[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"achilles-tendinopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:achilles-tendinopathy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,47,76,102,125,157,194,220,241,265],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100617842","single-row-versus-double-row-repair-for-achilles-insertional-tendinopathy-100617842",false,"NCT07323875","Single-Row Versus Double-Row Repair for Achilles Insertional Tendinopathy","Single-Row Versus Double-Row Repair in the Surgical Management of Achilles Insertional Tendinopathy: A Randomized Controlled Trial (STRIDE Trial)","STRIDE","Inclusion Criteria:\n\n1. Must be deemed to have capacity to provide informed consent;\n2. Must sign and date the informed consent form;\n3. Stated willingness to comply with all study procedures;\n4. Adult patients between the ages of 18 and 75 years with symptomatic chronic Achilles insertional tendinopathy for a minimum of 3 months\n5. Failure of non-operative management (which includes physiotherapy, stretching exercises, heel lifts, nonsteroidal anti-inflammatory drugs (NSAIDs), activity modification, etc.) for at least 3 months.\n6. Preoperative imaging (x-ray and Medical Resonance Imaging (MRI)) is available and completed;\n7. Willingness of patients to follow the postoperative rehabilitation protocol;\n8. Willingness of patients to be available for follow up appointments for up to 2 years.\n\nExclusion Criteria:\n\n1. Non-insertional Achilles tendinopathy;\n2. Achilles tendon rupture;\n3. Previous Achilles tendon surgery;\n4. Oral steroid use or steroid injection within 3 months of surgery;\n5. History of connective tissue or collagen disorder (e.g. Marfan Syndrome)\n6. History of chronic inflammatory disorders\n7. History of neurological disease (stroke, cerebral palsy)\n8. History of using more than 30mg of oxycodone or equivalent per day;\n9. Current cigarette smoker (Former smokers must have quit for minimum of one year)\n10. Diabetes type I or II\n11. Pregnancy\n12. Hypersensitivity to metal, Polylactic Acid (PLA), or Polyetheretherketone (PEEK) materials\n13. Active infection\n14. Worker's compensation claim (e.g. WSIB)\n15. History of cognitive or mental health conditions that would make the participant unable to complete study procedures\n16. Non-English speaking","ALL","18 Years","75 Years",{"count":21,"type":22},166,"ESTIMATED","INTERVENTIONAL",[25],"NA","Achilles insertional tendinopathy may require surgical debridement and tendon reattachment when non-operative treatment fails. Single-row and double-row repairs are used, with biomechanical studies favoring double-row, but clinical evidence of improved outcomes is lacking and costs are higher. This multi-center randomized trial will use the VISA-A score to compare outcomes and inform cost-effective, evidence-based surgical care.",[28,29],"Achilles Insertional Tendinopathy","Achilles Tendinopathy",[31,32,33],"single row repair","double row repair","calcaneal insertion","NOT_YET_RECRUITING","2026-06-15",{"date":37,"type":38},"2026-06-17","ACTUAL",{"date":40,"type":22},"2026-09",{"date":42,"type":22},"2030-03",{"name":44,"class":45},"Women's College Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100523831","phase-1-managing-chronic-tendon-pain-by-metformin-100523831","NCT06100822","Managing Chronic Tendon Pain by Metformin","Managing Chronic Tendon Pain by Repurposing Metformin","Inclusion Criteria:\n\n* Willing and able to provide informed consent for participation\n* Clinical diagnosis of Achilles tendinopathy\n* Pain disability index score of between 20 - 70 points (0-100 scale VISA-A)\n* Sonopalpation tenderness with tendon thickening and\u002For loss of fibrillary architecture.\n* Ability to read, speak, and understand English\n\nExclusion Criteria:\n\n* Any intervention (corticosteroids or other orthobiologic intervention as injection) to targeted tissue within the last 6 months.\n* Previous Achilles tendon surgery.\n* Known platelet abnormality or hematological disorder.\n* Presence of other conditions that might affect the functional scale of the indexed limb.\n* Unwillingness to be randomized.\n* Body Mass Index (BMI) greater than 30.\n* Occult tear in the indexed tendon.\n* Systemic inflammatory disease.\n* Use of fluoroquinolone in the past 6 months.\n* Subjects must not be pregnant or breastfeeding, or planning to become pregnant or breastfeed during the course of the trial\n* Chronic kidney disease (eGFR \\\u003C60)\n* Diagnosis of diabetes mellitus or elevated HbA1c at screening (\\> 6.5)\n* Unable to take an oral medication in a non crushable pill form\n* Taking metformin presently or within the last 6 months\n* History of allergy to metformin\n* History of lactic acidosis or elevated lactate at screening (\\> 2.2)\n* Severe Hepatic dysfunction\n* Currently taking a diabetic medication such as sitagliptin, saxagliptin, linagliptin, alogliptin, sitagliptin with metformin\n* Currently taking a Carbonic anhydrase inhibitor such as topiramate, zonisamide, acetazolamide, dichlorphenamide, methazolamide\n* Currently taking cimetidine","50 Years",{"count":56,"type":22},40,[58],"PHASE1","The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain. The trial has two aims; 1) to assess the effects of OIM treatment on tendon pain, and 2) to determine the effects of OIM capsules on tendon healing and repair. Twenty participants will be treated with metformin capsules for 16 weeks combined with a home exercise program. A comparison group of 20 participants will be treated with placebo tablets along with home exercise program.",[61,62,29],"Tendinopathy","Chronic Pain",[64,65,29,62],"Achilles Tendon","Metformin","RECRUITING","2026-06-02",{"date":69,"type":38},"2026-06-04",{"date":71,"type":38},"2024-05-24",{"date":73,"type":22},"2026-09-30",{"name":75,"class":45},"James Wang",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100462461","efficacy-of-percutaneous-electrolysis-in-the-treatment-of-achilles-tendinopathy-100462461","NCT05301959","Efficacy of Percutaneous Electrolysis in the Treatment of Achilles Tendinopathy","Evaluation of the Efficacy of Adding Low-intensity Percutaneous Musculoskeletal Electrolysis to the Conservative Treatment of Noninsertional Achilles Tendinopathy: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Presence of symptoms in one or both Achilles tendons with a minimum duration of two months. In case the symptoms are bilateral, the intervention or placebo will only be administered and its results evaluated- in the limb with greater symptomatology. If it is not possible to differentiate which one presents greater pain, the right Achilles tendon will be chosen.\n* Spontaneous pain of at least three points measured by a visual analog scale (VAS), reproducible by palpation between 2 and 6 cm above the insertion of the Achilles tendon in the calcaneal bone.\n* Evidence of tendinopathy by MRI.\n* Presence of post-static dyskinesia.\n* Willingness to not perform additional treatments (such as footwear modifications, physical therapy, orthotics, injections, or surgery) for Achilles tendon pain during the conduct of the trial.\n* Willingness to attempt to discontinue self-administration of medications (NSAIDs) for pain relief Achilles tendon(s) pain for at least 14 days prior to baseline assessment and during the course of the trial.\n\nExclusion Criteria:\n\n* Presence or suspicion of pregnancy.\n* Previous surgical intervention on the AT in the symptomatic leg(s)\n* Total or partial rupture in the symptomatic AT\n* Chronic ankle instability, in the foot with symptomatic tendon(s).\n* Pathologies that can derive in pain in the region of the AT without being proper of the picture. (e.g.: osteoarthritis, impingement syndromes).\n* Presence of arthritis or any metabolic or endocrine disorder (type 1 or 2 diabetes).\n* Psychological disorders.\n* Oncologic history.\n* Treatment with quinolones or fluoroquinolones during the last two years.\n* Treatment with statins for the control of hypercholesterolemia for more than two months\n* Treatments within or at the periphery of the Achilles tendon, with anesthetics, corticosteroids or any other pharmacological agent during the last three months.\n* Needle phobia\n* Allergy to metal","65 Years",{"count":85,"type":22},102,[25],"Achilles tendinopathy (AT) is one of the most reported myotendinous pathologies due to overuse in the literature. In the general adult population, its incidence is 2.35 cases per 1,000 patients, with no difference between men and women. The international literature reports that up to 29% of patients fail with conservative treatment.\n\nWithin physiotherapy, new alternatives for the treatment of tendinopathies arise, applying electric currents percutaneously, which from a mechanical effect associated to the use of a needle and an electric effect by the use of galvanic currents, generate a local inflammatory response; activation of the central nervous system and analgesia.\n\nThe aim of the research is to evaluate the efficacy of adding low intensity percutaneous electrolysis to the treatment with a high load eccentric exercise program based on the protocol of Silbernagel et al. in adults with Achilles tendinopathy to improve its functionality.\n\nA randomized, double-blind, blinded, evaluator-blinded, controlled clinical trial will be conducted in parallel groups (experimental treatment vs. sham treatment), with a follow-up at 26 and 52 weeks after the first intervention. Non-probability and intentional sampling will be performed.",[29],[90,91,92],"tendinopathy","physiotherapy","percutaneous electrolysis","2026-04-24",{"date":95,"type":38},"2026-04-29",{"date":97,"type":38},"2023-07-01",{"date":99,"type":22},"2027-12",{"name":101,"class":45},"Maimonides University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":111,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":46},"100575612","early-implementation-of-plyometric-exercises-in-the-rehabilitation-of-individuals-suffering-from-lower-extremity-tendinopathies-100575612","NCT06774547","Early Implementation of Plyometric Exercises in the Rehabilitation of Individuals Suffering From Lower-Extremity Tendinopathies","The Efficacy of Early Implementation of Plyometric Exercises in the Rehabilitation of Individuals Suffering From Lower-Extremity Tendinopathies: A Randomised Clinical Trial","Inclusion Criteria:\n\n1. participants are required to have performed either recreational running or participated in sports that include running or jumping activities (e.g., football, basketball, handball, volleyball) at least once per week for at least three months immediately prior to pain onset\n2. have had symptoms for at least three months\n3. have pain\u002Fsoreness with palpation of the tendon\u002Ffascia\n4. mean pain during the past week of at least 2 on a 0 to 10 Numerical Rating Scale\n5. pain during a pain provocation test (patellar tendinopathy: five single-legged decline squats, Achilles tendinopathy and plantar fasciopathy: ten single-legged heel raises)\n\nExclusion Criteria:\n\n1. previous lower-extremity surgery\n2. other lower-extremity musculoskeletal conditions that have required treatment by a healthcare professional during the past three months\n3. pregnancy\n4. diabetes\n5. history of inflammatory systemic diseases (e.g., rheumatoid arthritis or spondylarthritis)\n6. having received an injection with corticosteroid within the past six months.",{"count":110,"type":22},120,[25],"This clinical trial aims to compare the effectiveness of an early plyometric exercise approach with traditional heavy, slow resistance training in treating tendinopathies of the Achilles tendon, patellar tendon, and plantar fascia. These conditions, commonly seen in general and rheumatology practices, cause pain, reduced function, and stiffness, often leading to prolonged recovery and incomplete return to full physical activity. The study hypothesizes that introducing plyometric exercises early in rehabilitation will improve jump function after 12 weeks and reduce re-injury rates within 52 weeks compared to traditional methods.\n\nThe study is a randomized clinical trial including 120 participants aged 18-50 with tendinopathy in one of the targeted areas. Participants must regularly engage in running or jumping sports, have symptoms for at least three months, and meet other inclusion criteria. Exclusion criteria include recent surgery or specific medical conditions. Both groups will perform exercises three times weekly for 12 weeks, tailored to their tendinopathy. The intervention group will add progressive plyometric exercises to the standard strength training performed by the control group. Plyometric training will consist of three levels, with patients self-assessing readiness to progress.\n\nThe primary outcome is the change in the plyometric quotient, a measure of functional ability, based on a jump test using a force platform at 0 and 12 weeks. Secondary outcomes include dynamic strength, jump height, patient-reported symptoms (via questionnaires), return to sport, training compliance, adverse events, pain thresholds, re-injury rates, and psychological readiness for sports. Assessments will occur at baseline, 12 weeks, and 52 weeks.",[29,114,115],"Patellar Tendinopathy","Plantar Fasciopathy","2026-03-02",{"date":118,"type":38},"2026-03-04",{"date":120,"type":38},"2025-09-18",{"date":122,"type":22},"2028-01",{"name":124,"class":45},"Aalborg University",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":23,"phases":136,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":156},"100572709","progressive-achilles-loading-via-clinician-e-support-100572709","NCT06736795","Progressive Achilles Loading Via Clinician E-support","Progressive Achilles Loading Via Clinician E-support (PACE)","PACE","Inclusion Criteria:\n\n* Pain localized to the Achilles tendon (insertion or midportion)\n* AT pain greater than or equal to 3\u002F10 with tendon-loading exercise\n\nExclusion Criteria:\n\n* Younger than 18 years of age or older than 60 years of age\n* BMI \\> 45 kg\u002Fm2\n* Pain primarily due to a differential diagnosis, including paratendonitis, bursitis (retrocalcaneal or subcutaneous), posterior ankle impingement or os trigonum, irritation or neuropathy of the sural nerve, plantaris tendon involvement)\n* Presence of a partial Achilles tendon tear or rupture on imaging or a history of Achilles tendon rupture that was verified by surgical or conservative management\n* Attended physical therapy for AT in the past 3 months\n* History of steroid injection to lower extremity tendons\u002Ffascia, ESWT or any injection to the Achilles tendon region in the past 3 months\n* History of taking fluoroquinolones in the past 6 months\n* History of surgery or invasive procedure for AT on side enrolling for treatment\n* Diagnosed systemic conditions affecting the foot and ankle (e.g., rheumatoid arthritis, ankylosing spondylitis), endocrine disorder with complications (e.g., uncontrolled Type I or II diabetes, diabetic peripheral neuropathy), connective tissue disorder (e.g., Marfan's syndrome, Ehlers Danlos), or pregnancy\n* At high risk for falls (four step square test \\>15 seconds)\n* Refusal of randomization or unable or uninterested in completing virtual visits with a webcam or smart phone or completing quizzes and surveys","60 Years",{"count":135,"type":22},160,[25],"This is a randomized controlled trial with individuals who have Achilles tendon pain. This study is designed to identify an effective rehabilitation program for Achilles tendon pain that expands access to care for military personnel and to predict treatment response. Limited or delayed access to healthcare can exacerbate the severity of pain and duration of disability due to AT. This is particularly relevant for individuals deployed to battlefield settings or are being seen in busy military treatment facilities. Therefore, it is crucial to identify efficient and effective treatment pathways that maximize healthcare access and facilitate a rapid and pain-free return to full duty.",[139,29],"Achilles Tendon Pain",[141,142,143,144,145,146],"ultrasound imaging","tendon health","pain","exercise","physical therapy","education","2025-10-01",{"date":149,"type":38},"2025-10-07",{"date":151,"type":38},"2025-08-20",{"date":153,"type":22},"2028-07",{"name":155,"class":45},"Ruth Chimenti",2,{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":23,"phases":168,"briefSummary":169,"conditions":170,"keywords":173,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":46},"100474945","evaluation-of-collagen-based-medical-device-treatment-combined-with-physiotherapy-in-subjects-with-achilles-tendinopathy-100474945","NCT05464498","Evaluation of Collagen-based Medical Device Treatment Combined With Physiotherapy in Subjects With Achilles Tendinopathy.","Evaluation of Collagen-based Medical Device Treatment Combined With Physiotherapy in Subjects With Achilles Tendinopathy. Multicenter Randomized Clinical Investigation; AKITENMED STUDY.","AKITENMED","Inclusion Criteria:\n\n* Male and female subjects aged 18 to 70 years;\n* Subjects with tendon pain for not more than 24 weeks;\n* Subjects with clinically diagnosed and ultrasonographically confirmed insertional\u002Fnoninsertional\u002Fmystic tendinopathy;\n* Subjects with a VISA A score between 50 and 75;\n* VAS ≥ 5;\n* Subjects able to understand and answer the SF12 questionnaire;\n* Subjects able to understand and sign the informed consent.\n\nExclusion Criteria:\n\n* subjects who have had surgery in the investigated area or lower extremity;\n* subjects who have previously undergone physiotherapy.\n* subjects with autoimmune diseases;\n* subjects with peripheral neuropathy;\n* subjects with calcific tendinopathy\n* subjects with pain of direct traumatic origin;\n* subjects with local\u002Fsystemic infections;\n* subjects with neoplastic diseases;\n* subjects with gout;\n* subjects on corticosteroid treatment at the time of enrollment;\n* subjects who have used corticosteroids or fluoroquinolones in the three months prior to enrollment;\n* subjects who have used NSAIDs in the week prior to enrollment;\n* subjects who are pregnant and lactating;\n* subjects with contraindications to acetaminophen use;\n* allergy to porcine collagen.","70 Years",{"count":167,"type":22},72,[25],"Achilles tendinopathy is a condition characterized by inflammation of the Achilles tendon. Achilles tendinopathies are classified into insertional tendinitis and noninsertional tendinitis. Insertional tendinitis involves the lower part of the tendon, where the tendon inserts at the level of the calcaneus, and can affect even patients who are not particularly athletically active. Noninsertional tendinitis occurs when the fibers in the middle portion of the tendon are affected, affects young and athletic people the most, and has a high incidence (30-50%) in middle-aged individuals.\n\nConsidering that there are no strong evidence-based guidelines in the area of treatment of achilles tendinopathy, the aim of this research project is to understand through a multicenter, randomized clinical investigation the impact of treatment with a porcine collagen-based medical device administered in the peri-tendon area in combination with physiotherapy on pain reduction and functional improvement of the investigated tendon.",[61,171,29,172],"Insertional Achilles Tendinopathy","Peritendinitis",[174,175,176,177,178,179,180,181,182,183],"Eccentric strengthening","Collagene Medical Device","Physiotherapy","Peritendinous area","Infiltration","Type I collagen","Eccentric strengthening protocol","Pain Visual Analog Scale","12-Item Short Form Survey","Victorian Institute of Sport Assessment- Achilles questionnaire","2025-08-01",{"date":186,"type":38},"2025-08-03",{"date":188,"type":38},"2022-06-13",{"date":190,"type":22},"2026-01-13",{"name":192,"class":193},"Guna S.p.a","INDUSTRY",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":23,"phases":204,"briefSummary":205,"conditions":206,"keywords":207,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":46},"100591925","comparative-effects-of-laser-and-extracorpeal-shock-wave-in-patients-with-achilles-tendinopathy-100591925","NCT06986759","Comparative Effects of Laser and Extracorpeal Shock Wave in Patients With Achilles Tendinopathy.","Comparative Effects of Laser and Extracorpeal Shock Wave Therapy on Pain, Range of Motion and Function in Patients With Achilles Tendinopathy.","Inclusion Criteria:\n\n* Age of patients 18-40.\n* Diagnosed with chronic Achillis tendinopathy and NPRS rating more than 2.\n* Both male and female.\n* Patient must be diagnosed with Achillis Tendinopathy by single leg raise or Thompson test.\n\nExclusion Criteria:\n\n* contraindications to LLLT to the area of the Achilles tendon.\n* comorbid musculoskeletal or serious conditions that may have confounded treatment or anticipated recovery .\n* nonsteroidal anti-inflammatory drug use steroid injections or surgery for the condition; insertional tendinopathy or bursitis (retrocalcaneal or Achilles; determined by clinical examination.\n* neurologic signs; and adverse neural tension affecting the sciatic or sural nerve.","40 Years",{"count":203,"type":22},44,[25],"Achilles tendinopathy is a prevalent condition characterized by pain, swelling, and impaired function of the Achilles tendon, commonly affecting athletes and active individuals. The disorder arises from a failed healing response, leading to degenerative changes in the tendon without significant inflammation. It is categorized into insertional (at the calcaneus-Achilles junction) and non-insertional (2-6 cm proximal to the insertion) types. Intrinsic risk factors include biomechanical abnormalities and systemic conditions like diabetes and hypertension, while extrinsic factors involve excessive mechanical load and training errors. Effective management of Achilles tendinopathy is crucial for preventing long-term disability and ensuring the continuation of physical activities.",[29],[208,209,210],"Pain","Function","Range of Motion","2025-07-03",{"date":213,"type":38},"2025-07-07",{"date":215,"type":22},"2025-07-24",{"date":217,"type":22},"2025-10-20",{"name":219,"class":45},"Riphah International University",{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":23,"phases":229,"briefSummary":230,"conditions":231,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":46},"100360092","electrical-dn-as-an-adjunct-to-eccentric-exercise-stretching--mt-for-achilles-tendinopathy-100360092","NCT03968614","Electrical DN as an Adjunct to Eccentric Exercise, Stretching + MT for Achilles Tendinopathy","Electrical Dry Needling as an Adjunct to Eccentric Exercise, Stretching and Manual Therapy for Mid-portion Achilles Tendinopathy: a Multicenter Randomized Clinical Trial","Inclusion Criteria:\n\n1. Adult \\>18 years old that is able to speak English.\n2. Report of at least 3 months of Achilles pain clinically diagnosed as Achilles tendonitis or Achilles tendinopathy\n3. Patient has not had physical therapy, massage therapy, chiropractic treatment or injections for Achilles pain in the last 6 months:\n4. Diagnosis of noninsertional tendinopathy, defined as the following\n\n   * Subjective report of pain located 2-6 cm proximal to the insertion of Achilles tendon to the calcaneus, particularly with running or jumping\n   * Tenderness to palpation of the Achilles tendon while the clinician gently squeezes the tendon between the thumb and index finger in a proximal to distal direction\n   * Positive Arc Sign - Intratendinous swelling moves relative to the malleoli with the tendon during active dorsi\u002Fplantar Flexion\n   * Royal London Test - Tenderness to palpation decreases significantly or disappears with max dorsiflexion\n\nExclusion Criteria:\n\n1. Report of red flags to manual physical therapy to include: hypertension infection, diabetes, peripheral neuropathy, heart disease, stroke, chronic ischemia, edema, severe vascular disease, malignancy, etc.\n2. History of previous Achilles tendon surgery, ankle arthrodesis, hind foot fracture, or leg length discrepancy of more than one half inch.\n3. History of arthrosis or arthritis of the ankle and\u002For foot.\n4. History of significant ankle and\u002For foot instability\n5. Two or more positive neurologic signs consistent with nerve root compression, including any two of the following:\n\n   1. Muscle weakness involving a major lower extremity muscle group\n   2. Diminished lower extremity patella or Achilles tendon reflexes\n   3. Diminished \u002F absent sensation in any lower extremity dermatome\n6. Involvement in litigation or worker's compensation regarding foot pain\n7. Any condition that might contraindicate the use of electro-needling\n8. The patient is pregnant.",{"count":228,"type":22},110,[25],"The purpose of this research is to compare two different approaches for treating patients with achilles tendinopathy: eccentric exercise, stretching and manual therapy VS Electric dry needling, eccentric exercise, stretching and manual therapy. Physical therapists commonly use all of these techniques to treat achilles tendinopathy. This study is attempting to find out if one treatment strategy is more effective than the other.",[29],"2025-05-14",{"date":234,"type":38},"2025-05-18",{"date":236,"type":38},"2019-06-10",{"date":238,"type":22},"2026-05-01",{"name":240,"class":45},"Alabama Physical Therapy & Acupuncture",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":247,"targetDuration":4,"studyType":23,"phases":249,"briefSummary":250,"conditions":251,"keywords":253,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":46},"100457791","effects-of-low-load-resistance-training-with-blood-flow-restriction-in-patients-with-achilles-tendinopathy-100457791","NCT05241197","Effects of Low-load Resistance Training With Blood Flow Restriction in Patients With Achilles Tendinopathy","Inclusion Criteria:\n\n* Clinical diagnosis of unilateral MAT.\n* Achilles pain \\> 3 months.\n* Age ranging between 18 to 50 years, both genders.\n* Read and speak Spanish well enough to provide informed consent and follow study instructions.\n* Can attend in-clinic treatments 2-3 x weekly for the next 12 weeks.\n\nExclusion Criteria:\n\n* Any ankle or foot surgery.\n* History of Achilles rupture.\n* Heel pain in the last 3 months.\n* Systemic disorders\u002Fdiseases.\n* History of deep venous thrombosis, hypertension or blood clotting disorder.\n* Body mass index \\> 30kg\u002Fm2.\n* Self-report of pregnancy.\n* Drug use (local steroid injection or systemic fluoroquinolones).\n* Pain \\\u003C 2\u002F10 of average pain on NPRS.\n* VISA A score \\> 90%.\n* Unable to perform any of the exercises of the study.",{"count":248,"type":22},52,[25],"Midportion Achilles tendinopathy (MAT) is a common overuse injury of the lower extremity characterized by the presence of pain, restricted function and interruption of sport activities. Conservative management of MAT has been suggested as the first line of treatment. Actually, there are several exercise programs with beneficial effects on pain and function among which high load training stands out. However, this training modality is inherently difficult to implement in certain populations and pathological conditions due to their inability to tolerate this mechanical stress. In this sense, low load training with blood flow restriction (BFR-LLT) emerges as an effective option in producing hypertrophic adaptations with low intensities (30% 1RM). However, this training modality has not yet been studied in tendon pathology. The aim of this study is to evaluate the potential clinical effects of BFR-LLT in comparison with HLT in patients with chronic MAT.",[29,139,252],"Tendon Injuries",[254,255],"Blood Flow Restriction","Rehabilitation","2024-12-03",{"date":258,"type":38},"2024-12-06",{"date":260,"type":38},"2022-04-29",{"date":262,"type":22},"2026-08",{"name":264,"class":45},"University of Gran Rosario",{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":273,"targetDuration":4,"studyType":23,"phases":275,"briefSummary":276,"conditions":277,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":4},"100542390","low-temperature-radiofrequency-coblation-micro-tenotomy-for-the-treatment-of-achilles-tendinopathy-100542390","NCT06342245","Low-temperature Radiofrequency Coblation Micro-tenotomy for the Treatment of Achilles Tendinopathy","Low-temperature Radiofrequency Coblation Micro-tenotomy for the Treatment of Achilles Tendinopathy; a Multicentre, Prospective, Randomized Controlled Clinical Trial.","AT RCT","Inclusion Criteria:\n\n* The inclusion is ultrasound-confirmed Achilles tendinopathy. Adults (age \\>18) with clinically diagnosed midportion Achilles tendinopathy will be recruited and scheduled for ultrasound screening. Ultrasonography diagnostic criteria include a thickened Achilles tendon and a Colour Doppler of at least 1 out of 3 in the Öhberg score 2-6 cm proximal to the Achilles tendon insertion. Victorian Institute of Sports Assessment -Achilles (VISA-A) scores below 60 points.\n\nExclusion Criteria:\n\n* Patients will be excluded if they had a history of major injury or surgery on the affected lower limb in the past year and have mental\u002Fphysical limitations hindering the participant's ability to complete assessments (ankle arthritis, neuromuscular disorders, etc.), including severe cognitive impairment and psychiatric disorders.",{"count":274,"type":22},48,[25],"This is a prospective randomized, double-blinded, placebo-controlled superiority trial with two parallel groups and a 1:1 allocation ratio to investigate the effectiveness of radiofrequency coblation micro-tenotomy for patients with Achilles tendinopathy. All participants will be randomized into two groups: the intervention group (n=24; radiofrequency coblation micro-tenotomy + endoscopic Achilles debridement) and the control group (n=24; endoscopic Achilles debridement only). Adults (age \\>18) with clinically diagnosed midportion Achilles tendinopathy will be recruited and scheduled for ultrasound screening. All participants will undergo a 12-week eccentric exercise program taught by a registered physiotherapist \u002F athletic trainer. Undergo Endoscopic Achilles debridement and Radiofrequency coblation micro-tenotomy intervention. Criteria for discontinuing or modifying allocated interventions, Strategies to improve adherence to interventions, Relevant concomitant care permitted or prohibited during the trial and Provisions for post-trial care. Outocme measure will use VISA-A, pain scores, ultrasound measurement of thickness and vascularity, calf muscle strength, and ankle range of motion.",[29],"2024-03-26",{"date":280,"type":38},"2024-04-02",{"date":282,"type":22},"2024-06-11",{"date":284,"type":22},"2027-06-11",{"name":286,"class":45},"Chinese University of Hong Kong"]