[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"above-knee-amputation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:above-knee-amputation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,57,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100054207","the-analgesic-efficacy-of-dexmedetomidine-versus-fentanyl-as-an-adjuvant-to-bupivacaine-in-ultrasound-guided-peripheral-nerve-blocks-as-a-solo-anesthetic-technique-in-high-risk-patients-undergoing-unilateral-above-knee-amputation--100054207",false,"NCT07640516","The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation .","The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation : A Randomized Double Blinded Study","Inclusion Criteria:\n\n* \\- Age ≥18 years\n* Both sexes\n* ASA III-IV\n* Documented cardiac disease (e.g., EF \\\u003C 40%, NYHA II or higher)\n* Documented pulmonary disease (e.g., COPD with FEV1 \\\u003C 60%)\n* Scheduled for above-knee amputations\n\nExclusion Criteria:\n\n* Neurological or intellectual disability\n* Drug abuse\n* Allergy to study drugs\n* Pregnancy\n* Contraindications to regional anesthesia (e.g., coagulopathy, local infection)\n* Significant renal or hepatic impairment( plts \\\u003C75000 or INR \\>1.5)\n* Current anticoagulant therapy\n* severe haemodynamically unstability at the time of block performance, defined as map \\> 65 mmhg but achieved by high-dose vasopressors (e.g., norepinephrine ≥ 0.1 mcg\u002Fkg\u002Fmin) after fluid ressuscitation .","ALL","18 Years",{"count":19,"type":20},64,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of this study is to compare the analgesic efficacy and safety of dexmedetomidine versus fentanyl as adjuvants to bupivacaine in ultrasound-guided combined supra-inguinal fascia iliaca and proximal sciatic nerve blocks used as a solo anesthetic technique in high-risk patients undergoing unilateral above knee amputation.",[26,27,28],"Analgesia Assessment","Above Knee Amputation","Fentanyl vs Dexmedetomidine",[30],"dexmedetomidine vs fentanyl PNBs AKA","RECRUITING","2026-07-10",{"date":34,"type":35},"2026-07-13","ACTUAL",{"date":37,"type":20},"2026-07-01",{"date":39,"type":20},"2027-03-01",{"name":41,"class":42},"Kasr El Aini Hospital","OTHER",1,{"id":45,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":47,"briefSummary":24,"conditions":48,"keywords":49,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":54,"completionDateStruct":55,"leadSponsor":56,"locationsCount":43},"100643114",{"count":19,"type":20},[23],[26,27,28],[30],"NOT_YET_RECRUITING","2026-06-06",{"date":53,"type":35},"2026-06-10",{"date":37,"type":20},{"date":39,"type":20},{"name":41,"class":42},{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":21,"phases":67,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":43},"100614228","intrathecal-dexmedetomidine-fentanyl-combination-versus-fentanyl-alone-as-adjuvant-to-bupivacaine-in-spinal-anesthesia-for-above-knee-amputation-in-sarcomas-of-lower-extremity-100614228","NCT07276867","Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity","Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity: A Randomized, Comparative Study","Inclusion Criteria:\n\n* Age from 18 to 60 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status of II-III.\n* Height between 150-185 cm.\n* Body mass index between 18-35 kg\u002Fm².\n* Scheduled for above-knee amputation due to lower limb sarcomas.\n\nExclusion Criteria:\n\n* Allergy to any of the investigated drugs.\n* History of heart block, arrhythmia, or ongoing therapy with beta- or calcium channel- blockers, or angiotensin-converting-enzyme inhibitors.\n* Contraindications to spinal anesthesia.\n* Pregnancy or lactation.\n* Presence of psychiatric illness or chronic pain conditions.","60 Years",{"count":66,"type":20},58,[23],"The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.",[70,71,72,73,74,27,75,76],"Intrathecal","Dexmedetomidine","Fentanyl","Bupivacaine","Spinal Anesthesia","Sarcomas","Lower Extremity","2025-11-30",{"date":79,"type":35},"2025-12-11",{"date":81,"type":35},"2025-10-20",{"date":83,"type":20},"2026-04-01",{"name":85,"class":42},"National Cancer Institute, Egypt",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":21,"phases":97,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":43},"100613328","gait-training-and-artificial-intelligence-100613328","NCT07265154","Gait Training and Artificial Intelligence","Gait Training in Above Knee Amputation Patients Using Artificial Intelligence","Inclusion Criteria:\n\n* All patients have above-knee amputations.\n* All patients have no other neurological diseases affecting gait.\n* All patients have no other neurological diseases affecting muscle balance.\n* All patients have no other complications affecting joint ROM.\n\nExclusion Criteria:\n\n* Patients have any complications affecting joint ROM.\n* Patients have any neurological condition affecting muscle balance.\n* Patients have any neurological condition affecting gait.","16 Years","50 Years",{"count":96,"type":20},40,[23],"Effect of Using Artificial Intelligence on Gait Training in Above Knee Amputation Patients",[27,100],"Amputation",[100,27,102,103],"Artificial Intelligence","Gait training","2025-11-23",{"date":106,"type":35},"2025-12-04",{"date":108,"type":20},"2025-12-01",{"date":110,"type":20},"2026-03-01",{"name":112,"class":42},"South Valley University"]