[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"abortion-medical\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:abortion-medical":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100581489","foley-balloon-for-cervical-preparation-before-dilation-and-evacuation-100581489",false,"NCT06850974","Foley Balloon for Cervical Preparation Before Dilation and Evacuation","Inclusion Criteria:\n\n* Women 18 years and older presenting to Hospital Central de Maputo requiring abortion for any legal indication between 16-21 weeks gestation.\n* Portuguese speaking\n\nExclusion Criteria:\n\n* Less than age 18\n* Incarcerated\n* Chorioamnionitis\n* Active heavy bleeding\n* A known bleeding diathesis\n* Hemodynamic instability\n* \\> 2 cm dilation\n* History of cervical cerclage\n* Allergy to any study medications\n* Eclampsia\n* Glasgow Coma Score Less than 15","FEMALE","18 Years",{"count":18,"type":19},102,"ESTIMATED","INTERVENTIONAL",[22],"NA","To evaluate the Foley Balloon technique for cervical preparation before second trimester surgical abortion between 16 and 21 weeks estimated gestational age in combination with misoprostol to prepare the cervix before dilation and evacuation (D\\&E) instead of osmotic dilators (Laminaria).\n\nSpecific Aim One: Assess definitively whether using a Foley Balloon and Misoprostol is non-inferior to osmotic dilators for cervical preparation before D\\&E.\n\nSpecific Aim Two: Evaluate patient satisfaction with the two methods of second trimester abortion.\n\nSpecific Aim Three: Evaluate provider satisfaction with the two methods of second trimester abortion.",[25,26],"Abortion, Second Trimester","Abortion, Medical",[28,29,30,31,32,33],"second","trimester","abortion","surgical","balloon","Foley","RECRUITING","2026-04-26",{"date":37,"type":38},"2026-04-30","ACTUAL",{"date":40,"type":38},"2025-02-10",{"date":42,"type":19},"2027-03",{"name":44,"class":45},"Stony Brook University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":20,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":73,"locationsCount":46},"100606384","phase-4-the-misoprostol-only-regimen-evidence-study-100606384","NCT07174856","The Misoprostol-Only Regimen Evidence Study","The Misoprostol-Only Regimen Evidence (MORE) Study: A Randomized Controlled Trial Comparing the Misoprostol-only Regimen Versus the Combined Mifepristone and Misoprostol Regimen for Medication Abortion","MORE","Inclusion Criteria:\n\n* Pregnancy of \\\u003C or = 77 days duration based on LMP or ultrasound\n* Positive pregnancy test (self-report or in-clinic)\n* Age: States without parental involvement laws : in-person patients ages 14 years and older; States with parental involvement or notification laws: 18 years or older\n* Willing and able to give informed consent\n* Willing to comply with study protocol\n* Willing to record requested information in the study surveys\n* English or Spanish speaking\n* Has a text message, email, or phone call capable device for survey completion\n* Understands and signs an Institutional Review Board (IRB) approved informed consent form prior to undergoing any study procedures or randomization\n\nExclusion Criteria:\n\n* concurrent participation in any other interventional trial\n* unwilling to comply with the study protocol and survey\u002Fvisit schedule\n* contraindication to mifepristone (chronic corticosteroid administration, adrenal disease)\n* contraindication to misoprostol (glaucoma, mitral stenosis, sickle cell anemia, or known allergy to prostaglandin)\n* cardiovascular disease (angina, valvular disease, arrhythmia, or cardiac failure)\n* diagnosis of porphyria\n* known bleeding disorder or receiving anticoagulants\n* pregnancy with an IUD in place\n* diagnosis of pregnancy of unknown location (PUL), early pregnancy failure, incomplete or inevitable abortion (absent gestational sac and\u002For open cervical os)\n* possibility of ectopic pregnancy\n* known or suspected pelvic infection\n* Have issues or concerns (in the judgement of the investigator) that may compromise the safety of the subject or confound the reliability of compliance and information acquired in this study.\n* Have previously participated in the study\n* Be a site staff member with delegated study responsibilities or a family member of, or have a close relationship with, a site staff member with delegated study responsibilities.","14 Years",{"count":57,"type":19},1900,[59],"PHASE4","The goal of this study is to evaluate the effectiveness, non-inferiority, and side-effect profile of an updated misoprostol-only regimen, as compared to the combined mifepristone-misoprostol regimen, among people seeking medication abortion (MAB) through 77 days of pregnancy in telehealth and in-person settings. The investigators aim to evaluate this in both in-clinic and telehealth medication abortion care in the United States.\n\nThe main questions it aims to answer are:\n\n1. What proportion of pregnant people using an updated misoprostol-only medication abortion regimen have a complete abortion using just the prescribed pills?\n2. Is the updated misoprostol-only medication abortion regimen no more than 5% less effective (non-inferior) than the standard combined medication abortion regimen?\n3. What is the pattern of beta hCG decline following use of a misoprostol-only medication abortion through 77 days of pregnancy?\n\nParticipants will:\n\n* be randomized to one of two medication regimens (misoprostol-only or the combined regimen) in a 1:1 ratio based on duration of pregnancy at enrollment. - self-report outcomes via daily surveys for the first 3 days, and thereafter weekly at 7, 14, 21, 28, and 35 days.\n* return to the clinical site for tests as instructed\n\nThe investigators hypothesize that the proportion with complete abortions in the misoprostol-only arm will be non-inferior to the proportion with complete abortions in the combined regimen arm within a 5% margin of inferiority",[26],[63,64,65],"misoprostol","mifepristone","medication abortion","NOT_YET_RECRUITING","2025-10-03",{"date":69,"type":38},"2025-10-08",{"date":71,"type":19},"2025-10-10",{"date":42,"type":19},{"name":74,"class":45},"Ibis Reproductive Health"]