[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acl---anterior-cruciate-ligament-rupture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acl---anterior-cruciate-ligament-rupture":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,45,67,90,123,142,166,184,204,235,257,283,311,335],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100641984","assessment-of-neuro-k-starts-following-primary-anterior-cruciate-ligament-acl-reconstruction-100641984",false,"NCT07659613","Assessment of NEURO-K-STARTS Following Primary Anterior Cruciate Ligament (ACL) Reconstruction","NEURO-K-STARTS","Inclusion Criteria (patients):\n\n* Patient who has undergone primary ACL reconstruction at least 6 months ago\n* Patient who has undergone an isokinetic strength test, the results of which do not indicate any contraindications to performing a functional test\n* Patient who has resumed performing horizontal jumps under the supervision of a healthcare professional\n* Patient with no history of surgery on the joints of the contralateral leg\n* Patient enrolled in or covered by a social security scheme\n* French-speaking patient who has signed an informed consent form\n\nExclusion Criteria (patients):\n\n* Patient with a history of ligament surgery on the affected or contralateral knee\n* Patient with a BMI \\\u003C 18.5 or \\> 30\n* Patient who is professional athlete\n* Patient with severe associated conditions (neurological, connective tissue disorders, congenital diseases)\n* Patient with colour blindness\n* Patient with multi-ligament injury or associated osteotomy\n* Patient enrolled in another study whose procedures may interfere with this study\n* Protected patient: adults under guardianship, curatorship or other legal protection, or deprived of their liberty by judicial or administrative decision\n\nInclusion Criteria (healthy volunteers):\n\n* Subject with no history of surgery on the joints of either leg\n* Subject who is member of or beneficiary of a social security scheme\n* French-speaking subject who has signed an informed consent form\n\nExclusion Criteria (healthy volunteers):\n\n* Subject with a BMI \\\u003C 18.5 or \\> 30\n* Subject who is professional athlete\n* Subject with severe associated conditions (neurological, connective tissue disorders, congenital diseases)\n* Subject with colour blindness\n* Subject with multi-ligament deficiency or associated osteotomy\n* Subject enrolled in another study whose procedures may interfere with this study\n* Subject under legal protection: adults under guardianship, curatorship or other legal protection, or deprived of their liberty by judicial or administrative decision",true,"ALL","18 Years","35 Years",{"count":21,"type":22},144,"ESTIMATED","INTERVENTIONAL",[25],"NA","Anterior cruciate ligament (ACL) reconstruction is the major treatment option for ACL injuries. Despite this, recurrence rates are high. Half of all recurrences occur within 8 months of reconstruction, and 70% within the first 6 months after return to sport (RTS). The decision to RTS is therefore a critical one, as returning too early can increase the risk of recurrence, whilst a delayed return delays a return to pre-injury performance levels.\n\nTo guide this decision-making process, objective data is required to determine fitness for RTS. This is why the K-STARTS (Knee Safety Athletic Return to Sport) was developed. It is a composite test comprising functional and psychological assessments that enable the calculation of an overall score used to determine the functional recovery of the knee six months after ACL reconstruction.\n\nCurrently, functional tests are limited to measuring physical performance, whereas athletes often manage complex visuospatial processing whilst performing physically. It is therefore necessary to develop clinical tests that integrate neurocognitive and physical functions in order to better simulate the sporting challenges that lead to injury and thus improve preparation for RTS NEURO-K-STARTS is a battery of functional tests based on three standard horizontal jump tests from the K-STARTS, supplemented by four neurofunctional tests.\n\nNo evaluation of the NEURO-K-STARTS in patients undergoing primary ACL reconstruction has been published. This is why this research is set up.",[28],"ACL - Anterior Cruciate Ligament Rupture",[30,14,31],"K-STARTS","ACL rupture","NOT_YET_RECRUITING","2026-06-15",{"date":35,"type":36},"2026-06-22","ACTUAL",{"date":38,"type":22},"2026-09",{"date":40,"type":22},"2029-02",{"name":42,"class":43},"GCS Ramsay Santé pour l'Enseignement et la Recherche","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":64,"leadSponsor":66,"locationsCount":44},"100641760","assessment-of-electromyographic-activity-in-the-quadriceps-and-hamstrings-of-the-operated-limb-versus-the-unaffected-limb-in-patients-who-have-undergone-acl-surgery-with-and-without-post-operative-ami---an-exploratory-study-100641760","NCT07659561","Assessment of Electromyographic Activity in the Quadriceps and Hamstrings of the Operated Limb Versus the Unaffected Limb in Patients Who Have Undergone ACL Surgery, With and Without Post-operative AMI - an Exploratory Study","AMIMYO","Inclusion Criteria:\n\n* Patient who has undergone ACL surgery at least 3 weeks ago\n* Patient with no severe knee inflammation: stroke test ≤ 1+ and pain ≤ 3\u002F10 (EN) at rest\n* Patient with a Tegner score ≥ 5\n* Patient with a Marx score ≥ 8\n* Patient with or without a diagnosis of subjective AMI (Sonnery-Cottet et al. classification)\n* French-speaking patients who do not object to the use of their data\n\nExclusion Criteria:\n\n* Patient with a previous injury or surgery to the same or opposite knee\n* Patient with a multi-ligament injury\n* Patient with an AMI \\> grade 2b (Sonnery-Cottet et al. classification)\n* Patient with a BMI \\> 30\n* Pregnant or breastfeeding woman\n* Patient with previous or current neurological and cardiovascular disorders or diseases\n* Patient under legal protection: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision","45 Years",{"count":54,"type":22},40,[25],"Traumatic injuries to the knee joint, such as an anterior cruciate ligament tear, can compromise the ability of the muscle at the front of your thigh-known as the quadriceps-to contract voluntarily, despite the anatomical integrity of the nerve and muscle structures responsible for contraction. This phenomenon, commonly known as 'arthrogenic motor inhibition' (AMI), is a major limiting factor for recovery and rehabilitation following an anterior cruciate ligament tear, as well as a potential cause of functional disability if left undiagnosed and untreated. Indeed, motor inhibition that persists during the early months of rehabilitation could lead to under-activation of the quadriceps and over-activation of the hamstrings (the muscles at the back of your thigh).\n\nIt is of interest to assess, during the rehabilitation phase, the contraction capacity of the various quadriceps and hamstring muscles in the operated limb compared with the unaffected limb in patients who have undergone anterior cruciate ligament surgery and who experience post-operative motor inhibition, and in patients who have undergone anterior cruciate ligament surgery but do not experience post-operative motor inhibition. This is why this study has been initiated.",[28],[31,59,60,61],"AMI","electromyography","thigh",{"date":35,"type":36},{"date":38,"type":22},{"date":65,"type":22},"2027-10",{"name":42,"class":43},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":23,"phases":77,"briefSummary":78,"conditions":79,"keywords":80,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":44},"100641387","intraoperative-analysis-of-knee-kinematics-during-acl-reconstruction---an-exploratory-study-100641387","NCT07655726","Intraoperative Analysis of Knee Kinematics During ACL Reconstruction - an Exploratory Study","CINEGEN","Inclusion Criteria:\n\n* Patient, male or female, aged between 18 and 40\n* Patient eligible for ACL and LAL reconstruction\n* Patient who is member of or covered by a social security scheme\n* Patient who speaks French and has signed an informed consent form\n\nExclusion Criteria:\n\n* Patient with a contraindication to MRI\n* Patient with osteoarthritis of the joint\n* Patient with a BMI \\> 30\n* Patient with history of trauma or previous knee surgery\n* Patient with knee trauma other than a sprain\n* Patient under legal guardianship: an adult under guardianship, curatorship or other legal protection, or deprived of liberty by judicial or administrative order\n* Pregnant or breastfeeding woman","40 Years",{"count":76,"type":22},30,[25],"Reconstruction of anterior cruciate ligament (ACL) is a common procedure in orthopaedic surgery, aimed at restoring stability to your knee. This procedure involves performing an anterior cruciate ligament (ACL) graft and an anterolateral ligament (ALL) graft.\n\nDespite technological advances and improvements in surgical techniques, failure rates remain high. In this context, a better understanding of knee movements (the position of the femur and tibia, as well as the ligaments) during flexion whilst reconstructing your ACL could improve the precision of reconstructions and reduce the long-term failure rate.\n\nUsing a surgical navigation system, it is possible to record data on the positioning of the femur and tibia during flexion and extension. This type of morpho-functional analysis of knee kinematics during ACL reconstruction has never been carried out before.",[28],[31,81],"Knee cinematics","2026-06-13",{"date":84,"type":36},"2026-06-18",{"date":86,"type":22},"2027-07",{"date":88,"type":22},"2028-03",{"name":42,"class":43},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":44},"100534200","do-patients-with-acl-tears-demonstrate-weakness-of-the-soleus-muscle-100534200","NCT06235736","Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?","Do Patients With Anterior Cruciate Ligament (ACL) Tears Demonstrate Weakness of the Soleus Muscle?","ACL","Inclusion Criteria:\n\nACL tear participants:\n\n* MRI-confirmed ACL tear.\n* Participant is willing and able to give informed consent in writing for participation in the study.\n* Male or Female, aged 18 years to 55 years of age.\n* No contraindications to strength testing (see exclusion criteria).\n\nNormative values from healthy individuals:\n\n* No current or previous history of significant lower limb injury, or a history of previous minor injury that is symptomatic at the time of recruitment.\n* No previous lower limb surgery.\n* No course of medication, whether prescribed or over the counter, other than vitamins and mineral supplements or, for females, oral contraceptives.\n\nExclusion Criteria:\n\n* History of chronic musculoskeletal disease or disorder in either leg that may put the participants at risk because of participation in the study including non-united fractures, epilepsy, cardiac insufficiency, severe peripheral vascular disease, aneurysms, anticoagulant therapy, recent (\\<3 months) radiotherapy or chemotherapy, long term steroid use (\\>3 months), pregnancy, neurological disorders (e.g., Parkinson's disease), skin conditions at point of force testing, severe osteoporosis, malignancy, rheumatoid arthritis.\n\n  * Conditions or symptoms that may influence the result of the study, or the participant's ability to participate in the study including pain, limited range of motion, knee effusion, or anaemia.","55 Years",{"count":100,"type":22},55,"OBSERVATIONAL","The goal of this prospective, cross-sectional study is to test the strength of the soleus muscle in participants who have a ACL tear confirmed by MRI. Previous studies have shown that the soleus muscle, which one of the muscles situated in the calf, decreases mechanical loading on the ACL. Therefore, we aim to test soleus muscle strength using a seated plantar flexor test.\n\nThe main questions we aim to answer are:\n\n* Do patients with ACL tears demonstrate inter-limb soleus strength asymmetry (\\>10%)\n* Do patients with ACL tears have soleus muscle weakness compared with uninjured (normative) participants?\n* Do changes in soleus strength values correlate with patient reported outcomes and stability, as measured by the IKDC questionnaire?\n\nTo achieve this the VALD force frame will be used as the testing device for plantar flexor strength testing. This device records the force generated by the movement. This will be repeated three times on each leg as part of the testing procedure. Furthermore, as part of the testing procedure participants will be required to fill out an IKDC form to assess their knee stability. Interrater reliability of the force frame will be investigated.\n\nFurther data from participants without ACL tears will be used to compare results. Thus allowing us to see if people with ACL tears have a weakness in the soleus muscle.",[104,105,28],"ACL Tear","ACL-injury",[107,96,108,109,110,111,112],"Acute cruciate ligament","soleus muscle","physiotherapy","orthopaedics","trauma","rehabilitation","RECRUITING","2026-04-30",{"date":116,"type":36},"2026-05-06",{"date":118,"type":36},"2024-01-17",{"date":120,"type":22},"2027-12-31",{"name":122,"class":43},"University of Liverpool",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":23,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":44},"100596293","clinical-randomized-trial-of-the-effect-of-rehabilitation-therapy-using-strength-and-blood-flow-restriction-training-on-muscular-fitness-and-regeneration-after-anterior-cruciate-ligament-reconstruction-100596293","NCT07043569","Clinical-randomized Trial of the Effect of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* ACL reconstruction\n* Ability to take part in an outpatient rehabilitation\n\nExclusion Criteria:\n\n* Sickle Cell anemia\n* iatrogenic changes in the vessels of the lower limbs (stents, bypasses)\n* inflammation of the lower extremities",{"count":76,"type":22},[25],"With the intention of improving rehabilitation after anterior cruciate ligament reconstruction, the present project investigates the influence of a targeted strength and blood flow restriction training intervention (BFR training) on the regeneration of muscle mass, strength and functionality of the knee joint. BFR training is characterized by the combination of external venous vascular occlusion with light strength training and still enables users to achieve gains in muscle mass and strength that are comparable to training with high mechanical loads. The positive effects of BFR training in the course of knee arthroplasty have already been demonstrated by our working group as a prehabilitative approach, i.e. as a training intervention prior to surgery. In the present project, the framework conditions of outpatient rehabilitation at the Bonn Center for Outpatient Rehabilitation will now be used to prove whether sports science-controlled strength and BFR training has a similar effect in the postoperative rehabilitation phase. The interventions are carried out as part of the exercise therapy units in outpatient rehabilitation ETM01 in accordance with the S2k guideline on anterior cruciate ligament rupture. Strength and BFR training in medical training therapy supplements the daily exercise therapy to ensure implementation in the rehabilitation process in line with the guidelines.",[28],"2025-12-05",{"date":135,"type":36},"2025-12-08",{"date":137,"type":36},"2025-06-20",{"date":139,"type":22},"2026-12-31",{"name":141,"class":43},"University Hospital, Bonn",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":23,"phases":153,"briefSummary":154,"conditions":155,"keywords":156,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100612135","description-of-return-to-sport-in-amateur-athletes-who-underwent-several-functional-tests-k-starts-vertical-jumps-and-soleus-muscle-strength-after-initial-acl-reconstruction-100612135","NCT07249645","Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction","Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction.","K-STARTS +","Inclusion Criteria:\n\n* Patient, male or female, aged between ≥ 18 and ≤ 30 years old\n* Amateur athlete with a Tegner score ≥ 5\n* Patient with primary ACL reconstruction dating back 6 months\n* Patients with ACL damage in one knee only\n* Patients who have undergone an isokinetic strength test with results that do not contraindicate functional testing\n* Patients affiliated with or covered by a social security scheme\n* French-speaking patients who have signed an informed consent form\n\nExclusion Criteria:\n\n* Patients treated for bilateral ACL reconstruction\n* Patients who are professional athletes or compete at a national level\n* Patients with severe associated disorders (neurological, connective tissue, congenital diseases)\n* Patients with multiple ligament defects or associated osteotomy\n* Patients already included in another study\n* Protected patients: adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision","30 Years",{"count":152,"type":22},230,[25],"ACL injuries are incapacitating for both professional and amateur athletes, with long-term repercussions on performance and return to sport (RTS).\n\nSurgical reconstruction of the ACL is the main treatment option. Despite this, recurrence rates are high. Half of all recurrences occur within 8 months of reconstruction, and 70% within the first 6 months after RTS. Decision to RTS is therefore an important one, as returning too early can increase the risk of recurrence, while returning too late delays a return to pre-injury performance levels. As described by the Bern Consensus, RTS consists of three phases :\n\n* Phase 1: Return to participation (RTp)\n* Phase 2: Return to sport (RTS)\n* Phase 3: Return to performance (RTP)\n\nRTS decision must be based on multiple factors, including psychological, athletic and functional components, as well as specific nature of the patient's activities. However, few individual tests have been associated with a specific level of RTS. Furthermore, the majority of studies rely on subjective and non-objective assessments to determine whether the athlete has returned to their pre-injury level.\n\nIt would therefore be relevant to study the RTS time of patients who have performed a combination of several objective functional tests whose results could be complementary, in particular the K-STARTS, the CMJ, the DJ and the measurement of soleus muscle strength.",[28],[157],"Return To Sport ACL injury","2025-11-18",{"date":160,"type":36},"2025-11-25",{"date":162,"type":22},"2025-12-01",{"date":164,"type":22},"2028-04-30",{"name":42,"class":43},{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":23,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":182,"leadSponsor":183,"locationsCount":44},"100588725","correlation-study-between-the-classification-of-arthrogenic-motor-inhibition-ami-and-clinical-assessment-after-acl-rupture-100588725","NCT06945133","Correlation Study Between the Classification of Arthrogenic Motor Inhibition (AMI) and Clinical Assessment After ACL Rupture","AMIVAL","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years and \\\u003C 45 years\n* Patient with an ACL rupture confirmed by MRI\n* Patient with an ACL rupture ≤ 30 days old\n* French speaking patient who does not object to the use of his\u002Fher data\n\nExclusion Criteria:\n\n* Patient with previous ipsi or contralateral knee injury\u002Fsurgery\n* Patient with multi-ligament injury\n* Pregnant or breastfeeding woman","44 Years",{"count":175,"type":22},90,[25],"The goal of this interventional study is to measure medial vastus inhibition and associate it with AMI classification in patients with ACL rupture. The main question it aims to answer is:\n\nIs there a correlation between AMI classification and clinical assessment after ACL rupture ? Participants will undergo surface EMG and Myotonometry.",[28],{"date":180,"type":36},"2025-11-19",{"date":162,"type":22},{"date":139,"type":22},{"name":42,"class":43},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":23,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":44},"100595308","comparison-of-arthrogenic-muscle-inhibition-ami-after-acl-reconstruction-in-patients-with-conventional-rehabilitation-or-conventional-rehabilitation-combined-with-digital-therapy-100595308","NCT07030764","Comparison of Arthrogenic Muscle Inhibition (AMI) After ACL Reconstruction in Patients With Conventional Rehabilitation or Conventional Rehabilitation Combined With Digital Therapy","AMITHENUM","Inclusion Criteria:\n\n* Patient, male or female, aged ≥ 18 years\n* Patient with a scheduled primary ACL reconstruction\n* Patient with a smartphone and able to use a mobile application on a smartphone\n* Patient affiliated to or benefiting from a social security scheme\n* French-speaking patient who has signed an informed consent form\n\nExclusion Criteria:\n\n* Patients with residual AMI\n* Patient with previous ipsi or contralateral knee surgery\n* Patient with a multi-ligament injury\n* Patient with contraindications to physical exercise: severe cardiovascular disease or uncontrolled metabolic disease\n* Patients with cognitive problems\n* Patient without internet access\n* Patient taking part in another study\n* Pregnant or breast-feeding women\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision",{"count":192,"type":22},448,[25],"Traumatic injury to the knee joint, such as rupture of the anterior cruciate ligament (ACL), can compromise the voluntary activation capacity of the quadriceps despite the anatomical integrity of the nerve and muscle structures responsible for contraction. This phenomenon is commonly known as 'arthrogenic muscle inhibition' (AMI).\n\nAMI is a major limiting factor in recovery and rehabilitation after ACL rupture, and a potential cause of functional disability if left undiagnosed and untreated.\n\nTraditional rehabilitation protocols for ACL reconstruction do not adequately address the underlying neuromuscular deficits caused by AMI, leading to sub-optimal recovery and prolonged rehabilitation. Furthermore, patient adherence to these protocols, outside of supervised settings, is variable and often poor, which can further delay recovery\n\nRecent advances in digital health technologies offer new ways of improving rehabilitation outcomes. Numerous studies highlight the effectiveness of digital therapies in the form of mobile applications in improving patient engagement and compliance with rehabilitation protocols. In addition, evidence suggests that the integration of these technologies enables faster recovery of muscle function, reduces pain levels, may reduce complications such as Cyclops syndrome and improves overall patient satisfaction with rehabilitation.\n\nHealing has developed a digital therapy called DOCT'UP® which, in addition to physiotherapy sessions, offers support programmes for patients following ACL reconstruction. These programmes include self-education exercises to be carried out at home, some of which specifically target the AMI phenomenon. DOCT'UP® digital therapy has already been used in rehabilitation after ACL reconstruction, with results at 3 weeks on quadriceps activation and post-operative pain, as well as at 1 year on Cyclops syndrome.\n\nGiven the limitations of current rehabilitation practices in the context of AMI and the potential of the DOCT'UP® application, there is a clear need to scientifically assess whether the DOCT'UP® application can effectively improve the results of rehabilitation on AMI after ACL reconstruction. This is why the sponsor wishes to set up this Clinical Investigation.",[28],"2025-09-26",{"date":198,"type":36},"2025-09-29",{"date":200,"type":36},"2025-07-25",{"date":202,"type":22},"2027-06-30",{"name":42,"class":43},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":74,"enrollmentInfo":212,"targetDuration":4,"studyType":23,"phases":214,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":44},"100465570","optimizing-graft-selection-for-acl-reconstruction-100465570","NCT05342441","Optimizing Graft Selection for ACL Reconstruction","Optimizing GRAft SElection for ACL Reconstruction (GRASE-ACL Trial) - a Three-armed Randomized Controlled Trial","GRASE-ACL","List of Inclusion criteria\n\n* clinically confirmed first-time ACL rupture\n* Current injury sustai´ned within 2 years\n* high activity level prior to ACL rupture (Tegner score ≥ 3) and personal goal of returning to physical activity.\n\nList of preoperative exclusion criteria\n\n* Inadequate Danish language skills to answer questionnaires.\n* Prior ligament surgery in the injured knee\n* Prior ligament surgery in the non-injured knee\n* Instability of the non-injured knee\n* Known osteoarthritis (Kelgren Lawrence score ≥ 2)\n* Prior open surgery to either knee\n* Prior severe fracture involving knee joint surfaces\n* Prior severe injury to thigh muscles in either leg (e.g. tear or compartment)\n* Prior severe injury to the patella tendon of either knee (e.g. subluxation)\n* Medical condition preventing full participation (e.g. active cancer, - rheumatoid arthritis)\n* Psychiatric condition preventing full participation\n* Pregnancy\n* Obesity (BMI \\> 30)\n\nList of Perioperative exclusion criteria (Arthroscopy)\n\n* Medial meniscus lesion \\> 50%\n* Lateral meniscus lesion \\> 50%\n* Treated Meniscal root lesion or radial meniscal tear that require restrictive regimen\n* Cartilage lesion \\>2cm2, Articular cartilage injury classification (ICRS) grade 3\n* Concurrent ligament injury (except medial collateral ligament (MCL) lesion grade 1-2)",{"count":213,"type":22},150,[25],"Purpose:\n\nTo investigate the differences between the three most common methods for reconstruction of the anterior cruciate ligament (ACL), to support the development of the best method for the individual patient.\n\nMain research area: ¨ Sports Orthopedic Surgical research.\n\nState of the art:\n\nEvery year in Denmark 2500 patients receive surgical reconstruction surgery to replace a ruptured ACL. Many patients experience a decline in knee function and 4-12% suffer a new ACL rupture within 5 years. According to data from the Danish ACL register, three methods of reconstruction are most prevalent, but with large variation between hospitals. This indicates lack of consensus on optimal surgical procedure.\n\nDesign:\n\nAssessor-blinded randomized controlled study. 150 patients aged 18-40 with ruptured ACL are allocated to reconstruction with tendon(s) harvested from either the semitendinosus and gracilis, or the patella tendon, or the quadriceps tendon. Patient follow-up will be conducted preoperatively and 1, 6, 12, 24 months postoperatively.\n\nPrimary technologies and outcomes:\n\n* Patient-reported knee-joint function, quality of life and donor-site morbidity is obtained with standardized questionnaires. Primary outcome is subjective knee function with the International Knee Documentation Committee evaluation form (IKDC)\n* Instrumented analysis of knee-joint coordination and neuromuscular control including 3-D motion capture and electromyography (EMG) during single leg jumps, landings and change-of-direction. Measurement of maximal explosive muscle power in knee extension and flexion. Primary outcome is relative difference between injured and healthy leg in rate of force development (RFD-LSI).\n* Standard clinical knee examination of range of motion and instrumented examination of knee-joint stability.\n* Magnetic Resonance Imaging (MRI) of the thigh muscles for examination of muscle morphology.\n\nThe trial is designed for publication in three primary publications\n\n1. \\- Patient reported effect of graft choice in ACL reconstruction\n2. \\- Biomechanical effect of graft choice in ACL reconstruction\n3. \\- Clinical effect of graft choice in ACL reconstruction\n\nAdditional secondary publications are in the pipeline. Reference to primary protocol and results will always be emphasized in secondary publication to ensure methodological transparency.",[28],[218,219,220,221,222,223,224,225],"ACL reconstruction","Graft choice","Quadriceps graft","Semitendinosus\u002Fgracilis graft","Muscle morphology","Neuromuscular control","BPTB graft","Patient reported function","2025-08-24",{"date":228,"type":36},"2025-08-28",{"date":230,"type":36},"2022-05-09",{"date":232,"type":22},"2028-05-31",{"name":234,"class":43},"Hvidovre University Hospital",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":23,"phases":245,"briefSummary":246,"conditions":247,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":255,"locationsCount":4},"100599715","the-clinical-study-of-bone-patellar-tendon-bone-and-quasi-anatomical-meniscus-allograft-transplantation-technique-100599715","NCT07088094","The Clinical Study of Bone-patellar Tendon-bone and Quasi-anatomical Meniscus Allograft Transplantation Technique","BPTB，Meniscus","Inclusion Criteria:\n\n* Aged 18-50 years\n* Clinical diagnosis of symptomatic meniscal deficiency and anterior cruciate ligament injury (complete rupture or severe damage)\n* Failure of conservative treatment (e.g., physical therapy, analgesia) for ≥6 months\n* Stable knee joint (no ligamentous instability confirmed via clinical exam and MRI)\n* Willingness to comply with postoperative rehabilitation and follow-up evaluations\n\nExclusion Criteria:\n\n* Severe tibiofemoral osteoarthritis (Kellgren-Lawrence grade ≥3)\n* History of prior knee infection or septic arthritis\n* Inflammatory arthritis (e.g., rheumatoid arthritis, gout)\n* BMI ≥35 kg\u002Fm²\n* Pregnancy or planning pregnancy during the study period\n* Concurrent full-thickness chondral defects (Outerbridge grade III-IV) in the affected compartment\n* Inability to undergo MRI (e.g., claustrophobia, metallic implants)","60 Years",{"count":244,"type":22},200,[25],"This clinical study investigates the outcomes of bone-patellar tendon-bone and quasi-anatomical meniscus allograft transplantation techniques in patients requiring joint reconstruction. The study aims to assess the safety, efficacy, and functional improvements following these transplant procedures, utilizing donor tissues to restore joint function and alleviate pain in individuals with severe knee damage. Participants will undergo the transplantation procedure and be monitored for post-operative recovery, complications, and long-term outcomes, including joint stability and mobility. The study seeks to provide valuable insights into the effectiveness of these advanced surgical techniques for knee joint repair.",[248,28],"Meniscal Tears","2025-07-17",{"date":251,"type":36},"2025-07-28",{"date":253,"type":22},"2025-08-01",{"date":232,"type":22},{"name":256,"class":43},"Beijing Tsinghua Chang Gung Hospital",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":74,"enrollmentInfo":264,"targetDuration":4,"studyType":23,"phases":266,"briefSummary":267,"conditions":268,"keywords":269,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":282},"100571983","conservative-treatment-with-blood-flow-restriction-in-patients-with-total-acl-rupture-randomized-clinical-trial-100571983","NCT06727344","Conservative Treatment With Blood Flow Restriction in Patients With Total ACL Rupture. \"Randomized Clinical Trial\"","Comparison of Conservative Treatment With Blood Flow Restriction With Standard Management in Total ACL Rupture. \"Randomized Clinical Trial\"","Inclusion Criteria:\n\n* MRI-confirmed complete rupture of ACL. Ability to communicate and read fluently in Greek and be willing to keep their leg immobilised for the required period based on the study protocol.\n\nExclusion Criteria:\n\n* Heart disease, overweight, diabetes, pregnancy, thrombophilia, atrial fibrillation, heart failure, cancer, use of drugs that may increase blood clotting, use of hormones or contraceptives, any reason for not using BFR e.g., an open wound or serious skin problems and\u002For allergies to the cuff material.",{"count":265,"type":22},20,[25],"The goal of this randomised clinical trial is to evaluate the effects of exercise with blood flow restriction (BFR) in patients with a complete anterior cruciate ligament (ACL) rupture.\n\nThe main questions it aims to answer are:\n\n1. Does blood flow restriction adds any additional benefits to conservative treatment of the ACL?\n2. Does bracing promotes spontaneous healing to the ACL\n\nResearchers will compare bracing and BFR to bracing and sham BFR to see if the intervention provides any additional benefits to the conservative management of this injury.\n\nParticipants will:\n\n1. Use a knee brace for 6 weeks with adjustments according to protocol\n2. Follow and identical exercise plan with either BFR (intervention group) or BFR sham (control group)\n3. Follow a home based exercise program.",[96,28],[270,271,272,31,96],"BFR","Blood Flow Restriction","Brace","2025-03-29",{"date":275,"type":36},"2025-04-03",{"date":277,"type":36},"2025-02-01",{"date":279,"type":22},"2025-09",{"name":281,"class":43},"European University Cyprus",2,{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":11,"sex":17,"minAge":291,"maxAge":18,"enrollmentInfo":292,"targetDuration":4,"studyType":23,"phases":294,"briefSummary":295,"conditions":296,"keywords":297,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":310},"100354557","soft-tissue-quadriceps-autograft-acl-reconstruction-in-the-skeletally-immature-vs-hamstrings-100354557","NCT03896464","Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings","Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings (SQuASH): A Multi-Centre Randomized Controlled Trial","SQuASH","Inclusion Criteria\n\n1. Patients aged 10-18 years.\n2. History, physical exam, and magnetic resonance imaging (MRI) or arthroscopic image confirmation of ACL insufficiency.\n3. Suitable for anatomic, single-bundle arthroscopic-assisted ACL reconstruction.\n4. X-ray or MRI evidence of skeletal immaturity (i.e., open physes) based on imaging that is closest to the time of injury (and correlated with standard bone age left hand posteroanterior (PA) radiographs).\n5. Patient involved in sport (competitive and\u002For recreational level) prior to injury.\n6. Patient and parent\u002Fguardian speak, read, and understand the language of the clinical site.\n7. Patient and parent\u002Fguardian provide informed consent and\u002For assent.\n\nExclusion Criteria\n\n1. Evidence (i.e. radiographic and\u002For arthroscopic) of International Cartilage Repair Society (ICRS) Cartilage Lesion Classification System Grade 2 (i.e., lesions extending down to 50% of the cartilage depth) and higher osteoarthritis that is symptomatic, requiring treatment other than debridement or microfracture.\n2. Tibial eminence\u002Fspine fractures treated surgically.\n3. Concomitant collateral, posterior cruciate, and\u002For cartilage pathology requiring surgical reconstruction and\u002For advanced restoration techniques (i.e., osteochondral allograft or autograft transfer, matrix-induced autologous chondrocyte implantation, particulate juvenile articular cartilage allograft transplantation).\n4. Previous ACL reconstruction in the affected knee or contralateral knee.\n5. Previous distal femur and\u002For proximal tibial\u002Ffibular physeal injury in the affected knee or contralateral knee.\n6. Allograft or allograft-augmentation, or synthetic augmentation of the ACL reconstruction.\n7. Biological-augmentation of the ACL reconstruction (i.e. platelet-rich-plasma, fibrin clot, reinforced bioinductive implants, etc.).\n8. ACL reconstruction utilizing synthetic grafts.\n9. Primary ACL repair.\n10. Patient diagnosed with inflammatory arthropathy.\n11. Significant medical co-morbidities (requiring daily assistance for activities of daily living).\n12. Patient, parent\u002Fguardian, and\u002For clinical investigator believe the patient will have difficulty maintaining follow-up.","10 Years",{"count":293,"type":22},352,[25],"To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied. The 2018 International Olympic Committee (IOC) Consensus Statement now outlines the quadriceps tendon as a possible autograft option. However, no Randomised Control Trial (RCT) has examined the efficacy of the quadriceps tendon autograft in primary paediatric ACL reconstruction compared to the historical \"gold-standard\" soft-tissue hamstring autograft in this population. In light of its evidence for favourable outcomes in the adult population, and the (albeit limited) evidence showing safety and promise in the paediatric population, clinical equipoise exists for assessing its impact on outcomes in paediatric patients at the index surgery. This is a parallel, international, multi-centre, blinded randomized controlled trial of 352 skeletally-immature (at the time of injury) patients (ages 10-18 years, inclusive) undergoing primary ACL reconstruction to compare the effect of autograft tendon choice (i.e. hamstring versus soft-tissue quadriceps) on the rates of ACL graft failure, return-to-sport, knee function, pain, health-related quality of life and health utility, psychological factors, range of motion and stability, and any other adverse events at 24 months.",[28],[298,299,300],"Autograft","Soft-tissue hamstring","Quadriceps Tendon","2025-03-25",{"date":303,"type":36},"2025-03-30",{"date":305,"type":36},"2020-01-01",{"date":307,"type":22},"2030-01-01",{"name":309,"class":43},"McMaster University",6,{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":315,"acronym":316,"eligibilityCriteria":317,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":318,"enrollmentInfo":319,"targetDuration":321,"studyType":101,"phases":4,"briefSummary":322,"conditions":323,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":4},"100576266","activation-failure-of-knee-extensors-after-anterior-cruciate-ligament-rupture-depending-on-the-contraction-mode-100576266","NCT06783062","Activation Failure of Knee Extensors After Anterior Cruciate Ligament Rupture Depending on the Contraction Mode","QUADFAIL","Inclusion Criteria:\n\nA. ACL-injured groups (surgically or conservatively treated):\n\n1. Age between 18 and 50 years\n2. Free, informed consent signed by the participant and the investigator.\n3. Session 1: Delay of 2 to 6 weeks after injury, with a quiet knee (range of motion 110- 0°, minimal effusion, maximal contraction pain ≤ 2\u002F10)\n4. Session 2: Duration of 36 to 42 weeks after injury, with a quiet knee (range of motion 110-0°, minimal effusion, maximal contraction pain ≤ 2\u002F10)\n5. Independent person (Unprotected: under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision)\n\nB. ControlGroup:\n\n1. Age between 18 and 50 years\n2. Free, informed consent signed by the participant and the investigator.\n3. Sport practitioners: at least once per week practicing activities like collective sports, racket sports, combat sports, skiing, or on-loading activities with changing of directions.\n4. Independent person (Unprotected: under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision)\n\nExclusion Criteria:\n\n* 1\\. Subjects fitted with an implanted electronic device such as a cardiac pacemaker 2. Professional athlete 3. Pregnant women 4. Subject with systemic pathology or treatment affecting the musculoskeletal system 5. Subject with a history of neurological pathology or traumatic pathology, or pathology that required orthopedic treatment and\u002For surgery of the knee, hip and\u002For lumbar spine 6. Contraindication to isokinetic testing: incapacitating pain, evolving pathological process, non- healed fracture, unbalanced cardiovascular pathology (angina pectoris, arterial hypertension) 7. Contralateral knee injury 8. Subject inability to follow procedures or insufficient knowledge of project language 9. Data acquisition issue or injury during testing","50 Years",{"count":320,"type":22},60,"9 Months","The primary objective of the study is to evaluate the impact of ACL injury and ACL reconstruction on voluntary activation during maximal voluntary contraction (measured by neurophysiological parameters) according to the contraction mode.\n\nThe goal is to provide elements of knowledge to clinicians about the mechanisms of the activation failure depending on contraction mode, but also the resulting adapted clinical recommendations for conducting rehabilitation, and particularly for the use of different contraction modes.\n\nThe main hypothesis is that activation failure is not equal according to the contraction mode during maximal voluntary contractions and neurophysiological parameters will be decreased in comparison with non-injured subjects.\n\nSecondary objectives are:\n\n* To analyze the evolution of neurophysiological parameters between sessions interspaced by several months according to the contraction mode.\n* To observe this time evolution depending on the treatment strategy chosen: rehabilitation or surgery plus rehabilitation.",[28,324,325],"Activation Failure","Contraction Mode","2025-01-14",{"date":328,"type":36},"2025-01-20",{"date":330,"type":22},"2025-02",{"date":332,"type":22},"2027-12",{"name":334,"class":43},"La Tour Hospital",{"id":336,"slug":337,"hasResults":11,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":16,"sex":342,"minAge":18,"maxAge":343,"enrollmentInfo":344,"targetDuration":346,"studyType":101,"phases":4,"briefSummary":347,"conditions":348,"keywords":353,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":4},"100563837","hemonirs-a-paradigm-shift-in-the-process-of-musculoskeletal-rehabilitation-of-acl-injuries-in-cyclic-sports-athletes-100563837","NCT06621355","HemoNIRS: a Paradigm Shift in the Process of Musculoskeletal Rehabilitation of ACL Injuries in Cyclic Sports Athletes.","HemoNIRS: Un Cambio De Paradigma En El Proceso De Rehabilitación Musculoesquelética De Lesiones De Ligamento Cruzado Anterior Mediante Dispositivos NIRS En Deportistas Que Realizan Deportes Cíclicos","General inclusion criteria\n\n* Men aged 18 to 65\n* An adipose layer of \\<2 cm in areas of NIRS placement, assessed with a plicometer\n* Understand written, read and spoken Spanish, English or Catalan.\n\nGeneral exclusion criteria\n\n* Having any cardio-metabolic, hormonal, neurological or other comorbidities that could affect participation in the study (e.g. severe mental illness, end-stage disease).\n\nEligibility criteria (LCA1 group)\n\n* Regular athlete with training and\u002For competition \\>3 days\u002Fwk prior to injury.\n* ACL injury \\<6 months after surgery.\n* Able to perform an incremental intervallic test on a cycloergometer or treadmill.\n\nEligibility criteria (LCA2 group)\n\n* Regular athlete with training and\u002For competition \\>3 days a week.\n* ACL injury \\>2 years after surgery.\n* Able to perform an incremental intervallic test on a cycloergometer or treadmill.\n\nEligibility criteria (CON group)\n\n* Regular athlete with training and\u002For competition \\>3 days a week.\n* Never suffered an ACL injury in any knee - Able to perform incremental intervallic test on cycleergometer or treadmill.\n\nAll the groups exclusion criteria\n\n\\- Incapacitating pain that prevents assessment","MALE","65 Years",{"count":345,"type":22},129,"1 Day","Muscle haemodynamics has so far been assessed using at most 2-3 near-infrared spectroscopy devices on isolated muscles and without correlating variables. At the same time, research on musculoskeletal pathologies is limited, and there are no studies that analyse the haemodynamic changes that occur when the anterior cruciate ligament (ACL) is injured and whether these changes last over time. The aim of the study is to monitor and evaluate the physiological changes produced by ACL injury on muscle performance using non-invasive near-infrared spectroscopy (NIRS) devices in trained athletes. This descriptive cross-sectional observational multicentre multicentre study, with Balearic Islands ethics committee IB 5585\u002F24PI, will include males aged 18-65 years who have undergone ACL surgery, divided into 3 groups that: have an evolution of less than 6 months (ACL1), more than 2 years since the surgical intervention and are already practising normal physical-sports activities (ACL2) and the control group (CON) that has never suffered an ACL affectation to date. The 3 groups will perform an incremental intervallic test (4:1) on a cycloergometer or treadmill (according to the specificity of their sport), where different muscular haemodynamic variables will be assessed using 12-24 NIRS devices. The main study variables will be the muscular haemodynamic values of each muscle analysed and their correlation between them: muscular oxygen saturation, absolute capillary haemoglobin, loaded and unloaded with oxygen and relative muscular haemoglobin blood flow, loaded and unloaded with oxygen. Secondary variables will be heart rate, socio-demographic variables (age, toxic habits, injury and sports history) and subjective perception of effort (RPE-20).",[28,349,350,351,352],"ACL Injury","Hemodynamics","Oxygen Consumption Based Assessment of Hemodynamics","Exercise",[354,350,352,355,356],"Spectroscopy, Near-Infrared","Vascular resistance","Oxygen consumption","2024-09-27",{"date":359,"type":36},"2024-10-01",{"date":361,"type":22},"2024-12-02",{"date":363,"type":22},"2026-12-02",{"name":365,"class":43},"Universitat de Lleida"]