[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"able-bodied\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:able-bodied":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,91,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100623788","stimulation-based-modulation-of-spinal-and-cortical-sensory-pathways-100623788",false,"NCT07401186","Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways","Stimulation Evoked Primary Afferent Depolarization to Modulate Sensory Transmission to Spinal Motoneurons and the Sensory Cortex","Inclusion Criteria:\n\n* All Subjects: Ages between 21 and 75 years. The minimum age is selected to age match control subjects with stroke subjects. In addition, participants outside this age range may be at an increased medical risk.\n* Control subjects: Patients undergoing elective posterior cervical spinal surgery that includes a decompressive laminectomy, and who will have electrophysiological monitoring performed as part of the standard of care for their procedure.\n* Stroke subjects: Participants must have a suffered a single, ischemic or hemorrhagic stroke more than 6 months prior to the time of enrollment with hemiparesis as a result, is undergoing a cervical epidural lead implant or undergoing elective posterior cervical spinal surgery that includes a decompressive laminectomy with electrophysiological monitoring performed as part of the standard of care.\n\nExclusion Criteria:\n\n* Patients will be excluded from the study if they have any known neurological diseases other than stroke, such as amyotrophic lateral sclerosis, spinal muscular atrophy, spinal cord injury, autoimmune neuropathy, or sensory nerve disorders, that may affect the integrity of cervical sensory afferents.\n* Only patients that are eligible for surgery will be enrolled. Therefore this automatically include as exclusion criteria: pregnancy and other clinical conditions eligible for surgery.\n* Participants must not be on anti-spasticity or anti-epileptic medications.",true,"ALL","21 Years","75 Years",{"count":21,"type":22},15,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons. This data is critical to reveal changes to the spinal sensory modulating circuitry in neurological disorders like stroke.",[28,29],"Stroke","Able Bodied",[31,32,33,34,35,36,28,37,38,39],"Central Nervous System Disease","Cerebrovascular Disorder","Brain Injury","Brain Disease","Movement Disorder","Nervous System","Spinal Cord Disease","Nervous System Disease","Sensorimotor Disorder","RECRUITING","2026-06-02",{"date":43,"type":44},"2026-06-04","ACTUAL",{"date":46,"type":44},"2026-05-26",{"date":48,"type":22},"2028-01",{"name":50,"class":51},"Peter C. Gerszten, MD","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":16,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":52},"100371592","phase-4-central-sleep-apnea--physiologic-mechanisms-to-inform-treatment-100371592","NCT04118387","Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment","Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment","CSA","Inclusion Criteria:\n\n* Men and women Veterans with central sleep apnea, defined as Apnea Hypopnea Index (AHI)\\>15\u002Fhour with CAHI\\>5\u002Fhour, will be included in the experiments\n\nExclusion Criteria:\n\n* less than 18 years old\n* pregnant or breastfeeding female\n* have severe respiratory disease that require to be on oxygen\n* recent health event that may affect the ability to participate in the study,\n* Body Mass Index (BMI) is \\>40 kg\u002Fm2\n* significant insomnia\n* mental instability\n* recent health event that may affect sleep\n* if at any time the principal investigator (PI) identifies that a certain drug is not suitable, or are unable to use the device that is used to treat sleep apnea, will be not be allowed to participate in the study","18 Years",{"count":63,"type":22},200,[65],"PHASE4","Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.",[68,29],"Sleep Disordered Breathing",[70,71,72,73,74,75,76,77,78,79,80],"Central sleep apnea","Polysomnography (PSG)","Respiratory arousal threshold","Apnea Hypopnea index","Central Apnea Hypopnea Index","Breathing instability","Apneic Threshold (AT)","Peripheral chemoreflex sensitivity","CO2 reserve","Plant gain","Controller gain","2026-03-11",{"date":83,"type":44},"2026-03-13",{"date":85,"type":44},"2021-01-07",{"date":87,"type":22},"2026-12-31",{"name":89,"class":90},"VA Office of Research and Development","FED",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":16,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":101,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":121},"100618696","phase-2-synergistic-effect-of-non-invasive-brain-and-spinal-cord-stimulation-100618696","NCT07334977","Synergistic Effect of Non-invasive Brain and Spinal Cord Stimulation","Synergistic Potential of Non-invasive Brain and Spinal Cord Stimulation for Improving Sensorimotor and Cognitive Functions After Neurological Injury","BrainSpineStim","Inclusion Criteria:\n\nCONTROL GROUP:\n\n* Over 18 years of age\n* Participant who has signed an informed consent form\n* Participant who is affiliated with and covered by the social security system\n\nPOST-STROKE GROUP:\n\n* Over 18 years of age\n* Who sustained a stroke more than 3 weeks ago\n* Considered medically stable by the medical investigator\n* Who has signed an informed consent form\n* Affiliated with and covered by the social security system\n\nSCI GROUP:\n\n* Over 18 years of age\n* Considered to have a complete or incomplete spinal cord injury (i.e., with a score on the Spinal Injury Association (ASIA) Impairment Scale (AIS) score from A to D)\n* Considered medically stable by the investigating physician\n* Presenting with quadriplegia due to cervical injury\n* Who has signed an informed consent form\n* Affiliated with and covered by the social security system.\n\nExclusion Criteria:\n\n* Suffering from a chronic condition\n* Skin problems or open wounds\n* History of epilepsy or seizures\n* Presence of a contraindication to the use of magnetic\u002Felectrical stimulation or MRI, including: cardiac pacemaker; implanted hearing aid; intraocular foreign body, shrapnel, or bullets; metal worker; pacemaker or neurostimulator; claustrophobia\n* Presence of implanted medical devices (cardiac valve, endovascular devices, ventricular shunt valve, surgical clips, metallic sutures, staples, stent, osteosynthesis or arthrodesis hardware) not classified as \"MR Conditional\" according to ASTM F2503.\n* Individuals who are legally incompetent, under judicial protection, guardianship, or trusteeship\n* Pregnant and\u002For breastfeeding women\n* Individuals who refuse to be informed of any abnormalities that may be detected by MRI.",{"count":100,"type":22},45,[102],"PHASE2","The goal of this clinical study is to investigate the potential synergy between non-invasive brain and spinal cord stimulation administered during a cognitive-motor task, in terms of their immediate effects on sensorimotor and cognitive functions after neurological injuries affecting the upper limb (cervical spinal cord injury and stroke). Secondary objectives are to evaluate the relevance of anatomical MRI, functional MRI, and neurophysiological measurements for optimizing and predicting the effects of these different interventions.",[28,105,29],"Spinal Cord Injury",[107,108,109,110,111],"Neuromodulation","Neuroplasticity","transcutaneous Spinal Cord Stimulation","transcranial Direct Current Stimulation","Neuroimaging","2026-01-06",{"date":114,"type":44},"2026-01-12",{"date":116,"type":44},"2024-12-11",{"date":118,"type":22},"2027-12",{"name":120,"class":51},"Centre National de la Recherche Scientifique, France",2,{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":16,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":66,"conditions":131,"keywords":132,"overallStatus":142,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":52},"100609134","phase-4-central-apnea-in-heart-failure-physiological-mechanisms-to-inform-treatment-100609134","NCT07210606","Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment","CSA-HF","Inclusion Criteria:\n\n* Men and Women Veterans with central sleep apnea, defined as Apnea Hypopnea Index (AHI)\\>15\u002Fhour with CAHI\\>5\u002Fhour, will be included with the experiments.\n* Those with chronic, stable heart failure with reduced ejection fraction, receiving stable optimized guideline-based therapy and no hospitalizations or change in the medical regimen for the past 90 days before enrollment.\n\nExclusion Criteria:\n\n* less than 18 years old\n* pregnant or breastfeeding females\n* moderate or severe obstructive or restrictive lung disease, including supplemental o2 use\n* current treatment for CSA, including any form of PAP in the past three months, or phrenic nerve situation.\n* too ill to engage in the study procedures, inability to provide consent for participation.\n* a history of cardiac arrhythmia\n* Alcohol or substance abuse (less than 90 days sobriety) or current participation in a treatment program\n* depression or a history of suicidality\n* severe insomnia (ISI\\>21) or reported short sleep duration (\\\u003C6 hours)\n* PAP-emergent central sleep apnea\n* Lack of PAP acceptance\u002Fadherence after a one-week home PAP trial after enrollment.\n\nAdditional Trazodone Exclusions:\n\n* Prolonged QT on baseline ECG, using medications that inhibit CYP3A4\n* Patients with severe renal impairment (GFR \\\u003C 20ml\u002Fmin\u002F1.73m2) or end-stage renal disease",{"count":63,"type":22},[65],[68,29],[133,71,134,135,74,136,76,137,78,79,80,138,139,140,141],"Central Sleep Apnea","Respiratory Arousal Threshold","Apnea Hypopnea Index","Breathing Instability","Peripheral Chemoreflex Sensitivity","Cheyne Stokes Breathing (CSB)","Carotid Body Function","Peripheral Chemoresponsiveness","Heart Failure","NOT_YET_RECRUITING",{"date":144,"type":44},"2026-01-07",{"date":146,"type":22},"2026-10-01",{"date":148,"type":22},"2030-12-31",{"name":89,"class":90}]