[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acl-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acl-injuries":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100596746","clinical-and-biomechanical-outcomes-of-anterior-cruciate-ligament-acl-reconstruction-associated-with-lateral-extra-articular-tenodesis-let-100596746",false,"NCT07049484","Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET)","Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET): a Short-term Prospective Arthrometric Study","LETOTT","Inclusion Criteria:\n\n* Patients undergoing isolated ACL reconstruction using gracilis and semitendinosus tendons with the over-the-top technique and LET.\n* Both male and female patients.\n* Patients who have given consent to participate in the study.\n* Age between 18 and 50 years at the time of surgery.\n\nExclusion Criteria:\n\n* Previous surgery on the same limb (meniscectomy, prior ACL reconstruction, displaced fractures).\n* Surgical technique different from Over-the-Top with LET using autologous gracilis and semitendinosus tendons.\n* Other concomitant ligament injuries requiring surgical treatment.\n* Patients undergoing additional procedures at the same time as ACL reconstruction and LET (e.g., concomitant osteotomy, meniscus transplant, cartilage procedure…).\n* Patients who did not provide informed consent.","ALL","18 Years","50 Years",{"count":21,"type":22},51,"ESTIMATED","OBSERVATIONAL","The anterior cruciate ligament (ACL) is one of the main stabilizers of the knee joint, and its injury is among the most common soft tissue injuries of the knee. Several surgical reconstruction techniques are available, utilizing various tissues as a graft for the neo-ligament, including both autografts and allografts.\n\nThe \"Over-the-top single-bundle technique with gracilis and semitendinosus tendons combined with lateral extra-articular tenodesis (LET)\" was developed in 1998 by Prof. Marcacci and Prof. Zaffagnini, and it is still the preferred method for ACL reconstruction at the Second Clinic of the Rizzoli Orthopaedic Institute.\n\nCadaveric biomechanical studies have shown that combining LET with ACL reconstruction improves knee joint stability in both the anteroposterior and rotational planes. However, a recent in vivo study has challenged this hypothesis, showing that in patients undergoing surgery, the addition of LET enhances knee stability only in the anteroposterior direction and only for a limited period of six months. At twelve months postoperatively, joint laxity appeared similar to that of patients who did not undergo the additional procedure. Furthermore, the same study did not assess rotational instability using the pivot-shift test, an essential parameter as it is closely linked to knee stability and the patient's subjective perception of surgical success.\n\nDespite the increasing use of LET in conjunction with ACL reconstruction, few studies have analyzed the short-term postoperative effects of lateral extra-articular tenodesis and its potential benefits during the early stages of rehabilitation and return to sport.\n\nThis study was conceived in response to this clinical question, with the goal of evaluating anteroposterior and rotational laxity in a group of patients who underwent ACL reconstruction combined with LET, in order to analyze clinical outcomes and, most importantly, any changes in stability during the early postoperative period.\n\nThe results aim to improve understanding of knee stability in the initial phase following surgery, providing valuable information for rehabilitation teams to optimize recovery protocols and more effectively guide return-to-sport decisions for patients undergoing both procedures.",[26,27,28],"ACL Reconstruction","Tenodesis","ACL Injuries","RECRUITING","2026-04-21",{"date":32,"type":33},"2026-04-22","ACTUAL",{"date":35,"type":33},"2026-03-24",{"date":37,"type":22},"2029-06",{"name":39,"class":40},"Stefano Zaffagnini","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100568857","treatment-of-post-traumatic-knee-osteoarthritis-with-extracorporeal-shockwave-therapy-100568857","NCT06686680","Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy","PTOA Knee","Inclusion Criteria:\n\n* Previous ACL reconstruction using an autograft or allograft in the knee with PTOA\n* Minimum of one year following ACL reconstruction surgery\n* Between ages of 18 and 55\n* No clear contraindication to complete protocol including mechanical symptoms which would limit ability to complete the study\n* Score on KOOS for 2 of 4 domains (pain, symptoms, activities of daily living (ADL), quality of life (QOL)) of 85 or lower\n* Primary pain is coming from the knee\n* Diagnosis of PTOA based on clinical diagnosis and confirmation with radiographic evidence by a medical professional prior to study enrollment. If individuals have suspected OA based on impairments such as pain, they must have a score on KOOS for 2 of 4 domains (pain, symptoms, activities of daily living (ADL), quality of life (QOL)) of 85 or lower to participate in the study.\n\nExclusion Criteria:\n\n* Have previously received injections to the knee joint within the past 3 months\n* Women who are pregnant or those who are planning to become pregnant. This is due to the fact that pregnancy will reduce participants activity after the treatment and the safety concerns related to shockwave treatment. - Participants with neuropathy affecting sensation to pain\n* Participants with a known underlying cardiac disease that could be affected by shockwave therapy\n* Chronic rheumatological conditions, immunodeficiency, severe asthma, connective tissue disorder (i.e. Ehlers-Danlos Syndrome), or other medical conditions (ex. active malignancy, severe asthma) outside of PTOA that are known to impact inflammatory state or requiring chronic use of oral or intravenous immune modulatory medications. Asthma requiring use of inhalers only is not an exclusion criteria\n* Neuropathy diagnosis that can affect response to pain\n* No active use of oral steroids or anti-inflammatories at the time of enrollment\n* Have bilateral ACL injury or reconstruction surgery, or have had ACL revision surgery\n* No active malignancy and at least five years in remission\n* Previous ESWT treatment using study treatment devices for management of knee osteoarthritis\n* Have a pacemaker, bone screws, or any other metal implants that would prohibit participation in an MRI scan or EWST\n* Non-English speaking individuals","55 Years",{"count":51,"type":22},70,"INTERVENTIONAL",[54],"NA","This study is recruiting current or former athletes who had ACL reconstruction surgery over a year ago and have been diagnosed with knee osteoarthritis (OA). We are doing the research to investigate the effects of extracorporeal shockwave therapy (ESWT) on pain, function, biomechanics, knee range of motion and strength, inflammation, and joint structure and integrity of the knee.",[57,28,58],"Knee Osteoarthristis","Post-Traumatic",[60,61,62],"Post-traumatic Knee Osteoarthritis","Extracorporeal shockwave therapy","acl","2025-12-03",{"date":65,"type":33},"2025-12-04",{"date":67,"type":33},"2025-04-01",{"date":69,"type":22},"2026-09",{"name":71,"class":40},"Spaulding Rehabilitation Hospital",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":52,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":5},"100591044","radiographic-findings-and-clinical-outcomes-after-bone-grafting-patellar-defect-in-acl-reconstruction-100591044","NCT06975306","Radiographic Findings and Clinical Outcomes After Bone Grafting Patellar Defect in ACL Reconstruction","BTB BackFill","Inclusion Criteria:\n\n* 18-40 years old,\n* male\u002Ffemale\u002Fgender neutral,\n* all races not including vulnerable\u002Fspecial consideration populations,\n* candidate for anterior cruciate ligament reconstruction with bone patellar bone autograft,\n* compliant post operative course.\n\nExclusion Criteria:\n\n* \\\u003C 18, \\>41 years of age,\n* prior bone patellar bone anterior cruciate ligament reconstruction,\n* non-compliance post-operatively,\n* nicotine dependence.","40 Years",{"count":81,"type":22},75,[54],"All patients will be randomly assigned using a computer randomization algorithm to one of two matched cohort groups. Patients will not be advised which group they belong to until after the completion of the study. One group will be treated with autologous bone graft for bone patellar-tendon bone (BTB) Anterior Cruciate Ligament Reconstruction (ACLR), and the other group will be treated with commercially available DBM (Demineralized bone matrix) putty. Patients will be enrolled from Banner University. Before and after surgery, patient reported outcomes including visual analog pain scale (VAS), Tegner-Lysholm and Cincinnati ACL Test. The principal investigator will evaluate the patients on subjective criteria such as pain and objective criteria including range of motion, arthritic changes seen on radiographs, infection, and ability to kneel.",[85,28],"Bone Graft; Complications","2025-05-14",{"date":88,"type":33},"2025-05-16",{"date":90,"type":33},"2025-02-11",{"date":92,"type":22},"2026-05-31",{"name":94,"class":40},"University of Arizona"]