[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ablation-of-arrhythmias\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ablation-of-arrhythmias":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100637729","cerebral-microembolization-during-pulmonary-vein-isolation-comparison-of-different-pulsed-field-ablation-systems-100637729",false,"NCT07610018","Cerebral Microembolization During Pulmonary Vein Isolation: Comparison of Different Pulsed Field Ablation Systems","Cerebral Microembolization During Pulmonary Vein Isolation: a Randomized Comparison of Different Pulsed Field Ablation Systems","MICROPFA","Inclusion Criteria:\n\n* Age 18 years or older\n* Paroxysmal or persistent atrial fibrillation\n* Indication for catheter ablation with pulmonary vein isolation\n* Feasibility of transcranial Doppler assessment\n* Signed informed consent\n\nExclusion Criteria:\n\n* Recent stroke or transient ischemic attack\n* Significant cerebrovascular disease preventing reliable transcranial Doppler assessment\n* Severe valvular or structural heart disease\n* Pregnancy or breastfeeding\n* Inability to receive anticoagulation","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, randomized, parallel-group interventional study will compare cerebral microembolization during pulmonary vein isolation between different pulsed field ablation systems in patients with paroxysmal or persistent atrial fibrillation. Adult patients with an indication for catheter ablation will be randomized to one of the included ablation systems: PulseSelect, Varipulse, Farapulse, Sphere-9, or Sphere-360. Microembolic signals will be assessed using transcranial Doppler before and after the procedure. The primary outcome will be the difference in the change in microembolic signal burden, expressed as ΔMES, between the different ablation systems.",[27],"Ablation of Arrhythmia's",[29,30,31,32],"Atrial fibrillation","Pulmonary vein isolation","Cerebral microembolization","Pulsed field ablation","NOT_YET_RECRUITING","2026-05-21",{"date":36,"type":37},"2026-05-27","ACTUAL",{"date":39,"type":21},"2026-06-01",{"date":41,"type":21},"2027-01-20",{"name":43,"class":44},"Ivan Zeljkovic","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":45},"100608434","real-time-intracardiac-echocardiography-for-ventricular-arrhythmia-ablation-100608434","NCT07201506","Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation","Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation: A Randomized Controlled Trial","REAL-ICE","Inclusion Criteria:\n\n* Patients (≥18y) undergoing a premature ventricular contraction or ventricular tachycardia ablation.\n\nExclusion Criteria:\n\n* Origin of ventricular arrhythmia with high likelihood in the right ventricular outflow tract (left-bundle-inferior axis, \\>V4 transition precordially)\n* Primary epicardial ablation planned\n* Congenital heart disease\n* Presence of a mechanical tricuspid valve prosthesis\n* Unwilling or unable to comply fully with study procedures and followup",{"count":55,"type":21},70,[24],"This study is investigating whether using ultrasound directly inside the heart during ablation of heart rhythm disorders in the ventricles can reduce radiation exposure for patients.\n\nDuring an ablation, catheters are guided through the heart to treat the abnormal electrical signals. Usually, X-ray imaging (fluoroscopy) is used to see where the catheters are, which exposes both patients and hospital staff to radiation.\n\nThe study is randomized and controlled: half of the participants will have the ablation with ultrasound inside the heart, and the other half will have the standard ablation without ultrasound during the procedure. The main goal is to compare the amount of X-ray time used during the procedure. Secondary goals are to look at safety, effectiveness, and the total procedure time.\n\nPatients with premature ventricular contractions or ventricular tachycardia can take part. A total of 70 people will be included, 35 in each group. Using ultrasound inside the heart makes it possible to see the catheters and heart structures directly, so many steps can be done without X-rays. This could make ablations safer and reduce radiation exposure.\n\nThe study is being carried out at Inselspital, Bern University Hospital, and at University Hospital Basel. All steps are standardized and data are collected carefully. The results will show whether ultrasound during ablations can significantly reduce radiation and make ablations more efficient and safer.",[59,60,61,62],"Ablation of Arrhythmias","Premature Ventricular Contractions","Ventricular Tachycardia","Ventricular Arrhythmia","RECRUITING","2026-03-26",{"date":66,"type":37},"2026-04-01",{"date":68,"type":37},"2026-03-25",{"date":70,"type":21},"2027-06-30",{"name":72,"class":44},"Insel Gruppe AG, University Hospital Bern",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100601034","virtual-reality-in-electrophysiological-procedures-and-device-implantation-the-vr-inep-trial-100601034","NCT07105241","Virtual Reality in Electrophysiological Procedures and Device Implantation: the VR inEP Trial","VR inEP","Inclusion Criteria:\n\n* ≥16 years of age\n* Planned to undergo an invasive electrophysiological procedure (e.g., catheter ablation or electrophysiological study) or cardiac device implantation (e.g., pacemaker or implantable cardioverter defibrillator).\n* The procedure must be performed under local anesthesia.\n\nExclusion Criteria:\n\n* Patients undergoing procedures using (conscious) sedation\n* Patients who do not speak or understand Dutch\n* History of dementia\n* Severe visual impairment.","16 Years",{"count":82,"type":21},115,[24],"Each year about 37,000 patients undergo a catheter ablation to treat cardiac arrhythmias or have a cardiac device such as a pacemaker or implantable cardioverter defibrillator implanted in the Netherlands. Although the procedures positively impact health related outcomes on the long term, they are often accompanied by periprocedural pain and anxiety on a shorter term. These negative effects can be prevented or treated by pharmacological interventions (e.g. analgesics or benzodiazepines), but side effects of these drugs may compromise patient safety and extend hospital admissions. Distraction using Virtual Reality (VR) may be an attractive non-pharmacological alternative.\n\nIt is the aim of the Virtual Reality in Electrophysiological Procedures and device implantation (VR inEP) trial to study the feasibility and efficacy of VR to decrease experienced pain and anxiety in patients undergoing invasive procedures for arrhythmias and conduction disorders. The study also serves as a stepping stone towards structural implementation of VR into clinical care, by familiarizing care personnel of the cardiac catheterization rooms with the use of VR, its indications and logistics, and identifying potential barriers for structural implementation of VR.\n\nVR inEP is a single-center, open label, randomized controlled trial performed in the catheterization rooms in the Radboudumc. Adult patients undergoing an electrophysiological procedure (e.g., catheter ablation or electrophysiological study) or cardiac device implantation (e.g., pacemaker or implantable cardioverter defibrillator) performed under local anesthesia are eligible for inclusion. Patients consenting to participate are randomized in a 1:1 ratio to the VR intervention or control group, stratified for the indication for the procedure (50% electrophysiological procedures, 50% cardiac device implantations). Patients and their treatment teams are unblinded for the treatment allocation. The primary outcomes are pain perception and anxiety during the procedure as a whole, quantified using the visual analog scale (VAS) for pain and the numeric ranking scale (NRS) for anxiety, 30 minutes after the procedure ends.",[86,87,59,88,89,90],"Arrhythmia","Cardiac Implantable Electronic Device","Electrophysiologic Study","Pacemaker","ICD","2025-07-29",{"date":93,"type":37},"2025-08-05",{"date":95,"type":21},"2025-11-15",{"date":97,"type":21},"2026-07-31",{"name":99,"class":44},"Radboud University Medical Center"]