[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Zagazig University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":606},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,43,0,25,[9,41,68,95,117,137,158,180,199,221,242,264,286,312,340,364,390,412,438,460,484,508,532,555,581],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100640862","analgesia-for-perineal-surgeries-in-high-risk-pediatric-patients-100640862",false,"NCT07602894","Analgesia for Perineal Surgeries in High-risk Pediatric Patients","Efficacy of Ultrasound-guided Sacral Multifidus Plane Block as Perioperative Analgesia for Anal and Penile Surgeries in High-risk Pediatric Patients","Inclusion Criteria:\n\n* Parents or caregivers' acceptance.\n* High-risk pediatric patients (the American Society of Anesthesiologists physical status class III-IV)\n* Body mass index equal to 5%: 85% of the same age and sex.\n\nExclusion Criteria:\n\n* Child with a contraindication to the regional block, such as infection at the site of injection, or coagulopathy.\n* Pre-existing neurological disorders.","ALL","12 Months","12 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Perioperative pain management in pediatric patients, especially for anorectal and penile surgeries, presents significant challenges for anesthetists. Complications associated with systemic analgesia, such as respiratory issues, cardiovascular problems, and neurological effects, can be avoided by using regional anesthesia. This study aims to evaluate the effectiveness of Ultrasound-Guided Sacral Multifidus Plane Block as a method for perioperative analgesia in high-risk pediatric patients undergoing anorectal and penile surgeries, to reduce the risks associated with systemic analgesia.",[28],"Analgesia","NOT_YET_RECRUITING","2026-05-21",{"date":32,"type":33},"2026-05-22","ACTUAL",{"date":35,"type":22},"2026-07",{"date":37,"type":22},"2027-12",{"name":39,"class":40},"Zagazig University","OTHER_GOV",{"id":42,"slug":43,"hasResults":12,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},"100630884","parascapular-sub-iliocostalis-plane-block-versus-thoracic-paravertebral-plane-block-for-traumatic-multiple-rib-fractures-100630884","NCT07493473","Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures","Continuous Block of Parascapular Sub-Iliocostalis Plane Versus Thoracic Paravertebral Plane for Analgesia in Patients With Traumatic Multiple Rib Fractures","Inclusion Criteria:\n\n* Patient written informed consent.\n* ASA I to III.\n* Age 21-60 years old.\n* Gender: Both.\n* BMI \\\u003C 35 Kg\u002FM2.\n* Accepted mental state of the patient.\n* Patient with unilateral multiple rib fractures (≥2 fractures)\n\nExclusion Criteria:\n\n* Any trauma in the patient that interfere with the positioning of patients for block.\n* Patients who needed mechanical ventilation before or during the study.\n* Patients with associated head trauma.\n* Patient with hemodynamic instability and need inotropic support. • Patient with abbreviated injury scale (AIS) in extremity more than 2 (10)\n* Pathological coagulopathy.\n* Infection at the injection site.\n* Disturbed conscious level.\n* An allergy to local anesthetics or any used drugs in this study.\n* Pregnancy.","21 Years","60 Years",{"count":51,"type":22},36,[25],"Pain control of rib fractures is essential for not only primary pain relief but also preventing secondary complications such as atelectasis or pneumonia which increase the hospital stay, as well as the transition to chronic pain.\n\nThe cornerstones of analgesic management are oral and intravenous medications such as paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids as well as regional block techniques as paravertebral block and thoracic epidural.\n\nTo avoid opioid as well as regional block related side effects such as pneumothorax and hemodynamic instability, previous studies showed that superficial chest wall block such as thoracic erector spinae plane block and serratus anterior plane block had shown a promising success in management of such pain with few side effects.\n\nIn an effort to reduce the pain score, hospital stay and improve the patient's capability of physiotherapy this study compares continuous block of parascapular sub-iliocostalis plane block versus continuous thoracic paravertebral block for analgesia in patients with traumatic multiple rib fractures.",[55],"Discitis of Thoracic Region",[57],"Paravertebral block","RECRUITING","2026-05-08",{"date":61,"type":33},"2026-05-13",{"date":63,"type":33},"2025-05-01",{"date":65,"type":22},"2026-08",{"name":39,"class":40},1,{"id":69,"slug":70,"hasResults":12,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":12,"sex":17,"minAge":75,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":23,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":67},"100640790","phase-1-impact-of-eradication-therapy-on-helicobacter-pylori-infection-with-chronic-obstructive-pulmonary-disease-100640790","NCT07574879","Impact of Eradication Therapy on Helicobacter Pylori Infection With Chronic Obstructive Pulmonary Disease:","Impact of Eradication Therapy on Helicobacter Pylori Infection in Patients With Chronic Obstructive Pulmonary Disease: A Prospective Study","Inclusion Criteria:\n\n* Adults aged ≥40 years.\n* Diagnosed with COPD confirmed by spirometry (post-bronchodilator FEV1\u002FFVC \\\u003C 0.70) and H. pylori positive.\n* Willing to participate and provide consent for testing and follow-up.\n\nExclusion Criteria:\n\n* patients with asthma, known peptic ulcers, acute exacerbation of COPD\n* patients who took antibiotics and PPIs within the last month,\n* Patients who took histamine-2-receptor antagonists within the last week or antacid within the last 24 hours a\n* those having H. pylori eradication treatment within the last 6 months","40 Years",{"count":77,"type":22},54,[79],"PHASE1","Helicobacter pylori (HP) is a well-established pathogen responsible for chronic gastritis and peptic ulcer disease. Its presence has been implicated in the development of gastric malignancies such as adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Chronic H. pylori infection is associated with systemic inflammatory responses and various extra gastric diseases, including cardiovascular, metabolic, and neurological disorders. Furthermore, H. pylori infection contributes to gastrointestinal dysbiosis by interacting with gastrointestinal microbiota, which may be involved in gastric carcinogenesis and other systemic disorders. Growing evidence highlights the role of dysbiosis in chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. Emerging epidemiological evidence suggests a potential association between H. pylori infection and respiratory diseases, including COPD. Several observational studies and meta-analyses have found that H. pylori infection in patients with COPD may be associated with systemic inflammatory markers and altered pulmonary function parameters. Despite these associations, the causal mechanisms underlying this relationship remain unclear. Furthermore, it is uncertain whether eradication of H. pylori yields measurable benefits on clinical outcomes in COPD patients. So, Our aim to evaluate changes in symptoms, pulmonary function, and inflammatory markers after H. pylori eradication therapy in the H. pylori-positive COPD patients.\n\nan intervention study (quasi experimental), study will be carried out in the inpatient and outpatient clinics of Chest Department, Faculty of Medicine, Zagazig University hospitals.\n\nPatients included in the study:\n\nwell controlled COPD patients attending outpatient clinics for a period of 6 months fulfilling inclusion and exclusion criteria will be included in this study.",[82,83],"Chronic Obstructive Pulmonary Disease (COPD)","With Poitive H Pylori",[85,86,87],"Chronic Obstructive Pulmonary disease","Helicobacter Pylori","eradication therapy","2026-05-03",{"date":59,"type":33},{"date":91,"type":33},"2026-03-01",{"date":93,"type":22},"2026-12",{"name":39,"class":40},{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":12,"sex":17,"minAge":102,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":23,"phases":105,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":67},"100636744","exososmes-in-atrophic-scars-management-100636744","NCT07569666","Exososmes in Atrophic Scars Management","Evaluation of Intralesional Exosomes Versus Intralesional Saline in The Treatment of Atrophic Scars: A Randomized Controlled Trial","Inclusion Criteria:\n\nAge \\>18 years\n\n* Either gender\n* Scars of any duration\n* Multiple scars at one side or both sides of the face.\n* Patients are willing to sign written informed consent statements before beginning treatment.\n\nExclusion Criteria:\n\n* Pregnant females.\n* Patients with one scar.\n* Hypersensitivity to any of the used treatments.\n* Patient with infection at the site of the scar.\n* Patients with unrealistic expectations.\n* Patient refusing to sign on the consent.","18 Years",{"count":104,"type":22},12,[25],"Lay Summary (Simple Explanation)\n\nAtrophic scars are depressed scars that form when the skin does not heal properly, commonly seen after acne or injuries. These scars can affect appearance and confidence, and current treatments may not always give satisfactory results.\n\nThis study aims to evaluate a new treatment using exosomes, which are tiny particles naturally released by cells that help in skin repair and regeneration. Researchers will compare the effect of injecting exosomes directly into scars versus injecting a simple saltwater solution (saline), which serves as a control.\n\nParticipants will be randomly assigned to receive either exosome injections or saline injections. Neither the patient nor the evaluator may know which treatment is given, to ensure fair comparison.\n\nThe goal is to determine whether exosomes can safely and effectively improve the appearance and texture of atrophic scars.",[108],"Atrophic Scar","2026-05-01",{"date":111,"type":33},"2026-05-06",{"date":113,"type":33},"2025-06-15",{"date":115,"type":22},"2027-02",{"name":39,"class":40},{"id":118,"slug":119,"hasResults":12,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":49,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":126,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":67},"100601063","total-intravenous-anesthesia-in-patients-undergoing-craniotomy-100601063","NCT07105618","Total Intravenous Anesthesia in Patients Undergoing Craniotomy","Comparison of Dexmedetomidine Versus Fentanyl or Magnesium Sulphate as Adjuncts to Propofol-Based Total Intravenous Anesthesia in Patients Undergoing Craniotomy","Inclusion Criteria:\n\n* Patient acceptance.\n* Physical status: American Society of Anesthesiologists Physical Status (ASA) 1\\& II.\n* Body mass index ≤ 30 kg\u002Fm2.\n* Type of operation: elective craniotomy for brain tumor resection.\n* Duration of surgery: within 4 hours.\n\nExclusion Criteria:\n\n* Patient with hemodynamic instability or anticipated postoperative mechanical ventilation.\n* Patients with a known history of allergy to the study drugs.\n* Advanced hepatic, renal, cardiovascular, and neurologic diseases.\n* Patients with chronic opioid use.",{"count":125,"type":22},108,[25],"Craniotomy presents true anesthetic challenges, mainly due to the need to optimize cerebral perfusion, facilitate brain relaxation, achieve rapid emergence for neurologic assessment, and minimize perioperative complications.",[129],"Anesthesia","2026-04-30",{"date":111,"type":33},{"date":133,"type":33},"2025-08-10",{"date":135,"type":22},"2027-04",{"name":39,"class":40},{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":12,"sex":17,"minAge":102,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":67},"100636450","intradermal-exosomes-platelet-rich-plasma-and-steroids-for-post-herpetic-neuralgia-100636450","NCT07565844","Intradermal Exosomes, Platelet-Rich Plasma, and Steroids for Post-Herpetic Neuralgia","A Comparative Study of Intradermal Injection of Exosomes, Platelet-Rich Plasma and Steroids in the Treatment of Post-Herpetic Neuralgia","Inclusion Criteria:\n\n* Patients with post-herpes zoster persistent dermatomal pain consistent with post-herpetic neuralgia for at least 90 days.\n\nMale or female patients. Age 18 years or older. Willingness to comply with study procedures and attend follow-up visits. Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* History of hypersensitivity to any of the study treatments. Pregnancy. Any type of skin infection involving the affected dermatome. Immunocompromised patients, including patients with cancer or HIV. Patients with bone marrow aplasia. Patients with known bleeding tendency, platelet dysfunction, or thrombocytopenia, defined as platelet count less than 150 × 10⁹\u002FL.\n\nRegular use of anticoagulant or antiplatelet drugs.",{"count":145,"type":22},45,[25],"This randomized controlled clinical trial will evaluate and compare the efficacy and safety of intradermal injection of exosomes, platelet-rich plasma, and corticosteroid in patients with post-herpetic neuralgia. Forty-five adult patients with dermatomal pain persisting for at least 90 days after herpes zoster will be enrolled from outpatient clinics. Participants will be assigned to one of three groups: intradermal exosome injection, intradermal autologous platelet-rich plasma injection, or intradermal triamcinolone acetonide injection. Each group will receive four treatment sessions every two weeks. Outcomes will include pain severity, neuropathic pain characteristics, quality of life, patient satisfaction, and adverse effects, assessed at baseline, at the final session, and during follow-up visits at 3 and 6 months after the last session.",[149],"Postherpetic Neuralgia ( PHN )","2026-04-27",{"date":152,"type":33},"2026-05-04",{"date":154,"type":33},"2025-02-02",{"date":156,"type":22},"2026-11-11",{"name":39,"class":40},{"id":159,"slug":160,"hasResults":12,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":12,"sex":17,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":168,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":67},"100635481","clinical-performance-of-laryseal-clear-versus-ambu-aura-40-laryngeal-mask-airway-for-preschool-children-100635481","NCT07553247","Clinical Performance of Laryseal Clear Versus Ambu Aura 40 Laryngeal Mask Airway for Preschool Children","Evaluation of the Clinical Performance of Laryseal Clear Versus Ambu Aura 40 Laryngeal Mask Airway for Preschool Children","Inclusion Criteria:\n\n* Consent of patient's parents or guardians of the first degree.\n* American Society of Anesthesiologists (ASA) Class I or II.\n* BMI: 5-85% of the children of the same age and sex.\n* Patients with mallampati grade I, II\n* Type of anesthesia: general anesthesia expected to last for less than 2 hours.\n\nExclusion Criteria:\n\n* Emergency surgeries.\n* Expected difficult airway.\n* Patients with congenital or acquired airway malformations.\n* Patients with active upper respiratory tract infection at the time of surgery.\n* Patients with history of gastroesophageal reflux disease (GERD).\n* Patients with neuromuscular disorders affecting airway tone or respiratory function.","3 Years","6 Years",{"count":77,"type":22},[25],"Preschool children have specific anatomical and physiological characteristics which necessitates careful selection of an appropriate airway management device. Supraglottic airway devices can be used in anticipated or unanticipated difficult airway providing continuous oxygenation and ventilation with less hemodynamic stress response and less postoperative complications. So alternative techniques such as SADs have gained prominence in pediatric anesthesia both as primary airway and as a conduit for endotracheal intubation. So this study will evaluate the clinical performance of Laryseal Clear and Ambu Aura40 laryngeal mask airway in preschool children undergoing surgical procedures.",[171,172],"Supraglottic Airway Devices","Laryseal Clear Laryngeal Mask","2026-04-25",{"date":130,"type":33},{"date":176,"type":33},"2025-06-25",{"date":178,"type":22},"2026-07-01",{"name":39,"class":40},{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":12,"sex":17,"minAge":102,"maxAge":49,"enrollmentInfo":187,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":198,"locationsCount":67},"100553393","phase-1-isotretinoin-versus-excimer-light-an-adjuvant-in-treating-onychomycosis-100553393","NCT06485505","Isotretinoin Versus Excimer Light an Adjuvant in Treating Onychomycosis","Efficacy of Low Dose Isotretinoin Versus Excimer Light as an Adjuvant for Itraconazole in Treatment of Onychomycosis: a Randomized Controlled Trial.","Inclusion Criteria:\n\n* patients with onychomycosis\n\nExclusion Criteria:\n\n* pregnant and lactating females patients on statin therapy or photosensitizing drugs patients with liver disease, heart disease and diabetes milletus.",{"count":51,"type":22},[79],"3 groups of patients with onychomycosis will be recruited. Group A will receive itraconazole alone. Group B will receive itraconazole + low dose isotretinoin and group C will be treated with itraconazole + excimer light sessions.",[191],"Onychomycosis","2026-04-19",{"date":194,"type":33},"2026-04-23",{"date":196,"type":33},"2024-07-12",{"date":93,"type":22},{"name":39,"class":40},{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":206,"sex":17,"minAge":102,"maxAge":75,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":67},"100633171","poly-l-lactic-acid-in-atrophic-acne-scars-100633171","NCT07523217","Poly-L-Lactic Acid in Atrophic Acne Scars","Poly-L-Lactic Acid: A Comparative Study of Injectable and Thread-Based Delivery in Atrophic Acne Scars","Inclusion Criteria:\n\n* included adult patients (≥18 years) of both sexes presenting with clinically diagnosed atrophic acne scars (Grades 2-4 according to the Goodman and Baron classification)\n\nExclusion Criteria:\n\n* active acne lesions, pregnancy or lactation, bleeding disorders, keloid tendency, systemic diseases affecting wound healing, recent acne scar treatment within the past six months, and known hypersensitivity to PLLA components.",true,{"count":208,"type":22},52,[25],"Background: Management of atrophic acne scars remains challenging due to their heterogeneous morphology and suboptimal response to conventional therapies. Poly-L-lactic acid (PLLA), a biostimulatory agent, promotes neocollagenesis and has emerged as a promising therapeutic option. However, comparative data on different delivery modalities of PLLA and their effects on dermal remodeling and skin physiology remain limited.\n\nObjective: To compare two delivery modalities of PLLA (injectable versus mono-thread) and evaluate their effects on dermal remodeling, clinical outcomes, and safety in atrophic acne scars.\n\nMethods: This prospective split-face study included 24 patients with atrophic acne scars. The right facial side was treated with a single session of PLLA mono-threads, while the left side received two sessions of injectable PLLA at 6-week intervals. Clinical outcomes were assessed using Goodman and Baron's qualitative and quantitative grading systems over a 3-month follow-up period.",[212],"Atrophic Acne Scarring","2026-04-03",{"date":215,"type":33},"2026-04-13",{"date":217,"type":33},"2024-03-15",{"date":219,"type":22},"2027-03-15",{"name":39,"class":40},{"id":222,"slug":223,"hasResults":12,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":49,"enrollmentInfo":228,"targetDuration":4,"studyType":229,"phases":4,"briefSummary":230,"conditions":231,"keywords":233,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":239,"leadSponsor":241,"locationsCount":4},"100625518","comparison-between-two-drugs-in-sedation-of-upper-gi-endoscopy-100625518","NCT07423676","Comparison Between Two Drugs in Sedation of Upper GI Endoscopy","Ketamine - Dexmedetomidine(Ketodex) Versus Propofol -Midazolam for Sedation in Patients Undergoing Upper Gastrointestinal Endoscopy","Inclusion Criteria\n\n* Patient acceptance\n* Adults aged 21-60 years.\n* Both sexes\n* BMI\\\u003C35 kg\u002Fm2\n* ASA physical status :I\\& II\n* Patients Undergoing Gastrointestinal endoscopy\n* Duration \\\u003C30mintues\n\nExclusion Criteria:\n\n* • Known allergy to any of the study drugs\n\n  * Unstable Cardiovascular disease\n  * Moderate to severe respiratory diseases",{"count":208,"type":22},"OBSERVATIONAL","The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs\n\nSecondary outcome :\n\n* Recovery time :is the time to reach score 2 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .\n* Hemodynamics (MAP,HR) \\& oxygen saturation\n* Drug side effects (nausea,vomitting,agitation)\n* Endoscopist satisfaction",[232],"Sedation During GI Endoscopy",[234],"Sedation","2026-02-14",{"date":237,"type":33},"2026-02-20",{"date":91,"type":22},{"date":240,"type":22},"2026-05-02",{"name":39,"class":40},{"id":243,"slug":244,"hasResults":12,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":12,"sex":17,"minAge":249,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":23,"phases":252,"briefSummary":253,"conditions":254,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":67},"100625105","comparison-between-combined-biceps-femoris-short-head-block-and-adductor-canal-block-versus-genicular-nerve-block-100625105","NCT07418307","Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block","Enhanced Analgesia in Elderly After Total Knee Arthroplasty Using Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block","Inclusion Criteria:\n\n* patient acceptance\n* Physical status: ASA I, II and Ⅲ.\n* Body mass index (BMI): 18.5 - 35 kg\u002Fm2.\n* Type of operations: total knee arthroplasty.\n\nExclusion Criteria:\n\n* Known hypersensitivity to dexamethasone or bupivacaine.\n* Coagulation disorders or taking drugs affect surgical hemostasis.\n* Patients with pre-existing neurological deficits.\n* Uncooperative patient or with altered mental status.\n* Patient with advanced cardiovascular or respiratory diseases or uncontrolled diabetes","65 Years",{"count":251,"type":22},50,[25],"The purpose of this study is to compare the analgesic outcomes (time to first analgesic request, total amount of analgesic consumption, and pain scores) following total knee arthroplasty by either combined biceps femoris short head block and adductor canal block or genicular nerve block in elderly patients.",[255],"Knee Arthroplasty, Total","2026-02-11",{"date":258,"type":33},"2026-02-18",{"date":260,"type":22},"2026-02-15",{"date":262,"type":22},"2026-11-15",{"name":39,"class":40},{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":12,"sex":17,"minAge":271,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":23,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":67},"100541263","combined-microneedling-with-either-1-lactic-acid-solution-or-vitamin-d3-or-triamcinolone-acetonide-in-the-treatment-of-alopecia-areata-100541263","NCT06327581","Combined Microneedling With Either 1% Lactic Acid Solution or Vitamin D3 or Triamcinolone Acetonide in The Treatment of Alopecia Areata","Comparative Study of Combined Microneedling With Either 1% Lactic Acid Solution or Vitamin D3 or Triamcinolone Acetonide in The Treatment of Alopecia Areata","Inclusion Criteria:\n\n* · Age ≥ 16 years old with localized patchy AA (up to 6 cm in diameter).\n\n  * Patients of both sexes\n  * Willing to participate in the study and to sign an informed consent.\n\nExclusion Criteria:\n\n* · Patients who received systemic or topical treatment for AA in the last 3 months prior to the start of the study\n\n  * Patients with Alopecia totalis, universalis, ophiasis, or sisaipho\n  * Pregnant or lactating females\n  * Patients who had bleeding or coagulation disorders\n  * Immunocompromised patients\n  * Patients with known history of hypersensitivity to vit D\n  * Patients taking vitamin D supplements in the last 6 months.","16 Years",{"count":273,"type":22},88,[25],"Alopecia areata (AA) is an immunologically mediated disease characterized by non-scarring hair loss (Madni and Shapiro, 2000). AA is presented by rapid and complete hair loss in one or more round or oval patches, usually on the scalp, beard area, eyebrows, eyelashes, and less commonly, on other hairy areas of the body (Berker et al., 2010 and James et al., 2011) Alopecia areata is a T-cell-mediated autoimmune disease. There is a complicated interplay between loss of immune privilege in the hair follicle, autoimmune-mediated hair follicle damage, and activation of inflammatory pathways that have been argued to explain the development of this disorder, but the exact pathophysiology of AA remains unknown. Hair follicles are infiltrated by autoreactive CD8 and CD4 T lymphocytes, which attack hair follicle-derived autoantigens while sparing the stem compartment (Rajabi et al., 2018).\n\nAlopecia areata can be treated with topical and\u002For intralesional corticosteroids, which are the treatment of choice. Anthralin, minoxidil, coal tar, and topical immunotherapy are examples of other topical treatments. Systemic immunosuppressants such as cyclosporine, systemic steroids, Janus kinase inhibitors, and methotrexate may be considered in severe resistant cases (lee and lee, 2017).\n\nIntralesional triamcinolone acetonide is preferred in cases of AA , as it is well known as anti-inflammatory and interferes with local immunity of the skin, which helps in the recovery of the disease, but if used in wrong technique or given in a high dose, it might cause all the side effects of corticosteroid, especially skin atrophy (Berker et al., 2010).\n\nLactic acid is a member of alpha-hydroxy acids. It has been used in the treatment of many skin diseases, like AA and vitiligo. Lactic acid stimulates spontaneous secretion of vascular endothelial growth factor (VEGF) by human reconstructed epidermis. VEGF is an angiogenic cytokine involved in angiogenesis and wound healing and stimulates the growth of hair follicles resulting in recovery of AA. Other studies suggest that lactic acid may act through its irritant effect (Al-Tammimy, 2005).\n\nVitamin D interacts with the innate and adaptive immune systems in a variety of ways, the majority of which contribute to its downregulation (Nancy and Yehuda, 2009). It has a powerful effect on T and B lymphocytes, influencing their activation responses (Arnson et al., 2007).\n\nAll cells of the immune system express 1,25-dihydroxyvitamin D3 receptors (VDRs) and are therefore vulnerable to calcitriol-mediated modulation. Vitamin D3 has the ability to influence the migration and maturation of different dendritic cell subtypes and their production of chemokines and cytokines, giving them an immunoregulatory and tolerogenic role (Illescas-Montes et al., 2019) It has been shown that VDRs are highly expressed in the keratinocytes of human hair follicles and the absence of their expression is associated with reduced hair follicle growth and epidermal differentiation. Reduced VDR expression in the hair follicles of affected areas has also been observed in studies of AA patients' scalp (Çerman et al., 2015).\n\nMicroneedling (MN) is a technique that comprises puncturing the skin repeatedly with sterile microneedles (Iriarte et al., 2017). It promotes hair regeneration by triggering stem cells in the hair bulge, which results in the generation of growth factors. It also improves blood circulation to the hair follicles and influences the local immune cells (Chandrashekar et al., 2014). Moreover, combining MN with applied topical drugs facilitates their absorption through the microchannels created within the epidermis (Fertig et al., 2018).",[277],"Alopecia Areata","2026-01-23",{"date":280,"type":33},"2026-01-26",{"date":282,"type":33},"2023-12-15",{"date":284,"type":22},"2026-12-30",{"name":39,"class":40},{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":17,"minAge":102,"maxAge":249,"enrollmentInfo":293,"targetDuration":4,"studyType":23,"phases":295,"briefSummary":296,"conditions":297,"keywords":299,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":311,"locationsCount":4},"100620574","dual-approach-external-oblique-fascial-plane-block-versus-erector-spinae-plane-block-for-post-operative-analgesia-in-percutaneous-nephrolithotomy-100620574","NCT07359391","Dual Approach External Oblique Fascial Plane Block Versus Erector Spinae Plane Block for Post Operative Analgesia in Percutaneous Nephrolithotomy","BLOCK-PCNL","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I or II\n\nBody mass index (BMI) between 18 and 35 kg\u002Fm²\n\nScheduled for unilateral percutaneous nephrolithotomy (PCNL)\n\nAbility to understand the study protocol and provide written informed conse\n\nExclusion Criteria:Refusal to participate\n\nKnown allergy or hypersensitivity to local anesthetics\n\nInfection at the site of block injection\n\nCoagulopathy or bleeding disorders\n\nChronic pain syndrome or long-term opioid use\n\nSevere hepatic, renal, or cardiac disease\n\n\\-",{"count":294,"type":22},90,[25],"Here is a \\*\\*patient-friendly, ClinicalTrials.gov-compliant Brief Summary\\*\\* written in \\*\\*plain language\\*\\*, avoiding technical jargon as much as possible while remaining accurate.\n\nYou can \\*\\*copy-paste this directly\\*\\* into the \\*\\*Brief Summary\\*\\* field.\n\n* \\*\\*Brief Summary\\*\\*\n\nPercutaneous nephrolithotomy (PCNL) is a common surgical procedure used to remove large kidney stones. Patients often experience moderate to severe pain after this surgery due to the surgical incision and irritation of the kidney and surrounding tissues. Effective pain control after PCNL is important to improve patient comfort, reduce the need for opioid medications, and enhance recovery.\n\nSeveral regional anesthesia techniques have been developed to reduce postoperative pain. Two of these techniques are the dual-approach external oblique fascial plane block and the erector spinae plane block. Both techniques involve injecting a local anesthetic near specific muscle planes using ultrasound guidance to reduce pain signals from the surgical area. However, it is not yet clear which of these two techniques provides better pain relief after PCNL.\n\nThis study aims to compare the effectiveness of the dual-approach external oblique fascial plane block and the erector spinae plane block in controlling pain after PCNL surgery. Adult patients scheduled for PCNL will be randomly assigned to receive one of the two nerve block techniques or standard general anesthesia alone. Pain levels, additional pain medication requirements, patient satisfaction, and any block-related complications will be assessed during the first 24 hours after surgery.\n\nThe results of this study may help determine the most effective regional anesthesia technique for improving postoperative pain management in patients undergoing PCNL.",[298],"Kidney Stones",[300,301,302,303,304],"Percutaneous Nephrolithotomy","Postoperative Analgesia","Dual Approach External Oblique Fascial Plane Block","Erector Spinae Plane Block","Pain Management","2026-01-14",{"date":307,"type":33},"2026-01-22",{"date":309,"type":22},"2026-01-12",{"date":65,"type":22},{"name":39,"class":40},{"id":313,"slug":314,"hasResults":12,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":318,"eligibilityCriteria":319,"healthyVolunteers":206,"sex":320,"minAge":48,"maxAge":75,"enrollmentInfo":321,"targetDuration":4,"studyType":23,"phases":323,"briefSummary":324,"conditions":325,"keywords":328,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":67},"100620587","lidocaine-vs-magnesium-sulfate-for-hemodynamic-stability-during-emergence-in-infertility-related-laparoscopic-surgery-100620587","NCT07359560","Lidocaine vs Magnesium Sulfate for Hemodynamic Stability During Emergence in Infertility-Related Laparoscopic Surgery\"","Intravenous Lidocaine Versus Magnesium Sulfate for Hemodynamic Stability During Emergence From General Anesthesia in Infertility-related Laparoscopic Gynecologic Surgeries","LidoMagGyna","Inclusion Criteria:\n\nFemale patients aged 21 to 40 years\n\nBody mass index (BMI) between 18.5 and 29 kg\u002Fm²\n\nAmerican Society of Anesthesiologists (ASA) physical status I or II\n\nScheduled for elective infertility-related laparoscopic gynecologic surgery (e.g., diagnostic laparoscopy, ovarian cystectomy, adhesiolysis) under general anesthesia\n\nExpected duration of anesthesia less than 2 hours\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nKnown allergy or contraindication to lidocaine or magnesium sulfate\n\nHistory of significant cardiac, renal, or hepatic disease\n\nChronic use of analgesics or history of drug dependence\n\nHistory of myasthenia gravis\n\nPregnancy or positive serum β-hCG test\n\n\\-","FEMALE",{"count":322,"type":22},69,[25],"This study is being conducted to compare two medications, intravenous lidocaine and intravenous magnesium sulfate, and their ability to keep blood pressure and heart rate stable during the period of waking up from general anesthesia in infertility-related laparoscopic gynecologic surgeries.\n\nLaparoscopic gynecologic procedures can cause changes in heart rate and blood pressure, especially during emergence from anesthesia, and these changes may affect patient safety.\n\nIn this randomized, double-blind clinical trial, women scheduled for elective infertility-related laparoscopic surgery will be assigned to one of three groups: lidocaine, magnesium sulfate, or a control group. The study will evaluate mean arterial pressure (primary outcome), heart rate, pain scores, sedation level, nausea and vomiting, and any side effects during and after surgery.\n\nThe goal is to determine which medication provides better hemodynamic stability and improves recovery in the early postoperative period.",[326,327],"Infertility Female","Hemodynamic Instability",[329,330,331,332],"lidocaine magnisium","hemodynamic instability","infertility female","laparoscopic surgery","2026-01-13",{"date":307,"type":33},{"date":336,"type":22},"2026-01-02",{"date":338,"type":22},"2026-07-02",{"name":39,"class":40},{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":17,"minAge":347,"maxAge":348,"enrollmentInfo":349,"targetDuration":4,"studyType":23,"phases":351,"briefSummary":352,"conditions":353,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":363},"100616755","impact-of-cooled-versus-thermal-radiofrequency-denervation-in-management-of-chronic-lumber-facet-joint-pain-100616755","NCT07309731","Impact OF Cooled Versus Thermal Radiofrequency Denervation In Management Of Chronic Lumber Facet Joint Pain","Impact OF Cooled Versus Thermal Radiofrequency Denervation In Management Of Chronic Lumber Facet Joint Pain.Prospective Study.","Inclusion Criteria:\n\n* Patient's acceptance .\n* Both sexes (male and female).\n* Age between 30 and 70 years .\n* Physical status; ASA I , II. (American society of anesthesiologist)\n* BMI; 22-30 Kg\u002Fm2.\n* Presence of\n\n  1. Chronic Lumbar Facet Joint Pain (numerical rating scale (NRS) ≥ 6) lasting for 3 months or more without any response to noninvasive conservative treatment methods like NSAIDs and gabapentin therapy for pain control, or physiotherapy,\n  2. Patients have two to three levels of bilateral facet arthropathy with normal motor power of lower extremities\n  3. Local paraspinal tenderness with increased pain on hyperextension, rotation, or lateral bending of the lower lumbar spine.\n* More than or equal to 50% temporary pain relief following an ultrasound guided diagnostic medial branch block with local anesthetic corticosteroid injection.\n\nExclusion Criteria:\n\n* Those with spondylolisthesis or disc herniation or internal disc disruption (IDD).\n* Previous spinal surgery at the level to be treated , Spinal canal stenosis or spinal instability.\n* Patient with previous radiofrequency ablation.\n* Patients having radicular pain, neurogenic claudication, or neurological deficits.\n* Coagulopathy, bleeding disorders .\n* Allergy to medications or contrast to be used .\n* Rheumatic disorders.\n* Systemic infections, or local infections in the field of intervention .\n* Any uncontrolled medical or psychiatric condition .\n* Pregnancy, lactating women .","30 Years","70 Years",{"count":350,"type":22},100,[25],"Chronic lumber facet joint pain is defined according to international association of study of pain (IASP)as multifactorial phenomenon of pain that persist more than 3 months after an injury and \u002For beyond the usual course of an acute lumber facet pain or a reasonable time for a comparable injury to heal .\n\nlumber facet joint degeneration (LRFJ) is the 1st source of chronic low back pain with an incidence of 15% t o 45 % among patients with low back pain . the spinal facet joint has an abundant nerve supply ; therefore, pain can be caused by arthritic change, degenerative change, inflammation, and injury .\n\nDegeneration of all LFJs (lumbar facet joints) was diagnosed using magnetic resonance image (MRI) , the most sensitive and diagnostic tool. Thus, hypertrophy, degeneration, and the accumulation of fluid within the joints are signs of LFJ degeneration it was found in all treated LFJs .\n\nfacet joint pain management can be achieved using medical therapy or facet joint therapeutic interventions, ultrasound guided injection,or fluoroscopically guided facet joint injection (FJI) , medial branch block (MBB) , or radiofrequency ablation .\n\nRadiofrequency is a minimally invasive procedure and is operated under light\n\nintravenous sedation or local anesthesia when necessary. Radiofrequency\n\nenergy is delivered to the target nerves through an insulated needle , and this\n\nenergy heats and denatures the nerve for the purpose of pain relief . The\n\nradiofrequency techniques include, thermal, and cooled radiofrequency .\n\nthermal radiofrequency (TRFA) uses more energy and higher temperature compared\n\nwith cooled radiofrequency , cooled radiofrequency ablation (CRFA) is a\n\nnewer technique, and may have some theoretical advantages over traditional\n\nradiofrequency whereas , cooled radiofrequency adopts internally probes to\n\nincrease lesion size , and it can increase the chance of complete denervation .\n\nbased on heat neurotomy (60°C (celsius) vs. 80°C in TRFA) with the resulting ablative area twice as long and extending distally from the tip of the electrode.",[354],"Lumber Facet Joint Pain(Lower Back Pain ) Relief by Cooled Radiofrequency or Thermal Radiofrequency Denervation","2026-01-01",{"date":357,"type":33},"2026-01-06",{"date":359,"type":22},"2026-01-15",{"date":361,"type":22},"2026-10-01",{"name":39,"class":40},2,{"id":365,"slug":366,"hasResults":12,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":4,"eligibilityCriteria":370,"healthyVolunteers":206,"sex":320,"minAge":48,"maxAge":249,"enrollmentInfo":371,"targetDuration":4,"studyType":23,"phases":372,"briefSummary":374,"conditions":375,"keywords":377,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":4},"100618342","phase-3-effect-of-intravenous-dexmedetomidine-and-ketamine-on-post-operative-analgesia-100618342","NCT07330375","Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia","The Effect of Intravenous Combination Dexmedetomidine - Ketamine Versus Dexmedetomidine on Post-Operative Analgesia in Patients Undergoing Vaginal Hysterectomy Under Spinal Anesthesia","Inclusion Criteria:\n\n* Patients who will accept written informed consent.\n* Age: 21-65 years old.\n* Sex: female.\n* BMI: \\\u003C35 kg\u002Fm2\n* Physical status: American Society of Anesthesiology (ASA) of Grade I-II\n* Type of operation: vaginal hysterectomy under spinal anesthesia.\n\nExclusion Criteria:\n\n* Uncooperative patients\n* Any contraindication for spinal anesthesia e.g. coagulopathy, infection at site of block, and hypersensitivity to any drug used in this study.\n* Patients who are known to be drug dependent.",{"count":251,"type":22},[373],"PHASE3","In this study the participants aim to Compare The Effect of Intravenous Combination Dexmedetomidine \\_ Ketamine versus Dexmedetomidine on Post-Operative Analgesia In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia regarding efficacy, hamemodynamic stability, outcomes and adverse effects.",[301,376],"Postoperative Pain Management",[378,379,380,381],"spinal anesthesia","vaginal hysterectomy","dexmedetomidine","ketamine","2025-12-28",{"date":384,"type":33},"2026-01-09",{"date":386,"type":22},"2026-01-20",{"date":388,"type":22},"2026-06-30",{"name":39,"class":40},{"id":391,"slug":392,"hasResults":12,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":17,"minAge":249,"maxAge":397,"enrollmentInfo":398,"targetDuration":4,"studyType":23,"phases":400,"briefSummary":401,"conditions":402,"keywords":404,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":409,"leadSponsor":411,"locationsCount":67},"100616436","comparative-study-of-subcoracoid-tunnel-block-versus-costoclavicular-block-100616436","NCT07305584","Comparative Study of Subcoracoid Tunnel Block Versus Costoclavicular Block","Regional Anesthesia for Elderly Patients Undergoing Distal Upper Limb Surgeries: A Randomized Comparative Study of Subcoracoid Tunnel Block Versus Costoclavicular Block","Inclusion Criteria:\n\n* Patients acceptance to share in the study.\n* Patients with ASA physical status I-II.\n* Patients with a body mass index (BMI): of 18.5-30 kg\u002Fm2.\n* Patients undergoing distal upper limb surgeries not more than 2 hours.\n\nExclusion Criteria:\n\n* Patients with a history of allergic reactions or contraindications to local anesthetics.\n* Patients with significant comorbidities (e.g., severe cardiovascular, neurological, or musculoskeletal disorders).\n* Patients with respiratory insufficiency.\n* Patients with coagulation disorders or taking drugs affecting surgical hemostasis.\n* Patients with pre-existing neurological deficits","85 Years",{"count":399,"type":22},70,[25],"The purpose of this study is to compare the analgesic outcomes (time to first analgesic request, total amount of analgesic consumption, and pain scores) following the ultrasound-guided subcoracoid tunnel block or costoclavicular block for elderly patients undergoing distal upper limb surgeries.",[403],"Distal Upper Limb Surgeries",[405],"distal Upper Limb Surgeries Subcoracoid Tunnel Block Costoclavicular Block",{"date":407,"type":33},"2025-12-30",{"date":355,"type":22},{"date":410,"type":22},"2026-04-01",{"name":39,"class":40},{"id":413,"slug":414,"hasResults":12,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":4,"eligibilityCriteria":418,"healthyVolunteers":206,"sex":17,"minAge":48,"maxAge":419,"enrollmentInfo":420,"targetDuration":4,"studyType":23,"phases":422,"briefSummary":423,"conditions":424,"keywords":426,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":67},"100614211","perioperative-opioid-sparing-effect-of-retrosuperior-costotransverse-ligament-block-versus-erector-spinae-block-in-laparoscopic-cholecystectomy-100614211","NCT07276646","Perioperative Opioid-sparing Effect of Retrosuperior Costotransverse Ligament Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy","Perioperative Opioid-sparing Effect of Retrosuperior Costotransverse Ligament Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy: A Randomized Clinical Trial.","Inclusion Criteria:\n\n1. patient acceptance\n2. Age: 21-64 years old.\n3. Sex: both sexes.\n4. Physical status: ASA I \\& II.\n5. Body mass index (BMI): 18.5 - 30 kg\u002Fm2.\n6. Type of operations: elective laparoscopic cholecystectomy.\n7. Duration of surgery not more than 2 hours.\n\nExclusion Criteria:\n\n1. Known hypersensitivity to lidocaine or bupivacaine.\n2. Patients with respiratory insufficiency.\n3. Coagulation disorders or taking drugs affect surgical hemostasis.\n\n7\\. Patients with pre-existing neurological deficits. 8. Uncooperative patient or with altered mental status. 9. Patient with advanced cardiovascular or respiratory diseases","64 Years",{"count":421,"type":22},80,[25],"This study aims to compare the analgesic effect of retro superior costotransverse ligament space block vs erector spinae plane block to Achieve high-quality perioperative opioid-sparing effect and postoperative analgesia after laparoscopic cholecystectomy with optimum hemodynamic stability and high patient and surgeon satisfaction",[425],"Perioperative Analgesia",[427,428,429],"retrosuperior costotransverse ligament block","erector spinae block","laparoscopic cholecystectomy","2025-12-11",{"date":432,"type":33},"2025-12-12",{"date":434,"type":33},"2025-12-10",{"date":436,"type":22},"2026-07-10",{"name":39,"class":40},{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":206,"sex":17,"minAge":48,"maxAge":249,"enrollmentInfo":445,"targetDuration":4,"studyType":23,"phases":447,"briefSummary":448,"conditions":449,"keywords":452,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":456,"startDateStruct":457,"completionDateStruct":458,"leadSponsor":459,"locationsCount":67},"100614119","comparative-study-between-ultrasound-guided-regional-anesthesia-for-awake-tympanoplasty-surgery-vs-general-anesthesia-100614119","NCT07275450","Comparative Study Between Ultrasound Guided Regional Anesthesia for Awake Tympanoplasty Surgery vs General Anesthesia","Safety and Efficacy of Regional Anesthesia for Awake Tympanoplasty Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients acceptance\n2. Age: 21-65 years old\n3. Sex: both sex (males or females).\n4. Physical status: American Society Anesthesiologist (ASA) І and II.\n5. Patients will be scheduled for elective unilateral tympanoplasty.\n\nExclusion Criteria:\n\n1. Contraindication of regional anesthesia: Coagulopathy or use of anticoagulant therapy -local infection at the site of injection- known allergy to local anesthetics (bupivacaine).\n2. Neurological disorders affecting sensation in the head and neck.\n3. Psychiatric illness, severe anxiety, or inability to cooperate during awake surgery.\n4. History of previous neck or parotid surgery affecting nerve anatomy.\n5. BMI \\> 35 (if it may interfere with ultrasound visualization or landmark identification).\n6. Pregnancy.\n7. Advanced cardiovascular, respiratory, hepatic and renal diseases",{"count":446,"type":22},128,[25],"The aim of this study to evaluate efficacy of ultrasound guided regional anesthesia in performing awake tympanoplasty surgery versus traditional general anesthesia",[450,451],"Ultrasound Guided Nerve Block","Anesthesia , Analgesia",[453,454,455],"Ultrasound guided regional anesthesia","General anesthesia","Awake tympanoplasty",{"date":430,"type":33},{"date":434,"type":33},{"date":361,"type":22},{"name":39,"class":40},{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":17,"minAge":102,"maxAge":4,"enrollmentInfo":467,"targetDuration":4,"studyType":23,"phases":469,"briefSummary":470,"conditions":471,"keywords":474,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":479,"completionDateStruct":481,"leadSponsor":483,"locationsCount":67},"100611301","outcomes-of-using-fans-with-furs-in-ttt-of-lower-calyceal-stones-100611301","NCT07238803","Outcomes of Using FANS With FURS in TTT of Lower Calyceal Stones.","Outcomes of Using Flexible and Navigable Suction Sheath With Flexible Ureteroscopy in Treatment of Lower Calyceal Stones: A Prospective Study","Inclusion Criteria:\n\n1. Adult patients ≥ 18 years old.\n2. Patients with lower calyceal stones scheduled for FURS.\n\nExclusion Criteria:\n\n1. patients with active urinary tract infections.\n2. Patients with renal and ureteric anomalies.\n3. patients with coagulopathy\n4. patients who are refusing to participate.",{"count":468,"type":22},33,[25],"The aim of this study is to evaluate and assess the outcomes of flexible ureteroscopy (FURS) with flexible and navigable suction UAS (FANS) in the treatment of lower calyceal stones.",[472,473],"Kidney Stone","Kidney Calculi",[475],"Flexible Ureteroscopy","2025-11-18",{"date":478,"type":33},"2025-11-20",{"date":480,"type":33},"2024-12-01",{"date":482,"type":22},"2026-02-01",{"name":39,"class":40},{"id":485,"slug":486,"hasResults":12,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":4,"eligibilityCriteria":490,"healthyVolunteers":206,"sex":17,"minAge":491,"maxAge":249,"enrollmentInfo":492,"targetDuration":4,"studyType":23,"phases":493,"briefSummary":494,"conditions":495,"keywords":496,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":67},"100611084","shoulder-anterior-capsular-block-and-intraarticular-steroid-injection-versus-intraarticular-steroid-injection-for-enhancing-pain-relief-in-adhesive-capsulitis-100611084","NCT07235982","Shoulder Anterior Capsular Block and Intraarticular Steroid Injection Versus Intraarticular Steroid Injection for Enhancing Pain Relief in Adhesive Capsulitis","Comparative Study Between Shoulder Anterior Capsular Block Plus Steroid Injection Versus Steroid Injection Alone for Pain Management in Adhesive Capsulitis: A Randomized Trial","Inclusion Criteria:\n\n* Patients acceptance\n* Age: 41-65 years old\n* Sex: both sex (males or females).\n* Physical status: American Society of Anesthesiologist (ASA) І, II.\n* Patients attend orthopedic or pain clinic with complaint of shoulder pain and stiffness. These patients received conservative management of pain with no relief of symptoms for at least 2 weeks.\n\nExclusion Criteria:\n\n* Shoulder pain due to secondary causes, e.g. acute trauma, fractures, bony deformity, glenohumeral joint pathology, acromioclavicular joint pathology and rotator cuff disorder.\n\n  * Patient with any contraindications of regional blocks (as coagulopathy or local infection at injection site)\n  * Patients with known history of allergy to the study drugs (bupivacaine and methylprednisolone).\n  * Advanced hepatic, renal, cardiovascular, neurologic and respiratory diseases, uncontrolled diabetes mellitus and thyroid.\n  * History of neuropathy in the involved limb or previous revision surgery.","41 Years",{"count":251,"type":22},[25],"Improving pain in the patients with adhesive capsulitis by comparing the effect of combined shoulder anterior capsular block and intraarticular steroid injection versus intraarticular steroid injection.",[28],[497,498,499],"shoulder anterior capsular block","intraarticular steroid injection","adhesive capsulitis","2025-11-17",{"date":502,"type":33},"2025-11-19",{"date":504,"type":33},"2025-10-01",{"date":506,"type":22},"2026-06-01",{"name":39,"class":40},{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":17,"minAge":48,"maxAge":49,"enrollmentInfo":515,"targetDuration":4,"studyType":23,"phases":517,"briefSummary":518,"conditions":519,"keywords":521,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":531,"locationsCount":67},"100522490","multifidus-cervicis-and-inter-semispinal-plane-blocks-in-analgesia-after-cervical-spine-surgery-100522490","NCT06083298","Multifidus Cervicis and Inter-Semispinal Plane Blocks in Analgesia After Cervical Spine Surgery","Comparison Between Multifidus Cervicis and Inter-semispinal Plane Blocks in Analgesia After Cervical Spine Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patient acceptance.\n\n  * Age 21-60 years old.\n  * BMI ≤ 30 kg\u002Fm2\n  * ASA I - II.\n  * Elective posterior cervical spine surgery under general anesthesia.\n\nExclusion Criteria:\n\n* History of allergy to the LA agents used in this study\n\n  * Skin lesion at the needle insertion site,\n  * Those with bleeding disorders, sepsis, liver disease, and psychiatric disorders\n  * History of chronic pain and taking analgesics\n  * History of cognitive dysfunction or mental illness",{"count":516,"type":22},105,[25],"Major spine surgery with multilevel instrumentation is followed by a large amount of opioid consumption, significant pain, and difficult mobilization Pain is one of the main factors limiting ambulation, increasing the risk of thromboembolism by immobility, and causing metabolic changes that affect other systems. Therefore, individualized pain management with the use of appropriate analgesic techniques is of paramount importance. Moreover, early intervention in rehabilitation aiming at a better postoperative recovery may reduce the length of hospital stay and return to daily activity. Effective pain management is one of the crucial components in enhanced recovery after surgery (ERAS).\n\nNumerous regional anesthetic techniques have been used to provide analgesia following cervical spine surgery, including patient-controlled epidural analgesia, cervical paravertebral block, cervical plexus block, cervical erector spinae plane blocks, and local infiltration analgesia, however, each of these techniques has specific limitations that prevent them from being the analgesic technique of choice for such surgeries.\n\nUp to the author's knowledge, there is no study done to compare multifidus cervicis plane block versus inter-semispinal plane block in a randomized controlled clinical trial as preemptive analgesia in patients undergoing cervical spine surgery.",[520],"Cervical Spine Surgery",[522,523,524],"Multifidus Cervicis plane block","Inter-Semispinal Plane Block","analgesia","2025-07-14",{"date":527,"type":33},"2025-07-17",{"date":529,"type":33},"2023-10-20",{"date":410,"type":22},{"name":39,"class":40},{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":4,"eligibilityCriteria":538,"healthyVolunteers":12,"sex":17,"minAge":49,"maxAge":4,"enrollmentInfo":539,"targetDuration":4,"studyType":23,"phases":541,"briefSummary":542,"conditions":543,"keywords":545,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":550,"startDateStruct":551,"completionDateStruct":553,"leadSponsor":554,"locationsCount":67},"100490013","circum-psoas-blocks-versus-combined-lumbar-and-sacral-plexus-blocks-in-hip-fracture-surgery-100490013","NCT05660603","Circum-Psoas Blocks Versus Combined Lumbar and Sacral Plexus Blocks in Hip Fracture Surgery","Circum-Psoas Blocks Versus Combined Lumbar and Sacral Plexus Blocks for Sensory Level and Postoperative Analgesia Obtained in Hip Fracture Surgery","Inclusion Criteria:\n\n* Patient acceptance.\n* BMI ≤ 30 kg\u002Fm2\n* ASA I-III.\n* First unilateral surgery for hip fracture including femoral neck, intertrochanteric or subtrochanteric fracture.\n* Patient with planned hip fracture surgery within 24-72 hours under general anesthesia.\n\nExclusion Criteria:\n\n* Multiple trauma, multiple fractures, or pathological fractures\n* Prosthetic fracture or usage of bone-cement fixation in the surgery.\n* Scheduled for bilateral hip fracture surgery.\n* Pre-existing neurological deficit in the lower extremity\n* Contraindication for peripheral nerve block (infection at the site of needle insertion, coagulopathy, allergy to local anesthetics used)\n* History of chronic pain and taking analgesics\n* History of cognitive dysfunction or mental illness",{"count":540,"type":22},63,[25],"Hip fracture (HF) is one of the major worldwide problems that constitute a significant mortality rate, ranging from 14- 36% in the first year after injury, and is associated with profound temporary and sometimes permanent impairment of independence and quality of life in the geriatric population. Surgical treatment is considered the best option for patients with hip fractures,s especially in the elderly, however, it is associated with moderate to severe postoperative pain.\n\nPain is one of the main factors limiting ambulation, increasing the risk of thromboembolism by immobility and causing metabolic changes that affect other systems. Therefore, individualized pain management with the use of appropriate analgesic techniques is of paramount importance. Moreover, early intervention of rehabilitation aiming at a better postoperative recovery may reduce the length of hospital stay and return to daily. Effective pain management is one of the crucial components in enhanced recovery after surgery (ERAS).\n\n• Numerous regional anesthetic techniques have been used to provide analgesia following hip fracture surgery, including intrathecal morphine, epidural analgesia, fascia iliaca block, lumber plexus block, and sacral plexus block, however, each of these techniques has specific limitations that prevent them from being the analgesic technique of choice for hip fracture surgery.\n\nTo our knowledge, there is no study done to compare circum-psoas block versus the combined lumbar and sacral plexus blocks as pre-emptive analgesia in patients undergoing hip fracture surgery under general anesthesia.",[544],"Hip Fractures",[546,547,548,549],"circum-psoas blocks","lumbar plexus block","sacral plexus block","hip fracture surgery",{"date":527,"type":33},{"date":552,"type":33},"2022-12-20",{"date":410,"type":22},{"name":39,"class":40},{"id":556,"slug":557,"hasResults":12,"nctId":558,"briefTitle":559,"officialTitle":560,"acronym":4,"eligibilityCriteria":561,"healthyVolunteers":12,"sex":17,"minAge":562,"maxAge":563,"enrollmentInfo":564,"targetDuration":4,"studyType":23,"phases":566,"briefSummary":567,"conditions":568,"keywords":570,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":67},"100482033","anterior-iliopsoas-muscle-space-block-versus-supra-iliac-anterior-quadratus-lumborum-block-in-total-hip-arthroplasty-100482033","NCT05556759","Anterior Iliopsoas Muscle Space Block Versus Supra-iliac Anterior Quadratus Lumborum Block in Total Hip Arthroplasty","Anterior Iliopsoas Muscle Space Block Versus Supra-Iliac Anterior Quadratus Lumborum Block for Analgesia in Total Hip Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patient acceptance.\n* Age 50-80 years old.\n* BMI ≤ 30 kg\u002Fm2\n* ASA I - III.\n* Elective total hip arthroplasty under general anesthesia.\n\nExclusion Criteria:\n\n* History of allergy to the LA agents used in this study\n* Skin lesion at the needle insertion site,\n* Those with bleeding disorders, sepsis, liver disease, and psychiatric disorders\n* Pre-existing neurological deficit in the lower extremity\n* History of chronic pain and taking analgesics\n* History of cognitive dysfunction or mental illness","50 Years","80 Years",{"count":565,"type":22},72,[25],"Approximately 1.66 million hip fractures happen in a year worldwide. About 95% of these fractures happen in individuals older than 60 years. Surgical treatment involving THA is considered the best option for patients with hip fractures and those with degenerative changes in the hip joint, especially in the elderly, however, it is associated with moderate to severe postoperative pain.\n\nPain is one of the main factors limiting ambulation, increasing the risk of thromboembolism by immobility, and causing metabolic changes that affect other systems. Therefore, individualized pain management with the use of appropriate analgesia techniques is of paramount importance. Moreover, early intervention of rehabilitation aiming at a better postoperative recovery may reduce the length of hospital stay and return to daily. Effective pain management is one of the crucial components of enhanced recovery after surgery (ERAS).\n\nNumerous regional anesthetic techniques have been used to provide analgesia following THA, including intrathecal morphine, epidural analgesia, fascia iliaca block, lumber plexus block, sacral plexus block, and local infiltration analgesia, however, each of these techniques has specific limitations that prevent them from being the analgesic technique of choice for THA.\n\nUp to investigators' knowledge, there is no study done to compare the supra-iliac approach to the anterior QL block versus the Anterior iliopsoas muscle space block as pre-emptive analgesia in patients undergoing THA under general anesthesia",[569],"Hip Arthropathy",[571,572,524,573],"Anterior iliopsoas muscle space block","suprailiac anterior quadratus lumborum block","hip arthroplasty",{"date":575,"type":33},"2025-07-15",{"date":577,"type":33},"2022-09-30",{"date":579,"type":22},"2025-11-01",{"name":39,"class":40},{"id":582,"slug":583,"hasResults":12,"nctId":584,"briefTitle":585,"officialTitle":586,"acronym":4,"eligibilityCriteria":587,"healthyVolunteers":206,"sex":17,"minAge":165,"maxAge":588,"enrollmentInfo":589,"targetDuration":4,"studyType":23,"phases":591,"briefSummary":592,"conditions":593,"keywords":595,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":603,"leadSponsor":605,"locationsCount":4},"100597338","effect-of-different-drugs-on-emergency-delirium-in-preschool-age-patient-100597338","NCT07057193","Effect of Different Drugs on Emergency Delirium in Preschool Age Patient","Effect of Dexmedetomidine, Ketamine or Midazolam on the Incidence and Severity of Emergence Delirium in Preschool-Aged Children Following Squint Surgeries Under Sevoflurane Anesthesia","Inclusion Criteria:\n\n* Parents or first degree relative acceptance. - Age: 3-5 years old. - Body weight: 5% -85% of BMI (kg \u002Fm2) of the same age and sex. - Sex: Both sexes. - Physical Status: Of class I and II according to American Society of Anesthesiologists (ASA) classification. - Type of surgery: Squint surgeries under sevoflurane anesthesia.\n\nExclusion Criteria:\n\n* \\- Children with score 3 (i.e. anxious and crying) according to the three-point anxiety scale (Kain et al. 2004). - Children with preexisting abnormal behavior, psychiatric disorders, developmental delay or central nervous system diseases (epilepsy). - Children with chronic use of sedative drugs. - Children with severe respira","5 Years",{"count":590,"type":22},92,[25],"Emergence delirium (ED) was first described by Eckenhoff and colleagues in the 1960s and is defined in pediatric anesthesia as 'dissociated state of consciousness in which child is irritable, uncompromising, uncooperative, incoherent, and inconsolably crying, moaning, and kicking or thrashing. The commonly reported incidence of postoperative ED in pediatric patients especially with the use of sevoflurane or desflurane was from 10% to 80% during their presence in the post-anesthesia care unit. This side effect of general anesthesia causes distressing for parents and staff and may cause parental dissatisfaction with their child's care. Children during postoperative ED have the risks of injuring themselves or their caregivers, disruption of surgical repair, operative site bleeding, removing Intravenous (iv) lines or drains and increasing pain. This behavior may require more nursing supervision, overloading nursing resources. Although postoperative ED episodes are of short duration, their prevention is essential. Children experiencing postoperative ED may exhibit new-onset maladaptive behavioral abnormalities in the postoperative period such as enuresis, night-time crying, and separation anxiety, up to 14 days post-surgery.\n\nThe risk factors to postoperative ED are patients' characters (preschool age and preexisting behavior), the surrounding environment as parental anxiety, type of anesthesia (volatile anesthetics) as sevoflurane or halothane and the type of surgery as tonsillectomy, adenoidectomy, and strabismus surgery which is one of the most commonly undertaken surgeries in pediatric patients. It may cause visual disturbance in the recovery phase, which can result. In order to diagnose ED, the presence of pain during recovery from general anesthesia must be ruled out because it leads to a change in behavior that resembles delirium. Fortunately, one of the advantages of using the Pediatric Anesthesia Emergence Delirium (PAED) scale is its ability to distinguish between the ED and the change in behavior resulting from pain, because it focuses on changes in awareness and knowledge that are not changed by pain. Prophylactic drugs against the occurrence of postoperative ED include the adjuvant use of α2 adrenoreceptor agonists such as dexmedetomidine, ketamine, midazolam, propofol, and fentanyl. The use of these drugs with them adverse effects should be weighed against the fact that postoperative ED is a self-limited disorder. Dexmedetomidine is a highly selective α2-adrenergic receptor agonist that is associated with sedative and analgesic sparing effects. It is commonly used for prevention of emergence delirium and agitation, perioperative sympatholysis, cardiovascular stabilization, and preservation of respiratory function. Ketamine is a dissociative anesthetic. Its mechanism of action is mainly via a noncompetitive antagonism of the N - methyl - D - aspartic acid (NMDA) receptor. It also targets other receptors, such as a - amino - 3 - hydroxy - 5 - methyl - 4 - isoxazolepropionic acid (AMPA) receptors, and has additional acts as an agonist of the sigma 1 receptor. It is commonly used for acute pain management, chronic pain management, prevention of ED, and postoperative nausea and vomiting. Midazolam is short acting benzodiazepine which is central nervous system depressant. It is commonly used for premedication during pediatric anesthesia, for prevention of emotional distress and ED due to its sedative and anxiolytic properties, additionally it used for reduction of the analgesic requirement and to prevent postoperative nausea and vomiting",[594],"Emergence Delirium, Anesthesia",[596,597,598],"emergency delirium","Dexmedetomidine","Midazolam","2025-07-10",{"date":601,"type":33},"2025-07-16",{"date":575,"type":22},{"date":604,"type":22},"2026-01-30",{"name":39,"class":40},""]