[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"achilles-tendon-rupture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:achilles-tendon-rupture":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,44,74,104,136,158,182,204,234,261],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100602964","the-effect-of-collagen-scaffold-augmentation-in-achilles-tendon-rupture-repair-100602964",false,"NCT07130357","The Effect of Collagen Scaffold Augmentation in Achilles Tendon Rupture Repair","Prospective Multi-Centre Randomised Controlled Trial on the Effect of Collagen Scaffold Augmentation in Achilles Tendon Rupture Repair","Inclusion Criteria:\n\n1. Achilles tendon rupture.\n2. Age \\> 18 and able to provide written informed consent.\n\nExclusion Criteria:\n\n1. Hypersensitive to bovine-derived materials.\n2. Prior foot\u002Fankle surgery or intervention within 1 year\n3. Ongoing litigation regarding current injury\n4. Active psychological or physical condition pre-empting participation, including psychosis, mental retardation, stroke.","ALL","18 Years",{"count":19,"type":20},48,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective multicenter randomized controlled trial evaluates the clinical efficacy of collagen scaffold augmentation in surgical repair for acute Achilles tendon ruptures. The study will enroll 48 adult participants randomly assigned to either the intervention group (surgical repair with collagen scaffold augmentation) or the control group (standard surgical repair without scaffold). The primary outcome is tendon function assessed using the VISA-A score, while secondary outcomes include tendon healing characteristics measured by ultrasound (thickness, neovascularity), calf muscle strength, ankle range of motion, and complication rates. Follow-up assessments will be conducted at 6 weeks, 3 months, 6 months, and 12 months post-surgery. The study aims to determine whether collagen scaffold augmentation enhances tendon healing and functional recovery compared to conventional repair methods, potentially offering a improved treatment approach for Achilles tendon injuries.",[26],"Achilles Tendon Rupture",[26,28,29,30],"Collagen Scaffold Augmentation","Regeneten","Achilles Tendon Rupture Repair","RECRUITING","2026-03-22",{"date":34,"type":35},"2026-03-25","ACTUAL",{"date":37,"type":35},"2025-12-25",{"date":39,"type":20},"2027-12-31",{"name":41,"class":42},"Chinese University of Hong Kong","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":43},"100627811","immediate-effects-of-neuromuscular-electrical-stimulation-on-pain-and-function-in-achilles-tendon-disorders-100627811","NCT07453485","Immediate Effects of Neuromuscular Electrical Stimulation on Pain and Function in Achilles Tendon Disorders","Immediate Effects of Neuromuscular Electrical Stimulation on Pain and Functional Performance in Individuals With Achilles Tendinopathy and Tendon Rupture: A Randomized Crossover Clinical Trial","Inclusion Criteria:\n\n* Primary complaint of pain localized in the midportion (2-6 cm proximal to the calcaneus) or insertion of the Achilles tendon, and\u002For a history of Achilles tendon rupture occurring at least 3 months prior to assessment.\n* Pain on palpation of the Achilles tendon.\n* Pain during load-bearing activities\n\nExclusion Criteria:\n\n* Exclusive diagnosis of bursitis confirmed by ultrasonographic assessment\n* Any other lower limb injury\n* History of lower limb surgery within the past year\n* Previous Achilles tendon tenoplasty performed less than 3 months prior to assessment","60 Years",{"count":53,"type":20},30,[23],"The Achilles tendon exhibits high tensile strength and can withstand extremely high loads. However, it is susceptible to injuries such as tendinopathies and ruptures, which are associated with structural alterations and loss of function. Strategies have been investigated to enhance clinical rehabilitation. Nevertheless, the effects of neuromuscular electrical stimulation on pain and functional improvement, as well as the optimal dosing parameters for the rehabilitation of Achilles tendon injuries, remain inconclusive. The aim of this study is to compare the immediate effects of two electrical stimulation protocols on pain, functional performance, peripheral oxygen extraction, and maximal tendon displacement during a single leg heel rise functional task in patients with Achilles tendinopathy and\u002For a history of Achilles tendon rupture. In addition, this study aims to characterize Achilles tendon structural properties and ankle plantarflexor muscle strength in this population.",[57,26],"Achilles Tendinopathy (AT)",[59,60,61,62,63,64],"Achilles tendon","Achilles tendinopathy","Achilles tendon rupture","Neuromuscular electrical stimulation","Pain","Functional performance","2026-03-02",{"date":67,"type":35},"2026-03-06",{"date":69,"type":35},"2026-01-06",{"date":71,"type":20},"2029-12-30",{"name":73,"class":42},"University of Brasilia",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":103},"100623047","achilles-tendon-rupture-patient-outcomes-at-12-months-100623047","NCT07391553","Achilles Tendon Rupture Patient Outcomes at 12 Months","What Are the Isokinetic Strength Outcomes and Self-reported Functional Outcomes (ATRS) at 12 Months Following Non-surgical Management of Achilles Tendon Rupture Using the SMART Protocol?","ATR-12","Inclusion Criteria:\n\n* Adults aged 18 years or older at the time of recruitment.\n* Confirmed diagnosis of Achilles tendon rupture, diagnosed clinically and recorded within the NHS database.\n* Injury managed non-surgically using the SMART (Swansea Morriston Achilles Rupture Treatment) protocol.\n* 12-15 months post-injury at the time of assessment.\n* Able and willing to provide informed written consent to participate in the study.\n\nExclusion Criteria:\n\n* Unable to provide informed consent.\n* Previous surgical repair of the Achilles tendon or documented re-rupture.\n* Presence of a neuromuscular disorder affecting lower limb strength or function.\n* Did not follow the SMART protocol for non-surgical management.\n* History of Achilles tendinopathy or rupture in the contralateral (uninjured) leg.\n* Unable to tolerate isokinetic strength testing due to pain, discomfort, or other medical reasons.",{"count":83,"type":20},115,"OBSERVATIONAL","The Achilles tendon is the strongest and largest tendon in the human body, playing a critical role in plantarflexion and facilitating activities such as walking, running, and jumping. However, it is also the most frequently ruptured tendon. The injury and associated disability have a significant impact on patient quality of life and healthcare services. Achilles tendon ruptures are increasingly common, particularly among middle-aged recreational athletes, with an incidence estimated at 18 per 100,000 person-years.\n\nThe Swansea Morriston Achilles Rupture Treatment (SMART) protocol represents a structured, progressive approach to non-operative rehabilitation. It emphasizes early mobilization, protected weight-bearing, and a gradual return to sport or high-level function through targeted strength and neuromuscular training. While short-term outcomes of non-surgical protocols have demonstrated promising results, there remains limited high-quality data on long-term isokinetic strength and patient-reported functional outcomes beyond six months in this patient group.\n\nThis study aims to evaluate isokinetic plantarflexor strength and self-reported functional outcomes at 12 months following non-surgical management of Achilles tendon ruptures using the SMART rehabilitation protocol. By assessing both objective and subjective recovery metrics, we aim to contribute to the growing evidence base for evidence-informed, conservative Achilles tendon rehabilitation. A secondary aim of the study is to examine the relationship between isokinetic strength scores and self reported functional recovery scores using the ATRS questionnaire.\n\nParticipants will attend one 60-90 minute visit to complete a short questionnaire and perform a safe, clinic-based ankle strength test using an isokinetic machine; the test feels like pushing against a footplate, similar to resisted ankle movements. The results of these tests will be collected and analysed. The study will help to gain further insight into patient recovery from this injury.",[26],[61,88,89,90,91],"Physiotherapy","orthopaedics","trauma","rehabilitation","NOT_YET_RECRUITING","2026-02-27",{"date":95,"type":35},"2026-03-03",{"date":97,"type":20},"2026-06-01",{"date":99,"type":20},"2029-01-01",{"name":101,"class":102},"Liverpool University Hospitals NHS Foundation Trust","OTHER_GOV",2,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":112,"minAge":17,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":21,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":43},"100586199","effects-of-strength-training-on-the-plantar-flexors-properties-after-achilles-tendon-rupture-100586199","NCT06912269","Effects of Strength Training on the Plantar Flexors' Properties After Achilles Tendon Rupture","Effects of Strength Training at Different Intensities on the Plantar Flexors' Functional, Neuromuscular, and Tendon Properties After Achilles Tendon Rupture","Inclusion Criteria:\n\n* Men aged 18 to 64 who have ruptured their Achilles tendon unilaterally no more than 5 years ago;\n* Who are not performing systematic and regular calf strength training.\n\nExclusion Criteria:\n\n* Non-surgical treatment for Achilles tendon rupture;\n* History of postsurgical complications (infection or re-rupture);\n* Presence of any type of ankle injury in the last six month;\n* Participation in a strength training program for plantar flexors in the last six months prior to participation in the study;\n* Having heart failure; autoimmune diseases; and\u002For diabetes;\n* Systematic use of antibiotics or steroids within the last 12 months;\n* Presence of any other clinical contraindication for performing maximum strength tests.",true,"MALE","64 Years",{"count":115,"type":20},67,[23],"Among the injuries that affect the Achilles tendon, rupture is one of the most frequent. This injury can generate functional, neuromuscular, and tendon deficits that can last for long periods or even be permanent. In the long term (i.e., more than a year after the injury), individuals present functional impairments related to the lower limb, deficits in the capacity to produce muscle force, as well as higher levels of muscle activation (as a compensatory response). Such changes may be due to injury adaptations in the plantar flexor muscles' architecture, which may have shorter, more pennate fibers, leading to reduced muscle thickness. Furthermore, the Achilles tendon may be elongated, with a greater cross-sectional area, presenting lower stiffness and quality (i.e., lower Young's modulus). Strength training can play an important role in recovering from Achilles tendon ruptures, as it promotes functional, neuromuscular, and tendon adaptations that can minimize deficits caused by the injury. However, there is a gap in the literature regarding strength training, as well as the dose vs response relationship, regarding functional, neuromuscular, and tendon adaptations after Achilles tendon rupture. Thus, the aim of the present study is to compare the effects of a strength training program of different intensities on plantar flexors' functional, neuromuscular, and tendon outcomes after Achilles tendon rupture. Men aged between 20 and 50 years old who suffered a total unilateral rupture of the Achilles tendon between one and five years after the rupture will be included in the study, as well as healthy men who did not suffer the rupture (control group). Participants who have suffered an Achilles tendon rupture will undergo a progressive lower limb strength training program twice a week for a total duration of 12 weeks, which will be randomized between two groups: low intensity (G55 - 55% of 1-RM) and moderate intensity (G70 - 70% of 1-RM). The following outcomes will be evaluated: a) Achilles tendon's morphological (length and cross-sectional area), mechanical (force-elongation relationship and stiffness) and material (stress-strain relationship and Young's modulus) properties; b) triceps surae muscles' morphological (architecture \\[fascicle length, pennation angle and thickness\\] and quality \\[measured by echointensity and specific tension\\]) properties; c) ankle functionality (maximum height in the heel raise test); d) the plantar flexors' force production capacity (peak and rate of torque development in different joint positions); e) the plantar flexors' muscle voluntary activation; and f) triceps suraes' neuromuscular capacity (i.e., recruitment curves). Assessments will be performed at two times (pre-training; and after 12 weeks of training \\[post-12\\]) through functional tests, ultrasound techniques, isokinetic dynamometry, electromyography, and percutaneous electrical stimulation. An intraclass correlation coefficient will be used to verify the test-retest reproducibility of ultrasound measurements. The Chi-Square test will be used to compare the level of physical activity (pre-training) between the groups. The results of the intervention will be expressed using descriptive statistics (mean, standard deviation, and standard error). The normality and sphericity of the data will be tested using the Shapiro-Wilk and Mauchly tests, respectively. A generalized estimating equation, followed by Bonferroni post-hoc, will be used to compare the effects of groups (G55 and G70) and times (pre-training, Post-6, and Post-12). A one-way ANOVA, followed by a Bonferroni post-hoc, will be used to compare the control group participants' limbs with the healthy and injured limbs from both intervention groups (G55 and G70) in the Pre and Post-12 times. The effect size will be estimated for each outcome. All statistical analyzes will be performed using SPSS software.",[26,119,120],"Strength Training Adaptations","Neuromuscular Adaptations",[122,123,124,125,126],"Neuromuscular plasticity","Stiffness","Functionality","Triceps surae","Calcaneal tendon rupture","2026-01-28",{"date":129,"type":35},"2026-01-30",{"date":131,"type":35},"2024-10-10",{"date":133,"type":20},"2026-08-30",{"name":135,"class":42},"Federal University of Rio Grande do Sul",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":103},"100603074","optimizing-rehabilitation-after-achilles-tendon-rupture-repair-the-role-of-blood-flow-restriction-training-in-tendon-and-muscle-recovery-100603074","NCT07131787","Optimizing Rehabilitation After Achilles Tendon Rupture Repair: The Role of Blood Flow Restriction Training in Tendon and Muscle Recovery","TENDON-BFR","Inclusion Criteria:\n\n* patients with total midrupture Achilles tendon rupture\n* surgical treatment\n* \\> 18 years old\n* able to understand and speak Dutch\n\nExclusion Criteria:\n\n* Bilateral Achilles tendon rupture\n* Previous Achilles tendon rupture\n* Previous treatment with fluoroquinolones or cortisone\n* other condition in either leg that would limit the ability to perform the exercises or evaluations\n* Diabetes or rheumatic diseases\n* History of deep venous thrombosis\n* severe cardiovascular disease",{"count":144,"type":20},82,[23],"The goal of this clinical trial is to investigate whether rehabilitation with blood flow restriction (BFR) offers added value compared to conventional rehabilitation in patients undergoing surgical repair for Achilles tendon rupture. The study will include adult patients of all sexes who have undergone surgical treatment at two selected hospitals.\n\nThe main questions it aims to answer are:\n\nDoes BFR-enhanced rehabilitation improve functional recovery compared to conventional rehabilitation? What are the effects of BFR on muscle strength and tendon recovery?\n\nResearchers will compare blood flow restriction (BFR) therapy with conventional rehabilitation to determine whether BFR leads to improved clinical, muscular, and tendon-related outcomes.\n\nParticipants will:\n\n1. Undergo standard surgical repair of the Achilles tendon\n2. Be randomly assigned to a 24-week exercise therapy program-either with or without blood flow restriction (BFR)-starting four weeks post-surgery\n3. Take part in follow-up assessments at weeks 4, 8, 12, 18, 24, and 52, which will include:\n\n   * Questionnaires on pain, quality of life, fear of movement, and return to sport\n   * Medical imaging techniques such as ultrasound, MRI, shear wave elastography, and power Doppler\n   * Muscle strength testing\n   * Blood sample collection, along with a tendon tissue sample taken during surgery",[26,148],"Blood Flow Restriction Therapy","2025-09-17",{"date":151,"type":35},"2025-09-23",{"date":153,"type":35},"2025-08-20",{"date":155,"type":20},"2028-11",{"name":157,"class":42},"University Hospital, Ghent",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":21,"phases":167,"briefSummary":168,"conditions":169,"keywords":170,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":43},"100535666","effect-of-bfr-rehab-after-achilles-tendon-rupture-100535666","NCT06254794","Effect of BFR Rehab After Achilles Tendon Rupture","Effect of Blood Flow Restriction (BFR) Rehabilitation After Achilles Tendon Rupture Reconstruction","Inclusion Criteria:\n\n* Achilles Rupture confirmed by MRI or Thompson Test\n* Adult\n* Receiving Percutaneous Achilles Repair System (PARS) or open repair\n* Proposed PT with Methodist Location\n\nExclusion Criteria:\n\n* Obesity (BMI\\>35)\n* Diabetes\n* Cardiovascular, renal, liver or pulmonary disease\n* Active infections\n* Cancer (current or treated within the past 2 years) or coagulation disorder\n* Physically unable to participate in the intervention\n* Unable to complete a minimum of 85% of the assigned rehabilitation sessions\n* Less than 18 years of age\n* Pregnant",{"count":166,"type":20},19,[23],"The purpose of this study is to determine if blood flow restriction therapy after Achilles tendon rupture reconstruction decreases post-operative calf atrophy, improves reported outcomes, and ultimately decreases return to play time.",[26],[171,172],"achilles tendon rupture","blood flow restriction","2025-05-05",{"date":175,"type":35},"2025-05-06",{"date":177,"type":35},"2018-11-13",{"date":179,"type":20},"2028-12",{"name":181,"class":42},"The Methodist Hospital Research Institute",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":21,"phases":192,"briefSummary":193,"conditions":194,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":43},"100549457","blood-flow-restriction-exercise-in-patients-with-an-achilles-tendon-rupture-100549457","NCT06434272","Blood Flow Restriction Exercise in Patients With an Achilles Tendon Rupture","The Effectiveness of Low-load Blood Flow Restriction Exercise in Patients With an Acute Achilles Tendon Rupture Treated Non-surgically","BEAN","Inclusion Criteria:\n\n* aged 18 years or older\n* have started initial treatment within 72 hours of Achilles tendon rupture\n* understand written and spoken Danish\n\nExclusion Criteria:\n\n* bilateral Achilles tendon rupture\n* previous Achilles tendon rupture in either leg\n* decreased lower extremity function, caused by conditions other than Achilles tendon rupture\n* treated with fluoroquinolones within the last six months\n* treated with corticosteroid injection(s) in the area near the Achilles tendon within the last six months.\n* diabetes\n* previous diagnosed thrombosis\n* Known atherosclerosis in the peripheral arteries of the lower limb\n* other reasons for exclusion (cognitive deficits, inability to provide informed consent, requiring cast-treatment due to low compliance regarding gradual wedge removal, etc.)",{"count":191,"type":20},218,[23],"The goal of this clinical trial is to gain insights into the effects of Blood Flow Restriction Exercise (BFRE) in patients with an acute Achilles tendon Rupture. The main questions it aims to answer are:\n\nIs BFRE an effective adjunct to usual care when compared with only usual care? When is the optimal timing for initiating BFRE: In the early treatment stage or at the later stage after hospital treatment? Participants will receive an intervention comprising 12 weeks of BFRE as an adjunct to usual care.\n\n* Either in the initial 1-12 weeks after Achilles tendon rupture, or\n* In the following 13-24 weeks after Achilles tendon rupture\n\nResearchers will compare the two groups at 13 weeks (3 months) to compare BFRE to usual care, and at 25 weeks (6 months) to compare the two time points for initiating BFRE (early vs. late).",[26],"2025-04-14",{"date":197,"type":35},"2025-04-17",{"date":199,"type":35},"2025-01-28",{"date":201,"type":20},"2028-01-09",{"name":203,"class":42},"University of Aarhus",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":212,"enrollmentInfo":213,"targetDuration":4,"studyType":21,"phases":215,"briefSummary":216,"conditions":217,"keywords":218,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":233},"100571698","restoring-anatomy-of-ruptured-achilles-tendon-100571698","NCT06723639","Restoring Anatomy of Ruptured Achilles Tendon","Effects of Restoring Achilles Tendon Anatomy After a Rupture: A Randomized Controlled Trial","RATAR","Inclusion Criteria:\n\n* Diagnosed with a complete mid-substance Achilles tendon rupture based on clinical exam, including Thompson\u002FMatles test, by an experienced physician.\n* Presented within 14 days from injury.\n* Understands and reads Danish.\n* No contraindications for MRI.\n\nExclusion Criteria:\n\n* Smoking\n* Diabetes\n* Other injuries affecting their lower limb function.\n* Contralateral Achilles tendon rupture.\n* Re-rupture.\n* Anticoagulation treatment.\n* Inability to follow rehabilitation or complete follow-up tests.\n* Immunosuppressive treatment, including systemic corticosteroid treatment.\n* Pregnant","67 Years",{"count":214,"type":20},120,[23],"The goal of this clinical trial is to investigate a new surgical approach to restore the anatomy of a ruptured Achilles tendon. We will use a new two-layer technique followed by rehabilitation and find out how it influence the patients clinical outcome, muscle and tendon structure, and function after one year and compare with a standard non-surgical approach followed by rehabilitation. Participants will be randomized to 1) NEWSUR: A new two-layer surgical technique followed by rehabilitation regime or 2) CONSER: A standard non-surgical treatment followed by rehabilitation .\n\nWe hypothesize that restoring the anatomy of the ruptured mid-substance Achilles tendon using a new two-layer surgery technique followed by rehabilitation will yield a more favorable patient reported outcome (ATRS) one year after rupture compared to standard non-surgical treatment followed by rehabilitation.",[26],[61,219,220,221,222,223],"MRI","Surgery","Restore anatomy","Heel-rise test","Rehabilitation","2025-04-11",{"date":226,"type":35},"2025-04-15",{"date":228,"type":35},"2025-02-28",{"date":230,"type":20},"2027-07-01",{"name":232,"class":42},"Bispebjerg Hospital",3,{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":16,"minAge":241,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":21,"phases":244,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":43},"100581258","flexor-hallucis-longus-tendon-transfer-vs-gastrocnemius-augmented-flexor-hallucis-longus-tendon-transfer-in-management-of-achilles-tendon-defect-100581258","NCT06847971","Flexor Hallucis Longus Tendon Transfer VS Gastrocnemius Augmented Flexor Hallucis Longus Tendon Transfer in Management of Achilles Tendon Defect","Isolated Flexor Hallucis Longus Tendon Transfer VS Gastrocnemius Augmented Flexor Hallucis Longus Tendon Transfer in Management of Achilles Tendon Defect: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age range: Adolescents and adults with skeletally mature feet (above 12 y in females and 14 years in males).\n* Achilles Tendon defects more than 4 cm resulted from acute or chronic rupture, post-debridement defects in case of neglected insertional tendinopathy, spontaneous ruptures due to tendinosis or after tumor resection.\n\nExclusion Criteria:\n\n* General medical contraindications to surgical interventions\n* Calcaneal Fracture, subtalar fusion\n* infection or previous surgery in the ipsilateral hindfoot or ankle\n* Systemic disease including seronegative inflammatory diseases, spondyloarthropathies or sarcoidosis.","12 Years",{"count":243,"type":20},72,[23],"This study aims to compare the functional outcome of Isolated Flexor hallucis longus tendon transfer and Gastrocnemius Augmented Flexor hallucis longus tendon transfer in repair of Achilles tendon defects. Also, compare the two procedures regarding complication rate, time to restore the function, and the need for secondary procedures.",[247,26],"Achilles Tendon Repairs\u002Freconstructions",[61,249,250,251],"flexor hallucis longus","gastrocnemius augmentation","Achilles tendon repairs\u002Freconstructions","2025-02-22",{"date":254,"type":35},"2025-02-26",{"date":256,"type":20},"2025-06",{"date":258,"type":20},"2028-06",{"name":260,"class":42},"Assiut University",{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":268,"enrollmentInfo":269,"targetDuration":4,"studyType":21,"phases":271,"briefSummary":272,"conditions":273,"keywords":275,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":43},"100516857","effect-of-additional-treatment-with-nmes-after-achilles-tendon-rupture-100516857","NCT06009978","Effect of Additional Treatment With NMES After Achilles Tendon Rupture","The Effect of Early Treatment With Neuromuscular, Electrical Stimulation (NMES) After Achilles Tendon Rupture","Inclusion Criteria:\n\n* Achilles Tendon rupture\n* The injury should have been treated within two days from the trauma\n* The rupture is located in the mid portion of the tendon\n\nExclusion Criteria:\n\n* Pregnancy\n* Having a pace maker, intra cardiac defibrillator or other active implant\n* Having had an Achilles Tendon rupture before, regardless of side\n* Having an earlier injury that will have an impact on lower leg function, regardless of side\n* Diabetes\n* Neuro vascular disease\n* Immunosuppressive treatment\n* Difficulties to understand the language or difficulties in understand instructions.\n* Unable to consent","65 Years",{"count":270,"type":20},70,[23],"Increased knowledge is needed about new methods how to treat patients with Achilles tendon ruptures (ATR). A goal is to be able to individualize as well as improve treatment beyond the question about if surgery should be used or not.\n\nAn overall aim of the project is to, in a randomized controlled trial (RCT), explore what impact a new treatment method with Neuromuscular Electrical Stimulation (NMES) - attached on the patients ́ calf muscles on the injured leg - in the early stages after an ATR, may have on tendon length, functional performance, biomechanical variables and patient reported outcome, both in the short and long term after the injury. 70 patients are planned to be included in this RCT and will be evaluated 3,6 and 12 months after their injury. Primary outcome will be heel-rise height. Secondary outcome will be tendon length, jumping ability, patient- reported outcome and biomechanical loading pattern.\n\nThere is also a need to explore if the patients ́ loading patterns improve after treatment with NMES. Therefore, biomechanical variables in lower leg during walking and jumping will also be evaluated one year after their injury.\n\nThe planned studies include completely new ways of exploring how to optimize the rehabilitation after an ATR.\n\nSince there might be an increased risk for overuse injuries in the healthy limb, there will also be focus on how the non- injured limb may be affected of an ATR.\n\nTaken together, this new knowledge can be helpful in the clinical setting to individualize and optimize patients' treatment and rehabilitation with the goal to guide the patient return to the same, or higher level of, physical activity as before the injury.",[26,274],"Physical Disability",[26,223,276],"Neuromuscular Electrical Stimulation","2024-11-13",{"date":279,"type":35},"2024-11-14",{"date":281,"type":35},"2023-11-01",{"date":283,"type":20},"2026-12",{"name":285,"class":102},"Vastra Gotaland Region"]