[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"abdominal-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:abdominal-injury":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,60,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":37,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100434493","developing-a-decision-instrument-to-guide-abdominal-pelvic-ct-imaging-of-blunt-trauma-patients-100434493",false,"NCT04937868","Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients","NEXUS AP CT","Inclusion Criteria:\n\nBlunt trauma patients who undergo abdominal-pelvic CT imaging during their initial trauma evaluation in the emergency department.\n\nExclusion Criteria:\n\nNone","ALL",{"count":18,"type":19},12000,"ESTIMATED","OBSERVATIONAL","Unrecognized abdominal and pelvic injuries can result in catastrophic disability and death. Sporadic reports of \"occult\" injuries have generated concern, and physicians, fearing that they may miss such an injury, have adopted the practice of obtaining computed tomography on virtually all patients with significant blunt trauma. This practice exposes large numbers patients to dangerous radiation at considerable expense, while detecting injuries in a small minority of cases.\n\nExisting data suggest that a limited number of criteria can reliably identify blunt injury victims who have \"no risk\" of abdominal or pelvic injuries, and hence no need for computed tomography (CT), without misidentifying any injured patient. It is estimated that nationwide implementation of such criteria could result in an annual reduction in radiographic charges of $75 million, and a significant decrease in radiation exposure and radiation induced malignancies.\n\nThis study seeks to determine whether \"low risk\" criteria can reliably identify patients who have sustained significant abdominal or pelvic injuries and safely decrease CT imaging of blunt trauma patients. This goal will be accomplished in the following manner:\n\nAll blunt trauma victims undergoing computed tomography of the abdomen\u002Fpelvis in the emergency department will undergo routine clinical evaluations prior to radiographic imaging. Based on these examinations, the presence or absence of specific clinical findings (i.e. abdominal\u002Fpelvic\u002Fflank pain, abdominal\u002Fpelvic\u002Fflank tenderness, bruising abrasions, distention, hip pain, hematuria, hypotension, tachycardia, low or falling hematocrit, intoxication, altered sensorium, distracting injury, positive FAST imaging, dangerous mechanism, abnormal x-ray imaging) will be recorded for each patient, as will the presence or absence of abdominal or pelvic injuries. The clinical findings will serve as potential imaging criteria. At the completion of the derivation portion of the study the criteria will be examined to find a subset that predicts injury with high sensitivity, while simultaneously excluding injury, and hence the need for imaging, in the remaining patients. These criteria will then be confirmed in a separate validation phase of the study.\n\nThe criteria will be considered to be reliable if the lower statistical confidence limit for the measured sensitivity exceeds 98.0%. Potential reductions in CT imaging will be estimated by determining the proportion of \"low-risk\" patients that do not have significant abdominal or pelvic injuries.",[23,24,25,26,27,28,29,30,31,32,33,34,35,36],"Abdominal Injury","Pelvic Fracture","Genital Hemorrhage","Lumbar Spine Injury","Hip Injuries","Liver Injury","Spleen Injury","Renal Injury","Diaphragm Injury","Aortic Rupture","Aortic Dissection","Bowel Disease","Vascular System Injuries","Sacral Fracture",[38,39,40,41,42,43,44,45,46],"Blunt trauma","Abdominal injury","Pelvic injury","Spine injury","Genital injury","Vascular injury","Hip injury","Computed tomography","Decision instrument","RECRUITING","2026-01-09",{"date":50,"type":51},"2026-01-13","ACTUAL",{"date":53,"type":51},"2018-01-15",{"date":55,"type":19},"2027-06-15",{"name":57,"class":58},"University of California, Los Angeles","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":16,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":72,"conditions":73,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":59},"100601693","pediatric-intravenous-contrast-enhanced-ultrasoundceus-in-china-100601693","NCT07113808","Pediatric Intravenous Contrast-Enhanced Ultrasound(CEUS) in China","Clinical Medical Quality Control Management of Pediatric Intravenous Contrast-Enhanced Ultrasound(CEUS) in China: A Multi-Center Study","CEUS","Inclusion Criteria:\n\n1. Age 29 days to 18 years old;\n2. The clinical diagnosis was abdominal space-occupying lesions, blunt abdominal trauma, ascites of unknown cause, and children with suspected abdominal disease but other examinations could not identify the cause.\n\nExclusion Criteria:\n\n1. Allergic to sulfur hexafluoride or other components;\n2. Heart disease with right-to-left shunt\u002Fsevere pulmonary hypertension \u002Funcontrolled systemic hypertension\u002Frespiratory failure\u002Fheart failure\u002Fsevere arrhythmia;\n3. Electrocardiogram, echocardiography or clinical manifestations of myocardial ischemia;\n4. Patients with severe blood system diseases or infectious diseases;\n5. Hypercoagulable state and recent history of thrombosis;\n6. Severe hepatic and renal insufficiency;\n7. Patients with respiratory tract infection or congenital respiratory malformation.","29 Days","18 Years",{"count":71,"type":19},108,"The goal of this clinical trial is to evaluate the application of intravenous contrast-enhanced ultrasound examination in children with intra-abdominal diseases that require clear diagnoses. The main questions it aims to answer are:\n\n* Is intravenous contrast-enhanced ultrasound helpful for the diagnosis of intra-abdominal diseases in children?\n* What medical problems do participants have when participating in intravenous contrast-enhanced ultrasound examination?\n* How can ultrasound doctors conduct intravenous contrast-enhanced ultrasound examinations in a standardized manner? Researchers will performing intravenous contrast-enhanced ultrasound examinations on participants and collecting research subjects to establish a multicenter clinical data database.\n\nParticipants will:\n\n* Perform abdominal ultrasound examination to assess the condition.\n* At least conduct one intravenous contrast-enhanced ultrasound examination. Based on the result of the contrast examination, decide whether to conduct another examination.\n* Keep a diary of their symptoms and therapeutic process in 30 days.",[74,23,75],"Abdominal Neoplasm","Ascites","2025-12-05",{"date":78,"type":51},"2025-12-08",{"date":80,"type":51},"2024-09-10",{"date":82,"type":19},"2026-09-30",{"name":84,"class":58},"The Children's Hospital of Zhejiang University School of Medicine",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":105,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":116},"100509218","a-research-study-of-abdominal-ultrasound-fast-in-children-with-blunt-torso-trauma-100509218","NCT05910567","A Research Study of Abdominal Ultrasound (FAST) in Children With Blunt Torso Trauma","A Randomized Controlled Trial of Abdominal Ultrasound (FAST) in Children With Blunt Torso Trauma","FAST","Children younger than 18 years of age (0 to 17.9999 years) with blunt abdominal trauma presenting to the participating EDs within 24 hours of the traumatic event will be eligible if the do not meet any exclusion criteria and meet any one of the following inclusion criteria.\n\nInclusion Criteria:\n\n1. Blunt torso trauma resulting from a significant mechanism of injury:\n\n   * Motor vehicle collision: greater than 60 mph, ejection, or rollover\n   * Automobile versus pedestrian\u002Fbicycle: automobile speed \\> 25 mph\n   * Falls greater than 20 feet in height\n   * Crush injury to the torso\n   * Physical assault involving the abdomen\n2. Decreased level of consciousness (Glasgow Coma Scale (GCS) score 9-14 or below age-appropriate behavior) in association with blunt torso trauma\n3. Blunt traumatic event with any of the following (regardless of the mechanism):\n\n   * Extremity paralysis\n   * Multiple long bone fractures (e.g., tibia and humerus fracture)\n4. History and physical examination suggestive of blunt torso trauma of any mechanism (including mechanisms of injury of less severity than mentioned above)\n\nExclusion Criteria:\n\nThe following patients will be excluded from the study:\n\n1. Age-adjusted low blood pressure (Hemodynamic instability)\n\n   * Patients will be excluded for prehospital or initial age-adjusted ED low blood pressure. This is because the standard evaluation of these patients involves immediate FAST based on prior work by our group. Low blood pressure is determined based upon the patient's age, and will be defined as a systolic blood pressure less than 70 mm Hg for patients younger than 1 month, less than 80 mm Hg for ages 1 month to 5 years, and less than 90 mm Hg for ages over 5 years.\n2. Penetrating trauma: Patients who are victims of stab or gunshot wounds\n3. Traumatic injury occurring \\> 24 hours prior to the time of presentation to the ED\n4. Transfer of the patient to the ED from an outside facility with abdominal CT scan, diagnostic peritoneal lavage, or laparotomy previously performed\n5. Transferred with FAST exam already performed at outside hospital\n6. Patients with known disease processes resulting in intraperitoneal fluid including liver failure and the presence of ventriculoperitoneal shunts\n7. Initial GCS score ≤ 8 as it is standard for children with GCS scores ≤ 8 to undergo abdominal CT if blunt abdominal trauma is suspected\n8. Known pregnancy\n9. Known prisoner\n10. Known intra-abdominal injury diagnosed within 30 days prior of this ED visit","17 Years",{"count":95,"type":19},4346,"INTERVENTIONAL",[98],"NA","Bleeding from intra-abdominal injuries is a leading cause of traumatic deaths in children. Abdominal CT is the reference standard test for diagnosing intra-abdominal injuries. Compelling reasons exist, however, to both aggressively evaluate injured children for intra-abdominal injuries with CT and to limit abdominal CT evaluation to solely those at non-negligible risk. The focused assessment sonography for trauma (FAST) examination can help focus patient evaluation in just this manner by potentially safely decreasing abdominal CT use in low risk children. This research study is a multicenter, randomized, controlled trial to determine whether use of the FAST examination, a bedside abdominal ultrasound, impacts care in 3,194 hemodynamically stable children with blunt abdominal trauma. The overall objectives of this proposal are 1) to determine the efficacy of using the FAST examination during the initial evaluation of children with blunt abdominal trauma, and 2) to identify factors associated with abdominal CT use in children considered very low risk for IAI after a negative FAST examination. The long-term objective of the research is to determine appropriate evaluation strategies to optimize the care of injured children, leading to improved quality of care and a reduction in morbidity and mortality.",[101,102,103,23,104],"Blunt Trauma to Abdomen","Wounds and Injuries","Abdomen Injury","Abdomen, Acute",[106,102,101,103,107],"Child","Blunt Abdominal Trauma",{"date":109,"type":51},"2025-12-11",{"date":111,"type":51},"2023-04-17",{"date":113,"type":19},"2027-04-30",{"name":115,"class":58},"University of California, Davis",6]