[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"abdominal-pain-discomfort\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:abdominal-pain-discomfort":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,75,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100570402","the-mechanism-underlying-the-analgesic-effect-of-the-music-of-ibs-pain-100570402",false,"NCT06706778","The Mechanism Underlying the Analgesic Effect of the Music of IBS Pain","Impacts of Music-based Intervention on Pain in Individuals With Irritable Bowel Syndrome (IBS): A Mechanistic Pilot Study","Inclusion Criteria:\n\n* aged between 18 and 50 years old,\n* can speak and read English,\n* having a confirmed diagnosis of IBS from a healthcare provider,\n* having experienced moderate pain (≥3 out of 10 on a numeric rating scale) at least four days a week for the past three months,\n* be willing to participate in a 4-week intervention and attend two lab visits, and\n* having daily access to an internet-enabled device for MBI.\n\nExclusion Criteria:\n\n* having a severe psychiatric disorder requiring inpatient treatment in the past six months,\n* regularly using opioids or illicit substances, or have used probiotics or antibiotics within two weeks prior to enrollment,\n* having celiac disease, inflammatory bowel disease, or a history of major gastrointestinal surgery,\n* concurrently participate in another IBS-related intervention study.","ALL","18 Years","50 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The proposed pilot study aims to assess the underlying mechanisms of the MBI on IBS pain and the feasibility of using novel technology in the outcome measurements. The specific aims of this pilot mechanistic clinical trial are to:\n\n1. . identify the mechanisms underlying the impact of MBI on IBS-related pain, stress responses, quantitative pain sensitivity, and gut microbiome profiles.\n2. . evaluate the technological feasibility of using a wearable abdominal sensor belt and smartwatch system in measuring MBI impacts on pain in home settings.\n\nResearchers will conduct a one-arm pre- and post-music intervention among patients with Irritable Bowel Syndrome, collect the IBS pain mechanistic biobehavioral markers, and analyze the underlying pathways of the music analgesic effect.\n\nParticipants will be asked to:\n\n1. . engage in a 4-week intervention of 20 minutes, both during the day and at night, for at least five days per week.\n2. . have two one-hour lab visits",[27,28],"Abdominal Pain\u002F Discomfort","Irritable Bowel Syndrome",[30,31,32,33,28],"abdominal pain","Music","Brain-gut axis","Stress","NOT_YET_RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-02","ACTUAL",{"date":40,"type":21},"2026-08",{"date":42,"type":21},"2027-03",{"name":44,"class":45},"Yale University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":46},"100625253","evaluation-of-the-synergistic-effect-of-combining-a-prebiotic-and-a-postbiotic-on-intestinal-discomfort-100625253","NCT07420231","Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort","Synfood","Inclusion Criteria:\n\n* Woman or man, aged of 18 to 75 years (inclusive);\n* Subject with a measurable level of intestinal discomfort, assessed using a questionnaire inspired by the ROME IV criteria. Eligible participants must meet all of the following conditions:\n\n  1. Experience recurrent abdominal pain present for at least three months and occurring on a regular basis;\n  2. The abdominal discomfort must have a low to moderate impact on quality of life;\n  3. In addition, participants must report at least two of the following gastrointestinal symptoms:\n\n     * Diarrhea\n     * Constipation\n     * Bloating\n     * Excessive flatulence\n     * Nausea\n     * Burping\n     * Sensation of incomplete evacuation\n     * Urgent need to defecate;\n* Body Mass Index (BMI) between 18 and 30 kg\u002Fm² (inclusive);\n* Provision of signed and dated informed consent form;\n* Stated willingness to comply with all study procedures and availability for the duration of the study;\n* Stated willingness to maintain their usual life habits (diet, physical activity, alcohol consumption…);\n* Speaking French.\n\nExclusion Criteria:\n\n* Subject with severe or chronic medical conditions which, in the opinion of the Principal Investigator, could interfere with the evaluation of the study outcomes or compromise participant safety;\n* Subject with a diagnosed gastrointestinal disorder (e.g., Crohn's disease, inflammatory bowel disease, or other chronic digestive conditions);\n* Subject with type 1 or type 2 diabetes;\n* Subject who has taken, within the 28 days prior to the screening visit, or are currently taking, drugs or food supplements intended to improve intestinal comfort, or any other substances that, in the opinion of the Principal Investigator, could interfere with intestinal comfort assessment or transit frequency (prebiotics, laxative, anti-diarrheal, probiotics, postbiotics, synbiotics). These products will also be avoided for the duration of the study;\n* Subject who has taken antibiotics within the 3 months prior to the screening visit. These products will also be avoided for the duration of the study;\n* Subjects undergoing medical treatment which, in the opinion of the Principal Investigator, could interfere with the evaluation of the study criteria or with participant safety: antidepressants, immunosuppressants, antipsychotics, antispasmodics, anxiolytics, neuroleptics. These products will also be avoided for the duration of the study;\n* Subject who had undergone bariatric surgery;\n* Subject consuming more than 5 cups of coffee per day;\n* Subject currently using drugs and\u002For with a history of drug addiction within the past 2 years;\n* Subject with regular alcohol consumption exceeding 3 standard drinks per day (10 g of pure alcohol each), equivalent to 3 glasses of wine (12 cl), 3 glasses of beer (5°, 25cl), or 3 glasses of spirits (18°, 7 cl);\n* Subject with known hypersensitivity to any component of the study product;\n* Subject currently participating in another interventional trial;\n* Woman of childbearing age who is pregnant or breastfeeding or who wishes to become pregnant within the next 12 weeks or who is not using an adequate method of contraception (e.g. oral contraception, IUD, abstinence, ...).","75 Years",{"count":56,"type":21},140,[24],"This study aims to investigate the beneficial effects of the daily consumption of a synbiotic formulation-combining a prebiotic (Berberine, BBR) and a postbiotic (inactivated Bifidobacterium Longum, B.longum)-in adults experiencing intestinal discomfort.",[60,27],"Intestinal Discomfort",[62,63,64],"Intestinal discomfort","B.Longum","Berberine","RECRUITING","2026-04-30",{"date":68,"type":38},"2026-05-06",{"date":70,"type":38},"2026-03-16",{"date":72,"type":21},"2026-12-24",{"name":74,"class":45},"Université Catholique de Louvain",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100614517","diagnostic-pcr-panel-in-children-with-acute-gastrointestinal-symptoms-100614517","NCT07280624","Diagnostic PCR Panel in Children With Acute Gastrointestinal Symptoms","Clinical Significance of Real Time PCR Panel in Children With Acute Gastrointestinal Symptoms","RealCAGI RCT","Inclusion Criteria:\n\n* Child or adolescent \\\u003C 16 years of age\n* Visiting pediatric ED\n* Presence of gastrointestinal symptom or symptoms (diarrhea, vomiting or abdominal pain)\n\nExclusion Criteria:\n\n* Need of cardiopulmonary resuscitation at the ED\n* Need of immediate transfer to the intensive care unit\n* Hemato-oncological disease\n* Severe immunosuppression\n* Bloody diarrhea\n* Clinical suspicion of typhoid\u002Fparatyphoid fever","16 Years",{"count":85,"type":21},526,[24],"This investigator-initiated randomized controlled trial compares the clinical impact of real time PCR of fecal samples in children with acute gastrointestinal symptoms at a pediatric emergency room. Specifically, the trial compares immediate testing of fecal samples using a multiplex PCR panel to a a control group with delayed test results.",[89,90,27,91],"Gastroenteritis Acute","Gastrointestinal Symptoms","Vomiting in Infants and\u002For Children",[93,94,95,96,97,98,99,100,101,102],"Multiplex PCR","Fecal samples","Diagnostic stewardship","Diarrhea","Vomiting","Abdominal pain","Gastrointestinal symptoms","Pediatrics","Children","Emergency department","2025-12-09",{"date":105,"type":38},"2025-12-12",{"date":107,"type":21},"2025-12-15",{"date":109,"type":21},"2028-02-15",{"name":111,"class":45},"University of Oulu",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":119,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":124,"conditions":125,"keywords":132,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":143},"100610081","feasibility-study-of-a-guided-imagery-therapy-mobile-application-for-functional-abdominal-pain-disorders-in-children-100610081","NCT07222943","Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children","Open-Labelled Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children","Inclusion Criteria:\n\n* Texas Children's Pediatrics patients 7 to 12 years old at enrollment\n* A Rome IV Functional Abdominal Pain Disorder as defined by a 2-week abdominal pain and stooling diary\n* Both children and their primary caregivers must be able to read and communicate in English proficiently to understand the intervention's audio therapy sessions and psychometric instruments.\n\nExclusion Criteria:\n\n* Previous abdominal surgeries\n* Co-morbid conditions associated with abdominal pain (e.g., cystic fibrosis)\n* Autism\n* Significant development delay\n* Psychosis\n* Prior experience with cognitive behavioral therapy or guided imagery therapy to treat chronic abdominal pain\n* Alarm symptoms that warrant further medical evaluation (e.g., blood in stool)","7 Years","12 Years",{"count":122,"type":21},36,[24],"Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help children's abdominal pain when delivered via a mobile application (app) on a smartphone or tablet.\n\nParticipants will complete a baseline abdominal pain and stooling diary to determine eligibility, as well as other surveys. Eligible participants will be given access to the guided imagery therapy mobile application.\n\nThis intervention asks participants to listen to a 10- to 15-minute GIT session 5 out of 7 days per week for 8 weeks, in addition to their usual care for their abdominal pain. Then, participants will complete another abdominal pain and stooling diary, along with other psychometric surveys, at the end of this intervention period. Participants will also collect another diary and surveys 3 months post-treatment.",[126,127,128,129,27,130,131],"Functional Abdominal Pain Disorders","Irritable Bowel Syndrome (IBS)","Functional Gastrointestinal Disorders (FGIDs)","Gastrointestinal and Digestive Disorder","Pain","Functional Dyspepsia",[30,133],"irritable bowel syndrome","2025-10-28",{"date":136,"type":38},"2025-10-30",{"date":138,"type":21},"2025-12-01",{"date":140,"type":21},"2026-11-30",{"name":142,"class":45},"Baylor College of Medicine",2]