[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"abdomen-acute\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:abdomen-acute":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100509218","a-research-study-of-abdominal-ultrasound-fast-in-children-with-blunt-torso-trauma-100509218",false,"NCT05910567","A Research Study of Abdominal Ultrasound (FAST) in Children With Blunt Torso Trauma","A Randomized Controlled Trial of Abdominal Ultrasound (FAST) in Children With Blunt Torso Trauma","FAST","Children younger than 18 years of age (0 to 17.9999 years) with blunt abdominal trauma presenting to the participating EDs within 24 hours of the traumatic event will be eligible if the do not meet any exclusion criteria and meet any one of the following inclusion criteria.\n\nInclusion Criteria:\n\n1. Blunt torso trauma resulting from a significant mechanism of injury:\n\n   * Motor vehicle collision: greater than 60 mph, ejection, or rollover\n   * Automobile versus pedestrian\u002Fbicycle: automobile speed \\> 25 mph\n   * Falls greater than 20 feet in height\n   * Crush injury to the torso\n   * Physical assault involving the abdomen\n2. Decreased level of consciousness (Glasgow Coma Scale (GCS) score 9-14 or below age-appropriate behavior) in association with blunt torso trauma\n3. Blunt traumatic event with any of the following (regardless of the mechanism):\n\n   * Extremity paralysis\n   * Multiple long bone fractures (e.g., tibia and humerus fracture)\n4. History and physical examination suggestive of blunt torso trauma of any mechanism (including mechanisms of injury of less severity than mentioned above)\n\nExclusion Criteria:\n\nThe following patients will be excluded from the study:\n\n1. Age-adjusted low blood pressure (Hemodynamic instability)\n\n   * Patients will be excluded for prehospital or initial age-adjusted ED low blood pressure. This is because the standard evaluation of these patients involves immediate FAST based on prior work by our group. Low blood pressure is determined based upon the patient's age, and will be defined as a systolic blood pressure less than 70 mm Hg for patients younger than 1 month, less than 80 mm Hg for ages 1 month to 5 years, and less than 90 mm Hg for ages over 5 years.\n2. Penetrating trauma: Patients who are victims of stab or gunshot wounds\n3. Traumatic injury occurring \\> 24 hours prior to the time of presentation to the ED\n4. Transfer of the patient to the ED from an outside facility with abdominal CT scan, diagnostic peritoneal lavage, or laparotomy previously performed\n5. Transferred with FAST exam already performed at outside hospital\n6. Patients with known disease processes resulting in intraperitoneal fluid including liver failure and the presence of ventriculoperitoneal shunts\n7. Initial GCS score ≤ 8 as it is standard for children with GCS scores ≤ 8 to undergo abdominal CT if blunt abdominal trauma is suspected\n8. Known pregnancy\n9. Known prisoner\n10. Known intra-abdominal injury diagnosed within 30 days prior of this ED visit","ALL","17 Years",{"count":20,"type":21},4346,"ESTIMATED","INTERVENTIONAL",[24],"NA","Bleeding from intra-abdominal injuries is a leading cause of traumatic deaths in children. Abdominal CT is the reference standard test for diagnosing intra-abdominal injuries. Compelling reasons exist, however, to both aggressively evaluate injured children for intra-abdominal injuries with CT and to limit abdominal CT evaluation to solely those at non-negligible risk. The focused assessment sonography for trauma (FAST) examination can help focus patient evaluation in just this manner by potentially safely decreasing abdominal CT use in low risk children. This research study is a multicenter, randomized, controlled trial to determine whether use of the FAST examination, a bedside abdominal ultrasound, impacts care in 3,194 hemodynamically stable children with blunt abdominal trauma. The overall objectives of this proposal are 1) to determine the efficacy of using the FAST examination during the initial evaluation of children with blunt abdominal trauma, and 2) to identify factors associated with abdominal CT use in children considered very low risk for IAI after a negative FAST examination. The long-term objective of the research is to determine appropriate evaluation strategies to optimize the care of injured children, leading to improved quality of care and a reduction in morbidity and mortality.",[27,28,29,30,31],"Blunt Trauma to Abdomen","Wounds and Injuries","Abdomen Injury","Abdominal Injury","Abdomen, Acute",[33,28,27,29,34],"Child","Blunt Abdominal Trauma","RECRUITING","2025-12-05",{"date":38,"type":39},"2025-12-11","ACTUAL",{"date":41,"type":39},"2023-04-17",{"date":43,"type":21},"2027-04-30",{"name":45,"class":46},"University of California, Davis","OTHER",6,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100487138","clinical-outcomes-and-equality-in-healthcare-for-emergency-general-surgery-patients-undergoing-emergency-laparotomy-100487138","NCT05623176","Clinical Outcomes and Equality in Healthcare for Emergency General Surgery Patients Undergoing Emergency Laparotomy","Improvement in Patient Survival and Equality in Care Provision for General Surgery Patients Undergoing Emergency Laparotomy - Can This be Achieved Through the Implementation of Standardised Care Protocols?","LAPTOP","Inclusion Criteria:\n\n* Undergoing emergency laparotomy due to general surgical indication\n\nExclusion Criteria:\n\n* Children under 16\n* Trauma laparotomy\n* Vascular, urological or gynaecological indication for laparotomy","16 Years",{"count":58,"type":21},2000,"OBSERVATIONAL","The goal of this observational cohort study is to evaluate the standard of care for general surgerical patients undergoing emergency laparotomy and assess factors affecting clinical outcomes, as well as evaluating the quality of life in the year after abdominal surgery.\n\nThe main questions it aims to answer are:\n\n1. what factors are associated with adverse post-operative events\n2. are patients treated differently based on sex or age\n3. how does quality of life look like and possibly change over the coarse of a year after surgery\n\nThis is an evaluation of the current standard of care and the outcomes of this patient group prior to the implementation of a standardised care protocols for emergency laparotomy patients. Secondly, the study aims to, over time, compare results before and after the introduction of this standardised care protocol.",[31],[63,64,65],"Emergency laparotomy","General surgery","Clinical outcomes","2024-12-05",{"date":68,"type":39},"2024-12-11",{"date":70,"type":39},"2015-01-01",{"date":72,"type":21},"2030-12",{"name":74,"class":75},"Region Stockholm","OTHER_GOV",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":18,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":76},"100528438","phase-3-intravenous-ketorolac-vs-morphine-in-children-with-acute-abdominal-pain-100528438","NCT06160778","Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain","Intravenous Ketorolac Vs. Morphine In Children Presenting With Acute Abdominal Pain And\u002For Suspected Appendicitis: A Multi-centre Non-Inferiority Randomized Controlled Trial","KETOAPP","Inclusion Criteria:\n\n1. Age 6 to 17 years\n2. Abdominal pain ≤5 days duration\n3. Acute abdominal pain that is being investigated (suspected) by the clinical team for appendicitis\n4. Patient with IV cannula in situ or ordered\n5. Currently experiencing moderate to severe abdominal pain at rest or with movement: self-reported pain score ≥5 using the verbal Numerical Rating Scale\n\nExclusion Criteria:\n\n1. Previous enrollment in the trial\n2. NSAID use within 3 hours and\u002For opioid use within 1 to 2 hours (1 hour post-IV or intra-nasal fentanyl and 2 hours post IV morphine).\n3. Children who need immediate resuscitation, are hemodynamically unstable as deemed by the clinical team or have a Canadian Triage Assessment Score of 1\n4. Significant caregiver and\u002For child cognitive impairment precluding the ability to complete study questions.\n5. Chronic pain requiring daily analgesic use: confounding as response to analgesics maybe altered.\n6. History of severe undiagnosed gastrointestinal bleeding requiring medical intervention, peptic or duodenal ulcer disease or inflammatory bowel disease, coagulation disorders, prior cerebrovascular bleeding, known arterio-vascular malformations. History of minor gastrointestinal bleeding from conditions such as resolved fissures, polyps or allergic colitis will not exclude patients from participating.\n7. History of chronic and active interstitial kidney disease\n8. History of chronic and active hepatocellular disease: ketorolac is metabolized by the liver.\n9. Known or suspected pregnancy at the time of enrollment or breastfeeding females\n10. Known hypersensitivity to NSAIDs or opioids.\n11. Absence of a parent\u002Fguardian for children who are \\\u003C16 years of age if they are not a mature minor.\n12. Inability to obtain consent due to a language barrier and the absence of language translator in person or by a phone translation service available in the ED.","6 Years",{"count":87,"type":21},495,[89],"PHASE3","Appendicitis is a common condition in children 6-17 years of age, and the top reason for emergency surgery in Canada. Children with appendicitis can have very bad pain in their belly. Children often need pain medications given to them through a needle in their arm called an intravenous (IV). The most common IV pain medication is a type of opioid called morphine. We know that opioids work well to improve pain, but there are risks and side effects when taking them. There are non-opioid medications that doctors can give to patients, like ketorolac. Ketorolac helps decrease inflammation and pain and has fewer side effects when a patient takes it for a short period of time. Our past and present overuse of opioids, driven by an unproven assumption that opioids work best for pain, resulted in an Opioid Crisis and doctors are now looking for alternatives. To do this, we need to prove that there are other options to treat children's pain that are just as good as opioids, with less side effects.\n\nThe goal of our study is to discover if school aged children who arrive at the emergency department with belly pain, improve just as much with ketorolac as they do with morphine. To answer this question, we will need a very large number of patients in a study that includes several hospitals across Canada. With a flip of a coin, each participant will either get a single dose of morphine or a single dose of ketorolac. To make sure that our pain assessment is impartial, no one will know which medicine the child received except the pharmacist who prepared the medicine.",[92,31,93,94,95,96],"Acute Pain","Abdominal Pain","Appendicitis","Emergencies","Child, Only","2024-06-21",{"date":99,"type":39},"2024-06-24",{"date":101,"type":39},"2024-05-27",{"date":103,"type":21},"2029-12",{"name":105,"class":46},"University of Calgary"]