[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"achilles-tendinopathy-at\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:achilles-tendinopathy-at":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,50,78,112,140,177,201,223,251,284],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100641411","phase-3-the-aspire-trial-achilles-tendinopathy-treated-with-corticosteroid-injections-100641411",false,"NCT07650396","The ASPIRE Trial: AchilleS tendinoPathy Treated With cortIcosteRoid injEctions","ASPIRE","Inclusion Criteria:\n\n* Age 18-65 years\n* Clinically diagnosed midportion Achilles tendinopathy confirmed by ultrasound\n* Symptoms for at least 6 months\n* Persistent complaints despite standard care, including education, load management advice and at least 3 months of exercise therapy \u002F exercise programme\n\nExclusion Criteria:\n\n* • Clinical suspicion of insertional Achilles tendinopathy\n\n  * Clinical suspicion of Achilles tendon rupture\n  * Clinical suspicion of plantar flexor tenosynovitis\n  * Clinical suspicion of sural nerve pathology\n  * Clinical suspicion of peroneal tendon subluxation or peroneal tendinopathy\n  * Clinical suspicion of posterior ankle impingement syndrome\n  * Suspected systemic\u002Finflammatory disorder as cause of symptoms\n  * Any condition preventing participation in active exercise programme\n  * History of Achilles tendon rupture of index tendon\n  * Previous local corticosteroid injection on index Achilles tendon\n  * Previous surgery on index Achilles tendon\n  * Refusal to undergo one of the study treatments\n  * Local skin infection, suspected systemic infection with fever, or other medical condition compromising injection safety\n  * Vitamin K antagonist use with INR \\>3.0 within 3 days before injection or unknown INR\n  * Current pregnancy or breastfeeding\n  * Medication-induced tendon pathology (quinolones or statins related to symptom onset)\n  * Inability to provide informed consent\n  * Participation in another concomitant interventional programme for Achilles tendinopathy\n  * Known hypersensitivity or allergy to Depo-Medrol or Lidocaine\n  * Participants with unstable or poorly controlled diabetes mellitus may be excluded at investigator discretion for safety reasons.","ALL","18 Years","65 Years",{"count":20,"type":21},276,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Achilles tendinopathy is a common and often persistent tendon disorder associated with pain, impaired function, and reduced participation in physical activities. Standard care consists of education, load management advice, and progressive calf-strengthening exercises, yet about half of patients remain symptomatic. Corticosteroid injections are frequently used in clinical practice, but evidence on long-term efficacy and safety remains inconclusive. The ASPIRE trial is a multicentre, randomized, double-blind, placebo-controlled phase III trial evaluating whether 1-3 ultrasound-guided peritendinous corticosteroid injections added to standard care are safe and more effective than placebo injections plus standard care in adults with chronic midportion Achilles tendinopathy. The primary outcomes are change in VISA-A score over 1 year and incidence of full-thickness Achilles tendon rupture during 1-year follow-up.",[27],"Achilles Tendinopathy (AT)",[29,30,31,32,33,34,35,36],"Corticosteroid injection","Lidocaine","Placebo injection","Exercise therapy","Ultrasound-guided injection","Methylprednisolone acetate","Depo-Medrol","VISA-A","RECRUITING","2026-06-16",{"date":40,"type":41},"2026-06-18","ACTUAL",{"date":43,"type":41},"2026-06-03",{"date":45,"type":21},"2028-10-31",{"name":47,"class":48},"Erasmus Medical Center","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":49},"100637358","effect-of-foot-position-during-rehabilitation-of-achilles-tendinopathy-on-tendon-mechanics-and-symptoms-100637358","NCT07623408","Effect of Foot Position During Rehabilitation of Achilles Tendinopathy on Tendon Mechanics and Symptoms.","The Effect of Foot Positioning During a 12-week Supervised Training Program on Achilles Tendon Mechanics and Function in Individuals With Mid-portion Achilles Tendinopathy.","The following inclusion criteria will be used:\n\nPATIENTS WITH ACHILLES TENDINOPATHY:\n\n* Voluntary written Informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures.\n* Age between 18 and 65 years old\n* BMI between 18.5-30\n* Showing history of intermittent episodes of Achilles tendon pain lasting more than 3 consecutive weeks within the past 6 months.\n* Presenting palpable focal thickening of the Achilles tendon.\n* Having pain originating from the Achilles tendon on palpation of thickened tendon and on loading activities (such as running, jumping).\n* Showing sonographic evidence of tendinopathy, i.e. focal thickening and hypoechocity, consistent with previously reported sonographic characteristics diagnosed of tendinopathy.\n\nPrior to start of the data collection, these inclusion criteria (specifically the ones concerning Achilles Tendinopathy presence) will be checked by a medical doctor at SMAC (Sports medical advisory centre Leuven). Only if they confirm the diagnosis, patients are included in the study.",{"count":58,"type":21},60,[60],"NA","This study will investigate whether a 12-week load-based exercise program performed with an externally rotated foot position (\"toes-out\") leads to different changes in intra-tendinous sliding, symptoms, and function compared to a standard exercise program performed with a neutral foot position in individuals with mid-portion Achilles tendinopathy. In addition, physical activity will be monitored during and after the intervention to examine how daily loading patterns relate to symptoms and functional recovery over a 6-month period.",[27],[64,65,66,67,68,69],"Achilles Tendinopathy","Exercise therapy program","Achilles Tendon","Rehabilitation","Foot position","homogeneous motions","2026-05-28",{"date":43,"type":41},{"date":73,"type":41},"2026-02-19",{"date":75,"type":21},"2027-08-31",{"name":77,"class":48},"KU Leuven",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":95,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":49},"100630103","extracorporeal-shockwave-therapy-and-platelet-rich-plasma-for-midportion-achilles-tendinopathy-100630103","NCT07483320","Extracorporeal Shockwave Therapy and Platelet-Rich Plasma for Midportion Achilles Tendinopathy","A Randomized Controlled Trial Evaluating the Influence of Physical Therapy, Shockwave Therapy, Platelet Rich Plasma or Combined Treatment in the Management of Midportion Achilles Tendinopathy","Inclusion Criteria:\n\n* Age 18-65 years\n* Diagnosis of unilateral midportion Achilles tendinopathy\n* Symptoms present for more than 3 months\n* VISA-A score \\\u003C80 at baseline\n* Pre-injury physical activity level ≥3 on the Physical Activity Scale\n* Ability to participate in rehabilitation program\n\nExclusion Criteria:\n\n* Symptoms present for less than 3 months\n* Prior PRP injection or ESWT treatment to the Achilles tendon within 3 months\n* Other lower extremity musculoskeletal injury affecting function\n* Symptomatic arthritis affecting the ankle or foot\n* Rheumatologic disease or connective tissue disorder\n* Coagulopathy or anticoagulant therapy affecting platelet function\n* Neuropathy affecting pain perception\n* Known cardiac condition contraindicating treatment\n* Poorly controlled diabetes (HbA1c \\>9.0)\n* Pregnancy",{"count":86,"type":21},100,[60],"Midportion Achilles tendinopathy is a common cause of pain and functional limitation in both athletes and the general population. Progressive tendon loading programs are considered first-line treatment but do not lead to satisfactory outcomes in all patients. Extracorporeal shockwave therapy (ESWT) and platelet-rich plasma (PRP) injections are commonly used interventions for refractory symptoms, yet evidence supporting their combined use is limited particularly in treating Achilles tendon disorders.\n\nThis randomized controlled trial will evaluate the effectiveness of a standardized exercise program alone or in combination with PRP injection, ESWT, or both therapies in active adults with midportion Achilles tendinopathy. Participants will be randomized to one of four treatment groups and followed for six months. The primary outcome will assess changes in Achilles tendon symptoms and function using the Victorian Institute of Sport Assessment-Achilles (VISA-A) score. Secondary outcomes will include patient-reported outcomes, physical function testing, ultrasound tendon structure measures, and gait biomechanics.",[90,27,91,92,93,94],"Achilles Injuries Tendon","Achilles Tendinitis, Left Leg","Achilles Tendinitis, Right Leg","Achilles Tendon Pain","Achilles Tendonitis",[96,97,98,99,100,101],"PRP","platelet rich plasma","extracorporeal shockwave","focus shockwave","radial pressure waves","rehabilitation","NOT_YET_RECRUITING","2026-05-08",{"date":105,"type":41},"2026-05-13",{"date":107,"type":21},"2026-06-01",{"date":109,"type":21},"2028-05-30",{"name":111,"class":48},"Spaulding Rehabilitation Hospital",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":139},"100635890","evaluation-of-platelet-rich-plasma-prp-treatment-in-tendinopathies-100635890","NCT07558564","Evaluation of Platelet-Rich Plasma (PRP) Treatment in Tendinopathies","Multicenter Real-World Evidence (RWE) Study: Evaluation of Platelet-Rich Plasma (PRP) Treatment in Tendinopathies","RWE-TDP-PRP","Inclusion Criteria:\n\n* Clinical and\u002For ultrasound diagnosis of chronic tendinopathy (duration \\>6 weeks)\n* Age \\>18 years\n* Provision of written informed consent\n* Willingness and ability to complete follow-up assessments for 12 months\n\nExclusion Criteria:\n\n* Surgical treatment of the affected tendon within the previous 6 months\n* Corticosteroid injection within the last month\n* Systemic inflammatory disease (e.g., rheumatoid arthritis)\n* Coagulopathies or ongoing anticoagulant therapy\n* Complete blood count showing a platelet concentration \\\u003C100 × 10⁹\u002FL (to exclude patients with potential thrombocytopenia)\n* Pregnancy or breastfeeding",{"count":121,"type":21},2000,"OBSERVATIONAL","This multicenter, prospective, observational study, based on real-world evidence (RWE), aims to evaluate the efficacy and safety of Platelet-Rich Plasma (PRP) treatment across four types of tendinopathies: patellar, Achilles, epicondylar, and plantar fasciosis. Data collection and analysis will be conducted using the BioSmartData® platform, including hematology analyzers for PRP characterization, clinical variables, treatment protocols, and longitudinal assessment of therapeutic response.",[125,27,126,127],"Patellar Tendinopathy","Epicondylitis, Lateral","Plantar Fasciitis, Chronic",[129],"tendinopathy, Real World Evidence (RWE), platelet-rich plasma, plantar fasciosis, epicondylitis, patellar tendon, Achilles tendon","2026-04-23",{"date":132,"type":41},"2026-04-30",{"date":134,"type":21},"2026-04",{"date":136,"type":21},"2028-03",{"name":138,"class":48},"ReSport Clinic",5,{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":149,"conditions":150,"keywords":154,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":49},"100635630","stick2it---understanding-why-people-do-or-do-not-stick-with-exercise-treatment-for-achilles-tendinopathy-100635630","NCT07555184","STICK2IT - Understanding Why People Do or Do Not Stick With Exercise Treatment for Achilles Tendinopathy","STICK2IT: Identifying and Prioritising Determinants of Adherence to Progressive Tendon-Loading Exercise in People With Achilles Tendinopathy","Inclusion Criteria:\n\n* • Adults aged 18 years or over with lived experience of Achilles tendinopathy (AT).\n\n  * Gender representation: A purposive sample including men and women, with inclusion of non-binary participants where self-identified, aiming for broad gender representation rather than fixed quotas.\n  * Ethnic and cultural diversity: Purposive sampling will seek representation from diverse ethnic and cultural backgrounds, informed by local population demographics and service user profiles.\n  * Socioeconomic diversity: Participants will be recruited across high, mid, and low socioeconomic deprivation groups, defined using postcode-derived Index of Multiple Deprivation (IMD) tertiles (lower, middle, upper thirds of national IMD distribution). Recruitment will aim for representation across all three IMD categories rather than predefined percentages.\n\nExclusion Criteria:\n\n* • Under 18 years of age\n\n  * Inability to confirm previous AT through either ELHT electronic medical records or through discussion with CI\n  * Individuals whose Achilles symptoms are due to a different primary pathology (e.g., Rheumatological, Achilles Rupture)\n  * Unable to provide informed consent\n  * Unable or unwilling to be audio-recorded.",{"count":148,"type":21},30,"Achilles tendinopathy is a common condition that causes pain and stiffness in the tendon at the back of the ankle. It can make walking, exercise, work, and everyday activities difficult. The main recommended treatment is a programme of progressive tendon-loading exercises, usually supported by an NHS physiotherapist. These exercises can help improve pain and function, but many people find them hard to continue over time. This means that, even though the treatment can work well, some people do not get the full benefit because they are unable to keep up with the exercise programme as advised.\n\nPeople with Achilles tendinopathy often describe worries about making the tendon worse, uncertainty about whether pain during exercise is safe, low confidence, slow progress, and difficulty fitting exercises into daily life. These challenges may be even greater for people from underserved groups, including those living with long-term health conditions, financial pressures, language barriers, or other forms of disadvantage. At present, there is limited research exploring these experiences in a structured way, especially in routine NHS care.\n\nThe aim of this study is to understand what helps or makes it harder for people to stick with NHS-prescribed progressive tendon-loading exercises for Achilles tendinopathy. The study will focus particularly on the experiences of people who may be at higher risk of poor outcomes or reduced access to support.\n\nUp to 30 adults with experience of Achilles tendinopathy and previous NHS physiotherapy treatment will take part in a one-to-one interview. Interviews will last up to 45 minutes and can take place in person, online, or by telephone, depending on what suits the participant best. Participants will be asked about their experiences of living with Achilles tendon pain, being given exercise treatment, and trying to follow that treatment in everyday life.\n\nThe information from these interviews will be analysed to identify the main barriers and supports affecting exercise adherence. The findings will be used to build a clearer understanding of the behavioural factors that influence whether people are able to continue with treatment. This will help inform the future development of a targeted support approach to improve adherence to exercise-based rehabilitation for Achilles tendinopathy in NHS practice.\n\nThe long-term goal of the study is to help make treatment more effective, more personalised, and more suitable for people from a wide range of backgrounds, including those whose needs are often overlooked in research and healthcare design.",[27,151,152,153],"Musculoskeletal Diseases or Conditions","Adherence","Behaviour Change",[155,156,157,158,159,160,161,162,163,164,165,166,167],"Achilles tendinopathy","Theoretical Domains Framework","Qualitative","Adherence to prescribed exercise","Tendon loading exercise","Musculoskeletal physiotherapy","Behaviour change","Underserved populations","Health inequalities","Multimorbidity","Socioeconomic deprivation","Semi-structured interviews","thematic analysis","2026-04-21",{"date":170,"type":41},"2026-04-29",{"date":172,"type":21},"2026-05-01",{"date":174,"type":21},"2027-05-01",{"name":176,"class":48},"East Lancashire Hospitals NHS Trust",{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":16,"minAge":184,"maxAge":185,"enrollmentInfo":186,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":198,"locationsCount":49},"100629683","phase-1-achilles-tendinopathy-embolization-100629683","NCT07477860","Achilles Tendinopathy Embolization","Achilles Tendinopathy Embolization (ATE) With LipioJoint: An Early Feasibility Study","Inclusion Criteria:\n\n* Age ≥ 25 years\n* Subject provides written informed consent\n* Patient with Achilles tendinopathy refractory to 3 months of conservative management\n* Self reported pain of at least 4\u002F10 on visual analog scale (VAS)\n* Non-surgical candidate\u002Flooking to avoid surgery\n\nExclusion Criteria:\n\n* Achilles tendon pain caused by acute fracture, recent trauma, inflammatory conditions, muscle\u002Fligament injury, tendon rupture, and etiologies related to bone mineral density\n* Steroid injection in the last 90 days from the embolization procedure\n* Known severe allergy to Lipiodol and\u002For iodinated contrast media\n* Diagnosis of peripheral arterial disease affecting the lower extremities\n* Pregnancy or breastfeeding\n* Anticoagulation or irreversible coagulopathy\n* GFR \\\u003C45 or Serum creatinine \\> 2.0 mg\u002Fdl\n* Type 1 Diabetes Mellitus","25 Years","80 Years",{"count":5,"type":21},[188],"PHASE1","The goal of this clinical trial is to learn determine the feasibility of arterial embolization using Lipiodol emulsion to safely and effectively treat chronic Achilles tendon pain due to Achilles tendinopathy in adults aged 25 to 80. The main questions it aims to answer are:\n\n1. Does this procedure successfully reduce chronic Achilles tendon pain as measured by the Visual Analog Scale (VAS) over 12 months?\n2. How safe is the procedure, specifically regarding the frequency of serious medical problems or adverse events related to the device?\n\nParticipants will:\n\n* Undergo a minimally invasive procedure where a doctor uses a small tube (catheter) to inject a temporary blocking agent (LipioJoint) into specific blood vessels supplying the Achilles tendon.\n* Receive a phone call one day after the procedure to check for early side effects.\n* Participate in four follow-up visits over the course of one year (at 1, 3, 6, and 12 months).\n\nComplete pain intensity surveys (VAS) and report any changes in their use of other therapies or medications during these visits.",[27],[192],"achilles","2026-04-20",{"date":130,"type":41},{"date":196,"type":41},"2026-04-01",{"date":136,"type":21},{"name":199,"class":200},"Joint & Vascular Institute","INDUSTRY",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":49},"100631172","change-in-ator-screening-test-scores-over-12-weeks-100631172","NCT07497217","Change in ATOR Screening Test Scores Over 12 Weeks","Validity of a Screening Test Compared to Other Measures in Senior Runners With Achilles Tendinopathy After a Physiotherapy Protocol","ATOR","Inclusion Criteria:\n\n* Senior runners\n* They belong to a running club\n* That they have run at least 5 10-kilometer races in the past year\n* They should work out at least three times a week\n\nExclusion Criteria:\n\n* Runners who have received physiotherapy treatment involving invasive techniques in the last 3 months\n* Runners who have received pharmacological treatment with fluoroquinolones (levofloxacin, ciprofloxacin) in the last year\n* Runners with autoimmune diseases\n* Individuals with limited comprehension who may be unable to answer surveys",{"count":210,"type":21},40,[60],"Achilles tendinopathy (AT) is one of the most common overuse injuries in runners, with an estimated incidence ranging from 0.6% to 18.5% of all running-related injuries, reaching up to 52% in elite runners. Its prevalence increases significantly from the fourth decade of life due to histological changes associated with aging, such as tissue degeneration, decreased vascularization, alterations in collagen structure, reduced recovery capacity, and increased tendon stiffness. The repetitive nature of running and the high proportion of the population practicing this sport make runners, especially those over 40 years old, a particularly vulnerable group.\n\nThe etiology of AT is multifactorial and includes biomechanical, physiological, and contextual factors. Major risk factors include sudden increases in load, planning errors in training, biomechanical alterations, overweight, metabolic comorbidities such as diabetes or dyslipidemia, and exposure to certain medications, especially corticosteroids and fluoroquinolones. In middle-aged individuals, the combination of intrinsic and extrinsic factors along with structural tendon changes explains both the higher prevalence and the worse prognosis observed in this population.\n\nPhysiotherapy is one of the preferred treatments for AT, with therapeutic exercise-particularly the Alfredson protocol-being the intervention with the strongest scientific support. Despite its efficacy, between 25% and 45% of patients do not achieve full recovery, suggesting the influence of clinical, personal, and contextual factors not always considered in studies. Additionally, there is high variability in return-to-sport times, which has led to the development of specific programs for runners over 40.\n\nIn the Aragón community, there are no studies describing the extent of AT in senior runners nor systematically analyzing their clinical characteristics, comorbidities, referral patterns, or healthcare service use. This lack of information hampers evidence-based decision-making and the planning of preventive and therapeutic strategies in physiotherapy. This study aims to fill this gap by providing contextualized information to improve clinical practice, healthcare pathways, and physiotherapeutic guidelines.\n\nThe hypothesis of the study is that an assessment system using screening has validity for detecting clinical changes in senior runners with Achilles tendon pain. The main objective is to determine the validity of this screening compared to other clinical measures after applying a physiotherapy protocol.\n\nA clinimetric validity design is proposed. The sample will include 40 runners over 40 years old, belonging to sports clubs, who train at least three days a week and have participated in at least five 10 km races in the past year. Participants will be recruited through running clubs and social media, and randomly assigned to two groups of 20 people each. Exclusion criteria include recent invasive treatments, use of fluoroquinolones in the last year, autoimmune diseases, or difficulties understanding questionnaires.\n\nData collected will include sociodemographic, anthropometric, sports activity, and clinical variables through validated scales (VISA-A, NPRS, IPAQ, and SMFA), as well as ultrasound characteristics of the tendon, ankle mobility, passive calcaneal mobility, and functional screening tests based on active movements and jumps.\n\nThe procedure involves initial measurements, random assignment to control or experimental groups, and a 12-week home self-treatment program. Both groups will perform the Alfredson exercise protocol and receive health education; the experimental group will add analytical stretching of the posterior chain following OMT methodology.\n\nStatistical analysis will assess intergroup and intragroup differences using repeated measures ANOVA, analyze time-group interactions, and include sensitivity-to-change statistics such as effect size, minimal clinically important difference, and reliable change index.\n\nA gender perspective will be incorporated, limiting the representation of one sex to a maximum of 70% of the sample and analyzing results separately by gender. Main limitations include the small sample size, short follow-up duration, and limited control over adherence to home treatment.\n\nFinally, the study clearly defines internal and external validity and clarifies the use of the term screening as a functional discrimination tool within a homogeneous and clinically defined population, without asserting generalization to the broader population.",[27],"2026-03-27",{"date":216,"type":41},"2026-04-02",{"date":218,"type":41},"2026-02-16",{"date":220,"type":21},"2026-07-18",{"name":222,"class":48},"Universidad de Zaragoza",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":49},"100627811","immediate-effects-of-neuromuscular-electrical-stimulation-on-pain-and-function-in-achilles-tendon-disorders-100627811","NCT07453485","Immediate Effects of Neuromuscular Electrical Stimulation on Pain and Function in Achilles Tendon Disorders","Immediate Effects of Neuromuscular Electrical Stimulation on Pain and Functional Performance in Individuals With Achilles Tendinopathy and Tendon Rupture: A Randomized Crossover Clinical Trial","Inclusion Criteria:\n\n* Primary complaint of pain localized in the midportion (2-6 cm proximal to the calcaneus) or insertion of the Achilles tendon, and\u002For a history of Achilles tendon rupture occurring at least 3 months prior to assessment.\n* Pain on palpation of the Achilles tendon.\n* Pain during load-bearing activities\n\nExclusion Criteria:\n\n* Exclusive diagnosis of bursitis confirmed by ultrasonographic assessment\n* Any other lower limb injury\n* History of lower limb surgery within the past year\n* Previous Achilles tendon tenoplasty performed less than 3 months prior to assessment","60 Years",{"count":148,"type":21},[60],"The Achilles tendon exhibits high tensile strength and can withstand extremely high loads. However, it is susceptible to injuries such as tendinopathies and ruptures, which are associated with structural alterations and loss of function. Strategies have been investigated to enhance clinical rehabilitation. Nevertheless, the effects of neuromuscular electrical stimulation on pain and functional improvement, as well as the optimal dosing parameters for the rehabilitation of Achilles tendon injuries, remain inconclusive. The aim of this study is to compare the immediate effects of two electrical stimulation protocols on pain, functional performance, peripheral oxygen extraction, and maximal tendon displacement during a single leg heel rise functional task in patients with Achilles tendinopathy and\u002For a history of Achilles tendon rupture. In addition, this study aims to characterize Achilles tendon structural properties and ankle plantarflexor muscle strength in this population.",[27,235],"Achilles Tendon Rupture",[237,155,238,239,240,241],"Achilles tendon","Achilles tendon rupture","Neuromuscular electrical stimulation","Pain","Functional performance","2026-03-02",{"date":244,"type":41},"2026-03-06",{"date":246,"type":41},"2026-01-06",{"date":248,"type":21},"2029-12-30",{"name":250,"class":48},"University of Brasilia",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":230,"enrollmentInfo":258,"targetDuration":4,"studyType":22,"phases":260,"briefSummary":261,"conditions":262,"keywords":269,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":283},"100606658","muscle-architecture-vs-alfredson-protocol-in-achilles-tendinopathy-100606658","NCT07178418","Muscle Architecture vs Alfredson Protocol in Achilles Tendinopathy","The Effects of a Muscle Architecture-Based Exercise Program and the Alfredson Protocol on Muscle-Tendon Architecture and Physical Performance in Subjects With Achilles Tendinopathy","Inclusion Criteria:\n\n* Presence of pain and tenderness in the mid-portion of the Achilles tendon (2-6 cm proximal to the insertion) persisting for at least 3 months\n* Clinical diagnosis of non-insertional Achilles tendinopathy\n* Pain aggravated by physical activity\n* Palpable tenderness localized to the mid-portion of the tendon\n* Voluntary participation in the study with signed informed consent\n\nExclusion Criteria:\n\n* Diagnosis of insertional Achilles tendinopathy\n* History of surgery or fracture in the affected lower limb within the past 12 months\n* Corticosteroid injection to the Achilles tendon within the past month\n* Presence of systemic diseases (e.g., diabetes mellitus, rheumatoid arthritis)\n* Presence of neurological disorders (e.g., peripheral neuropathy, central nervous system disorders)\n* Prior experience with eccentric exercise protocols targeting the Achilles tendon\n* Acute onset of symptoms suggestive of a tendon rupture",{"count":259,"type":21},20,[60],"Achilles tendinopathy is a frequent overuse disorder caused by repetitive loading of the tendon, particularly observed in athletes and middle-aged men. It is typically characterized by mid-portion pain, stiffness in the morning, and functional limitations, with structural alterations such as thickening and disrupted collagen alignment. Chronic progression often compromises performance and quality of life.\n\nEccentric training protocols, such as the Alfredson regimen, are commonly prescribed but their standardized nature does not fully address individual variability. Alternative approaches including Heavy Slow Resistance training and progressive loading models (e.g., Silbernagel protocol) have demonstrated clinical effectiveness and higher patient adherence, yet they still apply uniform loading across the triceps surae without accounting for architectural differences.\n\nGiven the heterogeneous structure of the soleus and gastrocnemii, targeted loading strategies may be required to optimize tendon adaptation. To address this, the present study employs a muscle architecture-based exercise program tailored to the functional and structural properties of each muscle. Ultrasound imaging will be used to evaluate muscle-tendon morphology, while isokinetic dynamometry and functional performance tests will quantify outcomes. Pain (VAS) and functional capacity (VISA-A) will also be assessed.\n\nThis randomized controlled trial aims to compare the effectiveness of an architecture-specific program with the Alfredson protocol on tendon remodeling, strength, endurance, functional performance, and symptom reduction in individuals with non-insertional Achilles tendinopathy.",[27,263,264,265,266,267,268],"Eccentric Exercise Training","Muscle Architecture","Isokinetic Test","Ultrasound","Balance","Anaerobic Power",[155,270,271,272,273],"muscle architecture","isokinetic strength","Alfredson protocol","tendon architecture","2025-09-10",{"date":276,"type":41},"2025-09-17",{"date":278,"type":21},"2025-10-15",{"date":280,"type":21},"2026-12-31",{"name":282,"class":48},"Halic University",2,{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":290,"enrollmentInfo":291,"targetDuration":4,"studyType":22,"phases":293,"briefSummary":294,"conditions":295,"keywords":296,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":4},"100602418","effects-of-rigid-tape-in-patients-with-chronic-achilles-tendinopathy-100602418","NCT07123246","\"Effects of Rigid Tape in Patients With Chronic Achilles Tendinopathy\"","Inclusion Criteria:\n\n* Clinical diagnosis of unilateral or bilateral MAT\n* Achilles pain \\> 3 months\n* Age ranging between 18 to 50 years, both genders\n* Read and speak Spanish well enough to provide informed consent and follow study instructions.\n* Pain during running and jumping.\n\nExclusion Criteria:\n\n* Any ankle or foot surgery\n* History of Achilles rupture\n* Heel pain in the last 3 months\n* Systemic disorders\u002Fdiseases\n* Body mass index \\> 30kg\u002Fm2\n* Self-report of pregnancy\n* Pain \\\u003C 2\u002F100 of average pain on VAS\n* VISA A score \\> 90 points","50 Years",{"count":292,"type":21},36,[60],"The aim of this study will be to determine the clinical effects of rigid tape in patients with chronic MAT. The secondary outcomes will be to evaluate the immediate and short term pain, the height and pain during the vertical jump, the satisfaction of the use of the tape and the global rating of change (GROC) of the intervention. This study will be a double-blinded randomized clinical trial comprising a total sample size of 36 participants with MAT of both genders and aged between 18 and 50 years. Subjects will undergo a screening process by a sports medicine doctor by different diagnostic tests to identify those presenting a diagnosis of painful MAT and then, they will be randomized into either a group performing experimental rigid tape (G1), or a group performing placebo tape (G2). The study will assess the subjects immediate and short-term tendon pain following the tape application during running and vertical jump. Also the tape satisfaction and GROC will be assessed. The rigid tape will be applied in the central portion of the Achilles tendon. Primary and secondary outcomes will be measured at baseline, immediate after the application of the tape and 72 hours after. The GROC will only be assessed at the end of the treatment. All the evaluations will be performed by a blinded physiotherapist. The patient will also be blinded.",[27],[297],"AT","2025-08-14",{"date":300,"type":41},"2025-08-19",{"date":302,"type":21},"2025-12",{"date":304,"type":21},"2028-12",{"name":306,"class":48},"University of Gran Rosario"]