[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acid-base-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acid-base-disorder":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,61],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100630219","evaluation-of-acid-base-disorders-and-ventilation-settings-in-cardiogenic-shock-and-post-cardiac-arrest-patients-comparison-with-ventilo-algorithm-100630219",false,"NCT07484828","Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm","VentilO CU","Inclusion Criteria:\n\n* Adult (Age \\>=18 years old)\n* Under mechanical ventilation with endotracheal tube for :\n\npost cardiac arrest or cardiogenic shock\n\n\\- Bood gases result availability up to 4 hours after coronary unit admission\n\nExclusion Criteria:\n\n* Lack of patient anthropometric data (height and weight) available in the patient record\n* No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.\n* Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.","ALL",{"count":18,"type":19},100,"ESTIMATED","OBSERVATIONAL","This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes.\n\nThe retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives:\n\nDetermine how often acid-base disorders occur in these patients and describe their characteristics.\n\nCompare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm.\n\nThe investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings.\n\nThis information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients.\n\nParticipation does not involve any intervention, as the study uses existing medical records.",[23,24,25,26],"Cardiac Arrest (CA)","Cardiogenic Shock","Mechanical Ventilation","Acid Base Disorder","NOT_YET_RECRUITING","2026-03-18",{"date":30,"type":31},"2026-03-20","ACTUAL",{"date":33,"type":19},"2026-05",{"date":35,"type":19},"2026-12",{"name":37,"class":38},"Laval University","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":39},"100627176","serum-bicarbonate-changes-during-laparoscopic-bariatric-surgery-100627176","NCT07445230","Serum Bicarbonate Changes During Laparoscopic Bariatric Surgery","Metabolic Effects of Pneumoperitoneum During Laparoscopic Bariatric Surgery: Association Between Perioperative Serum Bicarbonate Change and Early Discharge Readiness","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass)\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* ASA physical status IV or higher\n* Chronic obstructive pulmonary disease (COPD), asthma, or other severe chronic respiratory disease\n* Known chronic metabolic acidosis or renal failure\n* Major intraoperative complications (e.g., severe bleeding, conversion to open surgery)\n* Postoperative reoperation, intensive care requirement, or complications preventing standard recovery evaluation","18 Years",{"count":49,"type":19},85,"Pneumoperitoneum during laparoscopic bariatric surgery induces carbon dioxide absorption and may lead to perioperative alterations in acid-base balance. Serum bicarbonate (HCO₃-) plays a central role in metabolic compensation; however, the clinical relevance of perioperative bicarbonate changes remains insufficiently defined.\n\nThis prospective observational study aims to evaluate the association between pneumoperitoneum duration and perioperative serum bicarbonate change (ΔHCO₃-), and to investigate whether ΔHCO₃- is associated with early discharge readiness at 48 hours (DR-48) following laparoscopic bariatric surgery. Patients undergoing laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass will be enrolled consecutively. No alteration of routine clinical care will occur.",[26],"2026-02-25",{"date":54,"type":31},"2026-03-03",{"date":56,"type":19},"2026-03-01",{"date":58,"type":19},"2026-05-15",{"name":60,"class":38},"Istinye University",{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":4,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":16,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":39},"100593381","rapid-diagnostics-for-genetic-disorders-in-neonates-100593381","NCT07005700","Rapid Diagnostics for Genetic Disorders in Neonates","Development of Rapid Diagnostics for Genetic Disorders in Neonates Using a Novel Targeted Genomic DNA Sequencing Analysis Panel.","Inclusion Criteria: neonates of any gestational age.\n\n* Abnormality in routine neonatal screening test.\n* Unexplained neonatal hypotonia or neonate-onset seizures.\n* Unexplained and abnormal biochemical laboratory findings.\n* Skeletal dysplasia or joint problems.\n\nExclusion Criteria:\n\n* Parental refusal of consent to participate.\n* Provider refusal.\n* Any condition that, in the opinion of the investigator, would interfere with interpretation of study results.","1 Day","6 Months",{"count":18,"type":19},"INTERVENTIONAL",[73],"NA","The goal of this study is to test a prototype genomic blood analysis for identifying rare diseases in infants hospitalized in the neonatal intensive care unit (NICU).\n\nThe main question it aims to answer is: Does the prototype accurately identify genetic variation(s) associated with an infant's health condition?\n\nResearchers will compare the prototype's gene identification to traditional genome sequencing methods of gene identification.\n\nParticipants will be asked to provide a very small (one-tenth of a teaspoon) sample of blood, one-time.",[26],"2025-05-27",{"date":78,"type":31},"2025-06-05",{"date":80,"type":19},"2025-06-30",{"date":82,"type":19},"2027-05",{"name":84,"class":38},"Sharp HealthCare"]