[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acetaminophen\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acetaminophen":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":68},"100587065","phase-4-intravenous-acetaminophen-to-reduce-post-operative-opioid-consumption-100587065",false,"NCT06923540","Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption","Evaluating the Impact of IV Acetaminophen on Opioid Consumption in the Postoperative Period in Patients Undergoing Abdominal Surgery","ACETAPOP","Inclusion Criteria:\n\n* Age 18 years or older.\n* Underwent abdominal surgery\n* Underwent elective surgery.\n* Hospitalized in the digestive surgery, hepatobiliary and pancreatic surgery, or gynecology and gynecologic oncology units at CHUM.\n* Declared NPO immediately post-surgery, meaning they cannot take oral medications.\n\nExclusion Criteria:\n\n* Hypersensitivity to acetaminophen or an excipient in the administered formulations\n* Hepatic insufficiency with a Child-Turcotte-Pugh score of B or C.\n* Weight \\\u003C 50 kg (patients requiring a lower acetaminophen dose).\n* Active pregnancy or breastfeeding.\n* Opioid use disorder (OUD) under active treatment\n* Non-opioid-naïve patients: those who received a long-acting opioid within seven days preceding surgery. This criterion will be verified through patient interviews and cross-checked with medical records.\n* Use of illicit recreational substances.\n* Prior participation in this study.\n* Ectopic patients: physically located in a unit other than digestive surgery (11 South), hepatobiliary and pancreatic surgery (14 South), or gynecology and gynecologic oncology (12 South).","ALL","18 Years",{"count":20,"type":21},140,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Acetaminophen (Tylenol) is a commonly used medication after surgery to control pain. Tablets for oral use and suppositories for rectal use are the most frequently employed forms of acetaminophen after surgery. Intravenous (IV) acetaminophen is widely used in several countries but is not a standard medication for the adult population in Canada. It is mainly considered when it is impossible to take medication in tablet or suppository form. Opioids (Morphine, Hydromorphone, Oxycodone, etc.) are another class of medications commonly used after surgery for pain management. While they are generally very effective and stronger than acetaminophen or other pain relievers (e.g., ibuprofen\u002FAdvil), reducing their use is preferable, as they can cause various side effects such as nausea, dizziness, and dependence. IV acetaminophen may help control pain while also reducing opioid consumption. However, there are few high-quality scientific studies proving the benefits of IV acetaminophen compared to other forms, such as tablets or suppositories. Acetaminophen has been available in Canada for many years and has already been recommended for use in Quebec by the Institut national d'excellence en santé et services sociaux (INESSS) under certain conditions. This study aims to validate its benefits with clear data.",[27,28,29,30,31,32,33,34,35,36,37],"Post Operative Analgesia","Opioid Consumption, Postoperative","Acetaminophen","Abdominal Surgeries","Post Operative Bowel Dysfunction","Post Operative Nausea and Vomiting","Post Operative Pain Control","Mobility","Epidural Analgesia","Length of Stay","Pain Management",[39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55],"IV acetaminophen","intravenous acetaminophen","acetaminophen","post operative analgesia","nil per os","npo","post operative pain","opioid consumption","abdominal surgery","hepato-biliary surgery","digestive surgery","pancreatic surgery","gynecologic surgery","post operative nausea and vomiting","post operative mobility","hospitalization length of stay","co-analgesia","NOT_YET_RECRUITING","2025-04-04",{"date":59,"type":60},"2025-04-11","ACTUAL",{"date":62,"type":21},"2025-04-28",{"date":64,"type":21},"2025-08-15",{"name":66,"class":67},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":68},"100436519","screening-of-susceptibility-genes-for-apap-induced-drug-induced-liver-injury-in-chinese-population-a-case-control-study-100436519","NCT04964310","Screening of Susceptibility Genes for APAP Induced Drug Induced LIver Injury in ChiNese Population: a Case-control Study","Pharmacogenomics of APAP Induced DILI in Chinese Population.","PAIN","Inclusion criteria：\n\n* A clear history of acetaminophen (or acetaminophen-containing drugs) ingestion.\n* Plasma and\u002For urine testing for acetaminophen components if history of ingestion is unclear.\n* Monitoring of Alanine aminotransferase (ALT) or Aspartate Aminotransferase (AST) ≥ 1000 IU\u002FL at any time after APAP administration and Roussel Uclaf Causality Assessment Method(RUCAM) score \\> 6\n* Age ≥ 14 years old\n* The subject or guardian agrees to participate in this project and signs an informed consent form.\n\nExclusion criteria：\n\n* The use of drugs for which frequency of adverse reactions to liver damage is defined as \"common or very common\" (≥1%) in the instructions.\n* Concurrent use of herbs that are clearly susceptible to liver damage (see list of definitions in the Annex).\n* Have a known definite cause of liver damage: active viral hepatitis; alcoholic liver disease; autoimmune liver disease; primary or secondary liver tumors; and other underlying liver disease that has affected liver function.\n* Those who fail to provide complete general information and clinical information.\n* Subjects or guardians who do not agree to see this project do not sign the informed consent form.","14 Years",{"count":79,"type":21},339,"OBSERVATIONAL","Acetaminophen (APAP) is the most commonly used NSAIDS in clinic, and it is also a common cause of drug-induced liver injury (DILI). In 2012, the proportion of DILI caused by APAP in the United States was 51%, while in Asia, it was only 7.10%. Previously, a small cohort study in the United States screened for some of the susceptibility genes for DILI due to APAP by the Genome wide association study (GWAS) method. However, the genetic susceptibility loci based on the US cohort were not applicable to the Chinese population. Therefore, we make a study design include Chinese population who ingested APAP and divided them into case group and control group according to the occurrence of DILI. We hope to be able to find the root of differences at the genetic level and explore new pathogenic mechanisms.",[29,83,84,85],"Drug-Induced Liver Injury","Pharmacogenetics","China",[29,83,84,85,87,88],"Case-Control Studies","candidate gene","RECRUITING","2025-02-24",{"date":92,"type":60},"2025-02-26",{"date":94,"type":60},"2020-08-31",{"date":96,"type":21},"2026-12-31",{"name":98,"class":67},"The First Affiliated Hospital with Nanjing Medical University"]