[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acetabular-labrum-tear\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acetabular-labrum-tear":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100355529","use-of-bmac-with-hip-arthroscopy-treatment-of-fai-and-labral-tear-100355529",false,"NCT03909139","Use of BMAC With Hip Arthroscopy Treatment of FAI and Labral Tear","Prospective PROMs Outcomes in Arthroscopic Acetabular Labral Repair With and Without Application of Platelet-Rich Plasma (PRP) Harvested From the Body of the Ilium","Inclusion Criteria and Rationale:\n\n1. Age 18 or older: patients of any age have the capacity to potentially benefit from labral repair\n2. Symptoms consistent with a tear of the acetabular labrum (i.e., catching, clicking, popping, pain with sitting, episodic pain, pain with hip flexion, adduction, and\u002For internal rotation): asymptomatic labral tears do exist in the general population however there is not definitive evidence to suggest treatment of asymptomatic tears is beneficial.\n3. Symptoms not due to some other acute process in or around the hip (including septic arthritis, osteonecrosis, hemarthrosis, iliotibial band syndrome, fractures of the femoral neck or head, fractures of the acetabulum, greater trochanteric pain syndrome, sacroiliac joint pain, piriformis syndrome, low back pain associated with hip pain and not knee nor acute low back injury): certain conditions are not treatable by either arthroscopy or physical therapy. Some of these conditions can be managed with physical therapy but not arthroscopy.\n4. Availability of hip radiographs and magnetic resonance imaging (MRI and\u002For MRA): needed to assess eligibility\n5. Evidence of labral tear on MRI and\u002For MRA: documentation of acetabular labrum tear\n6. Willingness to participate and ability to understand and sign informed consent document: ability to understand study and consent willingly\n7. Returning subjects enrolled in protocol 2017P001391\u002FPHS\n\nExclusion Criteria and Rationale:\n\n1. Non-English speaking subjects: PROMs are only validated in English.\n2. Systemic infection: surgery is generally contraindicated when systemic infection is present.\n3. Systemic heparinization: the vascularity of the bone and adjacent tissues is significant, posing a potential problem for bleeding when the patient is anti-coagulated.\n4. Pregnant women\u002Ffetuses: although surgery can be performed on pregnant women, pregnant women are excluded under federal regulations.","ALL","18 Years",{"count":19,"type":20},400,"ESTIMATED","OBSERVATIONAL","Femoro-acetabular impingement is a well known cause of damage to the acetabular labrum and chondrolabral junction. Additionally, it has been proposed that disruption of hip biomechanics resulting from a labral tear causes a faster progression towards osteoarthritis (OA). This progression has been observed to begin with breakdown of the chondrolabral junction with later development of diffuse osteoarthritis. Use of hip arthroscopy has increased dramatically in recent years to treat symptomatic labral tears and potentially avoid the morbidity and cost associated with hip osteoarthritis.\n\nCorrection of labral pathology presents a technical challenge and many techniques currently exist. Increased understanding of the structure-functional relationship dictated by labral anatomy has led to the development of methods aimed at restoring functional anatomy by re-establishing the labrum's native position and contour on the rim of the acetabulum. Therefore, akin to repairing a torn meniscus in the knee, restoring the anatomic footprint of a torn labrum will reconstitute normal joint biomechanics.\n\nDespite the advances in techniques for labral repair, strategies for mitigating or repairing damage to the chondrolabral junction do not yet exist. This area has been shown to consist of hyaline and fibro cartilage. Many techniques for cartilage repair exist, although most are not feasible due to technical challenges specific to the hip joint.\n\nThe management of articular cartilage defects is one of the most challenging clinical problems for orthopaedic surgeons. Articular cartilage has a limited intrinsic healing capacity, and pathology frequently results in gradual tissue deterioration. Currently, the standard surgical intervention for end-stage degenerative joint pathology is total joint replacement. Early surgical interventions for symptomatic cartilage lesions including cell based therapies such as autologous chondrocyte implantation (ACI), bone marrow aspirate concentrate (BMAC) implantation, or microfracture have been suggested to restore normal joint congruity and minimize further joint deterioration. Techniques such as ACI, which have been successfully used in the knee joint, have limited application in the hip due to the technical difficulties of open procedures.",[24,25,26,27,28],"Acetabular Labrum Tear","Femoro Acetabular Impingement","Chondral Defect","Bone Marrow Aspirate Concentrate","Mesenchymal Stromal Cell",[24,25,26,27,28,30,31,32,33,34],"Chondrolabral Junction","Osteoarthritis","Femoroacetabuloplasty","Hip Arthroscopy","BMAC","RECRUITING","2025-10-24",{"date":38,"type":39},"2025-10-27","ACTUAL",{"date":41,"type":39},"2019-09-06",{"date":43,"type":20},"2027-06-30",{"name":45,"class":46},"Massachusetts General Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":47},"100516329","phase-3-effect-of-prp-ppp--bmac-on-functional-outcomes-following-hip-arthroscopy-for-acetabular-labral-pathologies-100516329","NCT06003101","Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies","Effect of Platelet-Rich Plasma, Platelet-Poor Plasma, & Bone Marrow Aspirate Concentrate Application on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies: A Prospective Randomized Controlled Trial","PRP; PPP; BMAC","Inclusion Criteria:\n\n* Age: \\> or equal to 18 years\n* Clinically indicated for hip arthroscopy (by the study PI) to address a labral pathology\n* Willingness to participate, amenable to randomization into either treatment arm of the research study, and the ability to understand \\& sign the informed consent document\n\nExclusion Criteria:\n\n* Non-English speaking (PROM surveys are only validated in English)\n* Prior same site (i.e., ipsilateral hip) surgery, including but not limited to previous hip arthroscopy, core decompression, or periacetabular osteotomies",{"count":57,"type":20},160,"INTERVENTIONAL",[60],"PHASE3","The goal of this clinical trial is to assess the effect of PRP\u002FPPP\u002FBMAC application on functional outcomes after hip arthroscopy to address acetabular labral pathologies. The main questions it aims to answer are:\n\n1. Does PRP\u002FPPP\u002FBMAC application improve functional outcomes after hip arthroscopy to address acetabular labral pathologies?\n2. Does PRP\u002FPPP\u002FBMAC application reduce the arthritic burden as measured by functional outcomes following hip arthroscopy to address labral pathologies with concomitant PRP\u002FPPP\u002FBMAC application?",[24,25,26,27],[24,25,26,27,30,31,33,34],"2024-11-18",{"date":66,"type":39},"2024-11-20",{"date":68,"type":39},"2023-08-30",{"date":70,"type":20},"2045-08-30",{"name":45,"class":46}]