[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"shaimaa hamdy\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":107},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100623034","thymoquinone-around-immediate-implant-100623034",false,"NCT07391384","Thymoquinone Around Immediate Implant","Evaluation of the Effect of Thymoquinone Hydrogel With Bone Graft in Comparison to Bone Graft Only Around Immediate Implant (Randomized Controlled Clinical Trials)","Thymoquinone","Inclusion Criteria:\n\n* 1- Patients ages more than 18 years old, Participants were chosen according to specific eligibility criteria, requiring them to be healthy individuals classified as ASA I by the American Society of Anesthesiologists.\n\n  2- Patients requiring extraction of posterior teeth with consequent immediate implant placement.\n\n  3- Indications for extraction included: non restorable teeth (posterior teeth), untreatable caries, endodontic failures, remaining roots, vertical fracture of the roots.\n\n  4- Natural teeth adjacent to the tooth to be extracted will required to have complete occlusal surfaces and be free from infections..\n\n  5\\. Patients will selected with a thick soft tissue phenotype and a minimum keratinized tissue width (KTW) of 2 mm.\n\nExclusion Criteria:\n\n* Pathologies or drugs that alter tissue integration with dental implants. 2- Head and neck radiation therapy. 3- Renal disease, bleeding disorders and anticoagulant therapy. 4- Pregnant females. 5- Patients with severe para-functional habits and unfavorable occlusion 6- Smokers. 7- Malaligned teeth and teeth with acute periapical pathosis.","ALL","20 Years","55 Years",{"count":21,"type":22},44,"ESTIMATED","INTERVENTIONAL",[25],"NA","use of Thymoquinone hydrogel with bone graft in comparison to bone graft only around immediate implant-this hydrogel fill the jumping zone in comparison to using hydrogel bone graft only to increase primary stability and enhance osseointegration",[28,29,30],"Immediate Dental Implant Placement","Jumping Gap","Primary Stability of the Implants",[32,33,34,35],"immediate implant","thymoquinone","hydrogel","bone graft","NOT_YET_RECRUITING","2026-01-29",{"date":39,"type":40},"2026-02-05","ACTUAL",{"date":42,"type":22},"2026-01-21",{"date":44,"type":22},"2026-04-11",{"name":46,"class":47},"shaimaa hamdy","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":77,"locationsCount":4},"100605081","gingival-crevicular-fluid-oxidized-low-density-lipoprotein-levels-in-health-and-stage-iiiiv-periodontitis-100605081","NCT07157878","Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III\u002FIV Periodontitis","Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III\u002FIV Periodontitis: A Cross-Sectional Comparative Study","LDL in GCF","Inclusion Criteria:\n\n* For all participants (applies to both groups):\n\n  1. Age 30-60 years.\n  2. Systemically healthy (based on medical history and physician clearance, if needed).\n  3. No history of periodontal treatment within the last 6 months.\n\nExclusion Criteria:\n\n* 1\\. History of systemic diseases affecting periodontium (e.g., uncontrolled diabetes, autoimmune diseases, osteoporosis).\n\n  2\\. Current or past diagnosis of Alzheimer's disease or other neurodegenerative disorders.\n\n  3\\. Use of medications affecting periodontal status (e.g., immunosuppressants, long-term corticosteroids, anticonvulsants).\n\n  4\\. Antibiotic or anti-inflammatory therapy within the past 3 months. 5. Current smokers or history of smoking in the past year.","30 Years","65 Years",{"count":59,"type":22},40,"2 Days","OBSERVATIONAL","Periodontitis is a chronic, multifactorial inflammatory disease primarily caused by dysbiotic plaque biofilms, characterized by the progressive destruction of the supporting structures of the teeth. In advanced stages (Stage III\u002FIV), periodontitis leads to significant attachment and bone loss, often culminating in tooth loss and a negative impact on the patient's quality of life. Recent evidence has emphasized the systemic implications of periodontal inflammation, suggesting a bidirectional relationship between periodontitis and various systemic conditions, especially cardiovascular diseases",[64,65],"Periodontal Diseases","LDL Hyperlipoproteinemia",[67,68,69,70],"Periodontitis","LDL","GCF","periodontal health","2025-09-02",{"date":73,"type":40},"2025-09-05",{"date":75,"type":22},"2025-09-15",{"date":75,"type":22},{"name":46,"class":47},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":19,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100603659","phase-3-a-clinical-comparison-of-connective-tissue-graft-and-alb-prf-for-rebuilding-interdental-papilla-100603659","NCT07139392","A Clinical Comparison of Connective Tissue Graft and Alb-PRF for Rebuilding Interdental Papilla","ALB-PRF & CTG","Inclusion Criteria:\n\n* Age 20-55 years\n* Nordland and Tarnow Class I\u002FII papillary loss\n* Good oral hygiene (FMPS \\& FMBS \\\u003C20%)\n* Systemically healthy\n\nExclusion Criteria:\n\n* Smoking\n* Periodontal pockets \\>4 mm in the target site\n* History of systemic diseases or medications affecting healing\n* Pregnant or lactating women","18 Years",{"count":87,"type":22},30,[89],"PHASE3","The interdental papilla, a small wedge of gingival tissue positioned between adjacent teeth, plays a crucial role in both dental esthetics and oral function. Loss or deficiency of the papilla results in the formation of \"black triangles,\" which not only compromise a patient's smile but also lead to challenges such as food impaction, phonetic difficulties, and increased risk of periodontal disease. The reconstruction of the interdental papilla is recognized as one of the most challenging procedures in periodontal therapy, particularly when aiming for enhanced esthetic outcomes and patient satisfaction",[92],"Papilla Reconstruction",[94,95,96,97,98],"ALB-PRF","papilla","connective tissue","reconstruction","MINST","2025-08-17",{"date":101,"type":40},"2025-08-24",{"date":103,"type":22},"2025-09-01",{"date":105,"type":22},"2025-09-23",{"name":46,"class":47},""]