[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"abscess\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:abscess":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100520160","phase-2-efficacy-of-methylene-blue-photodynamic-therapy-for-treatment-of-deep-tissue-abscesses-100520160",false,"NCT06052956","Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses","A Phase 2 Study to Assess Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses","Inclusion Criteria:\n\n* Adults 18 years or older\n* All patients with clinical symptoms (ex: fever, chills, pain, tachycardia, hypotension), laboratory (leukocytosis) and radiologic findings (thick walled, rim-enhancing collection with gas bubbles or air-fluid levels) compatible with an abscess that requires image- guided percutaneous drainage\n* Approval by the primary care team to pursue PDT and discuss enrollment with the patient\n\nExclusion Criteria:\n\n* Pregnancy\n* Lactation\n* Allergy to contrast media, narcotics, sedatives, atropine or eggs\n* Necrotic tissue that requires surgical debridement\n* Severely compromised cardiopulmonary function or hemodynamic instability\n* Thrombocytopenia (\\\u003C50,000\u002Fmm3)\n* Uncorrectable coagulopathy\n* Poor kidney function (serum creatinine \\>3mg\u002Fdl)\n* Lack of a safe pathway to the abscess or fluid collection\n* Unable or unwilling to understand or to provide informed consent\n* Unable or unwilling to undergo study procedures\n* Patient unable to cooperate with, or to be positioned for the procedure\n* Unable to comply with necessary follow up\n* Patients with pancreatic abscesses\n* Patients with known fistulous communication with their abscess\n* Abscess greater than 13 cm in diameter","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The objective of this Phase 2 study is to evaluate the efficacy of methylene blue photodynamic therapy (MB-PDT) performed at the time of percutaneous abscess drainage for disinfection of deep tissue abscesses. The study includes three arms: (1) MB-PDT at a fixed drug\u002Flight dose plus standard of care abscess drainage , (2) MB-PDT at a patient-specific dose determined by pre-treatment optical measurements plus standard of care abscess drainage , and (3) standard of care abscess drainage. The primary endpoint is reduction in time to removal of the drainage catheter.",[26],"Abscess",[26,28,29],"Drainage","Photodynamic Therapy","NOT_YET_RECRUITING","2026-02-05",{"date":33,"type":34},"2026-02-10","ACTUAL",{"date":36,"type":20},"2026-07-15",{"date":38,"type":20},"2031-06-30",{"name":40,"class":41},"University of Rochester","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100537949","phase-4-ketamine-as-a-supplement-to-local-anesthesia-for-minor-procedures-100537949","NCT06284473","Ketamine as a Supplement to Local Anesthesia for Minor Procedures","Intranasal Ketamine as a Supplement to Local Anesthesia to Reduce Pain Associated With Minor Procedures in the Emergency Department","INK-MP","Inclusion Criteria:\n\n* Undergoing Minor Procedure in the ED\n* Weight not to exceed 115kg\n\nExclusion Criteria:\n\n* Altered Mental Status\n* Pregnancy\n* Breastfeeding\n* Acute head or eye injury\n* Intercranial Hypertension\n* Hx of seizures\n* Hx of chronic pain\n* Unstable vital signs\n* Allergy to Ketamine\n* Hepatic or Renal Insufficiency\n* Hx of Psychiatric Illness\n* Hx of alcohol\u002Fdrug abuse","7 Years","70 Years",{"count":53,"type":20},108,[55],"PHASE4","This trial is a double-blind randomized controlled clinical trial of adults and children (ages 7 to less than 70 years). Patients who present to the ED and who undergo minor bedside procedures that require local anesthesia will be divided into two groups: The first group will be treated with 0.7 mg\u002Fkg intranasal ketamine as well as standard local anesthesia for the procedure (treatment cohort). The second group will be treated with a volume-based dose of intranasal saline solution as well as standard local anesthesia for the procedure (control cohort). The primary aim is to assess whether patients in the treatment cohort report lower pain scores on the Numerical Rating Scale (NRS-100) when compared to patients in the control cohort. For adult patients, a secondary aim is to compare agitation between the two cohorts using the Richmond Agitation Sedation Scale (RASS) and, for pediatric patients, a secondary aim is to compare alertness between the two cohorts using the University of Michigan Sedation Scale (UMSS).\n\nResults obtained from specific procedures will be analyzed on a spectrum of complexity and general length of recovery time. Scientific achievements may include finding a safe and effective way to reduce pain and discomfort during minor procedures in the Emergency Department. Additionally, it would provide opportunities for more research on sub-dissociative doses of ketamine during minor procedures: a topic in which there is still a gap in the published research",[58,59,26],"Pain, Procedural","Minor Laceration",[61,62,63],"IN Ketamine","Sub-dissociative dose","Minor procedure","RECRUITING","2025-09-30",{"date":67,"type":34},"2025-10-03",{"date":69,"type":34},"2022-05-25",{"date":71,"type":20},"2028-05-31",{"name":73,"class":41},"Loyola University",1]