 6, Week 12).\n* Complete a standardized patient satisfaction questionnaire (Week 12).",[25,26,27,28],"Perioral Wrinkles","Crow's Feet","Lip Volume Enhancement","Lip Aging",[30,31,32,33],"smoker's lines","perioral wrinkles","perioral lines","hyaluronic acid","RECRUITING","2026-03-12",{"date":37,"type":38},"2026-03-13","ACTUAL",{"date":40,"type":38},"2026-02-13",{"date":42,"type":21},"2026-07",{"name":44,"class":45},"Yuvell","OTHER",""]