[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"srdpiers\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100563787","left-bundle-branch-area-pacing-or-biventricular-pacing-in-af-and-left-ventricular-dysfunction-100563787",false,"NCT06620705","Left Bundle Branch Area Pacing or Biventricular Pacing in AF and Left Ventricular Dysfunction","Pacing Away from Heart Failure: Left Bundle Branch Area Pacing or Biventricular Pacing in Patients with Atrial Fibrillation and Left Ventricular Dysfunction","INCLUSION CRITERIA\n\nIn order to be eligible to participate in this study, a subject must meet all of the following criteria:\n\n* Adults ≥18 years with permanent AF and LVEF \\< 50% who either require ventricular pacing because of bradycardia including patients undergoing AV junction ablation, or have an indication for cardiac resynchronization therapy.\n* Expected percentage of ventricular pacing \\> 40%\n* ≥ 3 months of heart failure medication optimization\n\nOf note, patients who already have a device, but require an upgrade to a CRT device, can also be included\n\nEXCLUSION CRITERIA\n\nA potential subject who meets any of the following criteria will be excluded from participation in this study:\n\n* Age \\< 18 years\n* Pregnancy or active pregnancy wish\n* Not eligible for implantation of an RV lead, LBBAP lead, or LV lead in the coronary sinus\n* Recent valve intervention\u002Fsurgery or acute myocardial infarction (\\< 6 months)\n* NYHA functional class IV heart failure, left ventricular assist device or cardiac transplant","ALL","18 Years",{"count":19,"type":20},34,"ESTIMATED","INTERVENTIONAL",[23],"NA","It is unknown whether left bundle branch area pacing (LBBAP) or biventricular pacing best prevents or reverses left ventricular (LV) adverse remodelling in patients with atrial fibrillation (AF) who require ventricular pacing or CRT. This randomized non-inferiority cross-over trial will compare left ventricular end-systolic volume change and secondary endpoints between LBBAP and biventricular pacing in patients with AF and LV dysfunction.",[26,27,28],"Heart Failure","Block, Heart","Pacing-Induced Cardiomyopathy",[30,31,32,33,34,35],"pacing","cardiac resynchronization therapy","left bundle branch area pacing","conduction system pacing","heart failure","heart block","RECRUITING","2024-09-26",{"date":39,"type":40},"2024-10-01","ACTUAL",{"date":42,"type":40},"2024-09-10",{"date":44,"type":20},"2028-10",{"name":46,"class":47},"srdpiers","OTHER",2,""]