[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acdf-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acdf-surgery":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100588223","post-operative-outcomes-of-anterior-cervical-discectomy-and-fusion-surgery-with-and-without-drain-placement-100588223",false,"NCT06938607","Post-operative Outcomes of Anterior Cervical Discectomy and Fusion Surgery With and Without Drain Placement","Post-operative Outcomes Comparing Drain vs No Drain Placement Following Anterior Cervical Discectomy and Fusion Surgery","Inclusion Criteria:\n\n* 19-75 years of age\n* Having elective anterior cervical discectomy and fusion (ACDF) surgery\n\nExclusion Criteria:\n\n* Unable to stop anticoagulation medication\n* Cervical (neck) cancer or tumor\n* Combined anterior cervical discectomy and fusion, and posterior cervical fusion\n* Active infection or trauma","ALL","19 Years","75 Years",{"count":20,"type":21},360,"ESTIMATED","OBSERVATIONAL","Anterior Cervical Discectomy and Fusion (ACDF) is a widely performed surgical procedure used to treat cervical spondylosis and cervical disc herniations with cervical nerve root compression and or cervical spinal cord compression when conservative treatment options have been exhausted. The primary aim of ACDF is to alleviate neck, shoulder, and upper extremity pain associated with degenerative cervical disc disease by removing one or more affected discs, decompressing the nerves, and restoring cervical spine anatomy through the implantation of structural allograft\u002Fautograft bone or artificial spacers, plates, and screws. Historically, ACDF has demonstrated substantial long-term benefits in pain relief and quality of life improvements for patients. In the United States alone, the annual number of ACDF procedures exceeds 150,000 and is projected to rise significantly over the next four decades. Despite its technical complexity, ACDF is considered a relatively safe procedure. Common postoperative complications include dysphagia (1.7-9.5%), hematoma (0.4-5.6%), worsening myelopathy (0.2-3.3%), recurrent laryngeal nerve palsy (0.9-3.1%), cerebrospinal fluid leakage (0.5-1.7%), and surgical site infections (0.9-1.6%). One strategy employed to mitigate postoperative complications such as hematoma, surgical site infection, and the need for reoperation is the placement of an indwelling subfascial drain within the surgical site. These drains facilitate the removal of accumulated blood or serous fluid, thereby reducing localized pressure and potentially preventing adverse outcomes. Despite its theoretical benefits, the utility of subfascial drains remains a topic of debate among surgeons. Given the limited evidence on the efficacy of subfascial drain placement following ACDF, this study proposes a randomized controlled trial to evaluate the necessity and impact of subfascial drain placement on postoperative outcomes.\n\nThis study will determine whether subfascial drain placement reduces the incidence of postoperative complications, including hematoma, infection, airway compromise and secondary surgeries, compared to no drain placement following ACDF surgery; assess the impact of subfascial drain placement on the severity and duration of postoperative dysphagia compared to no drain placement; and evaluate participant-reported outcomes and satisfaction, including postoperative pain and recovery experience, between the drain and no-drain groups.",[25],"ACDF Surgery",[25],"NOT_YET_RECRUITING","2026-05-08",{"date":30,"type":31},"2026-05-12","ACTUAL",{"date":33,"type":21},"2026-06",{"date":35,"type":21},"2029-06",{"name":37,"class":38},"University of Nebraska","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100531641","function-after-anterior-cervical-discectomy-and-fusion-surgery-timing-of-physical-therapy-100531641","NCT06202443","Function After Anterior Cervical Discectomy and Fusion Surgery: Timing of Physical Therapy","Improving Surgical Outcomes With Early Physical Therapy After Anterior Cervical Discectomy and Fusion","FAST-PT","Inclusion Criteria:\n\n* Surgical treatment of a cervical degenerative condition using a 1- or 2-level ACDF procedure;\n* English speaking due to feasibility of employing study personnel to deliver and assess the study intervention; and\n* Age 18-75 years of age (individuals older than 75 are more likely to experience respiratory and nervous system complications and death following ACDF)\n\nExclusion Criteria:\n\n* Surgery secondary to trauma, fracture, tumor, infection, or spinal deformity;\n* Undergoing cervical corpectomy;\n* Prior history of cervical spine surgery in last 5 years;\n* Diagnosis or presence of osteoporosis;\n* Diagnosis or presence of severe psychiatric disorder such as schizophrenia or bipolar disorder;\n* Documented history of alcohol and\u002For drug abuse;\n* Currently involved in litigation due to injury;\n* Currently undergoing treatment for cancer;\n* Patients not able to return for follow-up visits due to time and travel limitation or other reasons; and\n* Unable to provide a stable telephone or physical address","18 Years",{"count":50,"type":21},76,"INTERVENTIONAL",[53],"NA","The goal of this two-group randomized clinical trial is to examine the effects of early postoperative PT compared to delayed postoperative PT for improving outcomes after hospital discharge for ACDF surgery.\n\nThe main question this clinical trial aims to answer are:\n\n* Whether early PT participants will demonstrate greater improvements in outcomes compared to delayed PT participants.\n* Whether improvements in handgrip strength, cervical endurance, and cervical range of motion will be associated with improvements in outcomes.\n\nParticipants will be randomized to one of two groups (early PT or delayed PT) and outcomes compared across groups.",[56,25],"Cervical Spine Degeneration","RECRUITING","2026-02-23",{"date":60,"type":31},"2026-02-27",{"date":62,"type":31},"2024-02-01",{"date":64,"type":21},"2027-07-31",{"name":66,"class":38},"Vanderbilt University Medical Center",4]