[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"abdominal-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:abdominal-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,42,73,104,136,168,194,218,244,279,301,322,341,376],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100053273","management-of-abdominal-post-surgical-scar-with-ozoaqua-versus-standard-care-100053273",false,"NCT07678372","Management of Abdominal Post-surgical Scar With Ozoaqua Versus Standard Care","Prospective, Randomized, Evaluator-blinded Clinical Study to Compare a Post-surgical Scar Care Protocol Using OzoAqua Products Versus Standard Care in Open Abdominal Surgery.","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled open abdominal surgery\n* Primary wound closure\n* Assessable linear abdominal scar\n* Signed informed consent\n* Ability to complete 3-month follow-up\n\nExclusion Criteria:\n\n* Known allergy to treatment components\n* Active infection or significant dehiscence in the immediate postoperative period\n* Planned use of specific scar treatments -silicone products, laser therapy, local corticosteroids- except as clinical rescue treatment\n* Inability to complete follow-up\n* Participation in another study that may interfere with wound healing","FEMALE","18 Years",{"count":19,"type":20},144,"ESTIMATED","INTERVENTIONAL",[23],"NA","A prospective, randomized clinical study with a blinded evaluator to compare a post-surgical abdominal scar care protocol using Ozoaqua products versus standard care in patients undergoing open abdominal surgery. The primary objective is to assess whether the use of Ozoaqua, initiated in the immediate postoperative period according to wound evolution, improves abdominal scar quality at 3 months compared with usual care.\n\nThe proposed design is an initial single-center study at the Clínica Universidad de Navarra, with 1:1 random allocation to two parallel arms: an intervention group receiving standard care plus Ozoaqua ozonated soap and oil, and a control group receiving standard care only. The primary scar assessment will be performed by a blinded evaluator, while treatment will be open-label due to the nature of the topical intervention.\n\nThe target population consists of adult patients undergoing scheduled open abdominal surgery, with primary wound closure and an assessable linear abdominal scar. Follow-up will be integrated into routine clinical care, including an in-hospital phase during the first postoperative days and outpatient visits at approximately 2 weeks, 1 month and 3 months, with the latter being the main study visit.\n\nThe primary endpoint will be scar quality at 3 months, assessed using the POSAS scale, particularly the blinded observer score. Secondary endpoints will include the patient POSAS score, scar evolution, wound complications, pain, pruritus, satisfaction, cutaneous adverse events, rescue treatments and adherence.",[26,27,28],"Wound Healing","Abdominal Surgery","Scar Improvement","NOT_YET_RECRUITING","2026-07-09",{"date":32,"type":33},"2026-07-13","ACTUAL",{"date":35,"type":20},"2026-07-06",{"date":37,"type":20},"2027-07-06",{"name":39,"class":40},"Laboratorios Ozoaqua","INDUSTRY",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100618424","external-oblique-intercostal-plane-block-for-postoperative-analgesia-after-major-upper-abdominal-surgery-100618424","NCT07331441","External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery","External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Obtain written informed consent from participants or their legal representatives\n* Age between 18 and 85 years\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Scheduled for elective laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery)\n* Expected surgical duration ≥ 2 hours\n* Ability to use the intravenous patient-controlled analgesia (IV PCA) system\n\nExclusion Criteria:\n\n* Hepatic disease (liver enzyme levels ≥ 2× the upper limit of normal)\n* Renal disease (serum creatinine levels ≥ 2× the upper limit of normal)\n* Allergy to local anesthetics or known study-related drugs\n* Pregnancy or lactation\n* Low surgical incision site (not involving the upper abdominal wall innervated by T6-T10 nerves)\n* Coagulopathy or current use of anticoagulant medications\n* Opioid use for more than 2 weeks in the past 6 months","ALL","85 Years",{"count":52,"type":20},78,[23],"Postoperative pain after laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) is often severe, and inadequate analgesia may lead to increased opioid use, opioid dependence, and poor functional recovery. Current analgesic techniques such as neuraxial block have safety concerns (e.g., hypotension, neurological injury), while transversus abdominis plane (TAP) block is ineffective for blocking the lateral cutaneous branches of intercostal nerves in the upper abdomen. The External Oblique Intercostal Plane Block (EOIB) is a novel regional block technique that has shown promise in reducing postoperative opioids and pain in small-scale studies, but evidence for its use in major upper abdominal surgery is limited. This randomized controlled trial (RCT) aims to evaluate the analgesic efficacy and safety of bilateral EOIB combined with standard multimodal analgesia versus standard multimodal analgesia alone in patients undergoing elective laparoscopic major upper abdominal surgery. The primary outcome is the total postoperative opioid consumption (measured as Morphine Milligram Equivalents, MME) within 24 hours. Secondary and additional outcomes include pain scores (Verbal Rating Scale, VRS), recovery quality (QoR-15 scale), incidence of adverse events, and hospital stay.",[27,56],"Postoperative Pain",[58,56,59,60,61],"External Oblique Intercostal Plane Block","Laparoscopic Surgery","Pain Management","Randomized Controlled Trial","RECRUITING","2026-06-21",{"date":65,"type":33},"2026-06-25",{"date":67,"type":33},"2026-02-01",{"date":69,"type":20},"2026-08-31",{"name":71,"class":72},"Jun Zhang","OTHER",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100638342","mechanical-power-for-ventilatory-settings-in-operating-room-100638342","NCT07620132","Mechanical Power for Ventilatory Settings in Operating Room","Mechanical Power for Ventilatory Settings in Operating Room: a Multicenter Randomized Controlled Trial","IMPROVEIII","Inclusion Criteria:\n\n* Adult (≥ 18 years)\n* Laparoscopic or non-laparoscopic abdominal surgery\n* With an expected duration of at least 2 hours\n\nExclusion Criteria:\n\n* Patients already receiving mechanical ventilation \\> 12 hours before surgery;\n* Chronic respiratory disease requiring oxygen therapy or mechanical ventilation at home;\n* Undrained pneumothorax or subcutaneous emphysema;\n* Intracranial hypertension;\n* Patients for which death is deemed imminent and inevitable or patients with an underlying disease process with a life expectancy of less than 3 months;\n* Patients already enrolled in the IMPROVE III trial;\n* Pregnancy in progress or planned during the study period or breastfeeding women (Art. L1121-5 of the French Public Health Code);\n* Patients protected by law (Art. L1121-6 to L1121-8 of the French Public Health Code): Individuals deprived of their liberty by judicial or administrative decision, vulnerable persons, minors, adults under guardianship or curatorship;\n* Patients not covered by a French social security scheme and not benefiting from such a scheme;\n* Absence of free and informed oral consent from the patient before inclusion (except in emergency situation where the patient is unable to provide consent), or absence of written informed consent from his\u002Fher proxy if present in an emergency situation (except in life-threatening emergency, where inclusion without consent from the patient or his\u002Fher proxy is permitted), in which case consent will be obtained as soon as possible after inclusion.",{"count":82,"type":20},490,[23],"Postoperative respiratory failure (PRF) is a dreaded complication that imposes a significant burden through unplanned admission to the ICU, post discharge disability and mortality. Despite widespread implementation of intraoperative lung-protective ventilation strategies over the past decade, results remain inconsistent. Interventions targeting individual parameters like tidal volume or positive end-expiratory pressure (PEEP) have shown equivocal results. The use of high PEEP and recruitment maneuvers raises safety concerns by possible negative hemodynamic effects. Recent studies suggest that individualizing ventilation strategies based on mechanical power-a composite parameter integrating tidal volume, plateau pressure, PEEP, and ventilator frequency-may better predict and help prevent PRF, independently of patients' baseline respiratory system compliance. These studies identified this parameter as interventional targets to reduce lung injury during mechanical ventilation. However, no multicenter randomized controlled trial has been performed in the field of ventilatory settings titration during invasive mechanical ventilation in operating room.\n\nThe investigators hypothesize that a ventilation strategy aimed at decreasing mechanical power will reduce the incidence of PRF and mortality in patients undergoing abdominal surgery, compared with a standard strategy using fixed tidal volume and PEEP",[86,27,87,88],"Postoperative Respiratory Failure","Postoperative Pulmonary Complications","Morality",[90,91,92,93,94],"Mechanical ventilation","Intubation","Mechanical power-guided ventilation","Laparoscopic or non-laparoscopic abdominal surgery","Intensive care unit","2026-05-26",{"date":97,"type":33},"2026-06-02",{"date":99,"type":20},"2026-06-01",{"date":101,"type":20},"2029-01-01",{"name":103,"class":72},"University Hospital, Montpellier",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":41},"100630886","virtual-reality-for-postoperative-recovery-after-major-abdominal-surgery-100630886","NCT07493499","Virtual Reality for Postoperative Recovery After Major Abdominal Surgery","Effect of Virtual Reality on Quality of Recovery and Hospital Stay After Major Abdominal Surgery","VR-RECOVER","Inclusion Criteria:\n\n* Adult patients aged 18 to 60 years.\n* Scheduled for elective major abdominal surgery (e.g., colorectal, gastric, or hepatobiliary procedures).\n* Physical and cognitive ability to provide informed consent.\n* Ability to use and interact with Virtual Reality (VR) equipment (head-mounted display).\n* Followed the standardized Enhanced Recovery After Surgery (ERAS) protocol at the hospital.\n\nExclusion Criteria:\n\n\\- Patients with a history of epilepsy or photosensitive seizures.\n\n* Significant cognitive impairment or diagnosed psychiatric disorders that may interfere with study participation.\n* Severe visual or auditory impairments that prevent effective interaction with VR content.\n* Patients with pre-existing motion sickness or severe vertigo.\n* Presence of open wounds or infections in the head or face area that prevent wearing the VR headset.","60 Years",{"count":114,"type":20},60,[23],"Major abdominal surgery often leads to significant postoperative pain, anxiety, and prolonged hospital stays, which can delay overall recovery. This study aims to evaluate the effectiveness of immersive Virtual Reality (VR) as a non-pharmacological intervention to enhance the quality of recovery and reduce the length of hospital stay. Patients in the intervention group will engage in standardized VR sessions featuring guided relaxation and mindfulness-based stress reduction, starting from the evening before surgery through the third postoperative day. The study compares this VR-enhanced protocol against standard perioperative care within an Enhanced Recovery After Surgery (ERAS) framework. The findings are expected to determine if VR can serve as a feasible and effective tool to improve clinical outcomes and patient well-being in surgical wards.",[27,118,56,119],"Postoperative Recovery","Length of Hospital Stay",[121,122,123,124,125,126],"Virtual Reality","VR Therapy","Distraction Therapy","ERAS (Enhanced Recovery After Surgery)","Perioperative Care","Non-pharmacological Pain Management","2026-04-19",{"date":129,"type":33},"2026-04-23",{"date":131,"type":33},"2026-03-28",{"date":133,"type":20},"2026-05",{"name":135,"class":72},"Alexandria University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":49,"minAge":112,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":21,"phases":146,"briefSummary":147,"conditions":148,"keywords":151,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":165,"locationsCount":167},"100630335","awareness-neuraxial-versus-general-anesthesia-in-frail-patients-undergoing-laparoscopic-or-robotic-abdominopelvic-surgery-100630335","NCT07486336","Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","Neuraxial Anesthesia Awareness Versus General Anesthesia in Frail Patients Undergoing Elective Laparoscopic or Robotic Abdominopelvic Surgery: A Pilot Randomized Controlled Trial.","SAFE-AWARENESS","Inclusion Criteria:\n\n* Age \\> 60 years\n* Willingness to participate in the study and written informed consent\n* ASA physical status \\> 2\n* Frailty score \\> 5 and\u002For AMT-10 \\\u003C 6\n* Laparoscopic or robotic major elective abdominopelvic surgery\n\nExclusion Criteria:\n\n* Patients undergoing open (laparotomic) or emergency surgery, or presenting contraindications to central locoregional (neuraxial) anesthesia, specifically:\n\n  * coagulation disorders\n  * severe spinal deformities\n  * known allergy to local anesthetics\n  * severe aortic stenosis\n  * systemic sepsis\n  * infection at the puncture site\n* Any systemic disease that, in the investigator's judgment, is not compatible with participation in the study",{"count":145,"type":20},100,[23],"This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major laparoscopic or robotic abdominopelvic surgery.\n\nA total of 100 frail patients aged over 60 years, with ASA physical status \\>2 and evidence of frailty and\u002For cognitive vulnerability, will be randomized to receive either standard general anesthesia with mechanical ventilation or thoracic neuraxial anesthesia combined with non-GABAergic sedation while maintaining spontaneous breathing.\n\nThe primary objective is to evaluate the feasibility in terms of recruitment of a RCT conducted in a population of frail or cognitively impaired patients undergoing major laparoscopic abdominal surgery, randomized to a neuraxial or general anesthetic approach in which the effects on the onset of postoperative delirium and postoperative cognitive dysfunction (POCD) will be determined. Secondary outcomes include the occurrence of postoperative organ dysfunction (respiratory, cardiovascular, renal, and metabolic), length of hospital stay, time to recovery after surgery, and postoperative mortality.\n\nPatients will undergo comprehensive perioperative clinical, laboratory, and ultrasound assessments, including lung and renal ultrasound evaluations. Neurological and functional status will be assessed during hospitalization, at 1 month, and via telephone follow-up at 1 year after surgery.\n\nThe aim of the study is to evaluate the feasibility and safety of performing two different anesthetic techniques on fragile patients.",[149,27,150],"Fraily","Postoperative Cognitive Dysfunction (POCD)",[152,153,154,155,156,157,158],"neuraxial anesthesia","awake surgery","frailty","postoperative delirium","cognitive outcomes","perioperative medicine","enhanced recovery after surgery","2026-03-17",{"date":161,"type":33},"2026-03-20",{"date":163,"type":20},"2026-09-01",{"date":101,"type":20},{"name":166,"class":72},"Ente Ospedaliero Ospedali Galliera",2,{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":178,"phases":4,"briefSummary":179,"conditions":180,"keywords":181,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":41},"100624986","analysis-of-the-composition-of-the-intestinal-microbiota-in-patients-post-intestinal-anastomosis-100624986","NCT07416760","Analysis of the Composition of the Intestinal Microbiota in Patients Post-intestinal Anastomosis","Analysis of the Composition of the Intestinal Microbiota and Its Evolution in Patients Post-intestinal Anastomosis","MIDESIN","Inclusion Criteria:\n\n* Patients who have undergone colorectal intestinal anastomosis.\n* Signing of the informed consent form.\n* Age ≥18 years with good functional status.\n* Availability for postoperative follow-up.\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Intra-abdominal sepsis or previous dehiscence.\n* Severe immunosuppression.\n* Use of antibiotics in the 3 months prior to preoperative preparation.\n* Pregnancy or breastfeeding.",{"count":177,"type":20},30,"OBSERVATIONAL","Recent research suggests a significant link between gut microbiota and anastomotic leakage (AL) in colorectal surgery. Patients who develop AL have a higher abundance of bacteria from the Lachnospiraceae family and lower microbial diversity.\n\nConsidering the bibliographic data, our main interest is to analyze the microbial population of patients in our social environment and then look for differences in the microbiome between those who have suffered an anastomotic dehiscence (around 8-9% according to the results of our hospital's Surgery Department) and those who have not.",[27],[182,183,184],"Microbiome","intestinal anastomosis","dehiscence","2026-02-13",{"date":187,"type":33},"2026-02-18",{"date":189,"type":33},"2026-02-14",{"date":191,"type":20},"2026-12-14",{"name":193,"class":72},"Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":4,"enrollmentInfo":201,"targetDuration":203,"studyType":178,"phases":4,"briefSummary":204,"conditions":205,"keywords":206,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":41},"100459885","development-intraoperative-demonstration-and-visualization-of-surgical-assistance-functions-100459885","NCT05268432","Development, Intraoperative Demonstration and Visualization of Surgical Assistance Functions","IDEMONSTRATE","Inclusion Criteria:\n\n* Indication for surgery using a laparoscopic or open surgical camera, a surgical robot (e.g., DaVinci system), or an intraoperative imaging modality (e.g. sonography, intraoperative CT)\n* Patient understands German\n\nExclusion Criteria:\n\n* Lack of ability to consent",{"count":202,"type":20},40,"90 Days","The aim of the planned study is the development of surgical assistance functions on the basis of clinical routine data and the evaluation of the technical feasibility of an intraoperative demonstration and visualization of such assistance functions in visceral surgery. Furthermore, this trial aims to provide preliminary data on the clinical outcome of such assistance systems.",[27],[207,208],"Surgical data science","computer vision","2026-02-06",{"date":211,"type":33},"2026-02-10",{"date":213,"type":33},"2021-05-19",{"date":215,"type":20},"2050-12-31",{"name":217,"class":72},"Technische Universität Dresden",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":21,"phases":227,"briefSummary":228,"conditions":229,"keywords":232,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":4},"100619431","effect-of-preoperative-abdominal-effleurage-on-postoperative-constipation-100619431","NCT07344532","Effect of Preoperative Abdominal Effleurage on Postoperative Constipation","The Effect of Preoperative Abdominal Superficial Effleurage Training on the Development of Postoperative Constipation in Patients Undergoing Abdominal Surgery","Inclusion Criteria:\n\n* Patients scheduled to undergo abdominal surgery\n* Patients who are able to communicate verbally\n* Patients who agree to participate in the study and provide written informed consent\n\nExclusion Criteria:\n\n* Patients with preoperative constipation\n* Patients with known gastrointestinal diseases affecting bowel motility\n* Patients who are unable to perform abdominal superficial effleurage\n* Patients with cognitive impairment or communication difficulties\n* Patients who refuse to participate in the study",{"count":226,"type":20},42,[23],"This randomized controlled study aims to evaluate the effect of preoperative abdominal superficial effleurage training on the development of postoperative constipation in patients undergoing abdominal surgery. Participants will be randomly assigned to an intervention group receiving abdominal superficial effleurage training in addition to routine care or to a control group receiving routine care only. The effleurage technique will be taught preoperatively and performed by patients postoperatively. Postoperative constipation will be assessed on the 10th postoperative day using the Bristol Stool Form Scale. The findings of this study are expected to contribute to non-pharmacological nursing interventions for the prevention of postoperative constipation.",[230,27,231],"Constipation","Postoperative Constipation",[231,27,233,234],"Abdominal Effleurage","Non-Pharmacological Intervention","2026-01-25",{"date":237,"type":33},"2026-01-27",{"date":239,"type":20},"2026-03-10",{"date":241,"type":20},"2026-09-10",{"name":243,"class":72},"Ege University",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":252,"enrollmentInfo":253,"targetDuration":4,"studyType":21,"phases":255,"briefSummary":256,"conditions":257,"keywords":263,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":41},"100614544","comparing-polyglactin-vs-polypropylene-sutures-for-rectus-sheath-closure-100614544","NCT07280975","Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure","Comparative Outcomes of Polyglactin Versus Polypropylene Sutures for Rectus Sheath Closure: A Randomized Controlled Trial","PolySuture","Inclusion Criteria:\n\n1. Age: 18-70 years.\n2. Type of Surgery: Patients undergoing elective or emergency midline laparotomy.\n3. Wound Classification: Clean or clean-contaminated wounds (CDC Class I or II).\n4. Ability to Provide Informed Consent: Participants must be able to understand and sign the informed consent form.\n5. Availability for Follow-Up: Participants must be available for 6 months follow-up.\n\nExclusion Criteria:\n\n1. Contaminated or Dirty Wounds: Patients with CDC Class III or IV wounds.\n2. Immunocompromised Conditions: Patients on steroids, chemotherapy, or those with HIV.\n3. Previous Midline Laparotomy with Incisional Hernia: Patients who have a history of incisional hernia after midline laparotomy.\n4. Severe Malnutrition: Patients with BMI \\\u003C 16 kg\u002Fm² or albumin \\\u003C 2.5 g\u002FdL.\n5. Emergency Laparotomy with Hemodynamic Instability: Patients who are unstable or in a critical condition.\n6. Pregnancy: Pregnant women.\n7. Need for Temporary Abdominal Closure or Planned Reoperation: Patients requiring staged reoperation or temporary closure.","70 Years",{"count":254,"type":20},156,[23],"This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy. The study will evaluate the rates of incisional hernia, surgical site infection (SSI), wound dehiscence, chronic pain, and suture sinus formation. Participants aged 18-70 years, undergoing either elective or emergency laparotomy, will be randomly assigned to receive either Polyglactin or Polypropylene sutures. The primary outcome measure is the incidence of incisional hernia at 6 months, with secondary outcomes including SSI, wound complications, and chronic pain. The study is particularly important in the context of Pakistan, where such comparative data is limited, and aims to provide evidence-based recommendations for optimal suture material selection in general surgery.",[258,259,260,261,262,27],"Chronic Pain","Wound Dehiscence","Surgical Site Infection (SSI)","Incisional Hernia","Rectus Sheath Closure",[264,265,266,267,268],"Polyglactin Sutures","Polypropylene Sutures","Non-Absorbable Sutures","Postoperative Complications","Midline Laparotomy","2025-12-09",{"date":271,"type":33},"2025-12-15",{"date":273,"type":20},"2026-04-01",{"date":275,"type":20},"2027-07-30",{"name":277,"class":278},"Lady Reading Hospital, Pakistan","OTHER_GOV",{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":21,"phases":288,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":300},"100566908","pip-care-to-improve-surgical-patient-outcomes-100566908","NCT06661291","Pip Care to Improve Surgical Patient Outcomes","Utilization of Digital Health Platform Plus Live Coaching Improves Surgical Patients Outcomes - Phase II","Inclusion Criteria:\n\n1. Adult patient ≥18 years old\n2. Planned elective, inpatient surgery between 2 to 8 weeks following enrollment in Pip within the following surgical specialties: complex abdominal surgery (general surgery, colorectal surgery, surgical oncology), gynecologic oncology, thoracic surgery, spine surgery, and orthopedic joint surgery\n3. Daily access to a smartphone or tablet.\n\nExclusion Criteria:\n\n1. Unable to speak English\n2. Unable to use a smartphone or tablet independently or with daily assistance.\n3. Currently pregnant (assessed via standard-of-care pre-operative workup)",{"count":287,"type":20},1300,[23],"Pip Care is developing a personalized, interactive surgical journey platform with a live health coach that works directly with health systems to optimize the perioperative care process. Our Health Insurance Portability and Accountability Act (HIPAA)-compliant platform, Pip, can be integrated into any electronic medical record (EMR), thus alleviating the administrative burden by making operational workflows more efficient. The PIP empowers patients and their families to be more involved in their care by breaking down a patient's healthcare plan into definable, easy-to-understand, and easy-to-complete tasks. Additionally, a health coach completes a health intake to create a personalized perioperative care plan, meets regularly with the patient to encourage goal accomplishment, and facilitates care coordination. This project has 2 phases; Phase I is to assess usability of the Pip Care platform in surgical patients, Phase II is a RCT (Randomized Controlled Trial) to assess surgical clinical outcomes while using Pip compared to standard of care.",[27],"2025-10-24",{"date":293,"type":33},"2025-10-28",{"date":295,"type":33},"2025-10-13",{"date":297,"type":20},"2028-09-01",{"name":299,"class":72},"University of Pittsburgh",8,{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":307,"sex":49,"minAge":17,"maxAge":308,"enrollmentInfo":309,"targetDuration":4,"studyType":21,"phases":311,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":320,"locationsCount":4},"100584702","effect-of-hot-pack-application-on-gastrointestinal-motility-after-abdominal-surgery-100584702","NCT06892782","Effect of Hot Pack Application on Gastrointestinal Motility After Abdominal Surgery","Inclusion Criteria:\n\n18 years of age or older\n\nUndergoing elective surgery\n\nASA I and III (American Society of Anesthesiologists physical status classification)\n\nIn the postoperative period, pulse, blood pressure, and body temperature within normal limits\n\nPatients without previous gastrointestinal system surgery\n\nExclusion Criteria:\n\nPrevious gastrointestinal tract surgery\n\nComplications in the postoperative period\n\nHistory of small bowel resection and ileostomy or colostomy\n\nHistory of inflammatory bowel diseases, emergency surgery, neoadjuvant therapy, appendectomy surgery\n\nChronic opioid use\n\nExperiencing chronic constipation (≤ 2 bowel movements per week)\n\nReceiving abdominal radiotherapy\n\nPatients admitted to intensive care unit and patients with bleeding",true,"65 Years",{"count":310,"type":20},80,[23],"Study Title:\n\nThe Effect of Hot Water Pack Application to the Lumbar Region on Gastrointestinal Motility in Postoperative Abdominal Surgery Patients\n\nStudy Type:\n\nInterventional (Randomized Controlled Trial)\n\nStudy Design:\n\nAllocation: Randomized Intervention Model: Parallel Assignment Masking: Single-blind (Outcome Assessor) Primary Purpose: Supportive Care\n\nCondition:\n\nPostoperative Gastrointestinal Motility in Abdominal Surgery Patients\n\nInterventions:\n\nExperimental: Hot Water Pack Application Intervention: Application of a hot water pack (heated to 40-42°C) to the lumbar region for 20 minutes, three times a day, in the first 48 postoperative hours.\n\nPurpose: To evaluate its effect on gastrointestinal motility and postoperative recovery.\n\nControl: Routine Care Intervention: Standard postoperative care without hot water pack application.\n\nPrimary Outcome Measures:\n\nTime to First Postoperative Gas (Hours) \\[Time Frame: Up to 72 hours\\]\n\nTime to First Postoperative Stool (Hours) \\[Time Frame: Up to 72 hours\\] Time to Initiation of Oral Intake (Hours) \\[Time Frame: Up to 72 hours\\]\n\nSecondary Outcome Measures:\n\nIncidence of Postoperative Nausea and Vomiting (PONV) \\[Time Frame: Up to 72 hours\\] Severity of Abdominal Distension \\[Time Frame: Up to 72 hours\\]\n\nQuality of Recovery-15 (QoR-15) Scale Score \\[Time Frame: Postoperative Days 1 and 3\\]\n\nGastrointestinal Symptom Rating Scale (GSRS) Score \\[Time Frame: Postoperative Days 1 and 3\\]\n\nEligibility Criteria:\n\nInclusion Criteria:\n\nAbdominal surgery in the general surgery ward Age ≥ 18 years BMI between 18.50-24.99 kg\u002Fm² Able to communicate verbally Conscious, oriented, and willing to participate\n\nExclusion Criteria:\n\nPrevious gastrointestinal surgery Postoperative complications History of small bowel resection, ileostomy, or colostomy History of inflammatory bowel disease, emergency surgery, neoadjuvant therapy, appendectomy Chronic opioid use Chronic constipation (≤ 2 bowel movements per week) Abdominal radiotherapy ICU admission or postoperative bleeding\n\nEstimated Enrollment:\n\n80 participants (40 intervention, 40 control)",[27],"2025-03-22",{"date":316,"type":33},"2025-03-25",{"date":318,"type":20},"2025-03-15",{"date":271,"type":20},{"name":321,"class":72},"TC Erciyes University",{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":326,"acronym":327,"eligibilityCriteria":328,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":178,"phases":4,"briefSummary":330,"conditions":331,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":41},"100578264","mobilisation-and-breathing-exercises-after-abdominal-surgery-at-sahlgrenska-university-hospital-100578264","NCT06809036","Mobilisation and Breathing Exercises After Abdominal Surgery at Sahlgrenska University Hospital","SUMO","Inclusion Criteria:\n\n* undergoing elective or emergency open, or robot-assisted abdominal surgery\n* has an expected anesthesia time of over 4 hours\n* is extubated on the operating table\n* planned overnight stay in the postoperative ward.\n\nExclusion Criteria:\n\n* plastic, trauma, transplant or orthopedic surgery.",{"count":145,"type":20},"The aim of the study is to evaluate the effect of a new care strategy, including earlier and more intensive mobilization and individually adapted breathing exercises, regarding length of stay, recovery, complications and which factors predict interventions early in the postoperative course after various abdominal surgical procedures.",[27],"2025-03-11",{"date":334,"type":33},"2025-03-12",{"date":336,"type":33},"2025-02-03",{"date":338,"type":20},"2026-12-31",{"name":340,"class":72},"Göteborg University",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":11,"sex":49,"minAge":17,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":21,"phases":350,"briefSummary":351,"conditions":352,"keywords":354,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":4},"100552686","virtual-reality-glasses-and-stress-ball-applications-in-dressing-change-100552686","NCT06476314","Virtual Reality Glasses and Stress Ball Applications in Dressing Change","Examination of the Effects of Virtual Reality Glasses and Stress Ball Applications on Pain, Vital Signs Anxiety, Fear, Satisfaction, and Comfort Levels During the Dressing Changes in Patients Who Underwent Abdominal Surgery","Inclusion Criteria:\n\n* Acceptance to participate in the study both in writing and verbally.\n* Being over 18,\n* Having undergone abdominal surgery,\n* Being on the 1st day after surgery,\n* Being subjected to first dressing after surgery,\n* Staying in the one-person room or being the only patient in the room,\n* Being conscious (person, place and time orientation),\n* Patients who have no vision, hearing or communication problems will be included in the study.\n\nExclusion Criteria:\n\n* Patients using analgesic, anxiolytic, and sedative medications before, during, and immediately after dressing changes.\n* Having chronic pain disorder\n* Having a disease that may affect primarily vital signs (such as Hypertension, COPD),\n* Not having any psychiatric and cognitive\u002Fmental disease (dementia, etc.),\n* Having chronic diseases like epilepsy, vertigo,\n* Being diagnosed with vision, hearing(auditory) and\u002For balance disorder\n* Having an addiction or abusing alcohol or drugs.",{"count":349,"type":20},120,[23],"According to the statistical data of the Ministry of Health for the year 2021 in Türkiye, approximately 4.7 million surgical interventions are performed annually. According to the 2017 data from the National Health Service-Associated Infections Surveillance Network, the Surgical Site Infection (SSI) rate in our country is 0.72%, and it is stated that it can be prevented by approximately 60%. Dressing application holds an important place in surgical wound management, wound healing, and preventing complications. Patients may experience pain, anxiety, and fear due to unknown factors and previous experiences during the dressing change which holds an important place in wound care management. The aim is to minimize patients\\' negative emotions\u002Fsituations during dressing changes by diverting their attention elsewhere using virtual reality (VR) glasses and stress balls. Upon reviewing the literature, no study was found that examines the effect of applying VR glasses and stress balls during abdominal surgery dressing changes on pain, vital signs, anxiety, fear, comfort, and satisfaction levels in adults. In this regard, the aim of the research is; to examine the effects of VR glasses and stress ball application on pain, vital signs, anxiety, fear, comfort, and satisfaction levels during dressing changes in patients undergoing abdominal surgery. The study was designed as a pre-test post-test control group randomized experimental model. The sample of the study consists of adult patients who underwent abdominal surgery in Isparta City Hospital General Surgery Service-1. In the study sample, 120 individuals were included in total 40 with VR glasses, 40 individuals using stress balls, and 40 in the control group. Patient Information Form, Visual Analog Scale, and State-Trait Anxiety Scale will be used in data collection. Data from the study will be analyzed with number, percent, average, x-square, variance, and t-test in a computer environment. In consideration of the data, it is believed that important findings will be obtained in increasing satisfaction and comfort by eliminating pain, anxiety, and fear during dressing changes in patients.",[353,27],"Surgical Wound",[355,356,357,358,359,360,361,362,363,364,365,366],"Dressing","surgical wound","incision","virtual reality glasses","stress ball","nursing care","pain","vital signs","anxiety","fear","satisfaction","comfort levels","2024-06-20",{"date":369,"type":33},"2024-06-26",{"date":371,"type":20},"2024-07",{"date":373,"type":20},"2025-01",{"name":375,"class":72},"Suleyman Demirel University",{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":4,"eligibilityCriteria":382,"healthyVolunteers":11,"sex":49,"minAge":383,"maxAge":384,"enrollmentInfo":385,"targetDuration":4,"studyType":21,"phases":387,"briefSummary":388,"conditions":389,"keywords":390,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":41},"100550993","effects-of-acbt-and-blow-bottle-technique-in-patients-with-abdominal-surgeries-under-general-anesthesia-100550993","NCT06454305","Effects of ACBT and Blow Bottle Technique in Patients With Abdominal Surgeries Under General Anesthesia","Comparative Effects of Active Cycle of Breathing Technique and Blow Bottle Technique to Prevent Post-operative Pulmonary Complications in Patients With Abdominal Surgeries Under General Anesthesia","Inclusion Criteria:\n\n* Age 30 to 50 Gender: male\u002FFemale Both Elective surgeries Under General Anesthesia (Cholecystectomy, Hysterectomy ,Appendectomy, Hemorrhoidectomy) Laparoscopic \u002Fopen both POCs: Sputum retention, hypoxemia, impair pulmonary function From the day 0 or immediate after surgery\n\nExclusion Criteria:\n\n* Elective surgeries under spinal anesthesia Emergency surgeries Cardiothoracic surgeries Neurological impairment, prolong surgeries Psychological impairment Head and neck surgeries and vascular surgeries Hemodynamically unstable","30 Years","50 Years",{"count":386,"type":20},44,[23],"A postoperative pulmonary complication (PPC) is the most common serious complication after Abdominal surgery under GA which lead to longer hospital stays and have deleterious outcomes on lung volumes, mucociliary clearance, accumulation of mucus, saliva and cough reflex. Chest physiotherapy for airway clearance which includes postural drainage, chest percussion, vibrations, Along with these, breathing exercises such ACBT and Blow bottle technique are recommended to clear secretion which aid in enhancing pulmonary function by effectively mobilizing and eliminating excess bronchial secretions.\n\nThis study of randomized clinical trial will check the comparative effect of ACBT and Blow Bottle Technique in patients with abdominal surgeries under GA by taking a sample of 44 patients through non probability convenience sampling technique. Subject of both gender will be included between the age of 30 to 50 years who will undergoes with elective abdominal surgeries under GA (Cholecystectomy, Hysterectomy ,Appendectomy, Hemorrhoidectomy) and Laparoscopic \u002Fopen. Elective surgeries under spinal anesthesia, emergency surgeries, cardiothoracic surgeries and hemodynamically unstable subjects will be excluded. 22 subjects will receive ACBT and other 22 subjects will receive Blow bottle technique for 20 minutes duration per session, two sessions per day for a period of 5 days. The status of airway clearance, oxygen saturation and lungs volumes will be measured pre and post intervention on day 1 and at the end of 5th day by using BCSS, Pulse oximeter and Spirometer.",[27],[391,392,393,394],"Abdominal Surgeries","Active cycle of breathing Technique","Blow Bottle Technique","Pulmonary Complications,","2024-06-06",{"date":397,"type":33},"2024-06-12",{"date":399,"type":33},"2024-01-15",{"date":401,"type":20},"2024-07-15",{"name":403,"class":72},"Riphah International University"]