[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Zhuan Zhang\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":138},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,73,92,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100630090","venous-congestion-and-cognitive-dysfunction-after-cardiac-surgery-100630090",false,"NCT07483151","Venous Congestion And Cognitive Dysfunction After Cardiac Surgery","Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n1. Patients scheduled to undergo elective cardiac surgery via a midline thoracic incision;\n2. ≥18 years;\n3. A preoperative MMSE score\\>23, without consciousness or language barriers, capable of cooperating with neurological examinations, cognitive function tests, and other assessments of neurological function.\n\nExclusion Criteria:\n\n1. Contraindications for TEE;\n2. Emergency cardiac surgery;\n3. Major vascular surgery;\n4. Redo cardiac surgery;\n5. Severe infection requiring continuous antibiotic therapy;\n6. Severe preoperative heart failure with left ventricular ejection fraction \\\u003C 30%;\n7. A critical preoperative state (mechanical circulatory support, extracorporeal membrane oxygenation, current renal replacement therapy, mechanical ventilation, or cardiac arrest necessitating resuscitation);\n8. Multi-organ dysfunction;\n9. Known conditions that may interfere with the assessment or interpretation of hepatic vein, portal vein blood flow (such as liver cirrhosis or portal vein thrombosis) or the renal vein blood flow (such as urinary tract obstruction);\n10. Planned cardiac transplantation or ventricular assist device implantation;\n11. Pregnancy;\n12. Insufficient ultrasonographic imaging;\n13. Restarting CPB after first CPB cessation during surgery;\n14. Requirement for cardiac assist devices (ECMO, IABP, or ventricular assist device) after CPB intraoperatively;\n15. Neurological or psychiatric diagnoses that may affect cognitive performance or cognitive testing;\n16. Documented delirium before surgery","ALL","18 Years",{"count":19,"type":20},110,"ESTIMATED","OBSERVATIONAL","Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after surgery and anesthesia. Its primary clinical manifestations include a significant decline in cognitive abilities after surgery and anesthesia, encompassing memory, attention, coordination, orientation, language fluency, and executive function. POCD may persist for weeks or even years, affecting patient recovery, prolonging hospital stays, and potentially leading to additional physical and mental illnesses, increased mortality, and a significant burden on patients and their families. In cardiac surgery patients, the incidence of POCD ranges from 30% to 80% in the weeks following the procedure. The brain tissue is enclosed in a rigid anatomical structure; when there is an obstruction to venous return from the brain, intracranial pressure can increase, and blood supply to the brain tissue can decrease, leading to central nervous system dysfunction.\n\nSystemic venous congestion can occur when there is right heart dysfunction or excessive volume load. When right heart failure and\u002For volume overload occurs, changes in right atrial pressure are transmitted to the venous system of organs throughout the body, with dilatation of the inferior vena cava (IVC), obstruction of blood return from the hepatic, portal, and renal veins, and abnormal venous flow signals and altered ultrasound Doppler flow patterns.\n\nThe primary objective of this prospective cohort study is to explore if intraoperative systemic venous congestion is associated with POCD after cardiac surgery. This study will also investigate the relationship between intraoperative systemic venous congestion and postoperative complications, and the relationship between each separate venous congestion and POD after cardiac surgery.",[24],"Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery",[26,27,28],"Venous Congestion","Cardiac Surgery","Postoperative cognitive dysfunction (POCD)","RECRUITING","2026-03-15",{"date":32,"type":33},"2026-03-19","ACTUAL",{"date":35,"type":33},"2024-11-01",{"date":37,"type":20},"2026-10-31",{"name":39,"class":40},"Zhuan Zhang","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},"100617165","effect-of-esketamine-on-postoperative-sleep-in-postmenopausal-women-100617165","NCT07315074","Effect of Esketamine on Postoperative Sleep in Postmenopausal Women","Inclusion Criteria:\n\n1. American Society of Anesthesiologists (ASA) physical status I-III.\n2. Aged ≥ 45 years.\n3. Women with natural menopause (aged ≥ 45 years and postmenopause for more than 12 months without surgical or medical intervention) .\n4. Scheduled to undergo elective lower-limb fracture surgery with an expected duration of more than 60 min under general anesthesia.\n5. Body Mass Index (BMI) between 18 and 28 kg\u002Fm².\n\nExclusion Criteria:\n\n1. Presence of preoperative sleep-related disorders, such as obstructive sleep apnea or restless legs syndrome.\n2. History of drug or alcohol abuse or dependence.\n3. Known contraindications or allergies to esketamine or other anesthetic agents.\n4. Use of psychotropic medications or sex hormones within the past 3 months.\n5. Shift work or taking medications affecting melatonin.\n6. Severe comorbid conditions, including but not limited to uncontrolled hypertension, coronary artery disease, cardiac insufficiency, pulmonary hypertension, intracranial hypertension or elevated intraocular pressure, hyperthyroidism, severe hepatic or renal dysfunction.\n7. History of cerebral infarction, intracerebral hemorrhage, or residual central nervous system deficits.\n8. Impairments of language, hearing, vision, or cognitive function that would prevent completion of questionnaires or cooperation with sleep monitoring.\n9. Active oral pathologies.\n10. Transfer to ICU postoperatively.","FEMALE","45 Years",{"count":51,"type":20},164,"INTERVENTIONAL",[54],"NA","The prevalence of sleep disturbance among postmenopausal women has been reported to reach 51.6%. Epidemiological studies consistently show that the incidence of sleep disorders increases with age and menopausal transition. Compared with premenopausal women, postmenopausal women demonstrate reduced circadian rhythm stability and a higher prevalence of sleep disturbance. In this population, levels of melatonin, total sleep time, sleep latency, N3 stage sleep, and the circadian amplitude of alertness are all diminished. Sleep disturbance can adversely affect both the mental and physical health of women and significantly impair their social functioning. Poor sleep is associated with decreased cognitive performance and heightened emotional distress, contributing to diminished quality of life.\n\nCircadian rhythms are endogenous physiological and behavioral cycles that oscillate over approximately 24 hours, governing critical processes such as sleep-wake cycles, hormonal fluctuations (e.g., cortisol and melatonin). These rhythms are regulated by the suprachiasmatic nucleus (SCN). Disruptions in circadian rhythms have been associated with sleep disturbances.\n\nEsketamine is the S (+) enantiomer of ketamine and has a higher affinity for the NMDA receptor than the R-enantiomer. Previous studies have demonstrated that intraoperative administration of esketamine can improve postoperative sleep quality and reduce the incidence of postoperative sleep disturbances, through its antidepressant efficacy, anti-inflammatory properties, analgesic efficacy, neurocognitive and anxiolytic effects. However, few studies have investigated whether esketamine can regulate perioperative circadian rhythms and subsequently affect sleep, especially in postmenopausal women.\n\nThe objective of this multi-center, prospective, randomized controlled clinical trial is to investigate the effects of esketamine on postoperative sleep in postmenopausal women.",[57,58],"Circadian Rhythm","Postoperative Sleep Disturbance",[60,57,61,58,62],"Esketamine","Melatonin","Postmenopause","NOT_YET_RECRUITING","2026-03-13",{"date":66,"type":33},"2026-03-17",{"date":68,"type":20},"2026-03-01",{"date":70,"type":20},"2026-12-31",{"name":39,"class":40},2,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":91,"locationsCount":41},"100614868","venous-congestion-and-delirium-after-cardiac-surgery-100614868","NCT07285187","Venous Congestion And Delirium After Cardiac Surgery","Intraoperative Venous Congestion And Delirium After Cardiac Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n1. Patients scheduled to undergo elective cardiac surgery via a midline thoracic incision;\n2. ≥18 years;\n3. A preoperative MMSE score\\>23, without consciousness or language barriers, capable of cooperating with neurological examinations, cognitive function tests, and other assessments of neurological function.\n\nExclusion Criteria:\n\n1. Contraindications for TEE;\n2. Emergency cardiac surgery;\n3. Major vascular surgery;\n4. Redo cardiac surgery;\n5. Severe infection requiring continuous antibiotic therapy;\n6. Severe preoperative heart failure with left ventricular ejection fraction \\\u003C 30%;\n7. A critical preoperative state (mechanical circulatory support, extracorporeal membrane oxygenation, current renal replacement therapy, mechanical ventilation, or cardiac arrest necessitating resuscitation);\n8. Multi-organ dysfunction;\n9. Known conditions that may interfere with the assessment or interpretation of hepatic vein, portal vein blood flow (such as liver cirrhosis or portal vein thrombosis) or the renal vein blood flow (such as urinary tract obstruction);\n10. Planned cardiac transplantation or ventricular assist device implantation;\n11. Pregnancy;\n12. Insufficient ultrasonographic imaging;\n13. Restarting CPB after first CPB cessation during surgery;\n14. Requirement for cardiac assist devices (ECMO, IABP, or ventricular assist device) after CPB intraoperatively;\n15. Neurological or psychiatric diagnoses that may affect cognitive performance or cognitive testing;\n16. Documented delirium before surgery.",{"count":81,"type":20},120,"Postoperative delirium (POD) is an acute brain dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances, and is a common complication after cardiac surgery. The high incidence of up to 52% of POD in cardiac surgery patients lead to a range of adverse clinical outcomes.The brain tissue is enclosed in a rigid anatomical structure; when there is an obstruction to venous return from the brain, intracranial pressure can increase, and blood supply to the brain tissue can decrease, leading to central nervous system dysfunction.\n\nSystemic venous congestion can occur when there is right heart dysfunction or excessive volume load. When right heart failure and\u002For volume overload occurs, changes in right atrial pressure are transmitted to the venous system of organs throughout the body, with dilatation of the inferior vena cava (IVC), obstruction of blood return from the hepatic, portal, and renal veins, and abnormal venous flow signals and altered ultrasound Doppler flow patterns.\n\nThe primary objective of this prospective cohort study is to explore if intraoperative systemic venous congestion is associated with POD after cardiac surgery. This study will also investigate the relationship between intraoperative systemic venous congestion and postoperative complications, and the relationship between each separate venous congestion and POD after cardiac surgery.",[84,26,85,27],"Intraoperative","Postoperative Delirium (POD)","2025-12-16",{"date":88,"type":33},"2025-12-23",{"date":35,"type":33},{"date":37,"type":20},{"name":39,"class":40},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":41},"100610799","venous-congestion-and-cardiac-surgery-associated-acute-kidney-injury-100610799","NCT07232277","Venous Congestion and Cardiac Surgery-Associated Acute Kidney Injury","Intraoperative Venous Congestion and Cardiac Surgery-associated Acute Kidney Injury (CSA-AKI): a Prospective Cohort Study","Inclusion Criteria:\n\n1. Patients scheduled to undergo elective cardiac surgery;\n2. ≥ 18 years.\n\nExclusion Criteria:\n\n1. Contraindications for TEE;\n2. Emergency cardiac surgery;\n3. Major vascular surgery;\n4. Redo cardiac surgery;\n5. Abnormal preoperative renal function;\n6. Severe chronic kidney disease (estimated glomerular filtration rate \\\u003C 15 ml\u002Fmin\u002F1.73 m2 or dialysis);\n7. History of kidney transplantation;\n8. Severe infection requiring continuous antibiotic therapy；\n9. Severe preoperative heart failure with left ventricular ejection fraction \\\u003C 30%;\n10. A critical preoperative state (mechanical circulatory support, extracorporeal membrane oxygenation, current renal replacement therapy \\[RRT\\], mechanical ventilation, or cardiac arrest necessitating resuscitation);\n11. Multi-organ dysfunction;\n12. Known conditions that may interfere with the assessment or interpretation of hepatic vein, portal vein blood flow (such as liver cirrhosis or portal vein thrombosis) or the renal vein blood flow and renal artery blood flow (such as urinary tract obstruction);\n13. Planned cardiac transplantation or ventricular assist device implantation;\n14. Pregnancy;\n15. Insufficient ultrasonographic imaging;\n16. Restarting CPB after first CPB cessation during surgery;\n17. Requirement for cardiac assist devices (ECMO, IABP, or ventricular assist device) after CPB intraoperatively.",{"count":100,"type":20},114,"Venous pressure is often overlooked as an important hemodynamic parameter. Elevated venous pressure and blood stasis in organ tissues can lead to interstitial edema. Intraoperative venous blood stasis can rapidly increase interstitial pressures within organ tissues, especially in organs encapsulated by tissue envelopes, such as the kidney, thereby rapidly reducing effective circulating blood flow to the organ. Systemic venous blood stasis, which tends to occur in patients with right heart failure or pulmonary hypertension, as well as in patients with fluid overload, can lead to intraoperative stasis in multiple organs and tissues, mediating the development of multisystem complications, including acute kidney injury. Therefore, timely, effective, and accurate intraoperative assessment of systemic venous blood stasis is particularly important.\n\nWhen right heart failure and\u002For volume overload occurs in the body, changes in right atrial pressure are transmitted to the venous system of organs throughout the body, with dilatation of the inferior vena cava (IVC), obstruction of blood return from the hepatic, portal, and renal veins, and abnormal venous flow signals and altered ultrasound Doppler flow patterns.\n\nThe primary objective of this prospective cohort study is to explore if intraoperative systemic venous congestion during cardiac surgery is associated with postoperative CSA-AKI. In doing so, we seek to identify a promising physiological marker that can provide cues for the prediction of CSA-AKI. This study will also investigate the relationship between intraoperative systemic venous congestion and postoperative complications, and explore the relationship between each separate venous congestion and AKI after cardiac surgery.",[84,26,103],"Cardiac Surgery-associated Acute Kidney Injury","2025-11-13",{"date":106,"type":33},"2025-11-18",{"date":108,"type":33},"2024-10-15",{"date":110,"type":20},"2026-09-30",{"name":39,"class":40},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":119,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":41},"100556883","ultrasound-of-the-inferior-vena-cava-in-the-prevention-of-hypotension-after-induction-of-general-anesthesia-100556883","NCT06530901","Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia","Multidimensional Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia","Inclusion Criteria:\n\n* Elderly patients undergoing elective non-cardiac surgery under general anesthesia;\n* Age 65-85 years old;\n* Body mass index (BMI) 18-28 kg\u002Fm2;\n* American society of anesthesiologists (ASA) class I-III.\n\nExclusion Criteria:\n\n* Patient refusal or lack of cooperation;\n* Inability to communicate properly;\n* Severe sinus bradycardia, pacemaker implantation, atrioventricular block, and atrial fibrillation;\n* Presence of severe hepatic and renal function abnormalities;\n* Preoperative cardiac ultrasound suggesting LVEF \\\u003C50%;\n* Tricuspid valve displacement \\\u003C16 mm by preoperative cardiac ultrasound;\n* Chronic obstructive pulmonary disease;\n* Pulmonary hypertension;\n* Administration of drugs that inhibit the renin-angiotensin-aldosterone system;\n* Possibility of a difficult airway.","65 Years","85 Years",{"count":122,"type":20},100,"Based on the preoperative ultrasound detection of various parametric indicators of the inferior vena cava cross-section, including the ratio of the inferior vena cava's long and short axes, cross-sectional area and circumference during two-dimensional and three-dimensional imaging, as well as the changes in respiratory variability of each parameter, we explored the predictive value of IVC ultrasound indicator parameters on hypotension after induction of general anesthesia in elderly patients undergoing elective non-cardiac surgery, screened the sensitive indicators, and calculated the cut-off values.",[125],"Elderly Patients Undergoing Elective Non-cardiac Surgery",[127,128,129],"hypotension","general anesthesia","inferior vena cava","2024-08-01",{"date":132,"type":33},"2024-08-05",{"date":134,"type":20},"2024-09-01",{"date":136,"type":20},"2025-03-31",{"name":39,"class":40},""]