[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"abdominal-wall-hernia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:abdominal-wall-hernia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,40,66,94,126,153,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100510401","preoperative-weight-loss-for-open-abdominal-wall-reconstruction-100510401",false,"NCT05925959","Preoperative Weight Loss for Open Abdominal Wall Reconstruction","Inclusion criteria\n\n* Adults having open retromuscular ventral hernia repair with an anticipated posterior component separation with transversus abdominis release and synthetic mesh\n* BMI 40-55 kg\u002Fm2 and who are not planning to pursue weight loss surgery for any of the following reasons: they are not a candidate for weight loss surgery, cannot pursue weight loss surgery for insurance reasons, or are not interested in pursuing weight loss surgery.\n\nExclusion criteria\n\n* Lack of English language fluency\n* Urgent need for repair as determined by surgeon judgement\n* Pregnant patients\n* Permanent stoma in place\n* Isolated flank hernia\n* Anticipated need for staged operation; for example, patients who will undergo a mesh excision separate from definitive reconstruction.\n* BMI \\\u003C40 or \\>55 kg\u002Fm2\n* Inability to participate in the Obesity Management Program due to lack of insurance coverage or history of mental illness (including eating disorders, schizophrenia, etc.).\n* Obstructive symptoms",true,"ALL","18 Years",{"count":19,"type":20},258,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this randomized controlled trial is to compare preoperative intensive weight management to upfront surgery in obese patients undergoing complex abdominal wall reconstruction. The main question is will abdominal wall specific quality of life (using the HerQLes survey) for the group undergoing upfront surgery be non-inferior compared to the group in the weight management program.",[26],"Abdominal Wall Hernia","RECRUITING","2026-03-19",{"date":30,"type":31},"2026-03-23","ACTUAL",{"date":33,"type":31},"2023-06-19",{"date":35,"type":20},"2027-06-01",{"name":37,"class":38},"Benjamin T. Miller","OTHER",2,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":65},"100629583","evaluating-the-efficacy-of-suture-mesh-vs-planar-mesh-in-ventral-hernia-treatment-100629583","NCT07476560","Evaluating the Efficacy of Suture Mesh vs. Planar Mesh in Ventral Hernia Treatment","Mesh Matters: Evaluating the Efficacy of Suture Mesh vs. Planar Mesh in Ventral Hernia Treatment - a Randomized, Blinded Multicenter Study","MeMa","Inclusion Criteria:\n\n* Ventral hernia (maximum size 3 × 3 cm) measured with Ultrasound or CT.\n* Participants must be eligible for surgical repair using either mesh-suture or planar mesh\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years.\n* Acute (emergent) operation.\n* Pregnancy.\n* Women with plans for future pregnancies.\n* Withdrawal of informed consent during admission.",{"count":49,"type":20},280,[23],"The goal of this clinical trial is to investigate whether mesh-suture affects wound complication rates, patient-reported quality of life, and operation time in adult patients undergoing surgery for small ventral hernias.\n\nThe main questions it aims to answer are:\n\nDoes mesh-suture reduce wound complication rates compared to planar mesh? Does mesh-suture improve patient-reported quality of life(QoL) and affect operation time compared to planar mesh?\n\nComparison group:\n\nResearchers will compare standard treatment with planar mesh to the interventional treatment with mesh-suture to see whether mesh-suture leads to fewer complications, better quality of life, and shorter operation time.\n\nParticipants will:\n\nBe randomized to receive either planar mesh or mesh-suture during hernia repair surgery.\n\nUndergo standardized preoperative assessment, including baseline data and QoL scoring.\n\nAttend a postoperative visit on day 7-13 for wound inspection and ultrasound. Complete QoL assessments at 90 days (telephone follow-up). Have operation time recorded and medical records reviewed for readmissions within 90 days.",[26,53,54],"Umbilical Hernia Repair","Epigastric Hernia Repair","2026-03-12",{"date":57,"type":31},"2026-03-17",{"date":59,"type":31},"2026-01-05",{"date":61,"type":20},"2032-12-31",{"name":63,"class":64},"Regionshospital Nordjylland","OTHER_GOV",1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":73,"targetDuration":75,"studyType":76,"phases":4,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":4},"100618069","hernia-repair-using-rectus-fascia-allograft-100618069","NCT07326826","Hernia Repair Using Rectus Fascia Allograft","Abdominal Wall Hernia Repair With Implantation of an Allogeneic Non-vascularised Rectus Abdominis Fascial Graft: A Pilot Prospective Observational Study","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Solid organ transplant recipients (liver, kidney, pancreas, heart, or combined transplantation) ≥ 6 months post-transplantation with a primary ventral or incisional hernia.\n* Non-transplant patients with a complex abdominal wall defect not amenable to currently established reconstructive methods (e.g., mesh repair, flap transposition, component separation).\n* ECOG performance status 0-2.\n* Written informed consent.\n\nExclusion Criteria:\n\n* ECOG performance status 3-4.\n* Pregnancy.\n* High-dose corticosteroid therapy.",{"count":74,"type":20},20,"12 Months","OBSERVATIONAL","Abdominal wall closure in highly complex patients is one of the most difficult tasks in abdominal surgery. Repeated laparotomies, enterocutaneous fistulas, loss of the fascial layer and contaminated operative fields may prevent safe fascial approximation, and closure under high tension can lead to serious complications such as abdominal compartment syndrome. These problems are frequently encountered after intestinal or multivisceral transplantation and are not uncommon after liver transplantation. While component separation, flap techniques and mesh reinforcement are available, standard approaches may be insufficient or inappropriate in extensive or contaminated defects, and synthetic mesh may be contraindicated due to infection risk.\n\nAn allogeneic non-vascularized rectus abdominis fascial graft (NVRF) offers a practical alternative for isolated fascial defects with preserved skin coverage. The technique is relatively simple, reproducible, and does not require vascular reconstruction, potentially filling a gap where synthetic mesh is unsuitable. However, current evidence is limited, heterogeneous and largely retrospective.\n\nThis pilot prospective observational study will assess the feasibility and outcomes of elective incisional or primary ventral hernia repair using NVRF in (1) solid organ transplant recipients and (2) highly selected patients with exhausted standard abdominal wall reconstruction options and contraindications to synthetic mesh. Key outcomes include 12-month hernia recurrence, 90-day surgical site infection, immunologic response measured by donor-specific anti-HLA antibodies, direct healthcare costs over 12 months, and patient-reported quality of life using the EuraHS-QoL questionnaire.",[26],[80,81,82,83],"hernia repair","fascia","transplant","abdominal wall reconstruction","NOT_YET_RECRUITING","2026-01-08",{"date":87,"type":31},"2026-01-12",{"date":89,"type":20},"2026-02-01",{"date":91,"type":20},"2029-02-10",{"name":93,"class":64},"Institute for Clinical and Experimental Medicine",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":113,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":65},"100309634","abdominal-wall-transplant-100309634","NCT03310905","Abdominal Wall Transplant","Abdominal Wall Transplantation for the Reconstruction of Abdominal Wall Defects as Adjunct to Abdominal Solid Organ Transplantation","Inclusion Criteria:\n\n* Candidates between 18-65 years old\n* Willingness and legal ability to give consent\n* Abdominal Wall in combination with another organ transplant: they must be eligible for the non-vascularized composite allograft organ transplant at Duke\n\nExclusion Criteria:\n\n* Malignancy at evaluation or history of malignancy that precludes transplantation\n* Pregnancy: Women who are of childbearing potential must have a negative serum pregnancy test within 48 hours of transplant and agree to use reliable contraception with two contraceptive methods for a minimum of 2 years following abdominal wall transplantation. Subjects seeking to become pregnant following 2 years will be made aware during the consent process that the effect of pregnancy on the transplanted abdominal wall and vice versa is unknown.\n* Medical exclusion criteria for general anesthesia\n* Ongoing substance abuse or history of untreated substance abuse","65 Years",{"count":103,"type":20},5,[23],"The purpose of this protocol is to determine the safety and efficacy of abdominal wall transplantation as a treatment for the reconstruction of abdominal wall defects. Abdominal wall transplantation may be performed alone or in combination with another transplant.",[107,108,109,110,111,26,112],"Transplant;Failure,Kidney","Transplant; Failure, Liver","Transplant; Failure, Bowel","Abdominal Wall Defect","Abdominal Wall Fistula","Abdominal Wall Injury",[114,115,116,117],"Research","Transplant","Abdominal Wall","Hernia",{"date":119,"type":31},"2026-01-07",{"date":121,"type":31},"2018-05-01",{"date":123,"type":20},"2028-06-01",{"name":125,"class":38},"Duke University",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":4},"100483446","robotic-versus-open-comparison-in-the-surgical-treatment-of-wide-abdominal-wall-hernias-rocstar-100483446","NCT05575141","Robotic Versus Open Comparison in the Surgical Treatment of Wide Abdominal Wall heRnias (ROCSTAR)","Robotic Versus Open Comparison in the Surgical Treatment of Wide Abdominal Wall Hernias: a Multicenter International Randomized Controlled Trial","ROCSTAR","Inclusion Criteria:\n\n\\- All patients requiring treatment of a wide ventral incisional hernia (of more than 8 centimetres in width)\n\nExclusion Criteria:\n\n* Pregnant or suspected pregnancy\n* Not-curatively treated malignancy, with life expectancy less than 24 months\n* Patients unable to give informed consent or complete study specific questionnaires\n* Emergency surgery\n* Primary ventral hernia repair\n* Exclusively lateral hernias not involving the midline\n* Incisional hernia repair after open abdomen or enterocutaneous fistula\n* Active wound infection\n* Previous anterior or posterior component separation\n* Patients with an existing ostomy\n* Patients with a life expectancy of less than 24 months\n* Patients suspected of being unable to comply with the study protocol",{"count":135,"type":20},100,[23],"In the treatment of ventral incisional hernias, a mesh repair in the retromuscular plane is considered as the gold standard. To allow for adequate medialization of the fascial borders and a complete closure of the defect in case of large incisional hernias, component separation techniques are increasingly being used. When compared to anterior component separation, posterior component separation by transversus abdominis release (TAR) seems to decrease postoperative wound problems. While laparoscopic techniques pose significant difficulties to perform TAR minimally invasively (mainly due to ergonomic and technical reasons), these limitations seem to be overcome by robotic platforms. Initial retrospective patient series report on significantly shorter postoperative hospital stay and fewer complications after robotic transversus abdominis release (rTAR), when compared to open transversus abdominis release (oTAR). High-quality prospective evidence on rTAR is currently lacking.",[139,26],"Ventral Incisional Hernia",[26,141,142,143],"robotic TAR (rTAR)","open TAR (oTAR)","transversus abdominis release (TAR)","2025-04-10",{"date":146,"type":31},"2025-04-11",{"date":148,"type":20},"2025-07-01",{"date":150,"type":20},"2033-01-01",{"name":152,"class":38},"Algemeen Ziekenhuis Maria Middelares",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":21,"phases":162,"briefSummary":163,"conditions":164,"keywords":168,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":4},"100583148","effects-of-a-multicomponent-training-program-on-health-outcomes-in-patients-with-abdominal-wall-hernia-100583148","NCT06872554","Effects of a Multicomponent Training Program on Health Outcomes in Patients with Abdominal Wall Hernia","Effects of a Pre Surgery Multicomponent Training Program on Strength, Pain, and Quality of Life in Patients with Abdominal Wall Hernias","Inclusion Criteria:\n\n* Patients ≥ 18 years\n* Ventral hernia ≥ 4cm (W2-3 per EHS classification)\n* Signed informed consent\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years\n* Ventral hernia \\\u003C4cm (W1 per EHS classification)\n* Severe physical\u002Fcognitive impairment affecting mobility and daily activities",{"count":161,"type":20},75,[23],"Abdominal wall hernias are among the most prevalent pathologies today, characterized by specific symptoms such as pain, a sensation of tightness in the affected area, and potential gastrointestinal complications. These symptoms negatively impact patients' health and quality of life.\n\nIn other clinical conditions, such as osteoarthritis, sarcopenia, and fibromyalgia, participation in multicomponent training programs (which integrate strength, mobility, and stretching exercises) has been documented to significantly improve quality of life, reduce pain, and optimize patients' functional capacity. Likewise, scientific literature highlights that in the context of injuries requiring surgical intervention, such as anterior cruciate ligament or meniscus tears, patients who underwent prehabilitation programs based on multicomponent training experienced fewer losses in functional and structural aspects, such as strength and muscle mass. These programs also contributed to a reduction in postoperative pain perception.\n\nTherefore, the primary objective of this study is to evaluate the effects of a multicomponent training program on health variables (pain, quality of life, perceived exertion, and recurrence) and functional capacity (trunk isometric strength, grip strength, and lower limb dynamic strength) in patients with abdominal wall hernias. As a secondary objective, the impact of this program on the aforementioned variables after abdominal wall repair surgery will be investigated.",[26,165,166,167],"Prevention","Exercise","Physical Activity",[169,170,171,172,173,174],"hernia","abdominal wall","exercise intervention","quality of life","pain","incisional hernial","2025-03-06",{"date":177,"type":31},"2025-03-12",{"date":179,"type":20},"2025-04-15",{"date":181,"type":20},"2025-12-15",{"name":183,"class":38},"University of Seville",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":191,"targetDuration":193,"studyType":76,"phases":4,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":65},"100335153","web-based-international-register-of-emergency-surgery-and-trauma-100335153","NCT03643718","Web-based International Register of Emergency Surgery and Trauma","WIRES-T","Inclusion Criteria:\n\n* Patients affected by an acute surgical disease\n* Patients with indication to be referred to the emergency surgeon attention\n* Patients to be operated or to be treated with non-operative approach without surgical intervention\n\nExclusion Criteria:\n\n* Patients not affected by an acute surgical disease\n* Patients without indication to be referred to the emergency surgeon attention",{"count":192,"type":20},10000,"2 Weeks","The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a worldwide register of traumatic and non traumatic surgical emergencies. This will give the opportunity to evaluate results on a macro-data basis and to give index allowing stratifying, evaluating and improving the outcomes.",[196,197,198,199,200,201,202,203,204,205,206,26,207,208,209],"Acute Appendicitis","Acute Cholecystitis","Acute Diverticulitis","Post-operative Complications","Acute Pancreatitis","Perforated Gastro-duodenal Ulcers","Adhesive Small Bowell Occlusion","Colonic Neoplastic Emergencies","Gynecological Emergencies","Vascular Emergencies","Intestinal Ischemia","Foreign Bodies","Caustic Ingestion","Trauma","2020-07-10",{"date":212,"type":31},"2020-07-14",{"date":214,"type":20},"2020-07",{"date":216,"type":20},"2030-09",{"name":218,"class":38},"A.O. Ospedale Papa Giovanni XXIII"]