[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"liyumei\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100575950","etiology-and-prognostic-analysis-of-acute-liver-failure-in-chinese-children-100575950",false,"NCT06778941","Etiology and Prognostic Analysis of Acute Liver Failure in Chinese Children","Etiology and Prognostic Analysis of Acute Liver Failure in Chinese Children: a Multi-center Bidirectional Observational Cohort Study","EPOCH-ALF","Inclusion Criteria:\n\n1. According to the diagnostic criteria for PALF, the following conditions must be met:\n\n   ① Severe biochemical liver abnormalities occurring within 8 weeks;\n\n   ② Coagulation disorders uncorrectable by vitamin K: if hepatic encephalopathy is present, prothrombin time (PT) \\> 15s or international normalized ratio (INR) \\> 1.5; regardless of the presence of hepatic encephalopathy, PT \\> 20s or INR \\> 2.0.\n2. For patients who were admitted twice, only the information from the first hospitalization will be used.\n3. Patients with a history of chronic liver disease (e.g., genetic metabolic factors, drug-induced factors) or biliary obstruction that led to the acute episode are categorized under acute liver failure.\n4. The child's legal guardian has signed a written informed consent form.\n\nExclusion Criteria:\n\n1. Age \\> 18 years;\n2. Significant data missing (\\>10%);\n3. The child's legal guardian refuses participation.","ALL","28 Days","18 Years",{"count":21,"type":22},400,"ESTIMATED","OBSERVATIONAL","Research Background:\n\nPediatric acute liver failure (PALF) refers to the sudden onset of severe liver injury in children without known chronic liver disease, leading to multi-system organ dysfunction, with a mortality rate as high as 50%-70%. The etiology of PALF is complex and varied, including infections, metabolic disorders, and toxins. In developed countries, it is often caused by drug and toxin exposure, while in developing countries, viral infections are the primary cause. Additionally, 30%-50% of PALF cases have an unknown etiology, which increases the difficulty of treatment. Current treatment options include medical management, artificial liver support, and liver transplantation. Liver transplantation is the only proven effective treatment, but issues such as organ shortages and the timing of transplantation affect treatment outcomes. Improving diagnostic capabilities for the etiology and exploring optimal treatment strategies are of significant importance in enhancing the clinical success rate of PALF management.\n\nResearch Objective:\n\nTo explore the etiology and prognostic factors of pediatric acute liver failure (PALF), analyze the relationship between different causes of PALF and prognosis, and the relationship between different treatment modalities and prognosis. This study aims to investigate the correlation between etiology, treatment methods, and outcomes, providing scientific evidence to improve the precision in diagnosis and treatment of PALF and to enhance decision-making and timing judgments for liver transplantation.",[26],"Acute Liver Failure","NOT_YET_RECRUITING","2025-01-12",{"date":30,"type":31},"2025-01-16","ACTUAL",{"date":33,"type":22},"2025-02-01",{"date":35,"type":22},"2029-06-30",{"name":37,"class":38},"liyumei","OTHER",""]