[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acid-base-imbalance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acid-base-imbalance":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100613511","heart-lung-machine-impact-of-the-priming-solution-on-acid-base-balance-electrolytes-and-outcome-on-patients-undergoing-cardiac-surgery-100613511",false,"NCT07267546","Heart-Lung Machine: Impact of the Priming Solution on Acid-Base Balance, Electrolytes and Outcome on Patients Undergoing Cardiac Surgery","Heart-Lung Machine: Impact of the Priming Solution on the Body's Acid-Base Balance, Electrolyte Composition and Clinical Outcome (PRIMEII)","PRIMEII","Inclusion Criteria:\n\n* Patients 18 years and above\n* Undergoing coronary artery bypass graft (CABG) surgery as single surgery\n* Undergoing aortic valve replacement (AVR) as single surgery (AtriClip is allowed)\n* Given consent to participate, both verbal and written\n\nExclusion Criteria:\n\n* Subnormal heart function (defined as an ejection fraction \\\u003C45%), and no signs of heart failure (edema).\n* Body weight \\\u003C60 kg or \\>120 kg\n* Preoperative hemoglobin \\\u003C120 g\u002FL,\n* Subnormal kidney function (defined as GFR \\\u003C30 ml\u002Fmin),\n* Blood sodium outside normal range (135-145 mmol\u002Fl),\n* Need of acute surgery\n* AVR due to aortic valve insufficiency\n* Changes in operating method or addition of intraoperative procedures.","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Most cardiac surgery procedures requires the use of heart-lung machine. The heart-lung machine circuit needs to be filled with a fluid before connecting it to the patients circulation. This is called priming and is accomplished by filling the circuit with a solution used for fluid replacement. The circuit in our institution requires 1100 mL to be filled.\n\nThe body has several mechanisms with the purpose to maintain its state of balance. When a large amount of clear solution suddenly enters the blood stream this balance can be altered. The goal of this clinical trial is to investigate different priming solutions in the heart-lung machine circuit. The main questions it aims to answer are:\n\nHow do different priming solutions alter the acid-base balance, osmolality and electrolytes which reflects the body's water balance for patients undergoing cardiac surgery with the use of heart-lung machine?\n\nThere will be 4 different groups:\n\n1. Ringer-Acetate, 1100 mL \u002F no addition\n2. Ringer-Acetate, 1100 mL + 80 mmol sodium chloride (NaCl)\n3. Ringer-Acetate, 1100 mL + 160 mmol NaCl\n4. Plasmalyte, 1100 mL \u002F no addition Blood samples will be taken before, during and after surgery, post operative day 1 and 4 to analyze acid-base balance, electrolytes, and plasma osmolality. Urine output and hydration status will also be collected until post operative day 1. After 3 months, a blood sample will be taken for analysis of electrolytes and kidney function.",[27,28,29,30,31],"Acid Base Imbalance","Osmolality Disturbance","Crystalloid Solutions","Electrolyte Changes","Cardiopulmonary Bypass",[33,34,35,36,37],"cardiopulmonary bypass","priming solution","acid base balance","electrolytes","plasma osmolality","RECRUITING","2025-12-04",{"date":41,"type":42},"2025-12-05","ACTUAL",{"date":44,"type":42},"2025-09-01",{"date":46,"type":21},"2026-11-01",{"name":48,"class":49},"Region Skane","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":71,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":50},"100603393","effects-of-single-sodium-bicarbonate-supplementation-on-national-level-finswimming-performance-100603393","NCT07135934","Effects of Single Sodium Bicarbonate Supplementation on National-Level Finswimming Performance","Evaluation of the Effects of Single Sodium Bicarbonate Supplementation on Finswimming Performance of National Level Finswimmers: A Randomized, Double-Blind, Placebo-Controlled Crossover Study","Inclusion Criteria:\n\n1. Member of a wider national selection in finswimming (junior or senior level)\n2. Regular participation in competitive finswimming training (≥4 sessions per week)\n3. Age between 15 and 30 years\n4. Absence of chronic illness or injury\n5. No use of medications or dietary supplements during the study period\n6. Signed informed consent (for minors, also signed by a legal guardian)\n\nExclusion Criteria:\n\n1. History of gastrointestinal disorders affecting supplement tolerance\n2. Presence of cardiovascular, metabolic, or musculoskeletal disorders\n3. Current illness or acute infection\n4. Regular use of substances that may interfere with acid-base balance\n5. Refusal to comply with pre-test restrictions (e.g., 48 hours without training)",true,"15 Years","30 Years",{"count":62,"type":21},20,[24],"This randomized, double-blind, placebo-controlled crossover trial will investigate the acute effects of sodium bicarbonate supplementation on performance, stroke biomechanics, and selected physiological and perceptual responses during a simulated 200-meter Bi-Fins race in elite finswimmers.",[66,27,67,68,69,70],"Sport Performance","Ergogenic Support","Sodium Bicarbonate","Water Sports","Biomechanics",[68,72,73,74,75,70,76,77],"Stroke Rate","Finswimming","Stroke Length","Athletes","Gastrointestinal Discomfort","Rate of Perceived Exertion","2025-08-20",{"date":80,"type":42},"2025-08-22",{"date":82,"type":42},"2025-07-01",{"date":84,"type":21},"2026-12-20",{"name":86,"class":49},"Palacky University"]