[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aatd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aatd":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100197847","lung-disease-and-its-affect-on-the-work-of-white-blood-cells-in-the-lungs-100197847",false,"NCT01851642","Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs","The Role of Conformational Diseases on Macrophage Function","Inclusion Criteria:\n\n* Signed informed consent\n* Male or female 18 years of age or older\n* Negative pregnancy test for women of childbearing potential\n* Hemoglobin \\>12.5 g\u002Fdl measured on the day of participation\n* Negative urine nicotine test\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Weight \\\u003C 50 kg\n* History of anemia requiring blood transfusions, erythropoietin supplementation, or iron supplementation within the past 36 months\n* Known hemoglobin \\\u003C12.5 g\u002Fdl within the past 90 days\n* Systolic blood pressure \\> 180 mmHg and\u002For diastolic blood pressure \\>100 mmHg\n* Poor venous access\n* Large volume blood donation (\\>200 ml or 7 ounces) within the previous 56 days (e.g. blood donation for the purposes of blood banking)\n* Clinically significant cardiac, hemostatic or neurological impairment or any other significant medical condition that, in the opinion of the investigator would affect subject safety (e.g., recent myocardial infarction, history of prolonged bleeding time, cerebral vascular accident, advanced cancer or uncontrolled medical condition)\n* Psychiatric or cognitive disturbance or illness that would affect subject safety\n* Current smoker",true,"ALL","18 Years",{"count":20,"type":21},220,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.",[25,26,27,28],"Alpha-1 Antitrypsin Deficiency","AAT Deficiency","AATD","Cystic Fibrosis (CF)",[30,25,31],"Macrophage","Cystic Fibrosis","RECRUITING","2025-11-05",{"date":35,"type":36},"2025-11-06","ACTUAL",{"date":38,"type":36},"2007-08-09",{"date":40,"type":21},"2033-07-20",{"name":42,"class":43},"University of Florida","OTHER"]